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Maxillofacial Chondromyxoid Fibroma

MedGen UID:
1767922
•Concept ID:
C5420438
•
Neoplastic Process

Definition

An uncommon benign cartilaginous neoplasm arising in a maxillofacial bone. It is characterized by the presence of spindle-shaped or stellate chondrocytes, a lobulated growth pattern, myxoid stroma formation, and sometimes multinucleated giant cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMaxillofacial Chondromyxoid Fibroma

Recent clinical studies

Etiology

Unilocular anterior mandibular swelling.
Khatana S, Singh V, Gupta A
Int J Pediatr Otorhinolaryngol 2013 Jun;77(6):964-71. Epub 2013 Apr 6 doi: 10.1016/j.ijporl.2013.03.018. PMID: 23571019
Reverse facial artery-submental artery mandibular osteomuscular flap for the reconstruction of maxillary defects following the removal of benign tumors.
Chen WL, Ye JT, Yang ZH, Huang ZQ, Zhang DM, Wang K
Head Neck 2009 Jun;31(6):725-31. doi: 10.1002/hed.21025. PMID: 19260126
Pedicled mandibular osteomuscular flap for zygomatic reconstruction through a modified Weber-Ferguson incision.
Chen WL, Chen ZW, Yang ZH, Huang ZQ, Li JS, Zhang B, Wang JG
J Craniofac Surg 2008 Jan;19(1):235-40. doi: 10.1097/SCS.0b013e31815ca211. PMID: 18216694
Chondromyxoid fibroma of the zygoma: a case report.
Bucci T, Dell'Aversana Orabona G, Insabato L, Califano L
Int J Oral Maxillofac Surg 2006 Jun;35(6):569-71. Epub 2005 Dec 15 doi: 10.1016/j.ijom.2005.10.006. PMID: 16343851

Diagnosis

Oestrogen receptor expression distinguishes non-ossifying fibroma from other giant cell containing bone tumours.
Cleven AHG, Schreuder WH, Groen E, de Lange J, Briaire-de Bruijn IH, Bovée JVMG
Virchows Arch 2022 Oct;481(4):671-675. Epub 2022 May 25 doi: 10.1007/s00428-022-03341-4. PMID: 35612673Free PMC Article
Unilocular anterior mandibular swelling.
Khatana S, Singh V, Gupta A
Int J Pediatr Otorhinolaryngol 2013 Jun;77(6):964-71. Epub 2013 Apr 6 doi: 10.1016/j.ijporl.2013.03.018. PMID: 23571019
Chondromyxoid fibroma of the zygoma: a case report.
Bucci T, Dell'Aversana Orabona G, Insabato L, Califano L
Int J Oral Maxillofac Surg 2006 Jun;35(6):569-71. Epub 2005 Dec 15 doi: 10.1016/j.ijom.2005.10.006. PMID: 16343851
Chondromyxoid fibroma of the mandible.
Macan D, Cabov T, Uglesić V, Manojlović S, Kaleb S, Spicek J
Br J Oral Maxillofac Surg 2003 Aug;41(4):261-3. doi: 10.1016/s0266-4356(03)00098-6. PMID: 12946671

Prognosis

Reverse facial artery-submental artery mandibular osteomuscular flap for the reconstruction of maxillary defects following the removal of benign tumors.
Chen WL, Ye JT, Yang ZH, Huang ZQ, Zhang DM, Wang K
Head Neck 2009 Jun;31(6):725-31. doi: 10.1002/hed.21025. PMID: 19260126
Pedicled mandibular osteomuscular flap for zygomatic reconstruction through a modified Weber-Ferguson incision.
Chen WL, Chen ZW, Yang ZH, Huang ZQ, Li JS, Zhang B, Wang JG
J Craniofac Surg 2008 Jan;19(1):235-40. doi: 10.1097/SCS.0b013e31815ca211. PMID: 18216694
Chondromyxoid fibroma of the zygoma: a case report.
Bucci T, Dell'Aversana Orabona G, Insabato L, Califano L
Int J Oral Maxillofac Surg 2006 Jun;35(6):569-71. Epub 2005 Dec 15 doi: 10.1016/j.ijom.2005.10.006. PMID: 16343851

Clinical prediction guides

Oestrogen receptor expression distinguishes non-ossifying fibroma from other giant cell containing bone tumours.
Cleven AHG, Schreuder WH, Groen E, de Lange J, Briaire-de Bruijn IH, Bovée JVMG
Virchows Arch 2022 Oct;481(4):671-675. Epub 2022 May 25 doi: 10.1007/s00428-022-03341-4. PMID: 35612673Free PMC Article

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