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Differential cyanosis

MedGen UID:
1814163
•Concept ID:
C5558435
•
Finding
HPO: HP:0034034

Definition

Differential degree of bluish discoloration between the upper and lower extremities. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDifferential cyanosis

Professional guidelines

PubMed

Hand and Foot Color Change: Diagnosis and Management.
Fleck DE, Hoeltzel MF
Pediatr Rev 2017 Nov;38(11):511-519. doi: 10.1542/pir.2016-0234. PMID: 29093119
Raynaud’s phenomenon - assessment and differential diagnoses.
Linnemann B, Erbe M
Vasa 2015 May;44(3):166-77. doi: 10.1024/0301-1526/a000426. PMID: 26098320
Echocardiographic differential diagnosis of the cyanotic newborn.
Deeg KH
Ultraschall Med 2015 Apr;36(2):104-18; quiz 119-20. Epub 2014 Dec 4 doi: 10.1055/s-0034-1385493. PMID: 25474186

Recent clinical studies

Etiology

A novel unidirectional-valved shunt approach for end-stage pulmonary arterial hypertension: Early experience in adolescents and adults.
Rosenzweig EB, Ankola A, Krishnan U, Middlesworth W, Bacha E, Bacchetta M
J Thorac Cardiovasc Surg 2021 Apr;161(4):1438-1446.e2. Epub 2019 Nov 14 doi: 10.1016/j.jtcvs.2019.10.149. PMID: 31839227
Persistent pulmonary hypertension of the newborn.
Fuloria M, Aschner JL
Semin Fetal Neonatal Med 2017 Aug;22(4):220-226. Epub 2017 Mar 23 doi: 10.1016/j.siny.2017.03.004. PMID: 28342684
Prognosis for patients with Eisenmenger syndrome of various aetiology.
Saha A, Balakrishnan KG, Jaiswal PK, Venkitachalam CG, Tharakan J, Titus T, Kutty R
Int J Cardiol 1994 Jul;45(3):199-207. doi: 10.1016/0167-5273(94)90166-x. PMID: 7960265
Transposition of the great arteries with intact ventricular septum and patent ductus arteriosus.
Waldman JD, Paul MH, Newfeld EA, Muster AJ, Idriss FS
Am J Cardiol 1977 Feb;39(2):232-8. doi: 10.1016/s0002-9149(77)80196-3. PMID: 835481

Diagnosis

Novel interrupted aortic arch: A case report.
Gan Y, Zhang P, Liao R, Nie Y, Fu Y
J Card Surg 2022 Dec;37(12):5639-5642. Epub 2022 Nov 15 doi: 10.1111/jocs.17223. PMID: 36378947
Reversed differential cyanosis during veno-arterial extracorporeal membrane oxygenation in infants: the reevaluation of an old phenomenon.
Di Nardo M, Stoppa F, David P, Lorusso R, Ranieri VM, Mascia L
Eur J Heart Fail 2017 May;19 Suppl 2:117-119. doi: 10.1002/ejhf.855. PMID: 28470924
Persistent pulmonary hypertension of the newborn.
Fuloria M, Aschner JL
Semin Fetal Neonatal Med 2017 Aug;22(4):220-226. Epub 2017 Mar 23 doi: 10.1016/j.siny.2017.03.004. PMID: 28342684
Differential cyanosis and clubbing sparing a single limb.
Sabnis GR, Phadke MS, Lanjewar CP, Kerkar PG, Nabar AA
J Am Coll Cardiol 2014 Apr 15;63(14):e33. Epub 2014 Feb 19 doi: 10.1016/j.jacc.2013.11.058. PMID: 24561142
Reverse differential cyanosis.
Aziz K, Sanyal SK, Goldblatt E
Br Heart J 1968 Mar;30(2):288-90. doi: 10.1136/hrt.30.2.288. PMID: 5644153Free PMC Article

Therapy

A rare cause of early neonatal cyanosis: absent right pulmonary artery.
Joshi A, Kumar M, Arun S, Sheshrao MM
BMJ Case Rep 2017 Aug 9;2017 doi: 10.1136/bcr-2017-220978. PMID: 28794091Free PMC Article
Reversed differential cyanosis during veno-arterial extracorporeal membrane oxygenation in infants: the reevaluation of an old phenomenon.
Di Nardo M, Stoppa F, David P, Lorusso R, Ranieri VM, Mascia L
Eur J Heart Fail 2017 May;19 Suppl 2:117-119. doi: 10.1002/ejhf.855. PMID: 28470924
Eisenmenger syndrome in an adult patient with a large patent ductus arteriosus.
Dimopoulos K
Eur Respir Rev 2013 Dec;22(130):558-64. doi: 10.1183/09059180.00007013. PMID: 24293472Free PMC Article
The use of nifedipine in patients with Eisenmenger's syndrome complicating patency of the arterial duct.
Wong CK, Lau CP, Leung WH, Cheng CH
Int J Cardiol 1989 Nov;25(2):173-8. doi: 10.1016/0167-5273(89)90104-6. PMID: 2807605

Prognosis

Doppler echocardiographic evaluation of the hemodynamics in absent aortic valve.
Nakagawa M, Okamoto N, Fujino H, Hisano T, Nishizawa K, Kato H, Ueda T
Can J Cardiol 1999 Nov;15(11):1283-6. PMID: 10579744
Prognosis for patients with Eisenmenger syndrome of various aetiology.
Saha A, Balakrishnan KG, Jaiswal PK, Venkitachalam CG, Tharakan J, Titus T, Kutty R
Int J Cardiol 1994 Jul;45(3):199-207. doi: 10.1016/0167-5273(94)90166-x. PMID: 7960265
Transposition of the great arteries with intact ventricular septum and patent ductus arteriosus.
Waldman JD, Paul MH, Newfeld EA, Muster AJ, Idriss FS
Am J Cardiol 1977 Feb;39(2):232-8. doi: 10.1016/s0002-9149(77)80196-3. PMID: 835481

Clinical prediction guides

Reversed differential cyanosis in the newborn: a clinical finding in the supracardiac total anomalous pulmonary venous connection.
Yap SH, Anania N, Alboliras ET, Lilien LD
Pediatr Cardiol 2009 Apr;30(3):359-62. Epub 2008 Oct 16 doi: 10.1007/s00246-008-9314-0. PMID: 18923862
Observations on the compensatory response to hypoxemia in a case of reversed differential cyanosis.
Rosenthal A, Nathan DG, Nadas AS
Pediatrics 1972 Jun;49(6):911-5. PMID: 5041323

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