U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Tuberculosis(TB)

MedGen UID:
22513
•Concept ID:
C0041296
•
Disease or Syndrome
Synonyms: Kochs disease; TB
SNOMED CT: Tuberculous (371569005); Infection due to Mycobacterium tuberculosis (373576009); Infection caused by Mycobacterium tuberculosis (373576009); TB - Tuberculosis (56717001); Tuberculosis (56717001)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
Monarch Initiative: MONDO:0018076
Orphanet: ORPHA3389

Definition

Tuberculosis (TB) is a contagious-infectious disease caused mainly by <i>Mycobacterium tuberculosis</i> that in most individuals is usually asymptomatic but that in at risk individuals (e.g. with diabetes or with HIV infection) can cause weakness, fever, weight loss, night sweat, and respiratory anomalies such as chronic cough, chest pain, hemoptysis or respiratory insufficiency. [from ORDO]

Professional guidelines

PubMed

The Diagnosis and Treatment of Tuberculosis.
Suárez I, Fünger SM, Kröger S, Rademacher J, Fätkenheuer G, Rybniker J
Dtsch Arztebl Int 2019 Oct 25;116(43):729-735. doi: 10.3238/arztebl.2019.0729. PMID: 31755407
British Society of Gastroenterology consensus guidelines on the management of inflammatory bowel disease in adults.
Lamb CA, Kennedy NA, Raine T, Hendy PA, Smith PJ, Limdi JK, Hayee B, Lomer MCE, Parkes GC, Selinger C, Barrett KJ, Davies RJ, Bennett C, Gittens S, Dunlop MG, Faiz O, Fraser A, Garrick V, Johnston PD, Parkes M, Sanderson J, Terry H; IBD guidelines eDelphi consensus group, Gaya DR, Iqbal TH, Taylor SA, Smith M, Brookes M, Hansen R, Hawthorne AB
Gut 2019 Dec;68(Suppl 3):s1-s106. Epub 2019 Sep 27 doi: 10.1136/gutjnl-2019-318484. PMID: 31562236Free PMC Article
Position statement: LEPROSY: Diagnosis, treatment and follow-up.
Alemu Belachew W, Naafs B
J Eur Acad Dermatol Venereol 2019 Jul;33(7):1205-1213. Epub 2019 Apr 3 doi: 10.1111/jdv.15569. PMID: 30945360

Recent clinical studies

Etiology

Ophthalmic manifestations of tuberculosis.
Bates B, Crowell EL
Curr Opin Ophthalmol 2023 Nov 1;34(6):529-534. Epub 2023 Aug 18 doi: 10.1097/ICU.0000000000000991. PMID: 37593994
Surveillance of tuberculosis.
Schwoebel V
Indian J Tuberc 2020 Dec;67(4S):S33-S42. Epub 2020 Nov 15 doi: 10.1016/j.ijtb.2020.11.006. PMID: 33308670
Ocular tuberculosis: Where are we today?
Testi I, Agrawal R, Mehta S, Basu S, Nguyen Q, Pavesio C, Gupta V
Indian J Ophthalmol 2020 Sep;68(9):1808-1817. doi: 10.4103/ijo.IJO_1451_20. PMID: 32823397Free PMC Article
Managing latent tuberculosis infection and tuberculosis in children.
Carvalho I, Goletti D, Manga S, Silva DR, Manissero D, Migliori G
Pulmonology 2018 Mar-Apr;24(2):106-114. Epub 2018 Mar 2 doi: 10.1016/j.rppnen.2017.10.007. PMID: 29502937
What We Know About Tuberculosis Transmission: An Overview.
Churchyard G, Kim P, Shah NS, Rustomjee R, Gandhi N, Mathema B, Dowdy D, Kasmar A, Cardenas V
J Infect Dis 2017 Nov 3;216(suppl_6):S629-S635. doi: 10.1093/infdis/jix362. PMID: 29112747Free PMC Article

Diagnosis

Research progress of single-cell sequencing in tuberculosis.
Pan J, Chang Z, Zhang X, Dong Q, Zhao H, Shi J, Wang G
Front Immunol 2023;14:1276194. Epub 2023 Oct 13 doi: 10.3389/fimmu.2023.1276194. PMID: 37901241Free PMC Article
The unsustainable anachronism of tuberculosis diagnosis.
The Lancet Microbe
Lancet Microbe 2023 Jun;4(6):e379. doi: 10.1016/S2666-5247(23)00153-2. PMID: 37269864Free PMC Article
The diagnosis of tuberculosis.
Brodie D, Schluger NW
Clin Chest Med 2005 Jun;26(2):247-71, vi. doi: 10.1016/j.ccm.2005.02.012. PMID: 15837109
Tuberculosis.
BADGER TL
N Engl J Med 1959 Jul 2;261(1):30-6 contd. doi: 10.1056/NEJM195907022610106. PMID: 13666972
TUBERCULOSIS.
Br Med J 1951 Feb 10;1(4701):311. PMID: 14821403

Therapy

TB-PRACTECAL: study protocol for a randomised, controlled, open-label, phase II-III trial to evaluate the safety and efficacy of regimens containing bedaquiline and pretomanid for the treatment of adult patients with pulmonary multidrug-resistant tuberculosis.
Berry C, du Cros P, Fielding K, Gajewski S, Kazounis E, McHugh TD, Merle C, Motta I, Moore DAJ, Nyang'wa BT
Trials 2022 Jun 13;23(1):484. doi: 10.1186/s13063-022-06331-8. PMID: 35698158Free PMC Article
Pretomanid for tuberculosis: a systematic review.
Gils T, Lynen L, de Jong BC, Van Deun A, Decroo T
Clin Microbiol Infect 2022 Jan;28(1):31-42. Epub 2021 Aug 14 doi: 10.1016/j.cmi.2021.08.007. PMID: 34400340
Guidelines for the Treatment of Latent Tuberculosis Infection: Recommendations from the National Tuberculosis Controllers Association and CDC, 2020.
Sterling TR, Njie G, Zenner D, Cohn DL, Reves R, Ahmed A, Menzies D, Horsburgh CR Jr, Crane CM, Burgos M, LoBue P, Winston CA, Belknap R
MMWR Recomm Rep 2020 Feb 14;69(1):1-11. doi: 10.15585/mmwr.rr6901a1. PMID: 32053584Free PMC Article
The status of tuberculosis vaccine development.
Schrager LK, Vekemens J, Drager N, Lewinsohn DM, Olesen OF
Lancet Infect Dis 2020 Mar;20(3):e28-e37. Epub 2020 Jan 31 doi: 10.1016/S1473-3099(19)30625-5. PMID: 32014117
Long-term safety of secukinumab in patients with moderate-to-severe plaque psoriasis, psoriatic arthritis, and ankylosing spondylitis: integrated pooled clinical trial and post-marketing surveillance data.
Deodhar A, Mease PJ, McInnes IB, Baraliakos X, Reich K, Blauvelt A, Leonardi C, Porter B, Das Gupta A, Widmer A, Pricop L, Fox T
Arthritis Res Ther 2019 May 2;21(1):111. doi: 10.1186/s13075-019-1882-2. PMID: 31046809Free PMC Article

Prognosis

Challenges in urogenital tuberculosis.
Kulchavenya E, Kholtobin D, Shevchenko S
World J Urol 2020 Jan;38(1):89-94. Epub 2019 Apr 17 doi: 10.1007/s00345-019-02767-x. PMID: 30997530
Epidemiology of Tuberculosis in the United States.
Langer AJ, Navin TR, Winston CA, LoBue P
Clin Chest Med 2019 Dec;40(4):693-702. doi: 10.1016/j.ccm.2019.07.001. PMID: 31731978Free PMC Article
Diabetes Care in Nigeria.
Fasanmade OA, Dagogo-Jack S
Ann Glob Health 2015 Nov-Dec;81(6):821-9. doi: 10.1016/j.aogh.2015.12.012. PMID: 27108149
Tuberculosis in pregnancy.
Laibl VR, Sheffield JS
Clin Perinatol 2005 Sep;32(3):739-47. doi: 10.1016/j.clp.2005.04.010. PMID: 16085030
Pulmonary tuberculosis.
Hirsch CS, Johnson JL, Ellner JJ
Curr Opin Pulm Med 1999 May;5(3):143-50. doi: 10.1097/00063198-199905000-00004. PMID: 10228738

Clinical prediction guides

Clinical utility of tuberculosis RNA in the rapid diagnosis of bone and joint tuberculosis.
Zheng M, Wang Y, Ying X, Zhang P, Liu F, Zheng Q
Diagn Microbiol Infect Dis 2023 Jun;106(2):115941. Epub 2023 Mar 14 doi: 10.1016/j.diagmicrobio.2023.115941. PMID: 37030282
Integrating landmark modeling framework and machine learning algorithms for dynamic prediction of tuberculosis treatment outcomes.
Kheirandish M, Catanzaro D, Crudu V, Zhang S
J Am Med Inform Assoc 2022 Apr 13;29(5):900-908. doi: 10.1093/jamia/ocac003. PMID: 35139541Free PMC Article
Histochemistry in the diagnosis of non-neoplastic gastrointestinal disorders.
Fitzgibbons PL
Semin Diagn Pathol 2018 Nov;35(6):370-380. Epub 2018 Oct 16 doi: 10.1053/j.semdp.2018.10.002. PMID: 30366790
Automated tuberculosis detection.
Hripcsak G, Knirsch CA, Jain NL, Pablos-Mendez A
J Am Med Inform Assoc 1997 Sep-Oct;4(5):376-81. doi: 10.1136/jamia.1997.0040376. PMID: 9292843Free PMC Article
Sarcoidosis mythology.
Teirstein AS, Padilla ML, De Palo LR, Schilero GJ
Mt Sinai J Med 1996 Oct-Nov;63(5-6):335-41. PMID: 8898539

Recent systematic reviews

Global prevalence of drug-resistant tuberculosis: a systematic review and meta-analysis.
Salari N, Kanjoori AH, Hosseinian-Far A, Hasheminezhad R, Mansouri K, Mohammadi M
Infect Dis Poverty 2023 May 25;12(1):57. doi: 10.1186/s40249-023-01107-x. PMID: 37231463Free PMC Article
The natural history of untreated pulmonary tuberculosis in adults: a systematic review and meta-analysis.
Sossen B, Richards AS, Heinsohn T, Frascella B, Balzarini F, Oradini-Alacreu A, Odone A, Rogozinska E, Häcker B, Cobelens F, Kranzer K, Houben RMGJ, Esmail H
Lancet Respir Med 2023 Apr;11(4):367-379. Epub 2023 Mar 23 doi: 10.1016/S2213-2600(23)00097-8. PMID: 36966795
Post-tuberculosis sequelae in children and adolescents: a systematic review.
Igbokwe V, Ruby LC, Sultanli A, Bélard S
Lancet Infect Dis 2023 Apr;23(4):e138-e150. doi: 10.1016/S1473-3099(23)00004-X. PMID: 36963920
Pretomanid for tuberculosis: a systematic review.
Gils T, Lynen L, de Jong BC, Van Deun A, Decroo T
Clin Microbiol Infect 2022 Jan;28(1):31-42. Epub 2021 Aug 14 doi: 10.1016/j.cmi.2021.08.007. PMID: 34400340
A systemic review on tuberculosis.
Natarajan A, Beena PM, Devnikar AV, Mali S
Indian J Tuberc 2020 Jul;67(3):295-311. Epub 2020 Feb 28 doi: 10.1016/j.ijtb.2020.02.005. PMID: 32825856

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Reviews

    Related information

    • MeSH
      Related Medical Subject Headings
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...