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Male Reproductive System Precancerous Condition

MedGen UID:
233656
•Concept ID:
C1334555
•
Neoplastic Process

Definition

A premalignant pathologic process arising from an organ of the male reproductive system. It is characterized by cellular atypia and/or dysplasia but does not show morphologic evidence of stromal invasion at the time of diagnosis. Representative examples include prostatic intraepithelial neoplasia, giant condyloma acuminatum of the penis, and penile intraepithelial neoplasia. [from NCI]

Professional guidelines

PubMed

2022 European guideline for the management of balanoposthitis.
Edwards SK, Bunker CB, van der Snoek EM, van der Meijden WI
J Eur Acad Dermatol Venereol 2023 Jun;37(6):1104-1117. Epub 2023 Mar 21 doi: 10.1111/jdv.18954. PMID: 36942977
Balanitis xerotica obliterans: a review of diagnosis and management.
Charlton OA, Smith SD
Int J Dermatol 2019 Jul;58(7):777-781. Epub 2018 Oct 12 doi: 10.1111/ijd.14236. PMID: 30315576
Preneoplastic and Primary Scrotal Cancer: Updates on Pathogenesis and Diagnostic Evaluation.
Zhu Y, Ye DW
Urol Clin North Am 2016 Nov;43(4):523-530. doi: 10.1016/j.ucl.2016.06.013. PMID: 27717438

Recent clinical studies

Etiology

2022 European guideline for the management of balanoposthitis.
Edwards SK, Bunker CB, van der Snoek EM, van der Meijden WI
J Eur Acad Dermatol Venereol 2023 Jun;37(6):1104-1117. Epub 2023 Mar 21 doi: 10.1111/jdv.18954. PMID: 36942977
Shortcomings in bladder cancer etiology research and a model for its prevention.
Radosavljevic V, Belojevic G
Tumori 2014 Jan-Feb;100(1):1-8. doi: 10.1700/1430.15807. PMID: 24675483
Recurrent hypospadias surgery.
Barbagli G, Sansalone S, Djinovic R, Lazzeri M
Arch Esp Urol 2014 Jan-Feb;67(1):54-60. PMID: 24531672
Cervical cancer and HPV vaccines in developing countries.
Karimi Zarchi M, Behtash N, Chiti Z, Kargar S
Asian Pac J Cancer Prev 2009;10(6):969-74. PMID: 20192568
Prostatic intraepithelial neoplasia: recent advances.
Ayala AG, Ro JY
Arch Pathol Lab Med 2007 Aug;131(8):1257-66. doi: 10.5858/2007-131-1257-PINRA. PMID: 17683188

Diagnosis

2022 European guideline for the management of balanoposthitis.
Edwards SK, Bunker CB, van der Snoek EM, van der Meijden WI
J Eur Acad Dermatol Venereol 2023 Jun;37(6):1104-1117. Epub 2023 Mar 21 doi: 10.1111/jdv.18954. PMID: 36942977
Cribriform Lesions of the Prostate Gland.
Cai Q, Shah RB
Surg Pathol Clin 2022 Dec;15(4):591-608. Epub 2022 Oct 13 doi: 10.1016/j.path.2022.07.001. PMID: 36344177
Balanitis xerotica obliterans: a review of diagnosis and management.
Charlton OA, Smith SD
Int J Dermatol 2019 Jul;58(7):777-781. Epub 2018 Oct 12 doi: 10.1111/ijd.14236. PMID: 30315576
Prostatic intraepithelial neoplasia: recent advances.
Ayala AG, Ro JY
Arch Pathol Lab Med 2007 Aug;131(8):1257-66. doi: 10.5858/2007-131-1257-PINRA. PMID: 17683188
Carcinoma in situ of the penis.
Gerber GS
J Urol 1994 Apr;151(4):829-33. doi: 10.1016/s0022-5347(17)35099-1. PMID: 8126803

Therapy

2022 European guideline for the management of balanoposthitis.
Edwards SK, Bunker CB, van der Snoek EM, van der Meijden WI
J Eur Acad Dermatol Venereol 2023 Jun;37(6):1104-1117. Epub 2023 Mar 21 doi: 10.1111/jdv.18954. PMID: 36942977
Balanitis xerotica obliterans: a review of diagnosis and management.
Charlton OA, Smith SD
Int J Dermatol 2019 Jul;58(7):777-781. Epub 2018 Oct 12 doi: 10.1111/ijd.14236. PMID: 30315576
Shortcomings in bladder cancer etiology research and a model for its prevention.
Radosavljevic V, Belojevic G
Tumori 2014 Jan-Feb;100(1):1-8. doi: 10.1700/1430.15807. PMID: 24675483
Cervical cancer and HPV vaccines in developing countries.
Karimi Zarchi M, Behtash N, Chiti Z, Kargar S
Asian Pac J Cancer Prev 2009;10(6):969-74. PMID: 20192568
Minimising the risks of PUVA treatment.
van Praag MC, Tseng LN, Mommaas AM, Boom BW, Vermeer BJ
Drug Saf 1993 May;8(5):340-9. doi: 10.2165/00002018-199308050-00002. PMID: 8504016

Prognosis

Treatment Options and Outcomes for Men with Penile Intraepithelial Neoplasia: A Systematic Review.
Issa A, Sebro K, Kwok A, Janisch F, Grossmann NC, Lee E, Lucky M, Oliveira P, Lau M, Parnham A, Sangar V, Fankhauser CD
Eur Urol Focus 2022 May;8(3):829-832. Epub 2021 May 11 doi: 10.1016/j.euf.2021.04.026. PMID: 33994168
Cervical cancer and HPV vaccines in developing countries.
Karimi Zarchi M, Behtash N, Chiti Z, Kargar S
Asian Pac J Cancer Prev 2009;10(6):969-74. PMID: 20192568
Natural history of prostatic carcinoma: the pathologist's perspective.
Algaba F, Trias I, Arce Y
Recent Results Cancer Res 2007;175:9-24. doi: 10.1007/978-3-540-40901-4_2. PMID: 17432551
Testicular microlithiasis: what does it mean clinically?
Dagash H, Mackinnon EA
BJU Int 2007 Jan;99(1):157-60. Epub 2006 Oct 9 doi: 10.1111/j.1464-410X.2006.06546.x. PMID: 17026598
Carcinoma in situ of the penis.
Gerber GS
J Urol 1994 Apr;151(4):829-33. doi: 10.1016/s0022-5347(17)35099-1. PMID: 8126803

Clinical prediction guides

Clinicopathologic characterization of hepatocellular adenomas in men: a multicenter experience.
González IA, Torbenson M, Sharifai N, Byrnes K, Chatterjee D, Kakar S, Yeh MM, Wu TT, Zhang X, Jain D
Hum Pathol 2023 Aug;138:24-33. Epub 2023 May 26 doi: 10.1016/j.humpath.2023.05.010. PMID: 37245629
Treatment Options and Outcomes for Men with Penile Intraepithelial Neoplasia: A Systematic Review.
Issa A, Sebro K, Kwok A, Janisch F, Grossmann NC, Lee E, Lucky M, Oliveira P, Lau M, Parnham A, Sangar V, Fankhauser CD
Eur Urol Focus 2022 May;8(3):829-832. Epub 2021 May 11 doi: 10.1016/j.euf.2021.04.026. PMID: 33994168
Shortcomings in bladder cancer etiology research and a model for its prevention.
Radosavljevic V, Belojevic G
Tumori 2014 Jan-Feb;100(1):1-8. doi: 10.1700/1430.15807. PMID: 24675483
Recurrent hypospadias surgery.
Barbagli G, Sansalone S, Djinovic R, Lazzeri M
Arch Esp Urol 2014 Jan-Feb;67(1):54-60. PMID: 24531672
Cellular and molecular pathology of prostate cancer precursors.
Foster CS, Bostwick DG, Bonkhoff H, Damber JE, van der Kwast T, Montironi R, Sakr WA
Scand J Urol Nephrol Suppl 2000;(205):19-43. doi: 10.1080/003655900750169284. PMID: 11144897

Recent systematic reviews

Treatment Options and Outcomes for Men with Penile Intraepithelial Neoplasia: A Systematic Review.
Issa A, Sebro K, Kwok A, Janisch F, Grossmann NC, Lee E, Lucky M, Oliveira P, Lau M, Parnham A, Sangar V, Fankhauser CD
Eur Urol Focus 2022 May;8(3):829-832. Epub 2021 May 11 doi: 10.1016/j.euf.2021.04.026. PMID: 33994168
The critical role of the pathologist in determining eligibility for active surveillance as a management option in patients with prostate cancer: consensus statement with recommendations supported by the College of American Pathologists, International Society of Urological Pathology, Association of Directors of Anatomic and Surgical Pathology, the New Zealand Society of Pathologists, and the Prostate Cancer Foundation.
Amin MB, Lin DW, Gore JL, Srigley JR, Samaratunga H, Egevad L, Rubin M, Nacey J, Carter HB, Klotz L, Sandler H, Zietman AL, Holden S, Montironi R, Humphrey PA, Evans AJ, Epstein JI, Delahunt B, McKenney JK, Berney D, Wheeler TM, Chinnaiyan AM, True L, Knudsen B, Hammond ME
Arch Pathol Lab Med 2014 Oct;138(10):1387-405. Epub 2014 Aug 5 doi: 10.5858/arpa.2014-0219-SA. PMID: 25092589

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