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Clear cell hidradenoma

MedGen UID:
234584
•Concept ID:
C1370701
•
Neoplastic Process
Synonyms: Clear Cell Hidradenoma; clear cell hidradenoma; clear cell hidradenoma (morphologic abnormality); Clear cell myoepithelioma; clear cell myoepithelioma; Clear cell sweat gland adenoma
SNOMED CT: Clear cell hidradenoma (81143000); Clear cell hidradenoma (400099008); Clear cell sweat gland adenoma (400099008); Clear cell myoepithelioma (400099008)
 
Monarch Initiative: MONDO:0003447

Definition

An uncommon benign neoplasm of the sweat glands characterized by the presence of clear cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVClear cell hidradenoma

Professional guidelines

PubMed

Update on selective special types of breast neoplasms: Focusing on controversies, differential diagnosis, and molecular genetic advances.
Wei S
Semin Diagn Pathol 2022 Sep;39(5):367-379. Epub 2022 Mar 18 doi: 10.1053/j.semdp.2022.03.001. PMID: 35331622

Recent clinical studies

Etiology

Clear Cell Hidradenoma: Characteristic Imaging Features on Ultrasonography, Computed Tomography, and Magnetic Resonance Imaging.
Lee JY, Kang BS, Shim HS, Song IH, Kim M, Lee SH, Chung HW, Lee MH, Shin MJ
J Ultrasound Med 2018 Aug;37(8):1993-2001. Epub 2018 Feb 1 doi: 10.1002/jum.14552. PMID: 29388236
Neurothekeoma.
Ward JL, Prieto VG, Joseph A, Chevray P, Kronowitz S, Sturgis EM
Otolaryngol Head Neck Surg 2005 Jan;132(1):86-9. doi: 10.1016/j.otohns.2004.05.031. PMID: 15632914
Histogenesis of clear cell hidradenoma: immunohistochemical study of keratin expression.
Ohnishi T, Watanabe S
J Cutan Pathol 1997 Jan;24(1):30-6. doi: 10.1111/j.1600-0560.1997.tb00782.x. PMID: 9027630
Malignant clear cell hidradenoma of the upper lip.
Orlandi RR, Sercarz JA, Doberneck SA, Calcaterra TC
Head Neck 1994 Sep-Oct;16(5):443-9. doi: 10.1002/hed.2880160509. PMID: 7960742
Clear cell eccrine carcinomas of the skin. A clinicopathologic study of nine patients.
Wong TY, Suster S, Nogita T, Duncan LM, Dickersin RG, Mihm MC Jr
Cancer 1994 Mar 15;73(6):1631-43. doi: 10.1002/1097-0142(19940315)73:6<1631::aid-cncr2820730615>3.0.co;2-7. PMID: 7512435

Diagnosis

Trichilemmal cysts with proteinaceous material: A potential diagnostic pitfall.
Mitsui Y, Ogawa K, Koga K, Goto K, Takai T, Anan T, Fukumoto T, Asada H
J Cutan Pathol 2022 Jun;49(6):515-524. Epub 2022 Feb 22 doi: 10.1111/cup.14214. PMID: 35166386
Perineal Clear Cell Hidradenoma: A GATA3-positive Neoplasm With Potential for Misdiagnosis.
Hudacko R, Anderson P, Guerrieri C
Int J Gynecol Pathol 2021 Sep 1;40(5):465-469. doi: 10.1097/PGP.0000000000000713. PMID: 32925441
Clear Cell Hidradenoma-Basal Cell Carcinoma Collision.
Piqué-Duran E, Duran-Hernández M, Pérez-Cejudo JA, García-Vázquez O
Am J Dermatopathol 2021 Feb 1;43(2):e23-e26. doi: 10.1097/DAD.0000000000001763. PMID: 32804693
Clear Cell Hidradenoma: Characteristic Imaging Features on Ultrasonography, Computed Tomography, and Magnetic Resonance Imaging.
Lee JY, Kang BS, Shim HS, Song IH, Kim M, Lee SH, Chung HW, Lee MH, Shin MJ
J Ultrasound Med 2018 Aug;37(8):1993-2001. Epub 2018 Feb 1 doi: 10.1002/jum.14552. PMID: 29388236
Neurothekeoma.
Ward JL, Prieto VG, Joseph A, Chevray P, Kronowitz S, Sturgis EM
Otolaryngol Head Neck Surg 2005 Jan;132(1):86-9. doi: 10.1016/j.otohns.2004.05.031. PMID: 15632914

Therapy

Identification of a novel fusion gene MLL-MAML2 in secondary acute myelogenous leukemia and myelodysplastic syndrome with inv(11)(q21q23).
Nemoto N, Suzukawa K, Shimizu S, Shinagawa A, Takei N, Taki T, Hayashi Y, Kojima H, Kawakami Y, Nagasawa T
Genes Chromosomes Cancer 2007 Sep;46(9):813-9. doi: 10.1002/gcc.20467. PMID: 17551948
Metastatic hidradenocarcinoma with demonstration of Her-2/neu gene amplification by fluorescence in situ hybridization: potential treatment implications.
Nash JW, Barrett TL, Kies M, Ross MI, Sneige N, Diwan AH, Lazar AJ
J Cutan Pathol 2007 Jan;34(1):49-54. doi: 10.1111/j.1600-0560.2006.00570.x. PMID: 17214855

Prognosis

Three Cases of Clear Cell Hidradenoma With "Benign" Lymph Node Involvement.
Gonzalez-Lopez G, Garrido-Ruiz MC, Rios-Martin JJ, Rodriguez-Peralto JL
Am J Dermatopathol 2021 Jun 1;43(6):e76-e79. doi: 10.1097/DAD.0000000000001886. PMID: 33464750
Hidradenoma of the Chin.
Park SH, Kang SG, Choi HJ
J Craniofac Surg 2017 Jul;28(5):e454-e455. doi: 10.1097/SCS.0000000000003670. PMID: 28570408
Lymph node location of a clear cell hidradenoma: report of a patient and review of literature.
Tingaud C, Costes V, Frouin E, Delfour C, Cribier B, Guillot B, Szablewski V
J Cutan Pathol 2016 Aug;43(8):702-6. Epub 2016 May 17 doi: 10.1111/cup.12720. PMID: 27080562
t(11;19) translocation and CRTC1-MAML2 fusion oncogene in mucoepidermoid carcinoma.
O'Neill ID
Oral Oncol 2009 Jan;45(1):2-9. Epub 2008 May 16 doi: 10.1016/j.oraloncology.2008.03.012. PMID: 18486532
Malignant clear cell hidradenoma of the upper lip.
Orlandi RR, Sercarz JA, Doberneck SA, Calcaterra TC
Head Neck 1994 Sep-Oct;16(5):443-9. doi: 10.1002/hed.2880160509. PMID: 7960742

Clinical prediction guides

Expression of Early Growth Response 3 in Skin Cancers.
Zhou KY, Deng LJ, Luo SY, Wang QX, Fang S
Appl Immunohistochem Mol Morphol 2024 Apr 1;32(4):169-175. Epub 2024 Mar 14 doi: 10.1097/PAI.0000000000001191. PMID: 38478384
Trichilemmal cysts with proteinaceous material: A potential diagnostic pitfall.
Mitsui Y, Ogawa K, Koga K, Goto K, Takai T, Anan T, Fukumoto T, Asada H
J Cutan Pathol 2022 Jun;49(6):515-524. Epub 2022 Feb 22 doi: 10.1111/cup.14214. PMID: 35166386
Three Cases of Clear Cell Hidradenoma With "Benign" Lymph Node Involvement.
Gonzalez-Lopez G, Garrido-Ruiz MC, Rios-Martin JJ, Rodriguez-Peralto JL
Am J Dermatopathol 2021 Jun 1;43(6):e76-e79. doi: 10.1097/DAD.0000000000001886. PMID: 33464750
Expression and diagnostic implications of carbonic anhydrase IX in several tumours with predominantly clear cell morphology.
Lin XY, Zhang H, Tang N, Zhang XP, Zhang W, Wang EH, Han YC
Histopathology 2015 Apr;66(5):685-94. Epub 2015 Jan 22 doi: 10.1111/his.12536. PMID: 25431204
Recurrent clear cell hidradenoma of the foot.
Will R, Coldiron B
Dermatol Surg 2000 Jul;26(7):685-6. doi: 10.1046/j.1524-4725.2000.99183.x. PMID: 10886280

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