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Metastatic Malignant Mixed Mesodermal (Mullerian) Tumor

MedGen UID:
1747700
•Concept ID:
C5418883
•
Neoplastic Process

Definition

A malignant mixed mesodermal (Mullerian) tumor that has spread from its original site of growth to another anatomic site. [from NCI]

Recent clinical studies

Etiology

Ovarian sex cord-stromal tumours and their mimics.
Young RH
Pathology 2018 Jan;50(1):5-15. Epub 2017 Nov 11 doi: 10.1016/j.pathol.2017.09.007. PMID: 29132723
Carcinosarcoma (malignant mixed mesodermal tumor) of the uterus: clinicoimmunohistochemical and histogenetic characteristics.
Kedzia W, Pruski D, Iwaniec K, Przybylski M, Friebe Z, Rajpert-Kedzia H
Folia Histochem Cytobiol 2012;50(4):513-8. doi: 10.5603/19688. PMID: 23264213
Pathogenesis of ovarian cancer: lessons from morphology and molecular biology and their clinical implications.
Kurman RJ, Shih IeM
Int J Gynecol Pathol 2008 Apr;27(2):151-60. doi: 10.1097/PGP.0b013e318161e4f5. PMID: 18317228Free PMC Article
Malignant mixed mullerian tumor of the uterus in a patient taking raloxifene.
Goldman NA, de Los Angeles MM, Jones JG, Goldberg GL
Obstet Gynecol 2005 May;105(5 Pt 2):1278-80. doi: 10.1097/01.AOG.0000160480.55365.a8. PMID: 15863610
The significance of epithelial differentiation in mixed mesodermal tumors of the uterus. A clinicopathologic and immunohistochemical study.
Bitterman P, Chun B, Kurman RJ
Am J Surg Pathol 1990 Apr;14(4):317-28. doi: 10.1097/00000478-199004000-00002. PMID: 2157343

Diagnosis

Ovarian sex cord-stromal tumours and their mimics.
Young RH
Pathology 2018 Jan;50(1):5-15. Epub 2017 Nov 11 doi: 10.1016/j.pathol.2017.09.007. PMID: 29132723
Carcinosarcoma (malignant mixed mesodermal tumor) of the uterus: clinicoimmunohistochemical and histogenetic characteristics.
Kedzia W, Pruski D, Iwaniec K, Przybylski M, Friebe Z, Rajpert-Kedzia H
Folia Histochem Cytobiol 2012;50(4):513-8. doi: 10.5603/19688. PMID: 23264213
Malignant mixed mullerian tumor of the cervix including components of a rhabdomyosarcoma: case report and literature review.
Lee SH, Kim J, Kim JH, Lee KH, Park JS, Hur SY
Eur J Gynaecol Oncol 2010;31(4):462-6. PMID: 20882897
Malignant mixed mullerian tumor of the uterus in a patient taking raloxifene.
Goldman NA, de Los Angeles MM, Jones JG, Goldberg GL
Obstet Gynecol 2005 May;105(5 Pt 2):1278-80. doi: 10.1097/01.AOG.0000160480.55365.a8. PMID: 15863610
Coexistent choriocarcinoma and malignant mixed mesodermal tumor of the uterus.
Nguyen CP, Levi AW, Montz FJ, Bristow RE
Gynecol Oncol 2000 Dec;79(3):499-503. doi: 10.1006/gyno.2000.5976. PMID: 11104628

Therapy

Pathogenesis of ovarian cancer: lessons from morphology and molecular biology and their clinical implications.
Kurman RJ, Shih IeM
Int J Gynecol Pathol 2008 Apr;27(2):151-60. doi: 10.1097/PGP.0b013e318161e4f5. PMID: 18317228Free PMC Article
Malignant mixed mullerian tumor of the uterus in a patient taking raloxifene.
Goldman NA, de Los Angeles MM, Jones JG, Goldberg GL
Obstet Gynecol 2005 May;105(5 Pt 2):1278-80. doi: 10.1097/01.AOG.0000160480.55365.a8. PMID: 15863610
Systemic therapy for advanced uterine sarcoma: a systematic review of the literature.
Kanjeekal S, Chambers A, Fung MF, Verma S
Gynecol Oncol 2005 May;97(2):624-37. doi: 10.1016/j.ygyno.2005.01.041. PMID: 15863170
Endometrial mesodermal mixed tumor occurring after tamoxifen treatment: report on a new case and review of the literature.
Dumortier J, Freyer G, Sasco AJ, Frappart L, Zénone T, Romestaing P, Trillet-Lenoir V
Ann Oncol 2000 Mar;11(3):355-8. doi: 10.1023/a:1008338231169. PMID: 10811505
Cisplatin therapy for disseminated mixed mesodermal sarcoma of the uterus.
Gershenson DM, Kavanagh JJ, Copeland LJ, Edwards CL, Stringer CA, Wharton JT
J Clin Oncol 1987 Apr;5(4):618-21. doi: 10.1200/JCO.1987.5.4.618. PMID: 3559652

Prognosis

Carcinosarcoma (malignant mixed mesodermal tumor) of the uterus: clinicoimmunohistochemical and histogenetic characteristics.
Kedzia W, Pruski D, Iwaniec K, Przybylski M, Friebe Z, Rajpert-Kedzia H
Folia Histochem Cytobiol 2012;50(4):513-8. doi: 10.5603/19688. PMID: 23264213
Malignant mixed mullerian tumor of the cervix including components of a rhabdomyosarcoma: case report and literature review.
Lee SH, Kim J, Kim JH, Lee KH, Park JS, Hur SY
Eur J Gynaecol Oncol 2010;31(4):462-6. PMID: 20882897
Primary peritoneal malignant mixed mesodermal (Müllerian) tumor.
Hussein MR, Hussein SR, Abd-Elwahed AR
Tumori 2009 Jul-Aug;95(4):525-31. doi: 10.1177/030089160909500421. PMID: 19856669
Malignant mixed mullerian tumor of the uterus in a patient taking raloxifene.
Goldman NA, de Los Angeles MM, Jones JG, Goldberg GL
Obstet Gynecol 2005 May;105(5 Pt 2):1278-80. doi: 10.1097/01.AOG.0000160480.55365.a8. PMID: 15863610
Coexistent choriocarcinoma and malignant mixed mesodermal tumor of the uterus.
Nguyen CP, Levi AW, Montz FJ, Bristow RE
Gynecol Oncol 2000 Dec;79(3):499-503. doi: 10.1006/gyno.2000.5976. PMID: 11104628

Clinical prediction guides

Carcinosarcoma (malignant mixed mesodermal tumor) of the uterus: clinicoimmunohistochemical and histogenetic characteristics.
Kedzia W, Pruski D, Iwaniec K, Przybylski M, Friebe Z, Rajpert-Kedzia H
Folia Histochem Cytobiol 2012;50(4):513-8. doi: 10.5603/19688. PMID: 23264213
Endometrial mesodermal mixed tumor occurring after tamoxifen treatment: report on a new case and review of the literature.
Dumortier J, Freyer G, Sasco AJ, Frappart L, Zénone T, Romestaing P, Trillet-Lenoir V
Ann Oncol 2000 Mar;11(3):355-8. doi: 10.1023/a:1008338231169. PMID: 10811505
Simultaneous endometrial malignant mixed mesodermal tumor and ovarian serous adenocarcinoma.
Krigman HR, Coogan AC, Marks JR
Arch Pathol Lab Med 1995 Jan;119(1):99-103. PMID: 7802567
Primary malignant mixed Müllerian tumor (metaplastic carcinoma) of the female peritoneum. A clinical, pathologic, and immunohistochemical study of three cases and a review of the literature.
Garamvoelgyi E, Guillou L, Gebhard S, Salmeron M, Seematter RJ, Hadji MH
Cancer 1994 Aug 1;74(3):854-63. doi: 10.1002/1097-0142(19940801)74:3<854::aid-cncr2820740311>3.0.co;2-r. PMID: 7518735
Mixed mesodermal tumor of the ovary: analysis of prognostic factors in 31 cases.
Barakat RR, Rubin SC, Wong G, Saigo PE, Markman M, Hoskins WJ
Obstet Gynecol 1992 Oct;80(4):660-4. PMID: 1328975

Recent systematic reviews

Systemic therapy for advanced uterine sarcoma: a systematic review of the literature.
Kanjeekal S, Chambers A, Fung MF, Verma S
Gynecol Oncol 2005 May;97(2):624-37. doi: 10.1016/j.ygyno.2005.01.041. PMID: 15863170

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