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Cervical Squamous Cell Carcinoma, Not Otherwise Specified

MedGen UID:
1793102
•Concept ID:
C5556661
•
Neoplastic Process
Synonym: Cervical Squamous Cell Carcinoma, NOS

Definition

Cervical squamous cell carcinoma in which information on the p16 immunohistochemistry or HPV testing status is not available. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCervical Squamous Cell Carcinoma, Not Otherwise Specified

Professional guidelines

PubMed

HPV-associated oropharyngeal cancer: epidemiology, molecular biology and clinical management.
Lechner M, Liu J, Masterson L, Fenton TR
Nat Rev Clin Oncol 2022 May;19(5):306-327. Epub 2022 Feb 1 doi: 10.1038/s41571-022-00603-7. PMID: 35105976Free PMC Article
Delineation of the primary tumour Clinical Target Volumes (CTV-P) in laryngeal, hypopharyngeal, oropharyngeal and oral cavity squamous cell carcinoma: AIRO, CACA, DAHANCA, EORTC, GEORCC, GORTEC, HKNPCSG, HNCIG, IAG-KHT, LPRHHT, NCIC CTG, NCRI, NRG Oncology, PHNS, SBRT, SOMERA, SRO, SSHNO, TROG consensus guidelines.
Grégoire V, Evans M, Le QT, Bourhis J, Budach V, Chen A, Eisbruch A, Feng M, Giralt J, Gupta T, Hamoir M, Helito JK, Hu C, Hunter K, Johansen J, Kaanders J, Laskar SG, Lee A, Maingon P, Mäkitie A, Micciche' F, Nicolai P, O'Sullivan B, Poitevin A, Porceddu S, Składowski K, Tribius S, Waldron J, Wee J, Yao M, Yom SS, Zimmermann F, Grau C
Radiother Oncol 2018 Jan;126(1):3-24. Epub 2017 Nov 24 doi: 10.1016/j.radonc.2017.10.016. PMID: 29180076
Head and Neck Squamous Cell Carcinoma: Update on Epidemiology, Diagnosis, and Treatment.
Marur S, Forastiere AA
Mayo Clin Proc 2016 Mar;91(3):386-96. doi: 10.1016/j.mayocp.2015.12.017. PMID: 26944243

Recent clinical studies

Etiology

High-Risk Cutaneous Squamous Cell Carcinoma of the Head and Neck: A Clinical Review.
Yan F, Tillman BN, Nijhawan RI, Srivastava D, Sher DJ, Avkshtol V, Homsi J, Bishop JA, Wynings EM, Lee R, Myers LL, Day AT
Ann Surg Oncol 2021 Dec;28(13):9009-9030. Epub 2021 Jun 30 doi: 10.1245/s10434-021-10108-9. PMID: 34195900
Palliative Radiotherapy for Cutaneous Squamous Cell Carcinoma of the Head-and-Neck Region.
Staackmann C, Schild SE, Rades D
In Vivo 2021 Jul-Aug;35(4):2283-2288. doi: 10.21873/invivo.12501. PMID: 34182507Free PMC Article
Incidence and clinical predictors of cystic squamous cell carcinoma metastases in lateral cervical cysts.
Stefanicka P, Gnojcakova N, Kurinec F, Profant M
J Laryngol Otol 2019 May;133(5):430-435. Epub 2019 Apr 22 doi: 10.1017/S0022215119000823. PMID: 31006395
Supraglottic Squamous Cell Carcinoma: A Population-Based Study of 22,675 Cases.
Patel TD, Echanique KA, Yip C, Hsueh WD, Baredes S, Park RCW, Eloy JA
Laryngoscope 2019 Aug;129(8):1822-1827. Epub 2018 Dec 11 doi: 10.1002/lary.27592. PMID: 30536822
Metastatic cutaneous squamous cell carcinoma to the parotid and cervical lymph nodes: treatment and outcomes.
Bumpous J
Curr Opin Otolaryngol Head Neck Surg 2009 Apr;17(2):122-5. doi: 10.1097/MOO.0b013e32832924e0. PMID: 19346945

Diagnosis

High-Risk Cutaneous Squamous Cell Carcinoma of the Head and Neck: A Clinical Review.
Yan F, Tillman BN, Nijhawan RI, Srivastava D, Sher DJ, Avkshtol V, Homsi J, Bishop JA, Wynings EM, Lee R, Myers LL, Day AT
Ann Surg Oncol 2021 Dec;28(13):9009-9030. Epub 2021 Jun 30 doi: 10.1245/s10434-021-10108-9. PMID: 34195900
Imaging spectrum of NUT carcinomas.
Virarkar M, Saleh M, Ramani NS, Morani AC, Bhosale P
Clin Imaging 2020 Nov;67:198-206. Epub 2020 Aug 2 doi: 10.1016/j.clinimag.2020.07.025. PMID: 32866821
Squamous Cell Carcinoma: PET/CT and PET/MRI of the Pretreatment and Post-Treatment Neck.
Traylor KS, Koontz N, Mosier K
Semin Ultrasound CT MR 2019 Oct;40(5):400-413. Epub 2019 Jul 17 doi: 10.1053/j.sult.2019.07.004. PMID: 31635767
Supraglottic Squamous Cell Carcinoma: A Population-Based Study of 22,675 Cases.
Patel TD, Echanique KA, Yip C, Hsueh WD, Baredes S, Park RCW, Eloy JA
Laryngoscope 2019 Aug;129(8):1822-1827. Epub 2018 Dec 11 doi: 10.1002/lary.27592. PMID: 30536822
Cervical lymph node evaluation and diagnosis.
Bryson TC, Shah GV, Srinivasan A, Mukherji SK
Otolaryngol Clin North Am 2012 Dec;45(6):1363-83. doi: 10.1016/j.otc.2012.08.007. PMID: 23153753

Therapy

Xevinapant or placebo plus chemoradiotherapy in locally advanced squamous cell carcinoma of the head and neck: TrilynX phase III study design.
Bourhis J, Burtness B, Licitra LF, Nutting C, Schoenfeld JD, Omar M, Bouisset F, Nauwelaerts H, Urfer Y, Zanna C, Cohen EE
Future Oncol 2022 May;18(14):1669-1678. Epub 2022 Feb 17 doi: 10.2217/fon-2021-1634. PMID: 35172587
Immunotherapy for squamous cell carcinoma of the head and neck.
Yokota T, Homma A, Kiyota N, Tahara M, Hanai N, Asakage T, Matsuura K, Ogawa T, Saito Y, Sano D, Kodaira T, Motegi A, Yasuda K, Takahashi S, Tanaka K, Onoe T, Okano S, Imamura Y, Ariizumi Y, Hayashi R; Japan Clinical Oncology Group (JCOG) Head and Neck Cancer Study Group
Jpn J Clin Oncol 2020 Sep 28;50(10):1089-1096. doi: 10.1093/jjco/hyaa139. PMID: 32776100
Cutaneous Squamous Cell Carcinoma in Immunosuppressed Patients.
Tam S, Gross ND
Curr Oncol Rep 2019 Jul 29;21(9):82. doi: 10.1007/s11912-019-0831-1. PMID: 31359288
Meta-analysis of chemotherapy in head and neck cancer (MACH-NC): an update on 93 randomised trials and 17,346 patients.
Pignon JP, le Maître A, Maillard E, Bourhis J; MACH-NC Collaborative Group
Radiother Oncol 2009 Jul;92(1):4-14. Epub 2009 May 14 doi: 10.1016/j.radonc.2009.04.014. PMID: 19446902
Head and neck cancer.
Argiris A, Karamouzis MV, Raben D, Ferris RL
Lancet 2008 May 17;371(9625):1695-709. doi: 10.1016/S0140-6736(08)60728-X. PMID: 18486742Free PMC Article

Prognosis

Management of Subglottic Cancer.
Mann H, Seligman K, Colwell N, Burr A, Glazer TA
Otolaryngol Clin North Am 2023 Apr;56(2):305-312. doi: 10.1016/j.otc.2022.11.001. PMID: 37030943
Palliative Radiotherapy for Cutaneous Squamous Cell Carcinoma of the Head-and-Neck Region.
Staackmann C, Schild SE, Rades D
In Vivo 2021 Jul-Aug;35(4):2283-2288. doi: 10.21873/invivo.12501. PMID: 34182507Free PMC Article
Imaging spectrum of NUT carcinomas.
Virarkar M, Saleh M, Ramani NS, Morani AC, Bhosale P
Clin Imaging 2020 Nov;67:198-206. Epub 2020 Aug 2 doi: 10.1016/j.clinimag.2020.07.025. PMID: 32866821
Squamous Cell Carcinoma: PET/CT and PET/MRI of the Pretreatment and Post-Treatment Neck.
Traylor KS, Koontz N, Mosier K
Semin Ultrasound CT MR 2019 Oct;40(5):400-413. Epub 2019 Jul 17 doi: 10.1053/j.sult.2019.07.004. PMID: 31635767
Survival outcomes after treatment of cancer of the oral cavity (1985-2015).
Zanoni DK, Montero PH, Migliacci JC, Shah JP, Wong RJ, Ganly I, Patel SG
Oral Oncol 2019 Mar;90:115-121. Epub 2019 Feb 15 doi: 10.1016/j.oraloncology.2019.02.001. PMID: 30846169Free PMC Article

Clinical prediction guides

High-Risk Cutaneous Squamous Cell Carcinoma of the Head and Neck: A Clinical Review.
Yan F, Tillman BN, Nijhawan RI, Srivastava D, Sher DJ, Avkshtol V, Homsi J, Bishop JA, Wynings EM, Lee R, Myers LL, Day AT
Ann Surg Oncol 2021 Dec;28(13):9009-9030. Epub 2021 Jun 30 doi: 10.1245/s10434-021-10108-9. PMID: 34195900
Palliative Radiotherapy for Cutaneous Squamous Cell Carcinoma of the Head-and-Neck Region.
Staackmann C, Schild SE, Rades D
In Vivo 2021 Jul-Aug;35(4):2283-2288. doi: 10.21873/invivo.12501. PMID: 34182507Free PMC Article
Incidence and clinical predictors of cystic squamous cell carcinoma metastases in lateral cervical cysts.
Stefanicka P, Gnojcakova N, Kurinec F, Profant M
J Laryngol Otol 2019 May;133(5):430-435. Epub 2019 Apr 22 doi: 10.1017/S0022215119000823. PMID: 31006395
Cervicothoracoscopic Approach in Esophagectomy.
Okamura A, Watanabe M, Imamura Y, Hayami M, Yuda M, Yamashita K, Shoji Y, Mine S
Ann Surg Oncol 2018 Jan;25(1):333. Epub 2017 Oct 30 doi: 10.1245/s10434-017-6119-5. PMID: 29086127
Prognostic and predictive value of EGFR in head and neck squamous cell carcinoma.
Bossi P, Resteghini C, Paielli N, Licitra L, Pilotti S, Perrone F
Oncotarget 2016 Nov 8;7(45):74362-74379. doi: 10.18632/oncotarget.11413. PMID: 27556186Free PMC Article

Recent systematic reviews

Autoimmune disease and oral squamous cell carcinoma: A systematic review.
Pillai A, Adilbay D, Matsoukas K, Ganly I, Patel SG
J Oral Pathol Med 2021 Oct;50(9):855-863. Epub 2021 Jul 12 doi: 10.1111/jop.13218. PMID: 34145639Free PMC Article
Oral squamous cell carcinoma around dental implants: a systematic review.
Ramos JC, Dos Santos ES, Normando AGC, Alves FA, Kowalski LP, Santos-Silva AR, Vargas PA, Lopes MA
Oral Surg Oral Med Oral Pathol Oral Radiol 2021 Jun;131(6):660-674. Epub 2021 Jan 27 doi: 10.1016/j.oooo.2021.01.019. PMID: 33653646
Paediatric laryngeal squamous cell carcinoma: Systematic review and pooled analysis.
Mur T, Jaleel Z, Agarwal P, Edwards H, Levi JR
Clin Otolaryngol 2021 May;46(3):494-500. Epub 2021 Feb 2 doi: 10.1111/coa.13719. PMID: 33475248
Human papillomavirus infection and oral squamous cell carcinoma - a systematic review.
Melo BAC, Vilar LG, Oliveira NR, Lima PO, Pinheiro MB, Domingueti CP, Pereira MC
Braz J Otorhinolaryngol 2021 May-Jun;87(3):346-352. Epub 2020 Nov 29 doi: 10.1016/j.bjorl.2020.10.017. PMID: 33339760Free PMC Article
Cervical metastases of oral maxillary squamous cell carcinoma: A systematic review and meta-analysis.
Zhang WB, Peng X
Head Neck 2016 Apr;38 Suppl 1:E2335-42. Epub 2016 Feb 18 doi: 10.1002/hed.24274. PMID: 26890607

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