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Lobular breast carcinoma in situ

MedGen UID:
79007
•Concept ID:
C0279563
•
Neoplastic Process
Synonyms: Lobular carcinoma in situ; Lobular carcinoma in situ of breast
SNOMED CT: Lobular carcinoma in situ of breast (109888004); LCIS (lobular carcinoma in situ) of breast (109888004)
 
HPO: HP:0030076
Monarch Initiative: MONDO:0006270

Definition

A non-invasive adenocarcinoma of the breast characterized by a proliferation of monomorphic cells completely filling the lumina. The overall lobular architecture is preserved. It is frequently multifocal (90% in some series) and bilateral. It seldom becomes invasive; however there is an increased risk of infiltrating ductal adenocarcinoma. [from NCI]

Professional guidelines

PubMed

European guidelines for the diagnosis, treatment and follow-up of breast lesions with uncertain malignant potential (B3 lesions) developed jointly by EUSOMA, EUSOBI, ESP (BWG) and ESSO.
Rubio IT, Wyld L, Marotti L, Athanasiou A, Regitnig P, Catanuto G, Schoones JW, Zambon M, Camps J, Santini D, Dietz J, Sardanelli F, Varga Z, Smidt M, Sharma N, Shaaban AM, Gilbert F
Eur J Surg Oncol 2024 Jan;50(1):107292. Epub 2023 Nov 27 doi: 10.1016/j.ejso.2023.107292. PMID: 38061151
Diagnosis and Management of High-Risk Breast Lesions.
Thomas PS
J Natl Compr Canc Netw 2018 Nov;16(11):1391-1396. doi: 10.6004/jnccn.2018.7099. PMID: 30442737
Treatment of breast cancer.
Maughan KL, Lutterbie MA, Ham PS
Am Fam Physician 2010 Jun 1;81(11):1339-46. PMID: 20521754

Recent clinical studies

Etiology

Octreotide LAR and tamoxifen versus tamoxifen in phase III randomize early breast cancer trials: NCIC CTG MA.14 and NSABP B-29.
Chapman JA, Costantino JP, Dong B, Margolese RG, Pritchard KI, Shepherd LE, Gelmon KA, Wolmark N, Pollak MN
Breast Cancer Res Treat 2015 Sep;153(2):353-60. Epub 2015 Aug 15 doi: 10.1007/s10549-015-3547-4. PMID: 26276354Free PMC Article
The risk of a contralateral breast cancer among women diagnosed with ductal and lobular breast carcinoma in situ: data from the Connecticut Tumor Registry.
Claus EB, Stowe M, Carter D, Holford T
Breast 2003 Dec;12(6):451-6. doi: 10.1016/s0960-9776(03)00152-8. PMID: 14659121

Diagnosis

Ocular Tumor in a Woman With Breast and Kidney Carcinomas.
Zaloga AR, Card KR, Shields CL
JAMA Ophthalmol 2023 Feb 1;141(2):208-209. doi: 10.1001/jamaophthalmol.2022.5544. PMID: 36547944
Imaging in situ breast carcinoma (with or without an invasive component) with technetium-99m pentavalent dimercaptosuccinic acid and technetium-99m 2-methoxy isobutyl isonitrile scintimammography.
Papantoniou V, Tsiouris S, Mainta E, Valotassiou V, Souvatzoglou M, Sotiropoulou M, Nakopoulou L, Lazaris D, Louvrou A, Melissinou M, Tzannetaki A, Pirmettis I, Koutsikos J, Zerva C
Breast Cancer Res 2005;7(1):R33-45. Epub 2004 Nov 8 doi: 10.1186/bcr948. PMID: 15642168Free PMC Article
The risk of a contralateral breast cancer among women diagnosed with ductal and lobular breast carcinoma in situ: data from the Connecticut Tumor Registry.
Claus EB, Stowe M, Carter D, Holford T
Breast 2003 Dec;12(6):451-6. doi: 10.1016/s0960-9776(03)00152-8. PMID: 14659121

Therapy

Octreotide LAR and tamoxifen versus tamoxifen in phase III randomize early breast cancer trials: NCIC CTG MA.14 and NSABP B-29.
Chapman JA, Costantino JP, Dong B, Margolese RG, Pritchard KI, Shepherd LE, Gelmon KA, Wolmark N, Pollak MN
Breast Cancer Res Treat 2015 Sep;153(2):353-60. Epub 2015 Aug 15 doi: 10.1007/s10549-015-3547-4. PMID: 26276354Free PMC Article
Imaging in situ breast carcinoma (with or without an invasive component) with technetium-99m pentavalent dimercaptosuccinic acid and technetium-99m 2-methoxy isobutyl isonitrile scintimammography.
Papantoniou V, Tsiouris S, Mainta E, Valotassiou V, Souvatzoglou M, Sotiropoulou M, Nakopoulou L, Lazaris D, Louvrou A, Melissinou M, Tzannetaki A, Pirmettis I, Koutsikos J, Zerva C
Breast Cancer Res 2005;7(1):R33-45. Epub 2004 Nov 8 doi: 10.1186/bcr948. PMID: 15642168Free PMC Article

Prognosis

Octreotide LAR and tamoxifen versus tamoxifen in phase III randomize early breast cancer trials: NCIC CTG MA.14 and NSABP B-29.
Chapman JA, Costantino JP, Dong B, Margolese RG, Pritchard KI, Shepherd LE, Gelmon KA, Wolmark N, Pollak MN
Breast Cancer Res Treat 2015 Sep;153(2):353-60. Epub 2015 Aug 15 doi: 10.1007/s10549-015-3547-4. PMID: 26276354Free PMC Article
Imaging in situ breast carcinoma (with or without an invasive component) with technetium-99m pentavalent dimercaptosuccinic acid and technetium-99m 2-methoxy isobutyl isonitrile scintimammography.
Papantoniou V, Tsiouris S, Mainta E, Valotassiou V, Souvatzoglou M, Sotiropoulou M, Nakopoulou L, Lazaris D, Louvrou A, Melissinou M, Tzannetaki A, Pirmettis I, Koutsikos J, Zerva C
Breast Cancer Res 2005;7(1):R33-45. Epub 2004 Nov 8 doi: 10.1186/bcr948. PMID: 15642168Free PMC Article

Clinical prediction guides

Imaging in situ breast carcinoma (with or without an invasive component) with technetium-99m pentavalent dimercaptosuccinic acid and technetium-99m 2-methoxy isobutyl isonitrile scintimammography.
Papantoniou V, Tsiouris S, Mainta E, Valotassiou V, Souvatzoglou M, Sotiropoulou M, Nakopoulou L, Lazaris D, Louvrou A, Melissinou M, Tzannetaki A, Pirmettis I, Koutsikos J, Zerva C
Breast Cancer Res 2005;7(1):R33-45. Epub 2004 Nov 8 doi: 10.1186/bcr948. PMID: 15642168Free PMC Article

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