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Lumbosacral lipoma

MedGen UID:
232708
•Concept ID:
C1334438
•
Neoplastic Process
Synonyms: lipoma of sacral region of vertebral column; Lumbosacral Lipoma; lumbosacral lipoma; sacral region of vertebral column lipoma
 
Monarch Initiative: MONDO:0004077

Definition

A benign well-circumscribed tumor, composed of lobules of mature adipocytes, that arises within the lumbosacral tissue of the spine. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLumbosacral lipoma

Professional guidelines

PubMed

Conservative and surgical treatment of pediatric asymptomatic lumbosacral lipoma: a meta-analysis.
Xiong Y, Yang L, Zhen W, Fangyong D, Feng W, Ting L
Neurosurg Rev 2018 Jul;41(3):737-743. Epub 2016 Oct 28 doi: 10.1007/s10143-016-0796-6. PMID: 27796602
The natural history and management of patients with congenital deficits associated with lumbosacral lipomas.
Tu A, Hengel R, Cochrane DD
Childs Nerv Syst 2016 Apr;32(4):667-73. Epub 2016 Jan 11 doi: 10.1007/s00381-015-3008-8. PMID: 26753902
Closed spinal dysraphism: a review on diagnosis and treatment in infancy.
Cornette L, Verpoorten C, Lagae L, Plets C, Van Calenbergh F, Casaer P
Eur J Paediatr Neurol 1998;2(4):179-85. doi: 10.1016/s1090-3798(98)80017-2. PMID: 10726589

Recent clinical studies

Etiology

Lumbosacral lipoma in childhood, how strong is the evidence base? A systematic review.
Perera D, Craven CL, Thompson D
Childs Nerv Syst 2024 Mar;40(3):715-728. Epub 2023 Nov 4 doi: 10.1007/s00381-023-06203-9. PMID: 37924337
Does conus morphology have implications for outcome in lumbosacral lipoma?
Thompson DNP, Spoor J, Schotman M, Maestri S, Craven CL, Desai D
Childs Nerv Syst 2021 Jun;37(6):2025-2031. Epub 2021 Feb 18 doi: 10.1007/s00381-021-05081-3. PMID: 33604718
Whole spine MRI is not required in investigating uncomplicated paediatric lumbosacral lipoma. A retrospective single-institution review.
Layard Horsfall H, Chari A, Huttunen T, Simcock C, D'Arco F, Thompson D
Childs Nerv Syst 2019 Nov;35(11):2163-2169. Epub 2019 Sep 9 doi: 10.1007/s00381-019-04373-z. PMID: 31502036
Radical excision of lumbosacral lipoma: an early experience of "followers".
Chong S, Lee JY, Kim KH, Shin HI, Kim K, Park K, Kim SK, Wang KC
Childs Nerv Syst 2019 Sep;35(9):1591-1597. Epub 2019 May 31 doi: 10.1007/s00381-019-04212-1. PMID: 31152216
Occult spinal dysraphism.
Bajpai M, Kataria R, Gupta DK, Agarwala S
Indian J Pediatr 1997 Nov-Dec;64(6 Suppl):62-7. PMID: 11129883

Diagnosis

Whole spine MRI is not required in investigating uncomplicated paediatric lumbosacral lipoma. A retrospective single-institution review.
Layard Horsfall H, Chari A, Huttunen T, Simcock C, D'Arco F, Thompson D
Childs Nerv Syst 2019 Nov;35(11):2163-2169. Epub 2019 Sep 9 doi: 10.1007/s00381-019-04373-z. PMID: 31502036
Hydromyelia associated with spinal lipoma of the conus: case report.
Faggin R, Drigo P, Denaro L, Sartori S, d'Avella D
Spine (Phila Pa 1976) 2010 Sep 15;35(20):E1069-71. doi: 10.1097/BRS.0b013e3181ed0b50. PMID: 20802384
Closed spinal dysraphism: a review on diagnosis and treatment in infancy.
Cornette L, Verpoorten C, Lagae L, Plets C, Van Calenbergh F, Casaer P
Eur J Paediatr Neurol 1998;2(4):179-85. doi: 10.1016/s1090-3798(98)80017-2. PMID: 10726589
Occult spinal dysraphism.
Bajpai M, Kataria R, Gupta DK, Agarwala S
Indian J Pediatr 1997 Nov-Dec;64(6 Suppl):62-7. PMID: 11129883
Magnetic resonance imaging: lumbosacral lipoma.
Komiyama M, Hakuba A, Inoue Y, Yasui T, Yagura H, Baba M, Nishimura S
Surg Neurol 1987 Oct;28(4):259-64. doi: 10.1016/0090-3019(87)90303-x. PMID: 3629457

Therapy

Predictive value of intraoperative bulbocavernosus reflex during untethering surgery for post-operative voiding function.
Cha S, Wang KC, Park K, Shin HI, Lee JY, Chong S, Kim K
Clin Neurophysiol 2018 Dec;129(12):2594-2601. Epub 2018 Oct 30 doi: 10.1016/j.clinph.2018.09.026. PMID: 30448714
Conservative and surgical treatment of pediatric asymptomatic lumbosacral lipoma: a meta-analysis.
Xiong Y, Yang L, Zhen W, Fangyong D, Feng W, Ting L
Neurosurg Rev 2018 Jul;41(3):737-743. Epub 2016 Oct 28 doi: 10.1007/s10143-016-0796-6. PMID: 27796602
Spinal column shortening for tethered cord syndrome associated with myelomeningocele, lumbosacral lipoma, and lipomyelomeningocele in children and young adults.
Aldave G, Hansen D, Hwang SW, Moreno A, Briceño V, Jea A
J Neurosurg Pediatr 2017 Jun;19(6):703-710. Epub 2017 Mar 31 doi: 10.3171/2017.1.PEDS16533. PMID: 28362188
Results of the prophylactic surgery of lumbosacral lipomas 20 years of experience in the Paediatric Neurosurgery Department La Timone Enfants Hospital, Marseille, France.
da Rosa SP, Scavarda D, Choux M
Childs Nerv Syst 2016 Nov;32(11):2205-2209. Epub 2016 Aug 15 doi: 10.1007/s00381-016-3198-8. PMID: 27526098
Epilepsy in patients with spina bifida in the lumbosacral region.
Yoshida F, Morioka T, Hashiguchi K, Kawamura T, Miyagi Y, Nagata S, Mihara F, Ohshio M, Sasaki T
Neurosurg Rev 2006 Oct;29(4):327-32; discussion 332. Epub 2006 Aug 25 doi: 10.1007/s10143-006-0035-7. PMID: 16933125

Prognosis

Does conus morphology have implications for outcome in lumbosacral lipoma?
Thompson DNP, Spoor J, Schotman M, Maestri S, Craven CL, Desai D
Childs Nerv Syst 2021 Jun;37(6):2025-2031. Epub 2021 Feb 18 doi: 10.1007/s00381-021-05081-3. PMID: 33604718
Whole spine MRI is not required in investigating uncomplicated paediatric lumbosacral lipoma. A retrospective single-institution review.
Layard Horsfall H, Chari A, Huttunen T, Simcock C, D'Arco F, Thompson D
Childs Nerv Syst 2019 Nov;35(11):2163-2169. Epub 2019 Sep 9 doi: 10.1007/s00381-019-04373-z. PMID: 31502036
The natural history and management of patients with congenital deficits associated with lumbosacral lipomas.
Tu A, Hengel R, Cochrane DD
Childs Nerv Syst 2016 Apr;32(4):667-73. Epub 2016 Jan 11 doi: 10.1007/s00381-015-3008-8. PMID: 26753902
Closed spinal dysraphism: a review on diagnosis and treatment in infancy.
Cornette L, Verpoorten C, Lagae L, Plets C, Van Calenbergh F, Casaer P
Eur J Paediatr Neurol 1998;2(4):179-85. doi: 10.1016/s1090-3798(98)80017-2. PMID: 10726589
Occult spinal dysraphism.
Bajpai M, Kataria R, Gupta DK, Agarwala S
Indian J Pediatr 1997 Nov-Dec;64(6 Suppl):62-7. PMID: 11129883

Clinical prediction guides

Does conus morphology have implications for outcome in lumbosacral lipoma?
Thompson DNP, Spoor J, Schotman M, Maestri S, Craven CL, Desai D
Childs Nerv Syst 2021 Jun;37(6):2025-2031. Epub 2021 Feb 18 doi: 10.1007/s00381-021-05081-3. PMID: 33604718
Whole spine MRI is not required in investigating uncomplicated paediatric lumbosacral lipoma. A retrospective single-institution review.
Layard Horsfall H, Chari A, Huttunen T, Simcock C, D'Arco F, Thompson D
Childs Nerv Syst 2019 Nov;35(11):2163-2169. Epub 2019 Sep 9 doi: 10.1007/s00381-019-04373-z. PMID: 31502036
Radical excision of lumbosacral lipoma: an early experience of "followers".
Chong S, Lee JY, Kim KH, Shin HI, Kim K, Park K, Kim SK, Wang KC
Childs Nerv Syst 2019 Sep;35(9):1591-1597. Epub 2019 May 31 doi: 10.1007/s00381-019-04212-1. PMID: 31152216
Spinal column shortening for tethered cord syndrome associated with myelomeningocele, lumbosacral lipoma, and lipomyelomeningocele in children and young adults.
Aldave G, Hansen D, Hwang SW, Moreno A, Briceño V, Jea A
J Neurosurg Pediatr 2017 Jun;19(6):703-710. Epub 2017 Mar 31 doi: 10.3171/2017.1.PEDS16533. PMID: 28362188
The natural history and management of patients with congenital deficits associated with lumbosacral lipomas.
Tu A, Hengel R, Cochrane DD
Childs Nerv Syst 2016 Apr;32(4):667-73. Epub 2016 Jan 11 doi: 10.1007/s00381-015-3008-8. PMID: 26753902

Recent systematic reviews

Lumbosacral lipoma in childhood, how strong is the evidence base? A systematic review.
Perera D, Craven CL, Thompson D
Childs Nerv Syst 2024 Mar;40(3):715-728. Epub 2023 Nov 4 doi: 10.1007/s00381-023-06203-9. PMID: 37924337

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