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Female reproductive system neoplasm

MedGen UID:
9004
•Concept ID:
C0017416
•
Neoplastic Process
Synonyms: Female Genital Neoplasm; Female Genital Neoplasms; Genital Neoplasm, Female; Genital Neoplasms, Female; Gynecologic Neoplasm; Gynecologic Neoplasms; Neoplasm, Female Genital; Neoplasm, Gynecologic; Neoplasms, Female Genital; Neoplasms, Gynecologic
SNOMED CT: Neoplasm of female genital organ (126907002); Tumor of female genital organs (126907002)
 
HPO: HP:0033020
Monarch Initiative: MONDO:0021148

Definition

A neoplasm that affects the female reproductive system. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFemale reproductive system neoplasm

Professional guidelines

PubMed

Endometrial cancer: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up.
Oaknin A, Bosse TJ, Creutzberg CL, Giornelli G, Harter P, Joly F, Lorusso D, Marth C, Makker V, Mirza MR, Ledermann JA, Colombo N; ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org
Ann Oncol 2022 Sep;33(9):860-877. Epub 2022 Jun 8 doi: 10.1016/j.annonc.2022.05.009. PMID: 35690222
Management of Symptomatic Uterine Leiomyomas: ACOG Practice Bulletin, Number 228.
Obstet Gynecol 2021 Jun 1;137(6):e100-e115. doi: 10.1097/AOG.0000000000004401. PMID: 34011888
Consensus Recommendations for Radiation Therapy Contouring and Treatment of Vulvar Carcinoma.
Gaffney DK, King B, Viswanathan AN, Barkati M, Beriwal S, Eifel P, Erickson B, Fyles A, Goulart J, Harkenrider M, Jhingran A, Klopp A, Koh WJ, Lim K, Petersen I, Portelance L, Small W Jr, Stewart A, Wiebe E, Wolfson A, Yashar C, Bosch W
Int J Radiat Oncol Biol Phys 2016 Jul 15;95(4):1191-200. Epub 2016 Feb 21 doi: 10.1016/j.ijrobp.2016.02.043. PMID: 27130794Free PMC Article

Recent clinical studies

Etiology

Gynecological malignancies and obesity.
Agnew HJ, Kitson SJ, Crosbie EJ
Best Pract Res Clin Obstet Gynaecol 2023 Jun;88:102337. Epub 2023 Apr 8 doi: 10.1016/j.bpobgyn.2023.102337. PMID: 37117071
Hormone therapy (HT) in women with gynecologic cancers and in women at high risk for developing a gynecologic cancer: A Society of Gynecologic Oncology (SGO) clinical practice statement: This practice statement has been endorsed by The North American Menopause Society.
Sinno AK, Pinkerton J, Febbraro T, Jones N, Khanna N, Temkin S, Iglesias D, Pothuri B
Gynecol Oncol 2020 May;157(2):303-306. Epub 2020 Feb 15 doi: 10.1016/j.ygyno.2020.01.035. PMID: 32067815
Lower extremity lymphedema in patients with gynecologic malignancies.
Dessources K, Aviki E, Leitao MM Jr
Int J Gynecol Cancer 2020 Feb;30(2):252-260. Epub 2020 Jan 7 doi: 10.1136/ijgc-2019-001032. PMID: 31915136Free PMC Article
Gynecologic Malignancies.
Suneja G, Viswanathan A
Hematol Oncol Clin North Am 2020 Feb;34(1):71-89. doi: 10.1016/j.hoc.2019.08.018. PMID: 31739953
Genetics of gynaecological disorders.
Josifova DJ
Best Pract Res Clin Obstet Gynaecol 2017 Jul;42:100-113. Epub 2017 May 10 doi: 10.1016/j.bpobgyn.2017.05.001. PMID: 28684328

Diagnosis

Update on MRI in Evaluation and Treatment of Endometrial Cancer.
Maheshwari E, Nougaret S, Stein EB, Rauch GM, Hwang KP, Stafford RJ, Klopp AH, Soliman PT, Maturen KE, Rockall AG, Lee SI, Sadowski EA, Venkatesan AM
Radiographics 2022 Nov-Dec;42(7):2112-2130. Epub 2022 Aug 26 doi: 10.1148/rg.220070. PMID: 36018785
Lower extremity lymphedema in patients with gynecologic malignancies.
Dessources K, Aviki E, Leitao MM Jr
Int J Gynecol Cancer 2020 Feb;30(2):252-260. Epub 2020 Jan 7 doi: 10.1136/ijgc-2019-001032. PMID: 31915136Free PMC Article
Revising the WHO classification: female genital tract tumours.
Cree IA, White VA, Indave BI, Lokuhetty D
Histopathology 2020 Jan;76(1):151-156. doi: 10.1111/his.13977. PMID: 31846528
Gynecologic Pathology.
Clarke BA, McCluggage WG
Surg Pathol Clin 2016 Jun;9(2):ix-x. doi: 10.1016/j.path.2016.04.001. PMID: 27241113
Editorial.
Beller U
Int J Gynecol Cancer 2015 Sep;25(7):1143. doi: 10.1097/IGC.0000000000000573. PMID: 26302214

Therapy

Immuno-Oncology for Gynecologic Malignancies.
How JA, Patel A, Jazaeri AA
Adv Exp Med Biol 2021;1342:193-232. doi: 10.1007/978-3-030-79308-1_6. PMID: 34972966
Hormone therapy (HT) in women with gynecologic cancers and in women at high risk for developing a gynecologic cancer: A Society of Gynecologic Oncology (SGO) clinical practice statement: This practice statement has been endorsed by The North American Menopause Society.
Sinno AK, Pinkerton J, Febbraro T, Jones N, Khanna N, Temkin S, Iglesias D, Pothuri B
Gynecol Oncol 2020 May;157(2):303-306. Epub 2020 Feb 15 doi: 10.1016/j.ygyno.2020.01.035. PMID: 32067815
Cell-based immunotherapy in gynecologic malignancies.
Schaar B, Krishnan V, Tallapragada S, Chanana A, Dorigo O
Curr Opin Obstet Gynecol 2019 Feb;31(1):43-48. doi: 10.1097/GCO.0000000000000518. PMID: 30540582
Inherited gynaecological cancers.
George A
Curr Opin Oncol 2018 Sep;30(5):317-322. doi: 10.1097/CCO.0000000000000465. PMID: 30036195
Prediction of anti-angiogenesis escape.
Mitamura T, Gourley C, Sood AK
Gynecol Oncol 2016 Apr;141(1):80-5. Epub 2015 Dec 31 doi: 10.1016/j.ygyno.2015.12.033. PMID: 26748214Free PMC Article

Prognosis

Gynecologic Malignancies.
Suneja G, Viswanathan A
Hematol Oncol Clin North Am 2020 Feb;34(1):71-89. doi: 10.1016/j.hoc.2019.08.018. PMID: 31739953
Palliative care in gynecologic oncology.
Karlin D, Phung P, Pietras C
Curr Opin Obstet Gynecol 2018 Feb;30(1):31-43. doi: 10.1097/GCO.0000000000000426. PMID: 29227301
Epidemiology of gynecologic cancers in China.
Jiang X, Tang H, Chen T
J Gynecol Oncol 2018 Jan;29(1):e7. doi: 10.3802/jgo.2018.29.e7. PMID: 29185265Free PMC Article
Global Cancer in Women: Burden and Trends.
Torre LA, Islami F, Siegel RL, Ward EM, Jemal A
Cancer Epidemiol Biomarkers Prev 2017 Apr;26(4):444-457. Epub 2017 Feb 21 doi: 10.1158/1055-9965.EPI-16-0858. PMID: 28223433
European Journal of Obstetrics & Gynecology and Reproductive Biology. Editors' highlights.
Künzel W, Drife J
Eur J Obstet Gynecol Reprod Biol 2009 Apr;143(2):67-8. Epub 2009 Feb 28 doi: 10.1016/j.ejogrb.2009.02.007. PMID: 19251352

Clinical prediction guides

Unraveling the Mysteries of PAX8 in Reproductive Tract Cancers.
Chaves-Moreira D, Morin PJ, Drapkin R
Cancer Res 2021 Feb 15;81(4):806-810. Epub 2020 Dec 23 doi: 10.1158/0008-5472.CAN-20-3173. PMID: 33361393Free PMC Article
Moving From Mutation to Actionability.
Colombo I, Kurnit KC, Westin SN, Oza AM
Am Soc Clin Oncol Educ Book 2018 May 23;38:495-503. doi: 10.1200/EDBK_199665. PMID: 30231353
Gynecologic Cancers: Molecular Updates 2018.
Abdulfatah E, Ahmed Q, Alosh B, Bandyopadhyay S, Bluth MH, Ali-Fehmi R
Clin Lab Med 2018 Jun;38(2):421-438. doi: 10.1016/j.cll.2018.02.007. PMID: 29776639
Venous Thromboembolism in Gynecological Malignancy.
Cohen A, Lim CS, Davies AH
Int J Gynecol Cancer 2017 Nov;27(9):1970-1978. doi: 10.1097/IGC.0000000000001111. PMID: 28930804
PI3K pathway in gynecologic malignancies.
Salvesen HB, Werner HM, Krakstad C
Am Soc Clin Oncol Educ Book 2013 doi: 10.14694/EdBook_AM.2013.33.e218. PMID: 23714506

Recent systematic reviews

Global and regional estimates of genital human papillomavirus prevalence among men: a systematic review and meta-analysis.
Bruni L, Albero G, Rowley J, Alemany L, Arbyn M, Giuliano AR, Markowitz LE, Broutet N, Taylor M
Lancet Glob Health 2023 Sep;11(9):e1345-e1362. doi: 10.1016/S2214-109X(23)00305-4. PMID: 37591583Free PMC Article
Molecular Insights in Uterine Leiomyosarcoma: A Systematic Review.
Sparić R, Andjić M, Babović I, Nejković L, Mitrović M, Štulić J, Pupovac M, Tinelli A
Int J Mol Sci 2022 Aug 27;23(17) doi: 10.3390/ijms23179728. PMID: 36077127Free PMC Article
Role of human papillomavirus (HPV) vaccination on HPV infection and recurrence of HPV related disease after local surgical treatment: systematic review and meta-analysis.
Kechagias KS, Kalliala I, Bowden SJ, Athanasiou A, Paraskevaidi M, Paraskevaidis E, Dillner J, Nieminen P, Strander B, Sasieni P, Veroniki AA, Kyrgiou M
BMJ 2022 Aug 3;378:e070135. doi: 10.1136/bmj-2022-070135. PMID: 35922074Free PMC Article
Cervical Cancer Prevalence, Incidence and Mortality in Low and Middle Income Countries: A Systematic Review.
Shrestha AD, Neupane D, Vedsted P, Kallestrup P
Asian Pac J Cancer Prev 2018 Feb 26;19(2):319-324. doi: 10.22034/APJCP.2018.19.2.319. PMID: 29479954Free PMC Article
EULAR recommendations for women's health and the management of family planning, assisted reproduction, pregnancy and menopause in patients with systemic lupus erythematosus and/or antiphospholipid syndrome.
Andreoli L, Bertsias GK, Agmon-Levin N, Brown S, Cervera R, Costedoat-Chalumeau N, Doria A, Fischer-Betz R, Forger F, Moraes-Fontes MF, Khamashta M, King J, Lojacono A, Marchiori F, Meroni PL, Mosca M, Motta M, Ostensen M, Pamfil C, Raio L, Schneider M, Svenungsson E, Tektonidou M, Yavuz S, Boumpas D, Tincani A
Ann Rheum Dis 2017 Mar;76(3):476-485. Epub 2016 Jul 25 doi: 10.1136/annrheumdis-2016-209770. PMID: 27457513Free PMC Article

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