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Splenic Manifestation of Chronic Myelogenous Leukemia, BCR-ABL1 Positive

MedGen UID:
234811
•Concept ID:
C1336063
•
Neoplastic Process
Synonyms: Splenic Manifestation of Chronic Myelogenous Leukemia; Splenic Manifestation of Chronic Myelogenous Leukemia, BCR::ABL1 Positive

Definition

Infiltration and expansion of the red pulp and sinusoids of the spleen by chronic myelogenous leukemia, BCR-ABL1 positive. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSplenic Manifestation of Chronic Myelogenous Leukemia, BCR-ABL1 Positive

Recent clinical studies

Etiology

Younger patients with chronic myeloid leukemia do well in spite of poor prognostic indicators: results from the randomized CML study IV.
Kalmanti L, Saussele S, Lauseker M, Proetel U, Müller MC, Hanfstein B, Schreiber A, Fabarius A, Pfirrmann M, Schnittger S, Dengler J, Falge C, Kanz L, Neubauer A, Stegelmann F, Pfreundschuh M, Waller CF, Spiekermann K, Krause SW, Heim D, Nerl C, Hossfeld DK, Kolb HJ, Hochhaus A, Hasford J, Hehlmann R; German Chronic Myeloid Leukemia Study Group; Schweizerische Arbeitsgemeinschaft für Klinische Krebsforschung (SAKK)
Ann Hematol 2014 Jan;93(1):71-80. Epub 2013 Oct 27 doi: 10.1007/s00277-013-1937-4. PMID: 24162333Free PMC Article
Prognostic impact of bone marrow erythropoietic precursor cells and myelofibrosis at diagnosis of Ph1+ chronic myelogenous leukaemia--a multicentre study on 495 patients.
Kvasnicka HM, Thiele J, Schmitt-Graeff A, Diehl V, Zankovich R, Niederle N, Leder LD, Schaefer HE
Br J Haematol 2001 Mar;112(3):727-39. doi: 10.1046/j.1365-2141.2001.02555.x. PMID: 11260078
Listeriosis in hematological malignancies: report of two cases.
Ikehara O, Endo K, Hakamada K
Jpn J Clin Oncol 1989 Jun;19(2):159-62. PMID: 2733169

Diagnosis

Paraplegia as the presenting manifestation of extramedullary megakaryoblastic transformation of previously undiagnosed chronic myelogenous leukemia.
Bryant BJ, Alperin JB, Elghetany MT
Am J Hematol 2007 Feb;82(2):150-4. doi: 10.1002/ajh.20777. PMID: 17019692
Cutaneous sclerosing extramedullary hematopoietic tumor in chronic myelogenous leukemia.
Lane JE, Walker AN, Kulharya A, Marzec T
J Cutan Pathol 2002 Nov;29(10):608-12. doi: 10.1034/j.1600-0560.2002.291007.x. PMID: 12453299
Prognostic impact of bone marrow erythropoietic precursor cells and myelofibrosis at diagnosis of Ph1+ chronic myelogenous leukaemia--a multicentre study on 495 patients.
Kvasnicka HM, Thiele J, Schmitt-Graeff A, Diehl V, Zankovich R, Niederle N, Leder LD, Schaefer HE
Br J Haematol 2001 Mar;112(3):727-39. doi: 10.1046/j.1365-2141.2001.02555.x. PMID: 11260078
Chronic myeloid leukemia: manifesting as spontaneous splenic rupture and terminating in megakaryoblastic transformation.
Shih LY, Su IJ
Med Pediatr Oncol 1987;15(1):31-7. doi: 10.1002/mpo.2950150108. PMID: 3470594
Downgrading of non-Hodgkin's lymphoma following chemotherapy.
O'Brien CJ, Howard M, Child JA
Acta Haematol 1987;77(1):57-9. doi: 10.1159/000205952. PMID: 3107325

Therapy

Chronic myeloid leukaemia with extreme thrombocytosis.
Verma SP, Subbiah A, Jacob SE, Basu D
BMJ Case Rep 2015 Aug 19;2015 doi: 10.1136/bcr-2014-204564. PMID: 26290562Free PMC Article
Younger patients with chronic myeloid leukemia do well in spite of poor prognostic indicators: results from the randomized CML study IV.
Kalmanti L, Saussele S, Lauseker M, Proetel U, Müller MC, Hanfstein B, Schreiber A, Fabarius A, Pfirrmann M, Schnittger S, Dengler J, Falge C, Kanz L, Neubauer A, Stegelmann F, Pfreundschuh M, Waller CF, Spiekermann K, Krause SW, Heim D, Nerl C, Hossfeld DK, Kolb HJ, Hochhaus A, Hasford J, Hehlmann R; German Chronic Myeloid Leukemia Study Group; Schweizerische Arbeitsgemeinschaft für Klinische Krebsforschung (SAKK)
Ann Hematol 2014 Jan;93(1):71-80. Epub 2013 Oct 27 doi: 10.1007/s00277-013-1937-4. PMID: 24162333Free PMC Article
Prognostic impact of bone marrow erythropoietic precursor cells and myelofibrosis at diagnosis of Ph1+ chronic myelogenous leukaemia--a multicentre study on 495 patients.
Kvasnicka HM, Thiele J, Schmitt-Graeff A, Diehl V, Zankovich R, Niederle N, Leder LD, Schaefer HE
Br J Haematol 2001 Mar;112(3):727-39. doi: 10.1046/j.1365-2141.2001.02555.x. PMID: 11260078
Role of splenic irradiation in patients with chronic myeloid leukemia undergoing allogeneic bone marrow transplantation.
Jabro G, Koc Y, Boyle T, Schenkein DP, Ravalese J, Wazer D, Miller KB
Biol Blood Marrow Transplant 1999;5(3):173-9. doi: 10.1053/bbmt.1999.v5.pm10392963. PMID: 10392963
Treatment of chronic disseminated Geotrichum capitatum infection with high cumulative dose of colloidal amphotericin B and itraconazole in a leukaemia patient.
Cofrancesco E, Viviani MA, Boschetti C, Tortorano AM, Balzani A, Castagnone D
Mycoses 1995 Sep-Oct;38(9-10):377-84. doi: 10.1111/j.1439-0507.1995.tb00068.x. PMID: 8569813

Prognosis

Younger patients with chronic myeloid leukemia do well in spite of poor prognostic indicators: results from the randomized CML study IV.
Kalmanti L, Saussele S, Lauseker M, Proetel U, Müller MC, Hanfstein B, Schreiber A, Fabarius A, Pfirrmann M, Schnittger S, Dengler J, Falge C, Kanz L, Neubauer A, Stegelmann F, Pfreundschuh M, Waller CF, Spiekermann K, Krause SW, Heim D, Nerl C, Hossfeld DK, Kolb HJ, Hochhaus A, Hasford J, Hehlmann R; German Chronic Myeloid Leukemia Study Group; Schweizerische Arbeitsgemeinschaft für Klinische Krebsforschung (SAKK)
Ann Hematol 2014 Jan;93(1):71-80. Epub 2013 Oct 27 doi: 10.1007/s00277-013-1937-4. PMID: 24162333Free PMC Article
Prognostic impact of bone marrow erythropoietic precursor cells and myelofibrosis at diagnosis of Ph1+ chronic myelogenous leukaemia--a multicentre study on 495 patients.
Kvasnicka HM, Thiele J, Schmitt-Graeff A, Diehl V, Zankovich R, Niederle N, Leder LD, Schaefer HE
Br J Haematol 2001 Mar;112(3):727-39. doi: 10.1046/j.1365-2141.2001.02555.x. PMID: 11260078
Role of splenic irradiation in patients with chronic myeloid leukemia undergoing allogeneic bone marrow transplantation.
Jabro G, Koc Y, Boyle T, Schenkein DP, Ravalese J, Wazer D, Miller KB
Biol Blood Marrow Transplant 1999;5(3):173-9. doi: 10.1053/bbmt.1999.v5.pm10392963. PMID: 10392963
Treatment of chronic disseminated Geotrichum capitatum infection with high cumulative dose of colloidal amphotericin B and itraconazole in a leukaemia patient.
Cofrancesco E, Viviani MA, Boschetti C, Tortorano AM, Balzani A, Castagnone D
Mycoses 1995 Sep-Oct;38(9-10):377-84. doi: 10.1111/j.1439-0507.1995.tb00068.x. PMID: 8569813

Clinical prediction guides

Younger patients with chronic myeloid leukemia do well in spite of poor prognostic indicators: results from the randomized CML study IV.
Kalmanti L, Saussele S, Lauseker M, Proetel U, Müller MC, Hanfstein B, Schreiber A, Fabarius A, Pfirrmann M, Schnittger S, Dengler J, Falge C, Kanz L, Neubauer A, Stegelmann F, Pfreundschuh M, Waller CF, Spiekermann K, Krause SW, Heim D, Nerl C, Hossfeld DK, Kolb HJ, Hochhaus A, Hasford J, Hehlmann R; German Chronic Myeloid Leukemia Study Group; Schweizerische Arbeitsgemeinschaft für Klinische Krebsforschung (SAKK)
Ann Hematol 2014 Jan;93(1):71-80. Epub 2013 Oct 27 doi: 10.1007/s00277-013-1937-4. PMID: 24162333Free PMC Article
Prognostic impact of bone marrow erythropoietic precursor cells and myelofibrosis at diagnosis of Ph1+ chronic myelogenous leukaemia--a multicentre study on 495 patients.
Kvasnicka HM, Thiele J, Schmitt-Graeff A, Diehl V, Zankovich R, Niederle N, Leder LD, Schaefer HE
Br J Haematol 2001 Mar;112(3):727-39. doi: 10.1046/j.1365-2141.2001.02555.x. PMID: 11260078
Role of splenic irradiation in patients with chronic myeloid leukemia undergoing allogeneic bone marrow transplantation.
Jabro G, Koc Y, Boyle T, Schenkein DP, Ravalese J, Wazer D, Miller KB
Biol Blood Marrow Transplant 1999;5(3):173-9. doi: 10.1053/bbmt.1999.v5.pm10392963. PMID: 10392963
Hepatosplenic T-cell lymphoma: prolymphocytic transformation 18 months after splenectomy.
Sohn SK, Ahn T, Kim DH, Jung JT, Hyun DW, Lee YH, Suh CS, Lee J, Lee KB
Int J Hematol 1997 Aug;66(2):227-32. doi: 10.1016/s0925-5710(97)00594-x. PMID: 9277054
Treatment of chronic disseminated Geotrichum capitatum infection with high cumulative dose of colloidal amphotericin B and itraconazole in a leukaemia patient.
Cofrancesco E, Viviani MA, Boschetti C, Tortorano AM, Balzani A, Castagnone D
Mycoses 1995 Sep-Oct;38(9-10):377-84. doi: 10.1111/j.1439-0507.1995.tb00068.x. PMID: 8569813

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