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Metastatic Ovarian Carcinosarcoma

MedGen UID:
1756224
•Concept ID:
C5418887
•
Neoplastic Process

Definition

Ovarian carcinosarcoma that has spread from its original site of growth to another anatomic site. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic Ovarian Carcinosarcoma

Professional guidelines

PubMed

Past, Present, and Future of Serum Tumor Markers in Management of Ovarian Cancer: A Guide for the Radiologist.
Rao S, Smith DA, Guler E, Kikano EG, Rajdev MA, Yoest JM, Ramaiya NH, Tirumani SH
Radiographics 2021 Oct;41(6):1839-1856. doi: 10.1148/rg.2021210005. PMID: 34597221
Primary treatment and prognostic factors of carcinosarcoma of the ovary, fallopian tube, and peritoneum: a Taiwanese Gynecologic Oncology Group Study.
Lu CH, Chen IH, Chen YJ, Wang KL, Qiu JT, Lin H, Lin WC, Liou WS, Huang YF, Lin YS, Tee YT, Hung YC
Int J Gynecol Cancer 2014 Mar;24(3):506-12. doi: 10.1097/IGC.0000000000000083. PMID: 24557435

Recent clinical studies

Etiology

Preliminary study of confocal laser endomicroscopy for in vitro specimens of the endometrium.
Wen J, Yang X, Ye G, Chen R, Feng Y, Liao Q
BMC Cancer 2022 Oct 25;22(1):1094. doi: 10.1186/s12885-022-10137-x. PMID: 36284282Free PMC Article
Clinical implications of neoadjuvant chemotherapy in advanced endometrial cancer: a multi-center retrospective cohort study.
Lim H, Bang SH, Kim Y, Cho SH, Shin W, Kim SI, Kim TH, Suh DH, Lim MC, Kim JW
BMC Cancer 2022 Jun 27;22(1):703. doi: 10.1186/s12885-022-09746-3. PMID: 35761211Free PMC Article
How and where to expect endosalpingiosis intraoperatively.
Burla L, Kalaitzopoulos DR, Mrozek A, Eberhard M, Samartzis N
Fertil Steril 2022 Feb;117(2):461-462. Epub 2022 Jan 2 doi: 10.1016/j.fertnstert.2021.11.016. PMID: 34986982
Hormone Replacement Therapy in Cancer Survivors - Review of the Literature.
Deli T, Orosz M, Jakab A
Pathol Oncol Res 2020 Jan;26(1):63-78. Epub 2019 Jan 8 doi: 10.1007/s12253-018-00569-x. PMID: 30617760Free PMC Article
Pathogenesis of ovarian cancer: lessons from morphology and molecular biology and their clinical implications.
Kurman RJ, Shih IeM
Int J Gynecol Pathol 2008 Apr;27(2):151-60. doi: 10.1097/PGP.0b013e318161e4f5. PMID: 18317228Free PMC Article

Diagnosis

PRAME Expression in Cancer. A Systematic Immunohistochemical Study of >5800 Epithelial and Nonepithelial Tumors.
Kaczorowski M, Chłopek M, Kruczak A, Ryś J, Lasota J, Miettinen M
Am J Surg Pathol 2022 Nov 1;46(11):1467-1476. Epub 2022 Aug 16 doi: 10.1097/PAS.0000000000001944. PMID: 35973038Free PMC Article
Endometriosis-associated ovarian neoplasia.
Matias-Guiu X, Stewart CJR
Pathology 2018 Feb;50(2):190-204. Epub 2017 Dec 11 doi: 10.1016/j.pathol.2017.10.006. PMID: 29241974
Carcinosarcoma of the ovary: a review of the literature.
del Carmen MG, Birrer M, Schorge JO
Gynecol Oncol 2012 Apr;125(1):271-7. Epub 2011 Dec 8 doi: 10.1016/j.ygyno.2011.12.418. PMID: 22155675
Pathogenesis of ovarian cancer: lessons from morphology and molecular biology and their clinical implications.
Kurman RJ, Shih IeM
Int J Gynecol Pathol 2008 Apr;27(2):151-60. doi: 10.1097/PGP.0b013e318161e4f5. PMID: 18317228Free PMC Article
MR imaging of common and uncommon large pelvic masses.
Szklaruk J, Tamm EP, Choi H, Varavithya V
Radiographics 2003 Mar-Apr;23(2):403-24. doi: 10.1148/rg.232025089. PMID: 12640156

Therapy

Relacorilant + Nab-Paclitaxel in Patients With Recurrent, Platinum-Resistant Ovarian Cancer: A Three-Arm, Randomized, Controlled, Open-Label Phase II Study.
Colombo N, Van Gorp T, Matulonis UA, Oaknin A, Grisham RN, Fleming GF, Olawaiye AB, Nguyen DD, Greenstein AE, Custodio JM, Pashova HI, Tudor IC, Lorusso D
J Clin Oncol 2023 Oct 20;41(30):4779-4789. Epub 2023 Jun 26 doi: 10.1200/JCO.22.02624. PMID: 37364223Free PMC Article
Clinical implications of neoadjuvant chemotherapy in advanced endometrial cancer: a multi-center retrospective cohort study.
Lim H, Bang SH, Kim Y, Cho SH, Shin W, Kim SI, Kim TH, Suh DH, Lim MC, Kim JW
BMC Cancer 2022 Jun 27;22(1):703. doi: 10.1186/s12885-022-09746-3. PMID: 35761211Free PMC Article
Statistical analysis plan for the Dual mTorc Inhibition in advanCed/recurrent Epithelial ovarian, fallopian tube or primary peritoneal cancer (of clear cell, endometrioid and high-grade serous type, and carcinosarcoma) trial (DICE).
de la Rosa CN, Krell J, Day E, Clarke A, Reddi M, Webber L, Fiorentino F
Trials 2022 Jan 5;23(1):13. doi: 10.1186/s13063-021-05669-9. PMID: 34986897Free PMC Article
Hormone Replacement Therapy in Cancer Survivors - Review of the Literature.
Deli T, Orosz M, Jakab A
Pathol Oncol Res 2020 Jan;26(1):63-78. Epub 2019 Jan 8 doi: 10.1007/s12253-018-00569-x. PMID: 30617760Free PMC Article
Pathogenesis of ovarian cancer: lessons from morphology and molecular biology and their clinical implications.
Kurman RJ, Shih IeM
Int J Gynecol Pathol 2008 Apr;27(2):151-60. doi: 10.1097/PGP.0b013e318161e4f5. PMID: 18317228Free PMC Article

Prognosis

Gynecological carcinosarcomas: Overview and future perspectives.
Collet L, González López AM, Romeo C, Méeus P, Chopin N, Rossi L, Rowinski E, Serre AA, Rannou C, Buisson A, Treilleux I, Ray-Coquard I
Bull Cancer 2023 Nov;110(11):1215-1226. Epub 2023 Sep 9 doi: 10.1016/j.bulcan.2023.07.005. PMID: 37679206
Clinical implications of neoadjuvant chemotherapy in advanced endometrial cancer: a multi-center retrospective cohort study.
Lim H, Bang SH, Kim Y, Cho SH, Shin W, Kim SI, Kim TH, Suh DH, Lim MC, Kim JW
BMC Cancer 2022 Jun 27;22(1):703. doi: 10.1186/s12885-022-09746-3. PMID: 35761211Free PMC Article
Endometriosis-associated ovarian neoplasia.
Matias-Guiu X, Stewart CJR
Pathology 2018 Feb;50(2):190-204. Epub 2017 Dec 11 doi: 10.1016/j.pathol.2017.10.006. PMID: 29241974
Carcinosarcoma of the ovary: a review of the literature.
del Carmen MG, Birrer M, Schorge JO
Gynecol Oncol 2012 Apr;125(1):271-7. Epub 2011 Dec 8 doi: 10.1016/j.ygyno.2011.12.418. PMID: 22155675
Endometrial and ovarian carcinomas with undifferentiated components: clinically aggressive and frequently underrecognized neoplasms.
Tafe LJ, Garg K, Chew I, Tornos C, Soslow RA
Mod Pathol 2010 Jun;23(6):781-9. Epub 2010 Mar 19 doi: 10.1038/modpathol.2010.41. PMID: 20305618

Clinical prediction guides

Preliminary study of confocal laser endomicroscopy for in vitro specimens of the endometrium.
Wen J, Yang X, Ye G, Chen R, Feng Y, Liao Q
BMC Cancer 2022 Oct 25;22(1):1094. doi: 10.1186/s12885-022-10137-x. PMID: 36284282Free PMC Article
How and where to expect endosalpingiosis intraoperatively.
Burla L, Kalaitzopoulos DR, Mrozek A, Eberhard M, Samartzis N
Fertil Steril 2022 Feb;117(2):461-462. Epub 2022 Jan 2 doi: 10.1016/j.fertnstert.2021.11.016. PMID: 34986982
Endometriosis-associated ovarian neoplasia.
Matias-Guiu X, Stewart CJR
Pathology 2018 Feb;50(2):190-204. Epub 2017 Dec 11 doi: 10.1016/j.pathol.2017.10.006. PMID: 29241974
High-grade serous carcinomas arise in the mouse oviduct via defects linked to the human disease.
Zhai Y, Wu R, Kuick R, Sessine MS, Schulman S, Green M, Fearon ER, Cho KR
J Pathol 2017 Sep;243(1):16-25. Epub 2017 Jul 25 doi: 10.1002/path.4927. PMID: 28608929Free PMC Article
Endometrial and ovarian carcinomas with undifferentiated components: clinically aggressive and frequently underrecognized neoplasms.
Tafe LJ, Garg K, Chew I, Tornos C, Soslow RA
Mod Pathol 2010 Jun;23(6):781-9. Epub 2010 Mar 19 doi: 10.1038/modpathol.2010.41. PMID: 20305618

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