U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Infection-associated lymphopenia

MedGen UID:
1841534
•Concept ID:
C5826841
•
Finding
Synonym: Infection-associated lymphocytopenia
 
HPO: HP:4000034

Definition

Decreased lymphocyte count during infections. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVInfection-associated lymphopenia

Professional guidelines

PubMed

Opportunistic cytomegalovirus infection in a patient receiving temozolomide for treatment of malignant glioma.
Yaman E, Coskun U, Ozturk B, Buyukberber S, Kaya AO, Coskun O, Buyukberber N, Yildiz R, Benekli M
J Clin Neurosci 2009 Apr;16(4):591-2. Epub 2009 Feb 6 doi: 10.1016/j.jocn.2008.05.030. PMID: 19201195

Recent clinical studies

Etiology

Pneumocystis jiroveci pneumonia in patients treated with systemic immunosuppressive agents for dermatologic conditions: a systematic review with recommendations for prophylaxis.
Gonzalez Santiago TM, Wetter DA, Kalaaji AN, Limper AH, Lehman JS
Int J Dermatol 2016 Aug;55(8):823-30. Epub 2016 Mar 24 doi: 10.1111/ijd.13231. PMID: 27009930
Phase I study evaluating the safety and efficacy of oral panobinostat in combination with radiotherapy or chemoradiotherapy in patients with inoperable stage III non-small-cell lung cancer.
Takhar HS, Singhal N, Gowda R, Penniment M, Takhar P, Brown MP
Anticancer Drugs 2015 Nov;26(10):1069-77. doi: 10.1097/CAD.0000000000000282. PMID: 26317683
Immunological features in patients with pneumonitis due to influenza A H1N1 infection.
Wen Y, Deng BC, Zhou Y, Wang Y, Cui W, Wang W, Liu P
J Investig Allergol Clin Immunol 2011;21(1):44-50. PMID: 21370723
Disfiguring generalized verrucosis in an indonesian man with idiopathic CD4 lymphopenia.
Alisjahbana B, Dinata R, Sutedja E, Suryahudaya I, Soedjana H, Hidajat NN, Soetikno RD, Oktaliansah E, Deng A, Rady P, Tyring S, Gaspari AA
Arch Dermatol 2010 Jan;146(1):69-73. doi: 10.1001/archdermatol.2009.330. PMID: 20083696
Declining lymphocyte counts following cytomegalovirus (CMV) infection are associated with fatal CMV disease in bone marrow transplant patients.
Fries BC, Khaira D, Pepe MS, Torok-Storb B
Exp Hematol 1993 Sep;21(10):1387-92. PMID: 8395404

Diagnosis

Neonatal fever: A puzzling case.
Bonnet Ducrot S, Plantaz D, Mathieu N, Debillon T, Bost Bru C, Brenier-Pinchart MP, Fricker-Hidalgo H, Chevallier M
Arch Pediatr 2018 Oct;25(7):435-438. Epub 2018 Sep 21 doi: 10.1016/j.arcped.2018.08.004. PMID: 30249489
Pneumocystis jiroveci pneumonia in patients treated with systemic immunosuppressive agents for dermatologic conditions: a systematic review with recommendations for prophylaxis.
Gonzalez Santiago TM, Wetter DA, Kalaaji AN, Limper AH, Lehman JS
Int J Dermatol 2016 Aug;55(8):823-30. Epub 2016 Mar 24 doi: 10.1111/ijd.13231. PMID: 27009930
Opportunistic cytomegalovirus infection in a patient receiving temozolomide for treatment of malignant glioma.
Yaman E, Coskun U, Ozturk B, Buyukberber S, Kaya AO, Coskun O, Buyukberber N, Yildiz R, Benekli M
J Clin Neurosci 2009 Apr;16(4):591-2. Epub 2009 Feb 6 doi: 10.1016/j.jocn.2008.05.030. PMID: 19201195
CD4+ T lymphocytopenia with disseminated HPV.
Stetson CL, Rapini RP, Tyring SK, Kimbrough RC
J Cutan Pathol 2002 Sep;29(8):502-5. doi: 10.1034/j.1600-0560.2002.290809.x. PMID: 12207745
Infection-associated hemophagocytic syndrome complicated by infectious lymphoproliferation: a case report.
Syrůcková Z, Starý J, Sedlácek P, Smísek P, Vavrinec J, Komrska V, Roubalová K, Vandasová J, Sintáková B, Housková J, Hassan M
Pediatr Hematol Oncol 1996 Mar-Apr;13(2):143-50. doi: 10.3109/08880019609030804. PMID: 8721028

Therapy

Successful Use of Cidofovir in an Immunocompetent Child With Severe Adenoviral Sepsis.
Alcamo AM, Wolf MS, Alessi LJ, Chong HJ, Green M, Williams JV, Simon DW
Pediatrics 2020 Jan;145(1) Epub 2019 Dec 11 doi: 10.1542/peds.2019-1632. PMID: 31826930Free PMC Article
Neonatal fever: A puzzling case.
Bonnet Ducrot S, Plantaz D, Mathieu N, Debillon T, Bost Bru C, Brenier-Pinchart MP, Fricker-Hidalgo H, Chevallier M
Arch Pediatr 2018 Oct;25(7):435-438. Epub 2018 Sep 21 doi: 10.1016/j.arcped.2018.08.004. PMID: 30249489
Pneumocystis jiroveci pneumonia in patients treated with systemic immunosuppressive agents for dermatologic conditions: a systematic review with recommendations for prophylaxis.
Gonzalez Santiago TM, Wetter DA, Kalaaji AN, Limper AH, Lehman JS
Int J Dermatol 2016 Aug;55(8):823-30. Epub 2016 Mar 24 doi: 10.1111/ijd.13231. PMID: 27009930
Phase I study evaluating the safety and efficacy of oral panobinostat in combination with radiotherapy or chemoradiotherapy in patients with inoperable stage III non-small-cell lung cancer.
Takhar HS, Singhal N, Gowda R, Penniment M, Takhar P, Brown MP
Anticancer Drugs 2015 Nov;26(10):1069-77. doi: 10.1097/CAD.0000000000000282. PMID: 26317683
CD4+ T lymphocytopenia with disseminated HPV.
Stetson CL, Rapini RP, Tyring SK, Kimbrough RC
J Cutan Pathol 2002 Sep;29(8):502-5. doi: 10.1034/j.1600-0560.2002.290809.x. PMID: 12207745

Prognosis

Pneumocystis jiroveci pneumonia in patients treated with systemic immunosuppressive agents for dermatologic conditions: a systematic review with recommendations for prophylaxis.
Gonzalez Santiago TM, Wetter DA, Kalaaji AN, Limper AH, Lehman JS
Int J Dermatol 2016 Aug;55(8):823-30. Epub 2016 Mar 24 doi: 10.1111/ijd.13231. PMID: 27009930
Immunological features in patients with pneumonitis due to influenza A H1N1 infection.
Wen Y, Deng BC, Zhou Y, Wang Y, Cui W, Wang W, Liu P
J Investig Allergol Clin Immunol 2011;21(1):44-50. PMID: 21370723
Disfiguring generalized verrucosis in an indonesian man with idiopathic CD4 lymphopenia.
Alisjahbana B, Dinata R, Sutedja E, Suryahudaya I, Soedjana H, Hidajat NN, Soetikno RD, Oktaliansah E, Deng A, Rady P, Tyring S, Gaspari AA
Arch Dermatol 2010 Jan;146(1):69-73. doi: 10.1001/archdermatol.2009.330. PMID: 20083696

Clinical prediction guides

COVID-19 imparted immune manifestation can be combated by NLGP: Lessons from cancer research.
Bose A, Baral R
Cytokine 2022 Oct;158:155980. Epub 2022 Jul 31 doi: 10.1016/j.cyto.2022.155980. PMID: 35921791Free PMC Article
Short Communication: Extremely Severe CD4 Lymphopenia During HIV-1 Primary Infection.
Bonnet B, Blum L, Charpentier C, Martres P, Ritvo PG, Autran B, Guihot A
AIDS Res Hum Retroviruses 2019 Oct;35(10):930-933. Epub 2019 Sep 12 doi: 10.1089/AID.2019.0065. PMID: 31418284
Immunological features in patients with pneumonitis due to influenza A H1N1 infection.
Wen Y, Deng BC, Zhou Y, Wang Y, Cui W, Wang W, Liu P
J Investig Allergol Clin Immunol 2011;21(1):44-50. PMID: 21370723
Disfiguring generalized verrucosis in an indonesian man with idiopathic CD4 lymphopenia.
Alisjahbana B, Dinata R, Sutedja E, Suryahudaya I, Soedjana H, Hidajat NN, Soetikno RD, Oktaliansah E, Deng A, Rady P, Tyring S, Gaspari AA
Arch Dermatol 2010 Jan;146(1):69-73. doi: 10.1001/archdermatol.2009.330. PMID: 20083696

Recent systematic reviews

Pneumocystis jiroveci pneumonia in patients treated with systemic immunosuppressive agents for dermatologic conditions: a systematic review with recommendations for prophylaxis.
Gonzalez Santiago TM, Wetter DA, Kalaaji AN, Limper AH, Lehman JS
Int J Dermatol 2016 Aug;55(8):823-30. Epub 2016 Mar 24 doi: 10.1111/ijd.13231. PMID: 27009930

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...