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Cervical villoglandular adenocarcinoma

MedGen UID:: 927340
•Concept ID:: C4289808
•: Neoplastic Process

Synonyms:	Cervical Adenocarcinoma, Villoglandular Variant; cervical adenocarcinoma, villoglandular variant; Cervical Villoglandular Adenocarcinoma; cervical villoglandular adenocarcinoma; Cervical Villoglandular Carcinoma; cervical villoglandular carcinoma; villoglandular adenocarcinoma of the cervix; villoglandular variant cervical mucinous adenocarcinoma

Monarch Initiative:	MONDO:0006141

Definition

A cervical adenocarcinoma characterized by the presence of a prominent villoglandular pattern. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVCervical villoglandular adenocarcinoma

Abnormal uterine cervix morphology
- Neoplasm of uterine cervix
  - Cervical Glandular Neoplasm
    - Cervical adenocarcinoma
      - Human Papillomavirus-Related Cervical Adenocarcinoma
        Endocervical Adenocarcinoma, Usual-Type
        Cervical villoglandular adenocarcinoma

Professional guidelines

PubMed

International Endocervical Adenocarcinoma Criteria and Classification (IECC): An Independent Cohort With Clinical and Molecular Findings.

Ren H, Almadani N, Pors J, Leung S, Ho J, Chow C, Ta M, Park KJ, Stolnicu S, Soslow R, Huntsman D, Gilks BC, Hoang L
Int J Gynecol Pathol 2021 Nov 1;40(6):533-540. doi: 10.1097/PGP.0000000000000764. PMID: 34612210

International Endocervical Adenocarcinoma Criteria and Classification: Validation and Interobserver Reproducibility.

Hodgson A, Park KJ, Djordjevic B, Howitt BE, Nucci MR, Oliva E, Stolnicu S, Xu B, Soslow RA, Parra-Herran C
Am J Surg Pathol 2019 Jan;43(1):75-83. doi: 10.1097/PAS.0000000000001095. PMID: 29877920 Free PMC Article

Endocervical adenocarcinoma and its variants: their morphology and differential diagnosis.

Young RH, Clement PB
Histopathology 2002 Sep;41(3):185-207. doi: 10.1046/j.1365-2559.2002.01462.x. PMID: 12207781

See all (3)

Recent clinical studies

Etiology

Villoglandular adenocarcinoma of the uterine cervix: a systematic review and meta-analysis.

Dietl AK, Beckmann MW, Aumann K
Arch Gynecol Obstet 2021 Aug;304(2):317-327. Epub 2021 May 25 doi: 10.1007/s00404-021-06077-9. PMID: 34036437 Free PMC Article

Clinical features and prognostic factors of cervical villoglandular adenocarcinoma.

Chen JH, Duan H, Yu XB, Zhao HW, Chen X, Li P, Li ZQ, Li BX, Pan LY, Yan X, Chen C
Int J Gynecol Cancer 2021 Apr;31(4):512-517. Epub 2021 Feb 19 doi: 10.1136/ijgc-2020-002044. PMID: 33608452

Cervical adenocarcinoma: integration of HPV status, pattern of invasion, morphology and molecular markers into classification.

Park KJ
Histopathology 2020 Jan;76(1):112-127. doi: 10.1111/his.13995. PMID: 31846527

Recent advances in invasive adenocarcinoma of the cervix.

Stolnicu S, Hoang L, Soslow RA
Virchows Arch 2019 Nov;475(5):537-549. Epub 2019 Jun 17 doi: 10.1007/s00428-019-02601-0. PMID: 31209635 Free PMC Article

Cervical Adenocarcinoma: Diagnosis of Human Papillomavirus-Positive and Human Papillomavirus-Negative Tumors.

Pirog EC
Arch Pathol Lab Med 2017 Dec;141(12):1653-1667. Epub 2017 Jun 23 doi: 10.5858/arpa.2016-0356-RA. PMID: 28644686

See all (36)

Diagnosis

Villoglandular adenocarcinoma of the uterine cervix: a systematic review and meta-analysis.

Dietl AK, Beckmann MW, Aumann K
Arch Gynecol Obstet 2021 Aug;304(2):317-327. Epub 2021 May 25 doi: 10.1007/s00404-021-06077-9. PMID: 34036437 Free PMC Article

Clinical features and prognostic factors of cervical villoglandular adenocarcinoma.

Chen JH, Duan H, Yu XB, Zhao HW, Chen X, Li P, Li ZQ, Li BX, Pan LY, Yan X, Chen C
Int J Gynecol Cancer 2021 Apr;31(4):512-517. Epub 2021 Feb 19 doi: 10.1136/ijgc-2020-002044. PMID: 33608452

Cervical adenocarcinoma: integration of HPV status, pattern of invasion, morphology and molecular markers into classification.

Park KJ
Histopathology 2020 Jan;76(1):112-127. doi: 10.1111/his.13995. PMID: 31846527

Recent advances in invasive adenocarcinoma of the cervix.

Stolnicu S, Hoang L, Soslow RA
Virchows Arch 2019 Nov;475(5):537-549. Epub 2019 Jun 17 doi: 10.1007/s00428-019-02601-0. PMID: 31209635 Free PMC Article

Cervical Adenocarcinoma: Diagnosis of Human Papillomavirus-Positive and Human Papillomavirus-Negative Tumors.

Pirog EC
Arch Pathol Lab Med 2017 Dec;141(12):1653-1667. Epub 2017 Jun 23 doi: 10.5858/arpa.2016-0356-RA. PMID: 28644686

See all (61)

Therapy

Preclinical investigation of patient-derived cervical cancer organoids for precision medicine.

Seol HS, Oh JH, Choi E, Kim S, Kim H, Nam EJ
J Gynecol Oncol 2023 May;34(3):e35. Epub 2022 Dec 30 doi: 10.3802/jgo.2023.34.e35. PMID: 36659831 Free PMC Article

Villoglandular papillary adenocarcinoma of cervix associated with cervical intraepithelial neoplasia: a case report and review of literature.

Srilatha PS, Roy A
Indian J Pathol Microbiol 2007 Oct;50(4):819-21. PMID: 18306568

Microinvasive cervical adenocarcinoma (FIGO stage 1A tumors): results of surgical staging and outcome analysis.

Ceballos KM, Shaw D, Daya D
Am J Surg Pathol 2006 Mar;30(3):370-4. doi: 10.1097/01.pas.0000186398.18206.ff. PMID: 16538058

Villoglandular papillary adenocarcinoma of the uterine cervix responding to neoadjuvant chemotherapy with docetaxel and cisplatin: a case report.

Nagai N, Hirata E, Kusuda T, Mukai K, Arihiro K, Ohama K
Int J Gynecol Cancer 2005 Nov-Dec;15(6):1187-90. doi: 10.1111/j.1525-1438.2005.00186.x. PMID: 16343210

Well-differentiated villoglandular adenocarcinoma of the uterine cervix: a clinicopathological study of 24 cases.

Jones MW, Silverberg SG, Kurman RJ
Int J Gynecol Pathol 1993 Jan;12(1):1-7. doi: 10.1097/00004347-199301000-00001. PMID: 8418074

See all (7)

Prognosis

Villoglandular adenocarcinoma of the uterine cervix: a systematic review and meta-analysis.

Dietl AK, Beckmann MW, Aumann K
Arch Gynecol Obstet 2021 Aug;304(2):317-327. Epub 2021 May 25 doi: 10.1007/s00404-021-06077-9. PMID: 34036437 Free PMC Article

Clinical features and prognostic factors of cervical villoglandular adenocarcinoma.

Chen JH, Duan H, Yu XB, Zhao HW, Chen X, Li P, Li ZQ, Li BX, Pan LY, Yan X, Chen C
Int J Gynecol Cancer 2021 Apr;31(4):512-517. Epub 2021 Feb 19 doi: 10.1136/ijgc-2020-002044. PMID: 33608452

Cervical adenocarcinoma: integration of HPV status, pattern of invasion, morphology and molecular markers into classification.

Park KJ
Histopathology 2020 Jan;76(1):112-127. doi: 10.1111/his.13995. PMID: 31846527

Recent advances in invasive adenocarcinoma of the cervix.

Stolnicu S, Hoang L, Soslow RA
Virchows Arch 2019 Nov;475(5):537-549. Epub 2019 Jun 17 doi: 10.1007/s00428-019-02601-0. PMID: 31209635 Free PMC Article

Clinical and MRI Characteristics of Uterine Cervical Adenocarcinoma: Its Variants and Mimics.

Saida T, Sakata A, Tanaka YO, Ochi H, Ishiguro T, Sakai M, Takahashi H, Satoh T, Minami M
Korean J Radiol 2019 Mar;20(3):364-377. doi: 10.3348/kjr.2018.0458. PMID: 30799567 Free PMC Article

See all (51)

Clinical prediction guides

Villoglandular Pattern in HPV-associated Endocervical Adenocarcinoma is Associated With Excellent Prognosis: A Reappraisal of 31 Cases Using IECC and Silva Pattern Classification.

Stolnicu S, Brito MJ, Karpathiou G, Hoang L, Felix A, Mateoiu C, Fanni D, Reques A, Garcia A, Hardisson D, Talu CK, Furtado A, Abu-Rustum N, Soslow RA, Park KJ
Int J Gynecol Pathol 2023 May 1;42(3):270-277. Epub 2022 Nov 15 doi: 10.1097/PGP.0000000000000916. PMID: 36508680 Free PMC Article

International Endocervical Adenocarcinoma Criteria and Classification: Validation and Interobserver Reproducibility.

Prognostic factors influencing decisions about surgical treatment of villoglandular adenocarcinoma of the uterine cervix.

Kim HJ, Sung JH, Lee E, Ahn S, Song SY, Choi CH, Kim TJ, Kim BG, Bae DS, Lee JW
Int J Gynecol Cancer 2014 Sep;24(7):1299-305. doi: 10.1097/IGC.0000000000000197. PMID: 24987921

Well-differentiated villoglandular adenocarcinoma of the uterine cervix: assessment of cytological features by histological subtypes.

Hagiwara T, Kaku T, Kobayashi H, Wake N, Saito T
Acta Cytol 2013;57(1):61-8. Epub 2012 Dec 6 doi: 10.1159/000342917. PMID: 23221334

Histopathologic subtyping of cervical adenocarcinoma reveals increasing incidence rates of endometrioid tumors in all age groups: a population based study with review of all nonsquamous cervical carcinomas in Norway from 1966 to 1970, 1976 to 1980, and 1986 to 1990.

Alfsen GC, Thoresen SO, Kristensen GB, Skovlund E, Abeler VM
Cancer 2000 Sep 15;89(6):1291-9. PMID: 11002225

See all (12)

Recent systematic reviews

Villoglandular adenocarcinoma of the uterine cervix: a systematic review and meta-analysis.

Dietl AK, Beckmann MW, Aumann K
Arch Gynecol Obstet 2021 Aug;304(2):317-327. Epub 2021 May 25 doi: 10.1007/s00404-021-06077-9. PMID: 34036437 Free PMC Article

See all (1)

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Cervical villoglandular adenocarcinoma

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

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