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Unresectable Hepatocellular Carcinoma

MedGen UID:
207269
Concept ID:
C1112459
Neoplastic Process
Synonym: Non-Resectable Hepatocellular Carcinoma

Definition

A hepatocellular carcinoma that is not amenable to surgical resection. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVUnresectable Hepatocellular Carcinoma

Professional guidelines

PubMed

Leowattana W, Leowattana T, Leowattana P
World J Gastroenterol 2023 Mar 14;29(10):1551-1568. doi: 10.3748/wjg.v29.i10.1551. PMID: 36970588Free PMC Article
Su D, Wu B, Shi L
JAMA Netw Open 2021 Feb 1;4(2):e210037. doi: 10.1001/jamanetworkopen.2021.0037. PMID: 33625508Free PMC Article
Rimassa L, Pressiani T, Personeni N, Santoro A
Expert Rev Anticancer Ther 2017 Jul;17(7):567-576. Epub 2017 Jun 9 doi: 10.1080/14737140.2017.1338955. PMID: 28580808

Recent clinical studies

Etiology

Qin S, Chan SL, Gu S, Bai Y, Ren Z, Lin X, Chen Z, Jia W, Jin Y, Guo Y, Hu X, Meng Z, Liang J, Cheng Y, Xiong J, Ren H, Yang F, Li W, Chen Y, Zeng Y, Sultanbaev A, Pazgan-Simon M, Pisetska M, Melisi D, Ponomarenko D, Osypchuk Y, Sinielnikov I, Yang TS, Liang X, Chen C, Wang L, Cheng AL, Kaseb A, Vogel A; CARES-310 Study Group
Lancet 2023 Sep 30;402(10408):1133-1146. Epub 2023 Jul 24 doi: 10.1016/S0140-6736(23)00961-3. PMID: 37499670
Chiang CL, Chiu KWH, Chan KSK, Lee FAS, Li JCB, Wan CWS, Dai WC, Lam TC, Chen W, Wong NSM, Cheung ALY, Lee VWY, Lau VWH, El Helali A, Man K, Kong FMS, Lo CM, Chan AC
Lancet Gastroenterol Hepatol 2023 Feb;8(2):169-178. Epub 2022 Dec 15 doi: 10.1016/S2468-1253(22)00339-9. PMID: 36529152
Cheng AL, Qin S, Ikeda M, Galle PR, Ducreux M, Kim TY, Lim HY, Kudo M, Breder V, Merle P, Kaseb AO, Li D, Verret W, Ma N, Nicholas A, Wang Y, Li L, Zhu AX, Finn RS
J Hepatol 2022 Apr;76(4):862-873. Epub 2021 Dec 11 doi: 10.1016/j.jhep.2021.11.030. PMID: 34902530
Finn RS, Qin S, Ikeda M, Galle PR, Ducreux M, Kim TY, Kudo M, Breder V, Merle P, Kaseb AO, Li D, Verret W, Xu DZ, Hernandez S, Liu J, Huang C, Mulla S, Wang Y, Lim HY, Zhu AX, Cheng AL; IMbrave150 Investigators
N Engl J Med 2020 May 14;382(20):1894-1905. doi: 10.1056/NEJMoa1915745. PMID: 32402160
Kudo M, Finn RS, Qin S, Han KH, Ikeda K, Piscaglia F, Baron A, Park JW, Han G, Jassem J, Blanc JF, Vogel A, Komov D, Evans TRJ, Lopez C, Dutcus C, Guo M, Saito K, Kraljevic S, Tamai T, Ren M, Cheng AL
Lancet 2018 Mar 24;391(10126):1163-1173. doi: 10.1016/S0140-6736(18)30207-1. PMID: 29433850

Diagnosis

Abou-Alfa GK, Lau G, Kudo M, Chan SL, Kelley RK, Furuse J, Sukeepaisarnjaroen W, Kang YK, Dao TV, De Toni EN, Rimassa L, Breder V, Vasilyev A, Heurgué A, Tam VC, Mody K, Thungappa SC, Ostapenko Y, Yau T, Azevedo S, Varela M, Cheng AL, Qin S, Galle PR, Ali S, Gupta C, Makowsky M, Kurland JF, Negro A, Sangro B
Future Oncol 2023 Dec;19(38):2505-2516. Epub 2023 Sep 6 doi: 10.2217/fon-2023-0486. PMID: 37671641
Liu K, Zhu Y, Zhu H
Front Immunol 2022;13:1103055. Epub 2023 Jan 11 doi: 10.3389/fimmu.2022.1103055. PMID: 36713376Free PMC Article
Zhao M, Pan X, Yin Y, Hu H, Wei J, Bai Z, Tang W
Front Public Health 2022;10:869960. Epub 2022 Apr 15 doi: 10.3389/fpubh.2022.869960. PMID: 35493395Free PMC Article
Ren Z, Xu J, Bai Y, Xu A, Cang S, Du C, Li Q, Lu Y, Chen Y, Guo Y, Chen Z, Liu B, Jia W, Wu J, Wang J, Shao G, Zhang B, Shan Y, Meng Z, Wu J, Gu S, Yang W, Liu C, Shi X, Gao Z, Yin T, Cui J, Huang M, Xing B, Mao Y, Teng G, Qin Y, Wang J, Xia F, Yin G, Yang Y, Chen M, Wang Y, Zhou H, Fan J; ORIENT-32 study group
Lancet Oncol 2021 Jul;22(7):977-990. Epub 2021 Jun 15 doi: 10.1016/S1470-2045(21)00252-7. PMID: 34143971
Su D, Wu B, Shi L
JAMA Netw Open 2021 Feb 1;4(2):e210037. doi: 10.1001/jamanetworkopen.2021.0037. PMID: 33625508Free PMC Article

Therapy

Qin S, Chan SL, Gu S, Bai Y, Ren Z, Lin X, Chen Z, Jia W, Jin Y, Guo Y, Hu X, Meng Z, Liang J, Cheng Y, Xiong J, Ren H, Yang F, Li W, Chen Y, Zeng Y, Sultanbaev A, Pazgan-Simon M, Pisetska M, Melisi D, Ponomarenko D, Osypchuk Y, Sinielnikov I, Yang TS, Liang X, Chen C, Wang L, Cheng AL, Kaseb A, Vogel A; CARES-310 Study Group
Lancet 2023 Sep 30;402(10408):1133-1146. Epub 2023 Jul 24 doi: 10.1016/S0140-6736(23)00961-3. PMID: 37499670
Zhu AX, Abbas AR, de Galarreta MR, Guan Y, Lu S, Koeppen H, Zhang W, Hsu CH, He AR, Ryoo BY, Yau T, Kaseb AO, Burgoyne AM, Dayyani F, Spahn J, Verret W, Finn RS, Toh HC, Lujambio A, Wang Y
Nat Med 2022 Aug;28(8):1599-1611. Epub 2022 Jun 23 doi: 10.1038/s41591-022-01868-2. PMID: 35739268
Cheng AL, Qin S, Ikeda M, Galle PR, Ducreux M, Kim TY, Lim HY, Kudo M, Breder V, Merle P, Kaseb AO, Li D, Verret W, Ma N, Nicholas A, Wang Y, Li L, Zhu AX, Finn RS
J Hepatol 2022 Apr;76(4):862-873. Epub 2021 Dec 11 doi: 10.1016/j.jhep.2021.11.030. PMID: 34902530
Finn RS, Qin S, Ikeda M, Galle PR, Ducreux M, Kim TY, Kudo M, Breder V, Merle P, Kaseb AO, Li D, Verret W, Xu DZ, Hernandez S, Liu J, Huang C, Mulla S, Wang Y, Lim HY, Zhu AX, Cheng AL; IMbrave150 Investigators
N Engl J Med 2020 May 14;382(20):1894-1905. doi: 10.1056/NEJMoa1915745. PMID: 32402160
Kudo M, Finn RS, Qin S, Han KH, Ikeda K, Piscaglia F, Baron A, Park JW, Han G, Jassem J, Blanc JF, Vogel A, Komov D, Evans TRJ, Lopez C, Dutcus C, Guo M, Saito K, Kraljevic S, Tamai T, Ren M, Cheng AL
Lancet 2018 Mar 24;391(10126):1163-1173. doi: 10.1016/S0140-6736(18)30207-1. PMID: 29433850

Prognosis

Kudo M, Finn RS, Qin S, Han KH, Ikeda K, Cheng AL, Vogel A, Tovoli F, Ueshima K, Aikata H, López CL, Pracht M, Meng Z, Daniele B, Park JW, Palmer D, Tamai T, Saito K, Dutcus CE, Lencioni R
J Hepatol 2023 Jan;78(1):133-141. Epub 2022 Sep 20 doi: 10.1016/j.jhep.2022.09.006. PMID: 36341767
Lee PC, Wu CJ, Hung YW, Lee CJ, Chi CT, Lee IC, Yu-Lun K, Chou SH, Luo JC, Hou MC, Huang YH
J Immunother Cancer 2022 Jun;10(6) doi: 10.1136/jitc-2022-004779. PMID: 35738801Free PMC Article
Su D, Wu B, Shi L
JAMA Netw Open 2021 Feb 1;4(2):e210037. doi: 10.1001/jamanetworkopen.2021.0037. PMID: 33625508Free PMC Article
Kudo M, Ueshima K, Ikeda M, Torimura T, Tanabe N, Aikata H, Izumi N, Yamasaki T, Nojiri S, Hino K, Tsumura H, Kuzuya T, Isoda N, Yasui K, Aino H, Ido A, Kawabe N, Nakao K, Wada Y, Yokosuka O, Yoshimura K, Okusaka T, Furuse J, Kokudo N, Okita K, Johnson PJ, Arai Y; TACTICS study group
Gut 2020 Aug;69(8):1492-1501. Epub 2019 Dec 4 doi: 10.1136/gutjnl-2019-318934. PMID: 31801872Free PMC Article
Kudo M, Finn RS, Qin S, Han KH, Ikeda K, Piscaglia F, Baron A, Park JW, Han G, Jassem J, Blanc JF, Vogel A, Komov D, Evans TRJ, Lopez C, Dutcus C, Guo M, Saito K, Kraljevic S, Tamai T, Ren M, Cheng AL
Lancet 2018 Mar 24;391(10126):1163-1173. doi: 10.1016/S0140-6736(18)30207-1. PMID: 29433850

Clinical prediction guides

Chiang CL, Chiu KWH, Chan KSK, Lee FAS, Li JCB, Wan CWS, Dai WC, Lam TC, Chen W, Wong NSM, Cheung ALY, Lee VWY, Lau VWH, El Helali A, Man K, Kong FMS, Lo CM, Chan AC
Lancet Gastroenterol Hepatol 2023 Feb;8(2):169-178. Epub 2022 Dec 15 doi: 10.1016/S2468-1253(22)00339-9. PMID: 36529152
Kudo M, Finn RS, Qin S, Han KH, Ikeda K, Cheng AL, Vogel A, Tovoli F, Ueshima K, Aikata H, López CL, Pracht M, Meng Z, Daniele B, Park JW, Palmer D, Tamai T, Saito K, Dutcus CE, Lencioni R
J Hepatol 2023 Jan;78(1):133-141. Epub 2022 Sep 20 doi: 10.1016/j.jhep.2022.09.006. PMID: 36341767
Lee PC, Wu CJ, Hung YW, Lee CJ, Chi CT, Lee IC, Yu-Lun K, Chou SH, Luo JC, Hou MC, Huang YH
J Immunother Cancer 2022 Jun;10(6) doi: 10.1136/jitc-2022-004779. PMID: 35738801Free PMC Article
Yamashita T, Kudo M, Ikeda K, Izumi N, Tateishi R, Ikeda M, Aikata H, Kawaguchi Y, Wada Y, Numata K, Inaba Y, Kuromatsu R, Kobayashi M, Okusaka T, Tamai T, Kitamura C, Saito K, Haruna K, Okita K, Kumada H
J Gastroenterol 2020 Jan;55(1):113-122. Epub 2019 Nov 12 doi: 10.1007/s00535-019-01642-1. PMID: 31720835Free PMC Article
Kudo M, Finn RS, Qin S, Han KH, Ikeda K, Piscaglia F, Baron A, Park JW, Han G, Jassem J, Blanc JF, Vogel A, Komov D, Evans TRJ, Lopez C, Dutcus C, Guo M, Saito K, Kraljevic S, Tamai T, Ren M, Cheng AL
Lancet 2018 Mar 24;391(10126):1163-1173. doi: 10.1016/S0140-6736(18)30207-1. PMID: 29433850

Recent systematic reviews

Mohammadnezhad G, Noqani H, Rostamian P, Sattarpour M, Arabloo J
Eur J Clin Pharmacol 2023 Jul;79(7):885-895. Epub 2023 May 19 doi: 10.1007/s00228-023-03502-7. PMID: 37204440
Abdel-Rahman O, Elsayed Z
Cochrane Database Syst Rev 2020 Nov 16;11(11):CD011313. doi: 10.1002/14651858.CD011313.pub4. PMID: 33197051Free PMC Article
Abdel-Rahman O, Elsayed Z
Cochrane Database Syst Rev 2017 Mar 7;3(3):CD011314. doi: 10.1002/14651858.CD011314.pub2. PMID: 28267205Free PMC Article
Lobo L, Yakoub D, Picado O, Ripat C, Pendola F, Sharma R, ElTawil R, Kwon D, Venkat S, Portelance L, Yechieli R
Cardiovasc Intervent Radiol 2016 Nov;39(11):1580-1588. Epub 2016 Sep 1 doi: 10.1007/s00270-016-1426-y. PMID: 27586657
Abdel-Rahman OM, Elsayed Z
Cochrane Database Syst Rev 2016 Feb 16;2:CD011313. doi: 10.1002/14651858.CD011313.pub2. PMID: 26905230

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