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Clear cell adenoma

MedGen UID:
90761
•Concept ID:
C0334315
•
Neoplastic Process
Synonyms: adenoma, clear cell, benign; Clear Cell Adenoma; clear cell adenoma; clear cell adenoma (morphologic abnormality)
SNOMED CT: Clear cell adenoma (1752006)
 
Monarch Initiative: MONDO:0003426

Definition

A benign neoplasm composed of glands containing epithelial clear cells. [from NCI]

Professional guidelines

PubMed

The Genotype-Based Morphology of Aldosterone-Producing Adrenocortical Disorders and Their Association with Aging.
Gao X, Yamazaki Y, Tezuka Y, Omata K, Ono Y, Morimoto R, Nakamura Y, Satoh F, Sasano H
Endocrinol Metab (Seoul) 2021 Feb;36(1):12-21. Epub 2021 Feb 24 doi: 10.3803/EnM.2021.101. PMID: 33677921Free PMC Article
Clinical Utility of In Situ Hybridization Assays in Head and Neck Neoplasms.
Luk PP, Selinger CI, Cooper WA, Mahar A, Palme CE, O'Toole SA, Clark JR, Gupta R
Head Neck Pathol 2019 Sep;13(3):397-414. Epub 2018 Nov 22 doi: 10.1007/s12105-018-0988-1. PMID: 30467669Free PMC Article
The diagnosis and treatment of endometrial cancer: progress and controversies.
Denschlag D, Ulrich U, Emons G
Dtsch Arztebl Int 2010 Aug;108(34-35):571-7. Epub 2010 Aug 29 doi: 10.3238/arztebl.2011.0571. PMID: 21904591Free PMC Article

Recent clinical studies

Etiology

Central pancreatectomy without anastomosis.
Wayne M, Neragi-Miandoab S, Kasmin F, Brown W, Pahuja A, Cooperman AM
World J Surg Oncol 2009 Aug 31;7:67. doi: 10.1186/1477-7819-7-67. PMID: 19719851Free PMC Article
Clear cell tumors of the salivary glands, jaws, and oral mucosa.
Maiorano E, Altini M, Favia G
Semin Diagn Pathol 1997 Aug;14(3):203-12. PMID: 9279976
Parotid clear-cell adenoma of possible myoepithelial origin.
Saksela E, Tarkkanen J, Wartiovaara J
Cancer 1972 Sep;30(3):742-8. doi: 10.1002/1097-0142(197209)30:3<742::aid-cncr2820300323>3.0.co;2-x. PMID: 5075358

Diagnosis

Top 10 Clear Cell Head and Neck Lesions to Contemplate.
Cipriani NA, Kakkar A
Head Neck Pathol 2023 Mar;17(1):33-52. Epub 2023 Mar 16 doi: 10.1007/s12105-022-01518-6. PMID: 36928734Free PMC Article
Early stage clear cell adenocarcinoma coexisting with tubular adenoma and adenoma with clear cell change in the colon.
Tochio T, Baba Y, Asakawa H, Nose K, Tsuruga S, Kumazawa H, Isono Y, Tanaka H, Matsusaki S, Sase T, Saito T, Okano H, Mukai K, Kushima R
Clin J Gastroenterol 2021 Apr;14(2):589-593. Epub 2021 Jan 8 doi: 10.1007/s12328-020-01334-x. PMID: 33420668
Water-Clear Cell Adenoma of the Mediastinal Parathyroid Gland.
Arik D, Dündar E, Yilmaz E, Sivrikoz C
Turk Patoloji Derg 2019;35(2):157-161. doi: 10.5146/tjpath.2017.01407. PMID: 28832084
Water Clear Cell Adenoma of the Parathyroid Gland: A Forgotten Cause of Primary Hyperparathyroidism.
El Hussein S, Poppiti R
Int J Surg Pathol 2017 Aug;25(5):384-388. Epub 2017 Apr 6 doi: 10.1177/1066896917701577. PMID: 28382826
Water-clear cell adenoma associated with primary hyperparathyroidism: report of a case.
Murakami K, Watanabe M, Nakashima N, Fujimori K, Ishida K, Ohuchi N, Sasano H
Surg Today 2014 Apr;44(4):773-7. Epub 2013 Mar 29 doi: 10.1007/s00595-013-0568-7. PMID: 23539328

Therapy

A case of glucocorticoid-suppressible hyperaldosteronism with aldosterone producing adenoma.
Kato S, Haji M, Yanase T, Nawata H, Kato K, Ibayashi H
Endocrinol Jpn 1988 Apr;35(2):311-20. doi: 10.1507/endocrj1954.35.311. PMID: 3208706

Prognosis

Water-Clear Cell Adenoma of the Mediastinal Parathyroid Gland.
Arik D, Dündar E, Yilmaz E, Sivrikoz C
Turk Patoloji Derg 2019;35(2):157-161. doi: 10.5146/tjpath.2017.01407. PMID: 28832084
Central pancreatectomy without anastomosis.
Wayne M, Neragi-Miandoab S, Kasmin F, Brown W, Pahuja A, Cooperman AM
World J Surg Oncol 2009 Aug 31;7:67. doi: 10.1186/1477-7819-7-67. PMID: 19719851Free PMC Article
A rare case of primary hyperparathyroidism with clear cell adenoma.
Kanda K, Okada Y, Tanikawa T, Morita E, Tsurudome Y, Konishi T, Tanaka Y
Endocr J 2004 Apr;51(2):207-12. doi: 10.1507/endocrj.51.207. PMID: 15118272
Parotid clear-cell adenoma of possible myoepithelial origin.
Saksela E, Tarkkanen J, Wartiovaara J
Cancer 1972 Sep;30(3):742-8. doi: 10.1002/1097-0142(197209)30:3<742::aid-cncr2820300323>3.0.co;2-x. PMID: 5075358

Clinical prediction guides

Institutional characterisation of water clear cell parathyroid adenoma: a rare entity often unrecognised by TC-99m-sestamibi scintigraphy.
Juhlin CC, Nilsson IL, Falhammar H, Zedenius J
Pathology 2021 Dec;53(7):852-859. Epub 2021 May 14 doi: 10.1016/j.pathol.2021.02.011. PMID: 33994174
Water-Clear Cell Adenoma of the Mediastinal Parathyroid Gland.
Arik D, Dündar E, Yilmaz E, Sivrikoz C
Turk Patoloji Derg 2019;35(2):157-161. doi: 10.5146/tjpath.2017.01407. PMID: 28832084
Expression of parathyroid hormone-related protein (PTHrP) in parathyroid tissue under normal and pathological conditions.
Kitazawa R, Kitazawa S, Maeda S, Kobayashi A
Histol Histopathol 2002 Jan;17(1):179-84. doi: 10.14670/HH-17.179. PMID: 11813867
Immunohistochemical study of basal cell adenoma in the parotid gland.
Hamano H, Abiko Y, Hashimoto S, Inoue T, Shimono M, Takagi T, Noma H
Bull Tokyo Dent Coll 1990 Feb;31(1):23-31. PMID: 2133439
Distribution of S-100b protein in normal salivary glands and salivary gland tumors.
Hara K, Ito M, Takeuchi J, Iijima S, Endo T, Hidaka H
Virchows Arch A Pathol Anat Histopathol 1983;401(2):237-49. doi: 10.1007/BF00692648. PMID: 6314639

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