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Condyloma acuminata of vagina

MedGen UID:
224905
•Concept ID:
C1302539
•
Disease or Syndrome
Synonyms: Condylomata Acuminata of the Vagina; Condylomata Acuminata of Vagina; Vaginal Condyloma; Vaginal Condyloma Acuminatum
SNOMED CT: Condyloma acuminata of vagina (399599006)

Definition

A human papillomavirus-related neoplasm that arises from the vagina. It is characterized by papillomatosis, acanthotic changes, and hyperkeratosis. Koilocytosis is usually present. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCondyloma acuminata of vagina

Professional guidelines

PubMed

Application of a Thulium Laser for Treatment of Cervical Neoplasias and Condylomas: A Feasibility Study.
Henes M, Vogt B, Neis F, Rall K, Litzenburger T, Wallwiener D, Brucker SY, Rothmund R
Photomed Laser Surg 2015 Sep;33(9):481-5. doi: 10.1089/pho.2015.3935. PMID: 26332918
Treatment of vaginal condylomata acuminata by weekly topical application of 5-fluorouracil.
Krebs HB
Obstet Gynecol 1987 Jul;70(1):68-71. PMID: 3601270
The use of topical 5-fluorouracil in the treatment of genital condylomas.
Krebs HB
Obstet Gynecol Clin North Am 1987 Jun;14(2):559-68. PMID: 3323965

Recent clinical studies

Etiology

HPV vaccination in boys and men.
Stanley M
Hum Vaccin Immunother 2014;10(7):2109-11. doi: 10.4161/hv.29137. PMID: 25424825Free PMC Article
Green and black tea in relation to gynecologic cancers.
Butler LM, Wu AH
Mol Nutr Food Res 2011 Jun;55(6):931-40. Epub 2011 May 19 doi: 10.1002/mnfr.201100058. PMID: 21595018Free PMC Article
Antimicrobial topical agents used in the vagina.
Frey Tirri B
Curr Probl Dermatol 2011;40:36-47. Epub 2011 Feb 10 doi: 10.1159/000321047. PMID: 21325838
Human papillomavirus-related disease in men: not just a women's issue.
Palefsky JM
J Adolesc Health 2010 Apr;46(4 Suppl):S12-9. doi: 10.1016/j.jadohealth.2010.01.010. PMID: 20307839Free PMC Article
Condylomatous tumours of vulva, vagina, and penis. Relation between histological appearance and age.
Schmauz R, Owor R
J Clin Pathol 1980 Nov;33(11):1039-46. doi: 10.1136/jcp.33.11.1039. PMID: 7440752Free PMC Article

Diagnosis

Giant condyloma acuminatum (Buschke-Lowenstein tumour) of the vagina during pregnancy.
Harris SR, Wan KM
BMJ Case Rep 2023 Oct 3;16(10) doi: 10.1136/bcr-2023-255996. PMID: 37788919Free PMC Article
Reproductive system infections in women: lower genital tract syndromes.
Brunham RC, Paavonen J
Pathog Dis 2020 Jul 1;78(5) doi: 10.1093/femspd/ftaa022. PMID: 32463432
Condyloma Acuminatum of Urinary Bladder: Relation to Squamous Cell Carcinoma.
Samarska IV, Epstein JI
Am J Surg Pathol 2019 Nov;43(11):1547-1553. doi: 10.1097/PAS.0000000000001339. PMID: 31368913
Prepubertal vulvovaginopathies.
Pokorny SF
Obstet Gynecol Clin North Am 1992 Mar;19(1):39-58. PMID: 1584544
Condylomatous tumours of vulva, vagina, and penis. Relation between histological appearance and age.
Schmauz R, Owor R
J Clin Pathol 1980 Nov;33(11):1039-46. doi: 10.1136/jcp.33.11.1039. PMID: 7440752Free PMC Article

Therapy

HPV Vaccination: Does It Have a Role in Preventing Penile Cancer and Other Preneoplastic Lesions?
Elst L, Albersen M
Semin Oncol Nurs 2022 Jun;38(3):151284. Epub 2022 May 14 doi: 10.1016/j.soncn.2022.151284. PMID: 35577640
HPV vaccination in boys and men.
Stanley M
Hum Vaccin Immunother 2014;10(7):2109-11. doi: 10.4161/hv.29137. PMID: 25424825Free PMC Article
Green and black tea in relation to gynecologic cancers.
Butler LM, Wu AH
Mol Nutr Food Res 2011 Jun;55(6):931-40. Epub 2011 May 19 doi: 10.1002/mnfr.201100058. PMID: 21595018Free PMC Article
Antimicrobial topical agents used in the vagina.
Frey Tirri B
Curr Probl Dermatol 2011;40:36-47. Epub 2011 Feb 10 doi: 10.1159/000321047. PMID: 21325838
Monitoring of human papillomavirus vaccination.
Dillner J, Arbyn M, Unger E, Dillner L
Clin Exp Immunol 2011 Jan;163(1):17-25. Epub 2010 Nov 9 doi: 10.1111/j.1365-2249.2010.04268.x. PMID: 21062269Free PMC Article

Prognosis

Clinical observation of laser combined with 5-aminolevulinic acid photodynamic therapy for female vulva condyloma acuminatum.
Zhao Z, Jama AA, Gao H, Lu Y
J Obstet Gynaecol Res 2023 Aug;49(8):2010-2014. Epub 2023 May 25 doi: 10.1111/jog.15679. PMID: 37230948
Condyloma Acuminatum of Urinary Bladder: Relation to Squamous Cell Carcinoma.
Samarska IV, Epstein JI
Am J Surg Pathol 2019 Nov;43(11):1547-1553. doi: 10.1097/PAS.0000000000001339. PMID: 31368913
The burden of human papillomavirus infections and related diseases in sub-saharan Africa.
De Vuyst H, Alemany L, Lacey C, Chibwesha CJ, Sahasrabuddhe V, Banura C, Denny L, Parham GP
Vaccine 2013 Dec 29;31 Suppl 5(0 5):F32-46. doi: 10.1016/j.vaccine.2012.07.092. PMID: 24331746Free PMC Article
Global burden of human papillomavirus and related diseases.
Forman D, de Martel C, Lacey CJ, Soerjomataram I, Lortet-Tieulent J, Bruni L, Vignat J, Ferlay J, Bray F, Plummer M, Franceschi S
Vaccine 2012 Nov 20;30 Suppl 5:F12-23. doi: 10.1016/j.vaccine.2012.07.055. PMID: 23199955
Treatment of vaginal condylomata acuminata by weekly topical application of 5-fluorouracil.
Krebs HB
Obstet Gynecol 1987 Jul;70(1):68-71. PMID: 3601270

Clinical prediction guides

Clinical observation of laser combined with 5-aminolevulinic acid photodynamic therapy for female vulva condyloma acuminatum.
Zhao Z, Jama AA, Gao H, Lu Y
J Obstet Gynaecol Res 2023 Aug;49(8):2010-2014. Epub 2023 May 25 doi: 10.1111/jog.15679. PMID: 37230948
Real-world impact and effectiveness assessment of the quadrivalent HPV vaccine: a systematic review of study designs and data sources.
Wang W, Kothari S, Baay M, Garland SM, Giuliano AR, Nygård M, Velicer C, Tota J, Sinha A, Skufca J, Verstraeten T, Sundström K
Expert Rev Vaccines 2022 Feb;21(2):227-240. Epub 2021 Dec 13 doi: 10.1080/14760584.2022.2008243. PMID: 34845951
Management of human papillomavirus-related gynecological malignancies.
Heinzelmann-Schwarz VA, Kind AB, Jacob F
Curr Probl Dermatol 2014;45:216-24. Epub 2014 Mar 13 doi: 10.1159/000358408. PMID: 24643189
Green and black tea in relation to gynecologic cancers.
Butler LM, Wu AH
Mol Nutr Food Res 2011 Jun;55(6):931-40. Epub 2011 May 19 doi: 10.1002/mnfr.201100058. PMID: 21595018Free PMC Article
Condylomatous tumours of vulva, vagina, and penis. Relation between histological appearance and age.
Schmauz R, Owor R
J Clin Pathol 1980 Nov;33(11):1039-46. doi: 10.1136/jcp.33.11.1039. PMID: 7440752Free PMC Article

Recent systematic reviews

Real-world impact and effectiveness assessment of the quadrivalent HPV vaccine: a systematic review of study designs and data sources.
Wang W, Kothari S, Baay M, Garland SM, Giuliano AR, Nygård M, Velicer C, Tota J, Sinha A, Skufca J, Verstraeten T, Sundström K
Expert Rev Vaccines 2022 Feb;21(2):227-240. Epub 2021 Dec 13 doi: 10.1080/14760584.2022.2008243. PMID: 34845951

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