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Breast Florid Lobular Carcinoma In Situ

MedGen UID:
1785316
•Concept ID:
C5446878
•
Neoplastic Process

Definition

Breast lobular carcinoma in situ characterized by the presence of neoplastic cells with cytological features identical to classic lobular carcinoma in situ, but with marked distention of terminal ductal lobular units or ducts. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBreast Florid Lobular Carcinoma In Situ

Professional guidelines

PubMed

Lobular carcinoma in situ: diagnostic criteria and molecular correlates.
Sokolova A, Lakhani SR
Mod Pathol 2021 Jan;34(Suppl 1):8-14. Epub 2020 Oct 6 doi: 10.1038/s41379-020-00689-3. PMID: 33024303
Non-invasive lobular neoplasia of the breast: Morphologic features, clinical presentation, and management dilemmas.
Calle C, Kuba MG, Brogi E
Breast J 2020 Jun;26(6):1148-1155. Epub 2020 Jun 4 doi: 10.1111/tbj.13857. PMID: 32500575
Current Concepts in Diagnosis, Molecular Features, and Management of Lobular Carcinoma In Situ of the Breast With a Discussion of Morphologic Variants.
Ginter PS, D'Alfonso TM
Arch Pathol Lab Med 2017 Dec;141(12):1668-1678. Epub 2017 Jun 2 doi: 10.5858/arpa.2016-0421-RA. PMID: 28574280

Recent clinical studies

Etiology

Update on Lobular Neoplasia.
Heller SL, Gao Y
Radiographics 2023 Oct;43(10):e220188. doi: 10.1148/rg.220188. PMID: 37676825
Morphologic subtypes of lobular carcinoma in situ diagnosed on core needle biopsy: clinicopathologic features and findings at follow-up excision.
Kuba MG, Murray MP, Coffey K, Calle C, Morrow M, Brogi E
Mod Pathol 2021 Aug;34(8):1495-1506. Epub 2021 Apr 6 doi: 10.1038/s41379-021-00796-9. PMID: 33824462Free PMC Article
Lobular carcinoma in situ: diagnostic criteria and molecular correlates.
Sokolova A, Lakhani SR
Mod Pathol 2021 Jan;34(Suppl 1):8-14. Epub 2020 Oct 6 doi: 10.1038/s41379-020-00689-3. PMID: 33024303
Current Concepts in Diagnosis, Molecular Features, and Management of Lobular Carcinoma In Situ of the Breast With a Discussion of Morphologic Variants.
Ginter PS, D'Alfonso TM
Arch Pathol Lab Med 2017 Dec;141(12):1668-1678. Epub 2017 Jun 2 doi: 10.5858/arpa.2016-0421-RA. PMID: 28574280
Neuroendocrine Tumors of the Breast.
Visscher DW, Yasir S
Endocr Pathol 2017 Jun;28(2):121-127. doi: 10.1007/s12022-017-9477-4. PMID: 28389994

Diagnosis

Update on Lobular Neoplasia.
Heller SL, Gao Y
Radiographics 2023 Oct;43(10):e220188. doi: 10.1148/rg.220188. PMID: 37676825
Lobular carcinoma in situ: diagnostic criteria and molecular correlates.
Sokolova A, Lakhani SR
Mod Pathol 2021 Jan;34(Suppl 1):8-14. Epub 2020 Oct 6 doi: 10.1038/s41379-020-00689-3. PMID: 33024303
Pre-operative management of Pleomorphic and florid lobular carcinoma in situ of the breast: Report of a large multi-institutional series and review of the literature.
Foschini MP, Miglio R, Fiore R, Baldovini C, Castellano I, Callagy G, Bianchi S, Kaya H, Amendoeira I, Querzoli P, Poli F, Scatena C, Cordoba A, Pietribiasi F, Kovács A, Faistova H, Cserni G, Quinn C
Eur J Surg Oncol 2019 Dec;45(12):2279-2286. Epub 2019 Jul 5 doi: 10.1016/j.ejso.2019.07.011. PMID: 31301938
Current Concepts in Diagnosis, Molecular Features, and Management of Lobular Carcinoma In Situ of the Breast With a Discussion of Morphologic Variants.
Ginter PS, D'Alfonso TM
Arch Pathol Lab Med 2017 Dec;141(12):1668-1678. Epub 2017 Jun 2 doi: 10.5858/arpa.2016-0421-RA. PMID: 28574280
Subareolar Sclerosing Ductal Hyperplasia.
Cheng E, D'Alfonso TM, Arafah M, Marrero Rolon R, Ginter PS, Hoda SA
Int J Surg Pathol 2017 Feb;25(1):4-11. Epub 2016 Nov 10 doi: 10.1177/1066896916677288. PMID: 27831531

Therapy

Automated image morphometry of lobular breast carcinoma.
Rajesh L, Dey P, Joshi K
Anal Quant Cytol Histol 2002 Apr;24(2):81-4. PMID: 12026054
Florid papillomatosis of male nipple after diethylstilbestrol therapy.
Waldo ED, Sidhu GS, Hu AW
Arch Pathol 1975 Jul;99(7):364-6. PMID: 167700

Prognosis

The morphologic spectrum of lobular carcinoma in situ (LCIS) observations on clinical significance, management implications and diagnostic pitfalls of classic, florid and pleomorphic LCIS.
Brogi E
Virchows Arch 2022 Dec;481(6):823-837. Epub 2022 May 14 doi: 10.1007/s00428-022-03299-3. PMID: 35567633
Apocrine Variant of Pleomorphic Lobular Carcinoma In Situ: Further Clinical, Histopathologic, Immunohistochemical, and Molecular Characterization of an Emerging Entity.
Zhong E, Solomon JP, Cheng E, Baum J, Song W, Hoda SA
Am J Surg Pathol 2020 Aug;44(8):1092-1103. doi: 10.1097/PAS.0000000000001493. PMID: 32317606
Papillary Lesions of the Male Breast: A Study of 117 Cases and Brief Review of the Literature Demonstrate a Broad Clinicopathologic Spectrum.
Zhong E, Cheng E, Goldfischer M, Hoda SA
Am J Surg Pathol 2020 Jan;44(1):68-76. doi: 10.1097/PAS.0000000000001340. PMID: 31403965
Neuroendocrine Tumors of the Breast.
Visscher DW, Yasir S
Endocr Pathol 2017 Jun;28(2):121-127. doi: 10.1007/s12022-017-9477-4. PMID: 28389994
The florid subtype of lobular carcinoma in situ: marker or precursor for invasive lobular carcinoma?
Bagaria SP, Shamonki J, Kinnaird M, Ray PS, Giuliano AE
Ann Surg Oncol 2011 Jul;18(7):1845-51. Epub 2011 Feb 2 doi: 10.1245/s10434-011-1563-0. PMID: 21287281

Clinical prediction guides

Management of Lobular Neoplasia Diagnosed by Core Biopsy.
Jani C, Lotz M, Keates S, Gupta Y, Walker A, Al Omari O, Parvez A, Patel D, Gnata M, Perry J, Khorashadi L, Weissmann L, Pories SE
Breast J 2023;2023:8185446. Epub 2023 Apr 18 doi: 10.1155/2023/8185446. PMID: 37114120Free PMC Article
The morphologic spectrum of lobular carcinoma in situ (LCIS) observations on clinical significance, management implications and diagnostic pitfalls of classic, florid and pleomorphic LCIS.
Brogi E
Virchows Arch 2022 Dec;481(6):823-837. Epub 2022 May 14 doi: 10.1007/s00428-022-03299-3. PMID: 35567633
Evaluating agreement, histological features, and relevance of separating pleomorphic and florid lobular carcinoma in situ subtypes.
Singh K, Paquette C, Kalife ET, Wang Y, Mangray S, Quddus MR, Steinhoff MM
Hum Pathol 2018 Aug;78:163-170. Epub 2018 May 9 doi: 10.1016/j.humpath.2018.04.026. PMID: 29753007
Microinvasive lobular carcinoma arising in a fibroadenoma.
Hayes BD, Quinn CM
Int J Surg Pathol 2013 Aug;21(4):419-21. Epub 2013 Jan 24 doi: 10.1177/1066896912471854. PMID: 23349469
Differential expression of follistatin and FLRG in human breast proliferative disorders.
Bloise E, Couto HL, Massai L, Ciarmela P, Mencarelli M, Borges LE, Muscettola M, Grasso G, Amaral VF, Cassali GD, Petraglia F, Reis FM
BMC Cancer 2009 Sep 9;9:320. doi: 10.1186/1471-2407-9-320. PMID: 19740438Free PMC Article

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