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Gallbladder small cell neuroendocrine carcinoma

MedGen UID:
232229
•Concept ID:
C1333759
•
Neoplastic Process
Synonyms: gall bladder small cell carcinoma; gallbladder Oat cell carcinoma; Gallbladder Small Cell Carcinoma; gallbladder small cell carcinoma; Gallbladder Small Cell NEC; gallbladder small cell NEC; Gallbladder Small Cell Neuroendocrine Carcinoma; gallbladder small cell neuroendocrine carcinoma; Oat cell carcinoma of gallbladder; Oat cell carcinoma of the gallbladder; small cell carcinoma of gall bladder; Small Cell Carcinoma of Gallbladder; small cell carcinoma of gallbladder; Small Cell Carcinoma of the Gallbladder; small cell carcinoma of the gallbladder
 
Monarch Initiative: MONDO:0006219

Definition

An aggressive, high-grade and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the gallbladder. It is characterized by the presence of malignant small cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGallbladder small cell neuroendocrine carcinoma

Professional guidelines

PubMed

Intraductal tubulopapillary neoplasms of the bile ducts: identity, clinicopathologic characteristics, and differential diagnosis of a distinct entity among intraductal tumors.
Pehlivanoglu B, Adsay V
Hum Pathol 2023 Feb;132:12-19. Epub 2022 Aug 5 doi: 10.1016/j.humpath.2022.07.019. PMID: 35934108
Management of primary hepatopancreatobiliary small cell carcinoma.
Groeschl RT, Christians KK, Turaga KK, Gamblin TC
J Surg Oncol 2013 Jun;107(7):692-5. Epub 2012 Dec 27 doi: 10.1002/jso.23305. PMID: 23280574
Neuroendocrine tumors of the gallbladder: an evaluation and reassessment of management strategy.
Eltawil KM, Gustafsson BI, Kidd M, Modlin IM
J Clin Gastroenterol 2010 Nov-Dec;44(10):687-95. doi: 10.1097/MCG.0b013e3181d7a6d4. PMID: 20375728

Curated

NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Neuroendocrine and Adrenal Tumors, 2023

Recent clinical studies

Etiology

High tumor mutational burden predicts favorable response to anti-PD-(L)1 therapy in patients with solid tumor: a real-world pan-tumor analysis.
Jung J, Heo YJ, Park S
J Immunother Cancer 2023 Apr;11(4) doi: 10.1136/jitc-2022-006454. PMID: 37094985Free PMC Article
Clinical Analysis of Extrapulmonary Neuroendocrine Carcinoma: A Retrospective and Single Institution Experience.
Okumura T, Noguchi T, Sekiguchi N, Kobayashi T, Kanda S, Ida K, Minagawa T, Tokumaru S, Umemura T, Koizumi T
Chemotherapy 2023;68(2):87-94. Epub 2022 Nov 3 doi: 10.1159/000527377. PMID: 36327945
ISH-based HER2 diagnostics.
Rüschoff J, Nagelmeier I, Jasani B, Stoss O
Pathologe 2021 Nov;42(Suppl 1):62-68. Epub 2020 Dec 21 doi: 10.1007/s00292-020-00878-6. PMID: 33346874
Psoriasis and cancer. An Australian/New Zealand narrative.
Rademaker M, Rubel DM, Agnew K, Andrews M, Armour KS, Baker C, Foley P, Gebauer K, Goh MS, Gupta M, Marshman G, Prince HM, Sullivan J
Australas J Dermatol 2019 Feb;60(1):12-18. Epub 2018 Jul 10 doi: 10.1111/ajd.12889. PMID: 29992535
Genetic alteration regulated by microRNAs in biliary tract cancers.
Wang N, Xia S, Chen K, Xiang X, Zhu A
Crit Rev Oncol Hematol 2015 Nov;96(2):262-73. Epub 2015 Jun 4 doi: 10.1016/j.critrevonc.2015.05.015. PMID: 26095617

Diagnosis

Clinical features and outcomes analysis of Gallbladder neuroendocrine carcinoma.
Jiang M, Zhang Y
J Cancer Res Ther 2023 Aug;19(4):910-916. doi: 10.4103/jcrt.jcrt_1959_21. PMID: 37675716
Clinical Analysis of Extrapulmonary Neuroendocrine Carcinoma: A Retrospective and Single Institution Experience.
Okumura T, Noguchi T, Sekiguchi N, Kobayashi T, Kanda S, Ida K, Minagawa T, Tokumaru S, Umemura T, Koizumi T
Chemotherapy 2023;68(2):87-94. Epub 2022 Nov 3 doi: 10.1159/000527377. PMID: 36327945
ISH-based HER2 diagnostics.
Rüschoff J, Nagelmeier I, Jasani B, Stoss O
Pathologe 2021 Nov;42(Suppl 1):62-68. Epub 2020 Dec 21 doi: 10.1007/s00292-020-00878-6. PMID: 33346874
Psoriasis and cancer. An Australian/New Zealand narrative.
Rademaker M, Rubel DM, Agnew K, Andrews M, Armour KS, Baker C, Foley P, Gebauer K, Goh MS, Gupta M, Marshman G, Prince HM, Sullivan J
Australas J Dermatol 2019 Feb;60(1):12-18. Epub 2018 Jul 10 doi: 10.1111/ajd.12889. PMID: 29992535
Neuroendocrine tumors of the gallbladder: an evaluation and reassessment of management strategy.
Eltawil KM, Gustafsson BI, Kidd M, Modlin IM
J Clin Gastroenterol 2010 Nov-Dec;44(10):687-95. doi: 10.1097/MCG.0b013e3181d7a6d4. PMID: 20375728

Therapy

First-in-Humans PET Imaging of KRAS(G12C) Mutation Status in Non-Small Cell Lung and Colorectal Cancer Patients Using [(18)F]PFPMD.
Li X, Ye J, Wang J, Quan Z, Li G, Ma W, Zhang M, Yang W, Wang J, Ma T, Kang F, Wang J
J Nucl Med 2023 Dec 1;64(12):1880-1888. doi: 10.2967/jnumed.123.265715. PMID: 37827842
MRTX1719 Is an MTA-Cooperative PRMT5 Inhibitor That Exhibits Synthetic Lethality in Preclinical Models and Patients with MTAP-Deleted Cancer.
Engstrom LD, Aranda R, Waters L, Moya K, Bowcut V, Vegar L, Trinh D, Hebbert A, Smith CR, Kulyk S, Lawson JD, He L, Hover LD, Fernandez-Banet J, Hallin J, Vanderpool D, Briere DM, Blaj A, Marx MA, Rodon J, Offin M, Arbour KC, Johnson ML, Kwiatkowski DJ, Jänne PA, Haddox CL, Papadopoulos KP, Henry JT, Leventakos K, Christensen JG, Shazer R, Olson P
Cancer Discov 2023 Nov 1;13(11):2412-2431. doi: 10.1158/2159-8290.CD-23-0669. PMID: 37552839Free PMC Article
FIGHT-101, a first-in-human study of potent and selective FGFR 1-3 inhibitor pemigatinib in pan-cancer patients with FGF/FGFR alterations and advanced malignancies.
Subbiah V, Iannotti NO, Gutierrez M, Smith DC, Féliz L, Lihou CF, Tian C, Silverman IM, Ji T, Saleh M
Ann Oncol 2022 May;33(5):522-533. Epub 2022 Feb 14 doi: 10.1016/j.annonc.2022.02.001. PMID: 35176457
Psoriasis and cancer. An Australian/New Zealand narrative.
Rademaker M, Rubel DM, Agnew K, Andrews M, Armour KS, Baker C, Foley P, Gebauer K, Goh MS, Gupta M, Marshman G, Prince HM, Sullivan J
Australas J Dermatol 2019 Feb;60(1):12-18. Epub 2018 Jul 10 doi: 10.1111/ajd.12889. PMID: 29992535
Clinical outcomes of small cell neuroendocrine carcinoma and adenocarcinoma of the gallbladder.
Yun SP, Shin N, Seo HI
World J Gastroenterol 2015 Jan 7;21(1):269-75. doi: 10.3748/wjg.v21.i1.269. PMID: 25574101Free PMC Article

Prognosis

Clinical features and outcomes analysis of Gallbladder neuroendocrine carcinoma.
Jiang M, Zhang Y
J Cancer Res Ther 2023 Aug;19(4):910-916. doi: 10.4103/jcrt.jcrt_1959_21. PMID: 37675716
High tumor mutational burden predicts favorable response to anti-PD-(L)1 therapy in patients with solid tumor: a real-world pan-tumor analysis.
Jung J, Heo YJ, Park S
J Immunother Cancer 2023 Apr;11(4) doi: 10.1136/jitc-2022-006454. PMID: 37094985Free PMC Article
Clinical Analysis of Extrapulmonary Neuroendocrine Carcinoma: A Retrospective and Single Institution Experience.
Okumura T, Noguchi T, Sekiguchi N, Kobayashi T, Kanda S, Ida K, Minagawa T, Tokumaru S, Umemura T, Koizumi T
Chemotherapy 2023;68(2):87-94. Epub 2022 Nov 3 doi: 10.1159/000527377. PMID: 36327945
The state of therapy modalities in clinic for biliary tract cancer.
Chen W, Hu Z, Song J, Wu Y, Zhang B, Zhang L
Front Biosci (Landmark Ed) 2022 Jun 8;27(6):185. doi: 10.31083/j.fbl2706185. PMID: 35748261
Neuroendocrine tumors of the gallbladder: an evaluation and reassessment of management strategy.
Eltawil KM, Gustafsson BI, Kidd M, Modlin IM
J Clin Gastroenterol 2010 Nov-Dec;44(10):687-95. doi: 10.1097/MCG.0b013e3181d7a6d4. PMID: 20375728

Clinical prediction guides

First-in-Humans PET Imaging of KRAS(G12C) Mutation Status in Non-Small Cell Lung and Colorectal Cancer Patients Using [(18)F]PFPMD.
Li X, Ye J, Wang J, Quan Z, Li G, Ma W, Zhang M, Yang W, Wang J, Ma T, Kang F, Wang J
J Nucl Med 2023 Dec 1;64(12):1880-1888. doi: 10.2967/jnumed.123.265715. PMID: 37827842
MRTX1719 Is an MTA-Cooperative PRMT5 Inhibitor That Exhibits Synthetic Lethality in Preclinical Models and Patients with MTAP-Deleted Cancer.
Engstrom LD, Aranda R, Waters L, Moya K, Bowcut V, Vegar L, Trinh D, Hebbert A, Smith CR, Kulyk S, Lawson JD, He L, Hover LD, Fernandez-Banet J, Hallin J, Vanderpool D, Briere DM, Blaj A, Marx MA, Rodon J, Offin M, Arbour KC, Johnson ML, Kwiatkowski DJ, Jänne PA, Haddox CL, Papadopoulos KP, Henry JT, Leventakos K, Christensen JG, Shazer R, Olson P
Cancer Discov 2023 Nov 1;13(11):2412-2431. doi: 10.1158/2159-8290.CD-23-0669. PMID: 37552839Free PMC Article
High tumor mutational burden predicts favorable response to anti-PD-(L)1 therapy in patients with solid tumor: a real-world pan-tumor analysis.
Jung J, Heo YJ, Park S
J Immunother Cancer 2023 Apr;11(4) doi: 10.1136/jitc-2022-006454. PMID: 37094985Free PMC Article
Neuroendocrine Carcinomas of the Gallbladder: A Clinicopathologic and Immunohistochemical Analysis of 34 Resected Cases.
Lee SM, Sung CO
Am J Surg Pathol 2020 Oct;44(10):1308-1321. doi: 10.1097/PAS.0000000000001536. PMID: 32739935
Genetic alteration regulated by microRNAs in biliary tract cancers.
Wang N, Xia S, Chen K, Xiang X, Zhu A
Crit Rev Oncol Hematol 2015 Nov;96(2):262-73. Epub 2015 Jun 4 doi: 10.1016/j.critrevonc.2015.05.015. PMID: 26095617

Recent systematic reviews

Change of Circulating and Tissue-Based miR-20a in Human Cancers and Associated Prognostic Implication: A Systematic Review and Meta-Analysis.
Zhang Q, Wang Q, Sun W, Gao F, Liu L, Cheng L, Li Z
Biomed Res Int 2018;2018:6124927. Epub 2018 Nov 25 doi: 10.1155/2018/6124927. PMID: 30596096Free PMC Article

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    Curated

    • NCCN, 2023
      NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Neuroendocrine and Adrenal Tumors, 2023

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