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Eyelid Basal Cell Carcinoma

MedGen UID:
572964
•Concept ID:
C0339114
•
Neoplastic Process
Synonyms: Basal cell carcinoma of eyelid; Ocular Basal Cell Carcinoma; Rodent ulcer of eyelid
SNOMED CT: Basal cell carcinoma of eyelid (231832009); Rodent ulcer of eyelid (231832009)

Definition

A basal cell carcinoma that arises from the eyelid. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEyelid Basal Cell Carcinoma

Professional guidelines

PubMed

Periocular skin cancer: Diagnosis and management.
Moran JM, Phelps PO
Dis Mon 2020 Oct;66(10):101046. Epub 2020 Jun 27 doi: 10.1016/j.disamonth.2020.101046. PMID: 32600650
Management of periorbital basal cell carcinoma with orbital invasion.
Sun MT, Wu A, Figueira E, Huilgol S, Selva D
Future Oncol 2015 Nov;11(22):3003-10. Epub 2015 Oct 5 doi: 10.2217/fon.15.190. PMID: 26437207
Differential Diagnosis of the Swollen Red Eyelid.
Carlisle RT, Digiovanni J
Am Fam Physician 2015 Jul 15;92(2):106-12. PMID: 26176369

Recent clinical studies

Etiology

Eyelid basal cell carcinoma with neuroendocrine differentiation: a case report and literature review.
Chung IY, McKelvie P, Chen Y
Orbit 2021 Aug;40(4):316-319. Epub 2020 Jun 25 doi: 10.1080/01676830.2020.1778738. PMID: 32586182
Metabolic signature of eyelid basal cell carcinoma.
Huang J, Schaefer J, Wang Y, Gioia L, Pei Y, Shi X, Waris S, Zhao C, Nguyen J, Du J
Exp Eye Res 2020 Sep;198:108140. Epub 2020 Jul 7 doi: 10.1016/j.exer.2020.108140. PMID: 32649951Free PMC Article
Orbital Exenteration: A 23-year Report.
Kasaee A, Eshraghi B, Nekoozadeh S, Ameli K, Sadeghi M, Jamshidian-Tehrani M
Korean J Ophthalmol 2019 Aug;33(4):366-370. doi: 10.3341/kjo.2018.0052. PMID: 31389213Free PMC Article
Characteristics and Factors Related to Eyelid Basal Cell Carcinoma in Saudi Arabia.
Al Wohaib M, Al Ahmadi R, Al Essa D, Maktabbi A, Khandekar R, Al Sharif E, Al Katan H, Schellini SA, Al Shaikh O
Middle East Afr J Ophthalmol 2018 Apr-Jun;25(2):96-102. doi: 10.4103/meajo.MEAJO_305_17. PMID: 30122855Free PMC Article
Basal cell carcinoma of the eyelids.
Prabhakaran VC, Gupta A, Huilgol SC, Selva D
Compr Ophthalmol Update 2007 Jan-Feb;8(1):1-14. PMID: 17394754

Diagnosis

Eyelid basal cell carcinoma with neuroendocrine differentiation: a case report and literature review.
Chung IY, McKelvie P, Chen Y
Orbit 2021 Aug;40(4):316-319. Epub 2020 Jun 25 doi: 10.1080/01676830.2020.1778738. PMID: 32586182
Metabolic signature of eyelid basal cell carcinoma.
Huang J, Schaefer J, Wang Y, Gioia L, Pei Y, Shi X, Waris S, Zhao C, Nguyen J, Du J
Exp Eye Res 2020 Sep;198:108140. Epub 2020 Jul 7 doi: 10.1016/j.exer.2020.108140. PMID: 32649951Free PMC Article
Characteristics and Factors Related to Eyelid Basal Cell Carcinoma in Saudi Arabia.
Al Wohaib M, Al Ahmadi R, Al Essa D, Maktabbi A, Khandekar R, Al Sharif E, Al Katan H, Schellini SA, Al Shaikh O
Middle East Afr J Ophthalmol 2018 Apr-Jun;25(2):96-102. doi: 10.4103/meajo.MEAJO_305_17. PMID: 30122855Free PMC Article
Incidence of eyelid basal cell carcinoma in England: 2000-2010.
Saleh GM, Desai P, Collin JR, Ives A, Jones T, Hussain B
Br J Ophthalmol 2017 Feb;101(2):209-212. Epub 2016 Apr 29 doi: 10.1136/bjophthalmol-2015-308261. PMID: 27130914
Clinical, Histopathological and Therapeutical Analysis of Inferior Eyelid Basal Cell Carcinomas.
Totir M, Alexandrescu C, Pirvulescu R, Gradinaru S, Costache M
J Med Life 2014;7 Spec No. 4(Spec Iss 4):18-22. PMID: 27057245Free PMC Article

Therapy

Long-term efficacy and safety of imiquimod 5% and fluorouracil 1% creams in medical monotherapy of complex eyelid basal cell carcinomas.
Singh M, Mehta Grewal A, Singh H, Sharma M, Kaur M, Gupta P, Zadeng Z
Eur J Ophthalmol 2022 Jul;32(4):2093-2100. Epub 2021 Jul 28 doi: 10.1177/11206721211035614. PMID: 34320864
Comparison of imiquimod 5% cream versus radiotherapy as treatment for eyelid basal cell carcinoma.
Garcia-Martin E, Gil-Arribas LM, Idoipe M, Alfaro J, Pueyo V, Pablo LE, Fernandez FJ
Br J Ophthalmol 2011 Oct;95(10):1393-6. Epub 2011 Jan 17 doi: 10.1136/bjo.2010.193078. PMID: 21242584
Photodynamic therapy of eyelid basal cell carcinoma.
Kotimäki J
J Eur Acad Dermatol Venereol 2009 Sep;23(9):1083-7. Epub 2009 Mar 11 doi: 10.1111/j.1468-3083.2009.03195.x. PMID: 19470065
Photodynamic therapy using methyl aminolevulinate acid in eyelid basal cell carcinoma: a 5-year follow-up study.
Puccioni M, Santoro N, Giansanti F, Ucci F, Rossi R, Lotti T, Menchini U
Ophthalmic Plast Reconstr Surg 2009 Mar-Apr;25(2):115-8. doi: 10.1097/IOP.0b013e31819a4404. PMID: 19300153
Imiquimod in the treatment of eyelid basal cell carcinoma.
Leppälä J, Kaarniranta K, Uusitalo H, Kontkanen M
Acta Ophthalmol Scand 2007 Aug;85(5):566-8. Epub 2007 Mar 22 doi: 10.1111/j.1600-0420.2007.00896.x. PMID: 17376190

Prognosis

Eyelid basal cell carcinoma with neuroendocrine differentiation: a case report and literature review.
Chung IY, McKelvie P, Chen Y
Orbit 2021 Aug;40(4):316-319. Epub 2020 Jun 25 doi: 10.1080/01676830.2020.1778738. PMID: 32586182
Metabolic signature of eyelid basal cell carcinoma.
Huang J, Schaefer J, Wang Y, Gioia L, Pei Y, Shi X, Waris S, Zhao C, Nguyen J, Du J
Exp Eye Res 2020 Sep;198:108140. Epub 2020 Jul 7 doi: 10.1016/j.exer.2020.108140. PMID: 32649951Free PMC Article
Characteristics and Factors Related to Eyelid Basal Cell Carcinoma in Saudi Arabia.
Al Wohaib M, Al Ahmadi R, Al Essa D, Maktabbi A, Khandekar R, Al Sharif E, Al Katan H, Schellini SA, Al Shaikh O
Middle East Afr J Ophthalmol 2018 Apr-Jun;25(2):96-102. doi: 10.4103/meajo.MEAJO_305_17. PMID: 30122855Free PMC Article
Incidence of eyelid basal cell carcinoma in England: 2000-2010.
Saleh GM, Desai P, Collin JR, Ives A, Jones T, Hussain B
Br J Ophthalmol 2017 Feb;101(2):209-212. Epub 2016 Apr 29 doi: 10.1136/bjophthalmol-2015-308261. PMID: 27130914
Basal cell carcinoma of the eyelids.
Prabhakaran VC, Gupta A, Huilgol SC, Selva D
Compr Ophthalmol Update 2007 Jan-Feb;8(1):1-14. PMID: 17394754

Clinical prediction guides

The immunoexpression of MMP-1 and MMP-13 in eyelid basal cell carcinoma.
Mercuţ IM, Simionescu CE, Stepan AE, Andreiana BC, Ciurea AM, Mercuţ R, Ciurea ME
Rom J Morphol Embryol 2020 Oct-Dec;61(4):1221-1226. doi: 10.47162/RJME.61.4.23. PMID: 34171070Free PMC Article
Metabolic signature of eyelid basal cell carcinoma.
Huang J, Schaefer J, Wang Y, Gioia L, Pei Y, Shi X, Waris S, Zhao C, Nguyen J, Du J
Exp Eye Res 2020 Sep;198:108140. Epub 2020 Jul 7 doi: 10.1016/j.exer.2020.108140. PMID: 32649951Free PMC Article
Characteristics and Factors Related to Eyelid Basal Cell Carcinoma in Saudi Arabia.
Al Wohaib M, Al Ahmadi R, Al Essa D, Maktabbi A, Khandekar R, Al Sharif E, Al Katan H, Schellini SA, Al Shaikh O
Middle East Afr J Ophthalmol 2018 Apr-Jun;25(2):96-102. doi: 10.4103/meajo.MEAJO_305_17. PMID: 30122855Free PMC Article
Incidence of eyelid basal cell carcinoma in England: 2000-2010.
Saleh GM, Desai P, Collin JR, Ives A, Jones T, Hussain B
Br J Ophthalmol 2017 Feb;101(2):209-212. Epub 2016 Apr 29 doi: 10.1136/bjophthalmol-2015-308261. PMID: 27130914
Eyelid basal cell carcinoma: non-Mohs excision, repair, and outcome.
Hamada S, Kersey T, Thaller VT
Br J Ophthalmol 2005 Aug;89(8):992-4. doi: 10.1136/bjo.2004.058834. PMID: 16024851Free PMC Article

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