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Human Papillomavirus-Related Cervical Adenocarcinoma

MedGen UID:
232617
•Concept ID:
C1334053
•
Neoplastic Process
Synonyms: HPV-Related Endocervical Adenocarcinoma; HPVA Cervical Adenocarcinoma; Human Papilloma Virus Related Endocervical Adenocarcinoma; Human Papilloma Virus-Related Endocervical Adenocarcinoma; Human Papillomavirus- Associated Endocervical Adenocarcinoma; Human Papillomavirus-Associated Cervical Adenocarcinoma; Human Papillomavirus-Related Endocervical Adenocarcinoma

Definition

A cervical adenocarcinoma associated with the presence of human papillomavirus infection. [from NCI]

Professional guidelines

PubMed

An analysis of HER2 amplification in cervical adenocarcinoma: correlation with clinical outcomes and the International Endocervical Adenocarcinoma Criteria and Classification.
Shi H, Shao Y, Lu W, Lu B
J Pathol Clin Res 2021 Jan;7(1):86-95. Epub 2020 Oct 22 doi: 10.1002/cjp2.184. PMID: 33089969Free PMC Article
Clinical management of emerging sinonasal malignancies.
Contrera KJ, Woody NM, Rahman M, Sindwani R, Burkey BB
Head Neck 2020 Aug;42(8):2202-2212. Epub 2020 Mar 25 doi: 10.1002/hed.26150. PMID: 32212360

Recent clinical studies

Etiology

Association of Tumor Site With the Prognosis and Immunogenomic Landscape of Human Papillomavirus-Related Head and Neck and Cervical Cancers.
Zhu G, Amin N, Herberg ME, Maroun CA, Wang H, Guller M, Gourin CG, Rooper LM, Vosler PS, Tan M, D'Souza G, Koch WM, Eisele DW, Seiwert TY, Fakhry C, Pardoll DM, Mandal R
JAMA Otolaryngol Head Neck Surg 2022 Jan 1;148(1):70-79. doi: 10.1001/jamaoto.2021.3228. PMID: 34792560Free PMC Article
Human Papillomavirus Vaccine Impact on Cervical Precancers in a Low-Vaccination Population.
Shing JZ, Griffin MR, Chang RS, Beeghly-Fadiel A, Sudenga SL, Slaughter JC, Pemmaraju M, Mitchel EF, Hull PC
Am J Prev Med 2022 Mar;62(3):395-403. Epub 2021 Oct 29 doi: 10.1016/j.amepre.2021.08.017. PMID: 34756753Free PMC Article
An Unusual Case of Human Papillomavirus-Related Anorectal Adenocarcinoma With Progression to Perianal Paget's Disease.
Katerji R, Liao X, Huber A, Zhang D
Int J Surg Pathol 2021 Sep;29(6):672-676. Epub 2020 Dec 24 doi: 10.1177/1066896920982367. PMID: 33356675
Endocervical adenocarcinoma: selected diagnostic challenges.
Ronnett BM
Mod Pathol 2016 Jan;29 Suppl 1:S12-28. doi: 10.1038/modpathol.2015.131. PMID: 26715171
Human Papillomavirus-Related Ovarian Metastasis With Endocervical Adenocarcinoma: Report of 2 Cases and Review of Literature.
Turashvili G, Farmer P, Colgan T, Childs T
J Low Genit Tract Dis 2015 Oct;19(4):e60-3. doi: 10.1097/LGT.0000000000000146. PMID: 26360235

Diagnosis

Human papillomavirus-related multiphenotypic sinonasal carcinoma.
Morishita Y, Sakashita S, Tomioka T, Okano W, Shinozaki T, Higashino T, Matsuura K, Hayashi R
Auris Nasus Larynx 2023 Feb;50(1):151-155. Epub 2021 Nov 4 doi: 10.1016/j.anl.2021.10.008. PMID: 34742620
Clinical management of emerging sinonasal malignancies.
Contrera KJ, Woody NM, Rahman M, Sindwani R, Burkey BB
Head Neck 2020 Aug;42(8):2202-2212. Epub 2020 Mar 25 doi: 10.1002/hed.26150. PMID: 32212360
Human papillomavirus-related multiphenotypic sinonasal carcinoma: An emerging tumor type with a unique microscopic appearance and a paradoxical clinical behaviour.
Bishop JA, Westra WH
Oral Oncol 2018 Dec;87:17-20. Epub 2018 Oct 16 doi: 10.1016/j.oraloncology.2018.10.011. PMID: 30527234
Human Papillomavirus-Related Neuroendocrine Carcinomas of the Head and Neck.
Westra WH
Head Neck Pathol 2018 Mar;12(1):9-12. Epub 2018 Mar 20 doi: 10.1007/s12105-018-0886-6. PMID: 29556964Free PMC Article
Endocervical adenocarcinoma: selected diagnostic challenges.
Ronnett BM
Mod Pathol 2016 Jan;29 Suppl 1:S12-28. doi: 10.1038/modpathol.2015.131. PMID: 26715171

Therapy

An analysis of HER2 amplification in cervical adenocarcinoma: correlation with clinical outcomes and the International Endocervical Adenocarcinoma Criteria and Classification.
Shi H, Shao Y, Lu W, Lu B
J Pathol Clin Res 2021 Jan;7(1):86-95. Epub 2020 Oct 22 doi: 10.1002/cjp2.184. PMID: 33089969Free PMC Article
Association of Ipilimumab With Safety and Antitumor Activity in Women With Metastatic or Recurrent Human Papillomavirus-Related Cervical Carcinoma.
Lheureux S, Butler MO, Clarke B, Cristea MC, Martin LP, Tonkin K, Fleming GF, Tinker AV, Hirte HW, Tsoref D, Mackay H, Dhani NC, Ghatage P, Weberpals J, Welch S, Pham NA, Motta V, Sotov V, Wang L, Karakasis K, Udagani S, Kamel-Reid S, Streicher HZ, Shaw P, Oza AM
JAMA Oncol 2018 Jul 12;4(7):e173776. doi: 10.1001/jamaoncol.2017.3776. PMID: 29145543Free PMC Article

Prognosis

Association of Tumor Site With the Prognosis and Immunogenomic Landscape of Human Papillomavirus-Related Head and Neck and Cervical Cancers.
Zhu G, Amin N, Herberg ME, Maroun CA, Wang H, Guller M, Gourin CG, Rooper LM, Vosler PS, Tan M, D'Souza G, Koch WM, Eisele DW, Seiwert TY, Fakhry C, Pardoll DM, Mandal R
JAMA Otolaryngol Head Neck Surg 2022 Jan 1;148(1):70-79. doi: 10.1001/jamaoto.2021.3228. PMID: 34792560Free PMC Article
Clinical management of emerging sinonasal malignancies.
Contrera KJ, Woody NM, Rahman M, Sindwani R, Burkey BB
Head Neck 2020 Aug;42(8):2202-2212. Epub 2020 Mar 25 doi: 10.1002/hed.26150. PMID: 32212360
Human papillomavirus-related multiphenotypic sinonasal carcinoma: An emerging tumor type with a unique microscopic appearance and a paradoxical clinical behaviour.
Bishop JA, Westra WH
Oral Oncol 2018 Dec;87:17-20. Epub 2018 Oct 16 doi: 10.1016/j.oraloncology.2018.10.011. PMID: 30527234
Human Papillomavirus-Related Neuroendocrine Carcinomas of the Head and Neck.
Westra WH
Head Neck Pathol 2018 Mar;12(1):9-12. Epub 2018 Mar 20 doi: 10.1007/s12105-018-0886-6. PMID: 29556964Free PMC Article
Human papillomavirus-related carcinomas of the sinonasal tract.
Bishop JA, Guo TW, Smith DF, Wang H, Ogawa T, Pai SI, Westra WH
Am J Surg Pathol 2013 Feb;37(2):185-92. doi: 10.1097/PAS.0b013e3182698673. PMID: 23095507Free PMC Article

Clinical prediction guides

Diverse intratumoral heterogeneity and immune microenvironment of two HPV-related cervical cancer types revealed by single-cell RNA sequencing.
Li C, Liu D, Zhao Y, Ding Y, Hua K
J Med Virol 2023 Jun;95(6):e28857. doi: 10.1002/jmv.28857. PMID: 37287196
Human papillomavirus-related multiphenotypic sinonasal carcinoma.
Morishita Y, Sakashita S, Tomioka T, Okano W, Shinozaki T, Higashino T, Matsuura K, Hayashi R
Auris Nasus Larynx 2023 Feb;50(1):151-155. Epub 2021 Nov 4 doi: 10.1016/j.anl.2021.10.008. PMID: 34742620
Association of Tumor Site With the Prognosis and Immunogenomic Landscape of Human Papillomavirus-Related Head and Neck and Cervical Cancers.
Zhu G, Amin N, Herberg ME, Maroun CA, Wang H, Guller M, Gourin CG, Rooper LM, Vosler PS, Tan M, D'Souza G, Koch WM, Eisele DW, Seiwert TY, Fakhry C, Pardoll DM, Mandal R
JAMA Otolaryngol Head Neck Surg 2022 Jan 1;148(1):70-79. doi: 10.1001/jamaoto.2021.3228. PMID: 34792560Free PMC Article
Human Papillomavirus-Related Neuroendocrine Carcinomas of the Head and Neck.
Westra WH
Head Neck Pathol 2018 Mar;12(1):9-12. Epub 2018 Mar 20 doi: 10.1007/s12105-018-0886-6. PMID: 29556964Free PMC Article
Human papillomavirus-related carcinomas of the sinonasal tract.
Bishop JA, Guo TW, Smith DF, Wang H, Ogawa T, Pai SI, Westra WH
Am J Surg Pathol 2013 Feb;37(2):185-92. doi: 10.1097/PAS.0b013e3182698673. PMID: 23095507Free PMC Article

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