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Liver Non-Hodgkin Lymphoma

MedGen UID:
232596
•Concept ID:
C1333973
•
Neoplastic Process
Synonyms: Hepatic Non-Hodgkin Lymphoma; Hepatic Non-Hodgkin's Lymphoma; Non-Hodgkin's Liver Lymphoma; Non-Hodgkin's Lymphoma of Liver; Non-Hodgkin's Lymphoma of the Liver; Primary Hepatic Non-Hodgkin's Lymphoma; Primary Liver Non-Hodgkin Lymphoma

Definition

A rare non-Hodgkin lymphoma that arises from the liver and the bulk of the tumor is located in the liver. The most frequent types of non-Hodgkin lymphoma that arise from the liver are diffuse large B-cell lymphoma and mucosa-associated lymphoid tissue lymphoma. [from NCI]

Professional guidelines

PubMed

Hepatosplenic T-cell lymphoma: treatment challenges.
Bron D, De Leval L, Michiels S, Wittnebel S; EuroBloodNet for rare diseases
Curr Opin Oncol 2021 Sep 1;33(5):406-411. doi: 10.1097/CCO.0000000000000775. PMID: 34409955
Pathobiology and treatment of lymphomatoid granulomatosis, a rare EBV-driven disorder.
Melani C, Jaffe ES, Wilson WH
Blood 2020 Apr 16;135(16):1344-1352. doi: 10.1182/blood.2019000933. PMID: 32107539Free PMC Article
Recommendations for initial evaluation, staging, and response assessment of Hodgkin and non-Hodgkin lymphoma: the Lugano classification.
Cheson BD, Fisher RI, Barrington SF, Cavalli F, Schwartz LH, Zucca E, Lister TA; Alliance, Australasian Leukaemia and Lymphoma Group; Eastern Cooperative Oncology Group; European Mantle Cell Lymphoma Consortium; Italian Lymphoma Foundation; European Organisation for Research; Treatment of Cancer/Dutch Hemato-Oncology Group; Grupo Español de Médula Ósea; German High-Grade Lymphoma Study Group; German Hodgkin's Study Group; Japanese Lymphorra Study Group; Lymphoma Study Association; NCIC Clinical Trials Group; Nordic Lymphoma Study Group; Southwest Oncology Group; United Kingdom National Cancer Research Institute
J Clin Oncol 2014 Sep 20;32(27):3059-68. doi: 10.1200/JCO.2013.54.8800. PMID: 25113753Free PMC Article

Recent clinical studies

Etiology

Application of the Lugano Classification for Initial Evaluation, Staging, and Response Assessment of Hodgkin and Non-Hodgkin Lymphoma: The PRoLoG Consensus Initiative (Part 1-Clinical).
Ricard F, Cheson B, Barrington S, Trotman J, Schmid A, Brueggenwerth G, Salles G, Schwartz L, Goldmacher G, Jarecha R, Narang J, Broussais F, Galette P, Liu M, Bajpai S, Perlman E, Gillis J, Smalberg I, Terve P, Zahlmann G, Korn R
J Nucl Med 2023 Jan;64(1):102-108. Epub 2022 Jul 14 doi: 10.2967/jnumed.122.264106. PMID: 35835580Free PMC Article
Primary Sjögren's syndrome is associated with increased risk of malignancies besides lymphoma: A systematic review and meta-analysis.
Zhong H, Liu S, Wang Y, Xu D, Li M, Zhao Y, Zeng X
Autoimmun Rev 2022 May;21(5):103084. Epub 2022 Mar 24 doi: 10.1016/j.autrev.2022.103084. PMID: 35341972
Imaging for diagnosis, staging and response assessment of Hodgkin lymphoma and non-Hodgkin lymphoma.
McCarten KM, Nadel HR, Shulkin BL, Cho SY
Pediatr Radiol 2019 Oct;49(11):1545-1564. Epub 2019 Oct 16 doi: 10.1007/s00247-019-04529-8. PMID: 31620854
Recommendations for initial evaluation, staging, and response assessment of Hodgkin and non-Hodgkin lymphoma: the Lugano classification.
Cheson BD, Fisher RI, Barrington SF, Cavalli F, Schwartz LH, Zucca E, Lister TA; Alliance, Australasian Leukaemia and Lymphoma Group; Eastern Cooperative Oncology Group; European Mantle Cell Lymphoma Consortium; Italian Lymphoma Foundation; European Organisation for Research; Treatment of Cancer/Dutch Hemato-Oncology Group; Grupo Español de Médula Ósea; German High-Grade Lymphoma Study Group; German Hodgkin's Study Group; Japanese Lymphorra Study Group; Lymphoma Study Association; NCIC Clinical Trials Group; Nordic Lymphoma Study Group; Southwest Oncology Group; United Kingdom National Cancer Research Institute
J Clin Oncol 2014 Sep 20;32(27):3059-68. doi: 10.1200/JCO.2013.54.8800. PMID: 25113753Free PMC Article
Rituximab-associated infections.
Gea-Banacloche JC
Semin Hematol 2010 Apr;47(2):187-98. doi: 10.1053/j.seminhematol.2010.01.002. PMID: 20350666

Diagnosis

Application of the Lugano Classification for Initial Evaluation, Staging, and Response Assessment of Hodgkin and Non-Hodgkin Lymphoma: The PRoLoG Consensus Initiative (Part 1-Clinical).
Ricard F, Cheson B, Barrington S, Trotman J, Schmid A, Brueggenwerth G, Salles G, Schwartz L, Goldmacher G, Jarecha R, Narang J, Broussais F, Galette P, Liu M, Bajpai S, Perlman E, Gillis J, Smalberg I, Terve P, Zahlmann G, Korn R
J Nucl Med 2023 Jan;64(1):102-108. Epub 2022 Jul 14 doi: 10.2967/jnumed.122.264106. PMID: 35835580Free PMC Article
Gastrointestinal Tract Lymphomas.
Alvarez-Lesmes J, Chapman JR, Cassidy D, Zhou Y, Garcia-Buitrago M, Montgomery EA, Lossos IS, Sussman D, Poveda J
Arch Pathol Lab Med 2021 Dec 1;145(12):1585-1596. doi: 10.5858/arpa.2020-0661-RA. PMID: 33836528
Imaging for diagnosis, staging and response assessment of Hodgkin lymphoma and non-Hodgkin lymphoma.
McCarten KM, Nadel HR, Shulkin BL, Cho SY
Pediatr Radiol 2019 Oct;49(11):1545-1564. Epub 2019 Oct 16 doi: 10.1007/s00247-019-04529-8. PMID: 31620854
Hepatic Lymphoma Diagnosis.
Choi WT, Gill RM
Surg Pathol Clin 2018 Jun;11(2):389-402. Epub 2018 Mar 21 doi: 10.1016/j.path.2018.02.003. PMID: 29751882
Recommendations for initial evaluation, staging, and response assessment of Hodgkin and non-Hodgkin lymphoma: the Lugano classification.
Cheson BD, Fisher RI, Barrington SF, Cavalli F, Schwartz LH, Zucca E, Lister TA; Alliance, Australasian Leukaemia and Lymphoma Group; Eastern Cooperative Oncology Group; European Mantle Cell Lymphoma Consortium; Italian Lymphoma Foundation; European Organisation for Research; Treatment of Cancer/Dutch Hemato-Oncology Group; Grupo Español de Médula Ósea; German High-Grade Lymphoma Study Group; German Hodgkin's Study Group; Japanese Lymphorra Study Group; Lymphoma Study Association; NCIC Clinical Trials Group; Nordic Lymphoma Study Group; Southwest Oncology Group; United Kingdom National Cancer Research Institute
J Clin Oncol 2014 Sep 20;32(27):3059-68. doi: 10.1200/JCO.2013.54.8800. PMID: 25113753Free PMC Article

Therapy

Primary Ovarian Burkitts Lymphoma.
Jan Z, Khan AU, Ilyas A, Faiz S
J Ayub Med Coll Abbottabad 2023 Oct-Dec;35(Suppl 1)(4):S807-S809. doi: 10.55519/JAMC-S4-12410. PMID: 38406915
Primary Sjögren's syndrome is associated with increased risk of malignancies besides lymphoma: A systematic review and meta-analysis.
Zhong H, Liu S, Wang Y, Xu D, Li M, Zhao Y, Zeng X
Autoimmun Rev 2022 May;21(5):103084. Epub 2022 Mar 24 doi: 10.1016/j.autrev.2022.103084. PMID: 35341972
Imaging for diagnosis, staging and response assessment of Hodgkin lymphoma and non-Hodgkin lymphoma.
McCarten KM, Nadel HR, Shulkin BL, Cho SY
Pediatr Radiol 2019 Oct;49(11):1545-1564. Epub 2019 Oct 16 doi: 10.1007/s00247-019-04529-8. PMID: 31620854
Hepatic Manifestations of Lymphoproliferative Disorders.
Bunchorntavakul C, Reddy KR
Clin Liver Dis 2019 May;23(2):293-308. Epub 2019 Mar 2 doi: 10.1016/j.cld.2018.12.010. PMID: 30947878
Rituximab-associated infections.
Gea-Banacloche JC
Semin Hematol 2010 Apr;47(2):187-98. doi: 10.1053/j.seminhematol.2010.01.002. PMID: 20350666

Prognosis

PET/CT: Clinical role in lymphomas.
Papathanasiou N
Hell J Nucl Med 2023 May-Aug;26 Suppl:36-37. PMID: 37658560
Cancer Incidence and Mortality in Firefighters: A State-of-the-Art Review and Meta-َAnalysis.
Soteriades ES, Kim J, Christophi CA, Kales SN
Asian Pac J Cancer Prev 2019 Nov 1;20(11):3221-3231. doi: 10.31557/APJCP.2019.20.11.3221. PMID: 31759344Free PMC Article
Imaging for diagnosis, staging and response assessment of Hodgkin lymphoma and non-Hodgkin lymphoma.
McCarten KM, Nadel HR, Shulkin BL, Cho SY
Pediatr Radiol 2019 Oct;49(11):1545-1564. Epub 2019 Oct 16 doi: 10.1007/s00247-019-04529-8. PMID: 31620854
Evolving epidemiology of HIV-associated malignancies.
Shiels MS, Engels EA
Curr Opin HIV AIDS 2017 Jan;12(1):6-11. doi: 10.1097/COH.0000000000000327. PMID: 27749369Free PMC Article
Recommendations for initial evaluation, staging, and response assessment of Hodgkin and non-Hodgkin lymphoma: the Lugano classification.
Cheson BD, Fisher RI, Barrington SF, Cavalli F, Schwartz LH, Zucca E, Lister TA; Alliance, Australasian Leukaemia and Lymphoma Group; Eastern Cooperative Oncology Group; European Mantle Cell Lymphoma Consortium; Italian Lymphoma Foundation; European Organisation for Research; Treatment of Cancer/Dutch Hemato-Oncology Group; Grupo Español de Médula Ósea; German High-Grade Lymphoma Study Group; German Hodgkin's Study Group; Japanese Lymphorra Study Group; Lymphoma Study Association; NCIC Clinical Trials Group; Nordic Lymphoma Study Group; Southwest Oncology Group; United Kingdom National Cancer Research Institute
J Clin Oncol 2014 Sep 20;32(27):3059-68. doi: 10.1200/JCO.2013.54.8800. PMID: 25113753Free PMC Article

Clinical prediction guides

PET/CT: Clinical role in lymphomas.
Papathanasiou N
Hell J Nucl Med 2023 May-Aug;26 Suppl:36-37. PMID: 37658560
Application of the Lugano Classification for Initial Evaluation, Staging, and Response Assessment of Hodgkin and Non-Hodgkin Lymphoma: The PRoLoG Consensus Initiative (Part 1-Clinical).
Ricard F, Cheson B, Barrington S, Trotman J, Schmid A, Brueggenwerth G, Salles G, Schwartz L, Goldmacher G, Jarecha R, Narang J, Broussais F, Galette P, Liu M, Bajpai S, Perlman E, Gillis J, Smalberg I, Terve P, Zahlmann G, Korn R
J Nucl Med 2023 Jan;64(1):102-108. Epub 2022 Jul 14 doi: 10.2967/jnumed.122.264106. PMID: 35835580Free PMC Article
Primary Sjögren's syndrome is associated with increased risk of malignancies besides lymphoma: A systematic review and meta-analysis.
Zhong H, Liu S, Wang Y, Xu D, Li M, Zhao Y, Zeng X
Autoimmun Rev 2022 May;21(5):103084. Epub 2022 Mar 24 doi: 10.1016/j.autrev.2022.103084. PMID: 35341972
Imaging for diagnosis, staging and response assessment of Hodgkin lymphoma and non-Hodgkin lymphoma.
McCarten KM, Nadel HR, Shulkin BL, Cho SY
Pediatr Radiol 2019 Oct;49(11):1545-1564. Epub 2019 Oct 16 doi: 10.1007/s00247-019-04529-8. PMID: 31620854
Recommendations for initial evaluation, staging, and response assessment of Hodgkin and non-Hodgkin lymphoma: the Lugano classification.
Cheson BD, Fisher RI, Barrington SF, Cavalli F, Schwartz LH, Zucca E, Lister TA; Alliance, Australasian Leukaemia and Lymphoma Group; Eastern Cooperative Oncology Group; European Mantle Cell Lymphoma Consortium; Italian Lymphoma Foundation; European Organisation for Research; Treatment of Cancer/Dutch Hemato-Oncology Group; Grupo Español de Médula Ósea; German High-Grade Lymphoma Study Group; German Hodgkin's Study Group; Japanese Lymphorra Study Group; Lymphoma Study Association; NCIC Clinical Trials Group; Nordic Lymphoma Study Group; Southwest Oncology Group; United Kingdom National Cancer Research Institute
J Clin Oncol 2014 Sep 20;32(27):3059-68. doi: 10.1200/JCO.2013.54.8800. PMID: 25113753Free PMC Article

Recent systematic reviews

Cardiac Toxicity Associated with Immune Checkpoint Inhibitors: A Systematic Review.
Cozma A, Sporis ND, Lazar AL, Buruiana A, Ganea AM, Malinescu TV, Berechet BM, Fodor A, Sitar-Taut AV, Vlad VC, Negrean V, Orasan OH
Int J Mol Sci 2022 Sep 19;23(18) doi: 10.3390/ijms231810948. PMID: 36142866Free PMC Article
Primary Sjögren's syndrome is associated with increased risk of malignancies besides lymphoma: A systematic review and meta-analysis.
Zhong H, Liu S, Wang Y, Xu D, Li M, Zhao Y, Zeng X
Autoimmun Rev 2022 May;21(5):103084. Epub 2022 Mar 24 doi: 10.1016/j.autrev.2022.103084. PMID: 35341972
Vitamin D Receptor Polymorphisms and Cancer.
Gnagnarella P, Raimondi S, Aristarco V, Johansson HA, Bellerba F, Corso F, Gandini S
Adv Exp Med Biol 2020;1268:53-114. doi: 10.1007/978-3-030-46227-7_4. PMID: 32918214
Hepatitis C infection and lymphoproliferative disease: accidental comorbidities?
Khoury T, Chen S, Adar T, Jacob EO, Mizrahi M
World J Gastroenterol 2014 Nov 21;20(43):16197-202. doi: 10.3748/wjg.v20.i43.16197. PMID: 25473174Free PMC Article
Trichloroethylene and cancer: systematic and quantitative review of epidemiologic evidence for identifying hazards.
Scott CS, Jinot J
Int J Environ Res Public Health 2011 Nov;8(11):4238-72. Epub 2011 Nov 9 doi: 10.3390/ijerph8114238. PMID: 22163205Free PMC Article

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