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Eyelid carcinoma

MedGen UID:
182526
•Concept ID:
C0920196
•
Neoplastic Process
Synonyms: Carcinoma of Eyelid; carcinoma of eyelid; Carcinoma of the Eyelid; carcinoma of the eyelid; Eyelid Carcinoma; eyelid carcinoma
 
Monarch Initiative: MONDO:0003876

Definition

A carcinoma that arises from the eyelid. Examples include basal cell carcinoma and squamous cell carcinoma. [from NCI]

Professional guidelines

PubMed

Nordic treatment practices survey and consensus for treatment of eyelid sebaceous carcinoma.
Leivo T, Sarmela J, Enckell-Aaltonen M, Dafgård Kopp E, Schmitt C, Toft PB, Sigurdsson H, Uusitalo M
BMC Ophthalmol 2020 Mar 16;20(1):103. doi: 10.1186/s12886-020-01367-3. PMID: 32178641Free PMC Article
Treatment of Metastatic Eyelid Carcinoma.
Bonavolontà P, Dell'Aversana Orabona G, Abbate V, Iaconetta G, Bonavolontà G, Califano L
J Craniofac Surg 2017 Nov;28(8):e722-e725. doi: 10.1097/SCS.0000000000003847. PMID: 28885435
Patterns of lymphatic spread and the management of eyelid carcinomas.
Hashimoto K, Yasumatsu R, Toh S, Shiratsuchi H, Yoshida T, Nishiyama K, Yoshikawa H, Nakashima T, Nakagawa T
Auris Nasus Larynx 2016 Dec;43(6):666-71. Epub 2016 Mar 7 doi: 10.1016/j.anl.2016.02.011. PMID: 26965587

Recent clinical studies

Etiology

Eyelid carcinoma: An experience from a tertiary cancer center.
Thiagarajan S, Bahani A, Chaukar D, Dcruz AK
J Cancer Res Ther 2020 Dec;16(Supplement):S48-S52. doi: 10.4103/jcrt.JCRT_559_18. PMID: 33380651
Nordic treatment practices survey and consensus for treatment of eyelid sebaceous carcinoma.
Leivo T, Sarmela J, Enckell-Aaltonen M, Dafgård Kopp E, Schmitt C, Toft PB, Sigurdsson H, Uusitalo M
BMC Ophthalmol 2020 Mar 16;20(1):103. doi: 10.1186/s12886-020-01367-3. PMID: 32178641Free PMC Article
Treatment of Metastatic Eyelid Carcinoma.
Bonavolontà P, Dell'Aversana Orabona G, Abbate V, Iaconetta G, Bonavolontà G, Califano L
J Craniofac Surg 2017 Nov;28(8):e722-e725. doi: 10.1097/SCS.0000000000003847. PMID: 28885435
Merkel cell carcinoma of the eyelid: management and prognosis.
Herbert HM, Sun MT, Selva D, Fernando B, Saleh GM, Beaconsfield M, Collin R, Uddin J, Meligonis G, Leatherbarrow B, Ataullah S, Irion L, McLean CJ, Huilgol SC, Davis G, Sullivan TJ
JAMA Ophthalmol 2014 Feb;132(2):197-204. doi: 10.1001/jamaophthalmol.2013.6077. PMID: 24287584
Secondary orbital tumors.
Günalp I, Gündüz K
Ophthalmic Plast Reconstr Surg 1997 Mar;13(1):31-5. doi: 10.1097/00002341-199703000-00006. PMID: 9076781

Diagnosis

Prevalence of human papillomavirus in eyelid carcinoma among Koreans: a clinicopathological study.
Yang MK, Kim N, Choung H, Kim JE, Khwarg SI
BMC Ophthalmol 2023 Sep 26;23(1):390. doi: 10.1186/s12886-023-03131-9. PMID: 37752463Free PMC Article
Paracoccidioidomycosis Simulating Eyelid Carcinoma.
Peruzzo J, Casagrande LC, Cartell AS, Maestri MK, Procianoy F, Procianoy PDC
Arch Iran Med 2022 Mar 1;25(3):194-195. doi: 10.34172/aim.2022.33. PMID: 35429963
Eyelid carcinoma: An experience from a tertiary cancer center.
Thiagarajan S, Bahani A, Chaukar D, Dcruz AK
J Cancer Res Ther 2020 Dec;16(Supplement):S48-S52. doi: 10.4103/jcrt.JCRT_559_18. PMID: 33380651
Treatment of Metastatic Eyelid Carcinoma.
Bonavolontà P, Dell'Aversana Orabona G, Abbate V, Iaconetta G, Bonavolontà G, Califano L
J Craniofac Surg 2017 Nov;28(8):e722-e725. doi: 10.1097/SCS.0000000000003847. PMID: 28885435
Secondary orbital tumors.
Günalp I, Gündüz K
Ophthalmic Plast Reconstr Surg 1997 Mar;13(1):31-5. doi: 10.1097/00002341-199703000-00006. PMID: 9076781

Therapy

Impact of Food and Drug Administration Approval of Vismodegib on Prevalence of Orbital Exenteration as a Necessary Surgical Treatment for Locally Advanced Periocular Basal Cell Carcinoma.
Sagiv O, Ding S, Ferrarotto R, Glisson B, Altan M, Johnson F, Elamin Y, Thakar SD, Nagarajan P, Esmaeli B
Ophthalmic Plast Reconstr Surg 2019 Jul/Aug;35(4):350-353. doi: 10.1097/IOP.0000000000001251. PMID: 30365473
Ocular preservation with neoadjuvant vismodegib in patients with locally advanced periocular basal cell carcinoma.
Sagiv O, Nagarajan P, Ferrarotto R, Kandl TJ, Thakar SD, Glisson BS, Altan M, Esmaeli B
Br J Ophthalmol 2019 Jun;103(6):775-780. Epub 2018 Jul 18 doi: 10.1136/bjophthalmol-2018-312277. PMID: 30021814
Can the onset of orbital cancer be the result of a prosthetic eye?
Croce A, Mastronardi V, Laus M, Festa Kotelnikova E
Acta Otorhinolaryngol Ital 2017 Dec;37(6):519-522. doi: 10.14639/0392-100X-1043. PMID: 28530256Free PMC Article
Interstitial brachytherapy for eyelid carcinoma. Outcome analysis in 60 patients.
Krengli M, Masini L, Comoli AM, Negri E, Deantonio L, Filomeno A, Gambaro G
Strahlenther Onkol 2014 Mar;190(3):245-9. Epub 2014 Jan 16 doi: 10.1007/s00066-013-0495-y. PMID: 24424628
Carcinoma of the eyelid.
Bertelsen K, Gadeberg C
Acta Radiol Oncol Radiat Phys Biol 1978;17(1):58-64. doi: 10.3109/02841867809127691. PMID: 696401

Prognosis

Eyelid carcinoma: An experience from a tertiary cancer center.
Thiagarajan S, Bahani A, Chaukar D, Dcruz AK
J Cancer Res Ther 2020 Dec;16(Supplement):S48-S52. doi: 10.4103/jcrt.JCRT_559_18. PMID: 33380651
Nordic treatment practices survey and consensus for treatment of eyelid sebaceous carcinoma.
Leivo T, Sarmela J, Enckell-Aaltonen M, Dafgård Kopp E, Schmitt C, Toft PB, Sigurdsson H, Uusitalo M
BMC Ophthalmol 2020 Mar 16;20(1):103. doi: 10.1186/s12886-020-01367-3. PMID: 32178641Free PMC Article
Merkel cell carcinoma of the eyelid: management and prognosis.
Herbert HM, Sun MT, Selva D, Fernando B, Saleh GM, Beaconsfield M, Collin R, Uddin J, Meligonis G, Leatherbarrow B, Ataullah S, Irion L, McLean CJ, Huilgol SC, Davis G, Sullivan TJ
JAMA Ophthalmol 2014 Feb;132(2):197-204. doi: 10.1001/jamaophthalmol.2013.6077. PMID: 24287584
Radiation therapy for primary carcinoma of the eyelid: tumor control and visual function.
Hata M, Koike I, Maegawa J, Kaneko A, Odagiri K, Kasuya T, Minagawa Y, Kaizu H, Mukai Y, Inoue T
Strahlenther Onkol 2012 Dec;188(12):1102-7. Epub 2012 Oct 28 doi: 10.1007/s00066-012-0145-9. PMID: 23104519
Secondary orbital tumors.
Günalp I, Gündüz K
Ophthalmic Plast Reconstr Surg 1997 Mar;13(1):31-5. doi: 10.1097/00002341-199703000-00006. PMID: 9076781

Clinical prediction guides

Prognostic factors for local recurrence, metastasis and survival for sebaceous carcinoma of the eyelid: observations in 100 patients.
Sa HS, Rubin ML, Xu S, Ning J, Tetzlaff M, Sagiv O, Kandl TJ, Esmaeli B
Br J Ophthalmol 2019 Jul;103(7):980-984. Epub 2018 Aug 21 doi: 10.1136/bjophthalmol-2018-312635. PMID: 30131380
Correlation of American Joint Committee on Cancer T category for eyelid carcinoma with outcomes in patients with periocular Merkel cell carcinoma.
Sniegowski MC, Warneke CL, Morrison WH, Nasser QJ, Frank SJ, Pfeiffer ML, El-Sawy T, Esmaeli B
Ophthalmic Plast Reconstr Surg 2014 Nov-Dec;30(6):480-5. doi: 10.1097/IOP.0000000000000153. PMID: 24841735
Interstitial brachytherapy for eyelid carcinoma. Outcome analysis in 60 patients.
Krengli M, Masini L, Comoli AM, Negri E, Deantonio L, Filomeno A, Gambaro G
Strahlenther Onkol 2014 Mar;190(3):245-9. Epub 2014 Jan 16 doi: 10.1007/s00066-013-0495-y. PMID: 24424628

Recent systematic reviews

Prognostic Value of the Staging System for Eyelid Tumors in the 7th Edition of the American Joint Committee on Cancer Staging Manual.
Ford J, Thakar S, Thuro B, Esmaeli B
Ophthalmic Plast Reconstr Surg 2017 Sep/Oct;33(5):317-324. doi: 10.1097/IOP.0000000000000901. PMID: 28350693

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