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Digestive System Small Cell Neuroendocrine Carcinoma

MedGen UID:
1666553
Concept ID:
C4743673
Neoplastic Process
Synonyms: Digestive System Small Cell Carcinoma; Gastrointestinal System Small Cell Neuroendocrine Carcinoma

Definition

An aggressive, high-grade, and poorly differentiated carcinoma with neuroendocrine differentiation that arises from any part of the gastrointestinal system. It is characterized by the presence of malignant small cells. [from NCI]

Professional guidelines

PubMed

Horio Y, Kuroda H, Masago K, Matsushita H, Sasaki E, Fujiwara Y
Jpn J Clin Oncol 2024 Mar 9;54(3):229-247. doi: 10.1093/jjco/hyad160. PMID: 38018262
Chen W, Liu C, Liu Y, Yuan J, Wang Z
World J Surg Oncol 2023 Aug 22;21(1):258. doi: 10.1186/s12957-023-03100-y. PMID: 37608278Free PMC Article
Singh S, Osna NA, Kharbanda KK
World J Gastroenterol 2017 Sep 28;23(36):6549-6570. doi: 10.3748/wjg.v23.i36.6549. PMID: 29085205Free PMC Article

Recent clinical studies

Etiology

Katoh M, Loriot Y, Brandi G, Tavolari S, Wainberg ZA, Katoh M
Nat Rev Clin Oncol 2024 Apr;21(4):312-329. Epub 2024 Feb 29 doi: 10.1038/s41571-024-00869-z. PMID: 38424198
Mastracci L, Rindi G, Grillo F, Solcia E, Campora M, Fassan M, Parente P, Vanoli A, La Rosa S
Pathologica 2021 Feb;113(1):5-11. doi: 10.32074/1591-951X-229. PMID: 33686305Free PMC Article
Singh S, Osna NA, Kharbanda KK
World J Gastroenterol 2017 Sep 28;23(36):6549-6570. doi: 10.3748/wjg.v23.i36.6549. PMID: 29085205Free PMC Article
Ashktorab H, Kupfer SS, Brim H, Carethers JM
Gastroenterology 2017 Oct;153(4):910-923. Epub 2017 Aug 12 doi: 10.1053/j.gastro.2017.08.018. PMID: 28807841Free PMC Article
Aupérin A, Le Péchoux C, Rolland E, Curran WJ, Furuse K, Fournel P, Belderbos J, Clamon G, Ulutin HC, Paulus R, Yamanaka T, Bozonnat MC, Uitterhoeve A, Wang X, Stewart L, Arriagada R, Burdett S, Pignon JP
J Clin Oncol 2010 May 1;28(13):2181-90. Epub 2010 Mar 29 doi: 10.1200/JCO.2009.26.2543. PMID: 20351327

Diagnosis

Allmark A, Brubaker ML
JAAPA 2021 Aug 1;34(8):35-39. doi: 10.1097/01.JAA.0000742960.70174.8d. PMID: 34320538
Mastracci L, Rindi G, Grillo F, Solcia E, Campora M, Fassan M, Parente P, Vanoli A, La Rosa S
Pathologica 2021 Feb;113(1):5-11. doi: 10.32074/1591-951X-229. PMID: 33686305Free PMC Article
Lee JE, Hong SH, Jung HI, Son MW, Ahn TS, Han SW, Cho JH
BMC Surg 2019 Sep 12;19(1):135. doi: 10.1186/s12893-019-0591-8. PMID: 31510991Free PMC Article
Pepe G, Moncayo R, Bombardieri E, Chiti A
Eur J Nucl Med Mol Imaging 2012 Feb;39 Suppl 1:S41-51. doi: 10.1007/s00259-011-2019-2. PMID: 22388628
Saif MW
JOP 2007 Jan 9;8(1):55-63. PMID: 17228135

Therapy

Weng W, Meng T, Pu J, Ma L, Shen Y, Wang Z, Pan R, Wang M, Chen C, Wang L, Zhang J, Zhou B, Shao S, Qian Y, Liu S, Hu W, Meng X
Mol Cancer Ther 2023 Sep 5;22(9):1013-1027. doi: 10.1158/1535-7163.MCT-23-0198. PMID: 37302522Free PMC Article
Subbiah V, Iannotti NO, Gutierrez M, Smith DC, Féliz L, Lihou CF, Tian C, Silverman IM, Ji T, Saleh M
Ann Oncol 2022 May;33(5):522-533. Epub 2022 Feb 14 doi: 10.1016/j.annonc.2022.02.001. PMID: 35176457
Nogami N, Barlesi F, Socinski MA, Reck M, Thomas CA, Cappuzzo F, Mok TSK, Finley G, Aerts JG, Orlandi F, Moro-Sibilot D, Jotte RM, Stroyakovskiy D, Villaruz LC, Rodríguez-Abreu D, Wan-Teck Lim D, Merritt D, Coleman S, Lee A, Shankar G, Yu W, Bara I, Nishio M
J Thorac Oncol 2022 Feb;17(2):309-323. Epub 2021 Oct 7 doi: 10.1016/j.jtho.2021.09.014. PMID: 34626838
Xing R, Gao J, Cui Q, Wang Q
Front Immunol 2021;12:783236. Epub 2021 Nov 26 doi: 10.3389/fimmu.2021.783236. PMID: 34899747Free PMC Article
Singh S, Osna NA, Kharbanda KK
World J Gastroenterol 2017 Sep 28;23(36):6549-6570. doi: 10.3748/wjg.v23.i36.6549. PMID: 29085205Free PMC Article

Prognosis

Wu H, Yu Z, Liu Y, Guo L, Teng L, Guo L, Liang L, Wang J, Gao J, Li R, Yang L, Nie X, Su D, Liang Z
Cancer Commun (Lond) 2022 Dec;42(12):1367-1386. Epub 2022 Oct 20 doi: 10.1002/cac2.12372. PMID: 36264285Free PMC Article
Kasajima A, Klöppel G
Pathol Int 2022 Oct;72(10):488-495. Epub 2022 Aug 19 doi: 10.1111/pin.13266. PMID: 35983917
Li R, Yang Z, Shao F, Cheng H, Wen Y, Sun S, Guo W, Li Z, Zhang F, Xue L, Bi N, Wang J, Sun Y, Li Y, Tan F, Xue Q, Gao S, Shi S, Gao Y, He J
Nat Commun 2021 Jun 18;12(1):3785. doi: 10.1038/s41467-021-24043-6. PMID: 34145257Free PMC Article
Mastracci L, Rindi G, Grillo F, Solcia E, Campora M, Fassan M, Parente P, Vanoli A, La Rosa S
Pathologica 2021 Feb;113(1):5-11. doi: 10.32074/1591-951X-229. PMID: 33686305Free PMC Article
Saif MW
JOP 2007 Jan 9;8(1):55-63. PMID: 17228135

Clinical prediction guides

Lee JC, Green MD, Huppert LA, Chow C, Pierce RH, Daud AI
Clin Cancer Res 2022 Jan 1;28(1):5-12. Epub 2021 Jul 20 doi: 10.1158/1078-0432.CCR-21-1193. PMID: 34285059Free PMC Article
Li R, Yang Z, Shao F, Cheng H, Wen Y, Sun S, Guo W, Li Z, Zhang F, Xue L, Bi N, Wang J, Sun Y, Li Y, Tan F, Xue Q, Gao S, Shi S, Gao Y, He J
Nat Commun 2021 Jun 18;12(1):3785. doi: 10.1038/s41467-021-24043-6. PMID: 34145257Free PMC Article
Mastracci L, Rindi G, Grillo F, Solcia E, Campora M, Fassan M, Parente P, Vanoli A, La Rosa S
Pathologica 2021 Feb;113(1):5-11. doi: 10.32074/1591-951X-229. PMID: 33686305Free PMC Article
Jiang SH, Li J, Dong FY, Yang JY, Liu DJ, Yang XM, Wang YH, Yang MW, Fu XL, Zhang XX, Li Q, Pang XF, Huo YM, Li J, Zhang JF, Lee HY, Lee SJ, Qin WX, Gu JR, Sun YW, Zhang ZG
Gastroenterology 2017 Jul;153(1):277-291.e19. Epub 2017 Mar 15 doi: 10.1053/j.gastro.2017.03.008. PMID: 28315323
Filiz G, Yerci O, Adim SB, Gurel S, Dolar E, Memik F
Hepatogastroenterology 2007 Jun;54(76):1247-9. PMID: 17629080

Recent systematic reviews

Rodger FE, Brennan PT, Nair R, Holroyd DJ
Surg Oncol 2022 Sep;44:101819. Epub 2022 Jul 20 doi: 10.1016/j.suronc.2022.101819. PMID: 35940030
Wang J, Hao S, Gu J, Rudd SG, Wang Y
PeerJ 2022;10:e13141. Epub 2022 Mar 22 doi: 10.7717/peerj.13141. PMID: 35345582Free PMC Article
Pedersen TB, Kildsig J, Serup-Hansen E, Gocht-Jensen P, Klein MF
Int J Colorectal Dis 2020 Sep;35(9):1663-1671. Epub 2020 Jul 15 doi: 10.1007/s00384-020-03687-8. PMID: 32671458
Lin LL, Lin GF, Yang F, Chen XQ
Int Immunopharmacol 2020 Jun;83:106537. Epub 2020 May 1 doi: 10.1016/j.intimp.2020.106537. PMID: 32371246
Palma DA, Warner A, Louie AV, Senan S, Slotman B, Rodrigues GB
Clin Lung Cancer 2016 Jul;17(4):239-44. Epub 2015 Oct 1 doi: 10.1016/j.cllc.2015.09.007. PMID: 26498503

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