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Genital warts

MedGen UID:
40445
Concept ID:
C0009663
Disease or Syndrome
Synonyms: Condylomata Acuminata; Genital Wart; Genital Warts; Venereal Wart; Venereal Warts; Wart, Genital; Wart, Venereal; Warts, Genital; Warts, Venereal
SNOMED CT: Venereal wart (240542006); Venereal warts (240542006); Anogenital warts (240542006); Anogenital wart (240542006); AGW - Anogenital warts (240542006); Verruca acuminata (240542006); Condyloma acuminatum of the anogenital region (240542006); Condylomata acuminatum of the anogenital region (240542006); Genital warts (266113007); Genital wart (266113007)
 
HPO: HP:0032301

Definition

Warts affecting the skin in the genital area (penile shaft, scrotum, vagina, or labia majora). Warts can be small, beginning as a pinhead-size swelling that may become larger and take on a pedunculated appearance. Warts can spread and coalesce into large masses in the genital or anal area. Their color is variable but tends to be skin colored or darker, and they may occasionally bleed. Warts may cause itching, redness, or discomfort. An outbreak of genital warts may also cause psychological distress. [from HPO]

Professional guidelines

PubMed

Ntanasis-Stathopoulos I, Kyriazoglou A, Liontos M, A Dimopoulos M, Gavriatopoulou M
J BUON 2020 May-Jun;25(3):1281-1285. PMID: 32862567
Yuan J, Ni G, Wang T, Mounsey K, Cavezza S, Pan X, Liu X
Hum Vaccin Immunother 2018 Jul 3;14(7):1815-1819. Epub 2018 Apr 9 doi: 10.1080/21645515.2018.1445947. PMID: 29505317Free PMC Article
Workowski KA, Bolan GA; Centers for Disease Control and Prevention
MMWR Recomm Rep 2015 Jun 5;64(RR-03):1-137. PMID: 26042815Free PMC Article

Recent clinical studies

Etiology

Oyouni AAA
J Infect Public Health 2023 Apr;16(4):626-631. Epub 2023 Feb 21 doi: 10.1016/j.jiph.2023.02.014. PMID: 36868166
Ntanasis-Stathopoulos I, Kyriazoglou A, Liontos M, A Dimopoulos M, Gavriatopoulou M
J BUON 2020 May-Jun;25(3):1281-1285. PMID: 32862567
Yuan J, Ni G, Wang T, Mounsey K, Cavezza S, Pan X, Liu X
Hum Vaccin Immunother 2018 Jul 3;14(7):1815-1819. Epub 2018 Apr 9 doi: 10.1080/21645515.2018.1445947. PMID: 29505317Free PMC Article
Chelimo C, Wouldes TA, Cameron LD, Elwood JM
J Infect 2013 Mar;66(3):207-17. Epub 2012 Oct 26 doi: 10.1016/j.jinf.2012.10.024. PMID: 23103285
Tovar JM, Bazaldua OV, Vargas L, Reile E
Postgrad Med 2008 Jul;120(2):79-84. doi: 10.3810/pgm.2008.07.1794. PMID: 18654072

Diagnosis

Ntanasis-Stathopoulos I, Kyriazoglou A, Liontos M, A Dimopoulos M, Gavriatopoulou M
J BUON 2020 May-Jun;25(3):1281-1285. PMID: 32862567
Steben M, Garland SM
Best Pract Res Clin Obstet Gynaecol 2014 Oct;28(7):1063-73. Epub 2014 Jul 17 doi: 10.1016/j.bpobgyn.2014.07.002. PMID: 25155525
Markle W, Conti T, Kad M
Prim Care 2013 Sep;40(3):557-87. Epub 2013 Jun 29 doi: 10.1016/j.pop.2013.05.001. PMID: 23958358
Chelimo C, Wouldes TA, Cameron LD, Elwood JM
J Infect 2013 Mar;66(3):207-17. Epub 2012 Oct 26 doi: 10.1016/j.jinf.2012.10.024. PMID: 23103285
Zimmerman EE, Crawford P
Am Fam Physician 2012 Dec 15;86(12):1118-24. PMID: 23316984

Therapy

Goldstone SE, Giuliano AR, Palefsky JM, Lazcano-Ponce E, Penny ME, Cabello RE, Moreira ED Jr, Baraldi E, Jessen H, Ferenczy A, Kurman R, Ronnett BM, Stoler MH, Bautista O, Das R, Group T, Luxembourg A, Zhou HJ, Saah A
Lancet Infect Dis 2022 Mar;22(3):413-425. Epub 2021 Nov 12 doi: 10.1016/S1473-3099(21)00327-3. PMID: 34780705
Med Lett Drugs Ther 2018 May 7;60(1546):73-82. PMID: 29746447
Yuan J, Ni G, Wang T, Mounsey K, Cavezza S, Pan X, Liu X
Hum Vaccin Immunother 2018 Jul 3;14(7):1815-1819. Epub 2018 Apr 9 doi: 10.1080/21645515.2018.1445947. PMID: 29505317Free PMC Article
Steben M, Garland SM
Best Pract Res Clin Obstet Gynaecol 2014 Oct;28(7):1063-73. Epub 2014 Jul 17 doi: 10.1016/j.bpobgyn.2014.07.002. PMID: 25155525
Kwok CS, Gibbs S, Bennett C, Holland R, Abbott R
Cochrane Database Syst Rev 2012 Sep 12;2012(9):CD001781. doi: 10.1002/14651858.CD001781.pub3. PMID: 22972052Free PMC Article

Prognosis

Goldstone SE, Giuliano AR, Palefsky JM, Lazcano-Ponce E, Penny ME, Cabello RE, Moreira ED Jr, Baraldi E, Jessen H, Ferenczy A, Kurman R, Ronnett BM, Stoler MH, Bautista O, Das R, Group T, Luxembourg A, Zhou HJ, Saah A
Lancet Infect Dis 2022 Mar;22(3):413-425. Epub 2021 Nov 12 doi: 10.1016/S1473-3099(21)00327-3. PMID: 34780705
Markle W, Conti T, Kad M
Prim Care 2013 Sep;40(3):557-87. Epub 2013 Jun 29 doi: 10.1016/j.pop.2013.05.001. PMID: 23958358
Forman D, de Martel C, Lacey CJ, Soerjomataram I, Lortet-Tieulent J, Bruni L, Vignat J, Ferlay J, Bray F, Plummer M, Franceschi S
Vaccine 2012 Nov 20;30 Suppl 5:F12-23. doi: 10.1016/j.vaccine.2012.07.055. PMID: 23199955
Joura EA, Garland SM, Paavonen J, Ferris DG, Perez G, Ault KA, Huh WK, Sings HL, James MK, Haupt RM; FUTURE I and II Study Group
BMJ 2012 Mar 27;344:e1401. doi: 10.1136/bmj.e1401. PMID: 22454089Free PMC Article
Stanley M
Gynecol Oncol 2010 May;117(2 Suppl):S5-10. doi: 10.1016/j.ygyno.2010.01.024. PMID: 20304221

Clinical prediction guides

Kechagias KS, Kalliala I, Bowden SJ, Athanasiou A, Paraskevaidi M, Paraskevaidis E, Dillner J, Nieminen P, Strander B, Sasieni P, Veroniki AA, Kyrgiou M
BMJ 2022 Aug 3;378:e070135. doi: 10.1136/bmj-2022-070135. PMID: 35922074Free PMC Article
Ntanasis-Stathopoulos I, Kyriazoglou A, Liontos M, A Dimopoulos M, Gavriatopoulou M
J BUON 2020 May-Jun;25(3):1281-1285. PMID: 32862567
Patel C, Brotherton JM, Pillsbury A, Jayasinghe S, Donovan B, Macartney K, Marshall H
Euro Surveill 2018 Oct;23(41) doi: 10.2807/1560-7917.ES.2018.23.41.1700737. PMID: 30326995Free PMC Article
W Buck H Jr
BMJ Clin Evid 2010 Aug 13;2010 PMID: 21418685Free PMC Article
Stanley M
Gynecol Oncol 2010 May;117(2 Suppl):S5-10. doi: 10.1016/j.ygyno.2010.01.024. PMID: 20304221

Recent systematic reviews

Ju HJ, Park HR, Kim JY, Kim GM, Bae JM, Lee JH
Indian J Dermatol Venereol Leprol 2022 Nov-Dec;88(6):724-737. doi: 10.25259/IJDVL_1369_20. PMID: 35962514
Kechagias KS, Kalliala I, Bowden SJ, Athanasiou A, Paraskevaidi M, Paraskevaidis E, Dillner J, Nieminen P, Strander B, Sasieni P, Veroniki AA, Kyrgiou M
BMJ 2022 Aug 3;378:e070135. doi: 10.1136/bmj-2022-070135. PMID: 35922074Free PMC Article
Kwok CS, Gibbs S, Bennett C, Holland R, Abbott R
Cochrane Database Syst Rev 2012 Sep 12;2012(9):CD001781. doi: 10.1002/14651858.CD001781.pub3. PMID: 22972052Free PMC Article
W Buck H Jr
BMJ Clin Evid 2010 Aug 13;2010 PMID: 21418685Free PMC Article
W Buck H Jr
BMJ Clin Evid 2007 Aug 1;2007 PMID: 19454104Free PMC Article

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