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Spindle cell nodule

MedGen UID:
224751
•Concept ID:
C1265982
•
Cell or Molecular Dysfunction
Synonyms: Postoperative spindle cell nodule; Postoperative Spindle Cell Nodule; Posttraumatic Spindle Cell Nodule
SNOMED CT: Spindle cell nodule (110451006); Postoperative spindle cell nodule (110451006)

Definition

A benign, reactive lesion occurring status post instrumentation; histologic examination demonstrates a fascicular growth pattern of plump or elongated spindle cells infiltrating the wall of an organ without atypia or necrosis. [from NCI]

Professional guidelines

PubMed

Differential Diagnosis of Benign Spindle Cell Lesions.
Magro G
Surg Pathol Clin 2018 Mar;11(1):91-121. Epub 2017 Dec 9 doi: 10.1016/j.path.2017.09.005. PMID: 29413661
Inflammatory pseudotumor and sarcoma of urinary bladder: differential diagnosis and outcome in thirty-eight spindle cell neoplasms.
Iczkowski KA, Shanks JH, Gadaleanu V, Cheng L, Jones EC, Neumann R, Nascimento AG, Bostwick DG
Mod Pathol 2001 Oct;14(10):1043-51. doi: 10.1038/modpathol.3880434. PMID: 11598176

Recent clinical studies

Etiology

Spindle Cell Lesions of the Breast: A Diagnostic Algorithm.
Ni Y, Tse GM
Arch Pathol Lab Med 2023 Jan 1;147(1):30-37. doi: 10.5858/arpa.2022-0048-RA. PMID: 35976671
Pseudosarcomatous and sarcomatous proliferations of the bladder.
Spiess PE, Tuziak T, Tibbs RF, Bassett R, Tamboli P, Brown GA, Grossman HB, Ayala AG, Czerniak B
Hum Pathol 2007 May;38(5):753-61. Epub 2007 Feb 15 doi: 10.1016/j.humpath.2006.11.014. PMID: 17306332
Intradermal nodular fasciitis of the face.
Kang SK, Kim HH, Ahn SJ, Choi JH, Sung KJ, Moon KC, Koh JK
J Dermatol 2002 May;29(5):310-4. doi: 10.1111/j.1346-8138.2002.tb00269.x. PMID: 12081164
Inflammatory pseudotumor and sarcoma of urinary bladder: differential diagnosis and outcome in thirty-eight spindle cell neoplasms.
Iczkowski KA, Shanks JH, Gadaleanu V, Cheng L, Jones EC, Neumann R, Nascimento AG, Bostwick DG
Mod Pathol 2001 Oct;14(10):1043-51. doi: 10.1038/modpathol.3880434. PMID: 11598176
Mesenchymal tumors and tumor-like lesions of the female genital tract: a selective review with emphasis on recently described entities.
Nielsen GP, Young RH
Int J Gynecol Pathol 2001 Apr;20(2):105-27. doi: 10.1097/00004347-200104000-00002. PMID: 11293156

Diagnosis

Spindle Cell Lesions of the Breast: A Diagnostic Algorithm.
Ni Y, Tse GM
Arch Pathol Lab Med 2023 Jan 1;147(1):30-37. doi: 10.5858/arpa.2022-0048-RA. PMID: 35976671
Practical approach to diagnosis of bland-looking spindle cell lesions of the breast.
Magro G, Salvatorelli L, Puzzo L, Piombino E, Bartoloni G, Broggi G, Vecchio GM
Pathologica 2019 Dec;111(4):344-360. doi: 10.32074/1591-951X-31-19. PMID: 31965112Free PMC Article
Differential Diagnosis of Benign Spindle Cell Lesions.
Magro G
Surg Pathol Clin 2018 Mar;11(1):91-121. Epub 2017 Dec 9 doi: 10.1016/j.path.2017.09.005. PMID: 29413661
Inflammatory myofibroblastic tumor of the bladder.
Alderman M, Kunju LP
Arch Pathol Lab Med 2014 Oct;138(10):1272-7. doi: 10.5858/arpa.2014-0274-CC. PMID: 25268188
Benign and malignant spindle cell lesions of the breast.
Brogi E
Semin Diagn Pathol 2004 Feb;21(1):57-64. doi: 10.1053/j.semdp.2003.10.007. PMID: 15074560

Therapy

Postoperative spindle cell nodule after thyroidectomy: a case mimicking recurrence with anaplastic transformation of thyroid cancer.
Kim SW, Oh YL, Choi JY, Lee JI, Chung JH, Kim JS
Head Neck 2013 Jan;35(1):E13-7. Epub 2011 Nov 22 doi: 10.1002/hed.21784. PMID: 22106010
Postoperative spindle cell nodule of the breast: Pseudosarcomatous myofibroblastic proliferation following endo-surgery.
Garijo MF, Val-Bernal JF, Vega A, Val D
Pathol Int 2008 Dec;58(12):787-91. doi: 10.1111/j.1440-1827.2008.02312.x. PMID: 19067854

Prognosis

Practical approach to diagnosis of bland-looking spindle cell lesions of the breast.
Magro G, Salvatorelli L, Puzzo L, Piombino E, Bartoloni G, Broggi G, Vecchio GM
Pathologica 2019 Dec;111(4):344-360. doi: 10.32074/1591-951X-31-19. PMID: 31965112Free PMC Article
Benign and malignant spindle cell lesions of the breast.
Brogi E
Semin Diagn Pathol 2004 Feb;21(1):57-64. doi: 10.1053/j.semdp.2003.10.007. PMID: 15074560
Intradermal nodular fasciitis of the face.
Kang SK, Kim HH, Ahn SJ, Choi JH, Sung KJ, Moon KC, Koh JK
J Dermatol 2002 May;29(5):310-4. doi: 10.1111/j.1346-8138.2002.tb00269.x. PMID: 12081164
Inflammatory pseudotumor and sarcoma of urinary bladder: differential diagnosis and outcome in thirty-eight spindle cell neoplasms.
Iczkowski KA, Shanks JH, Gadaleanu V, Cheng L, Jones EC, Neumann R, Nascimento AG, Bostwick DG
Mod Pathol 2001 Oct;14(10):1043-51. doi: 10.1038/modpathol.3880434. PMID: 11598176
Mesenchymal tumors and tumor-like lesions of the female genital tract: a selective review with emphasis on recently described entities.
Nielsen GP, Young RH
Int J Gynecol Pathol 2001 Apr;20(2):105-27. doi: 10.1097/00004347-200104000-00002. PMID: 11293156

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