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Spindle cell variant squamous cell breast carcinoma

MedGen UID:
274270
•Concept ID:
C1519487
•
Neoplastic Process
Synonyms: Breast Squamous Cell Carcinoma, Spindle Cell Variant; metaplastic adenocarcinoma with spindle cell differentiation; spindle cell variant squamous cell breast carcinoma; Squamous Cell Breast Carcinoma, Spindle Cell Variant; squamous cell breast carcinoma, spindle cell variant
 
Monarch Initiative: MONDO:0004231

Definition

A squamous cell carcinoma that arises from the breast parenchyma and is characterized by the presence of spindle-shaped malignant cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSpindle cell variant squamous cell breast carcinoma

Professional guidelines

PubMed

Best Practice (Efficient) Immunohistologic Panel for Diagnosing Metaplastic Breast Carcinoma.
Han M, Zhang H, Dabbs DJ
Appl Immunohistochem Mol Morphol 2021 Apr 1;29(4):265-269. doi: 10.1097/PAI.0000000000000873. PMID: 32858538

Recent clinical studies

Etiology

Adenomyoepithelioma of the breast: a proposal for classification.
Rakha E, Tan PH, Ellis I, Quinn C
Histopathology 2021 Oct;79(4):465-479. Epub 2021 Jun 13 doi: 10.1111/his.14380. PMID: 33829532
Rare variant of metaplastic carcinoma of the breast: a case report and review of the literature.
Alaoui M'hamdi H, Abbad F, Rais H, Asmouki H, Soumani A, Khouchani M, Belbaraka R
J Med Case Rep 2018 Feb 21;12(1):43. doi: 10.1186/s13256-017-1553-3. PMID: 29463294Free PMC Article
Low-grade fibromatosis-like spindle cell carcinoma of the breast.
Dwyer JB, Clark BZ
Arch Pathol Lab Med 2015 Apr;139(4):552-7. doi: 10.5858/arpa.2013-0555-RS. PMID: 25822766
Genomic and immunohistochemical analysis of adenosquamous carcinoma of the breast.
Geyer FC, Lambros MB, Natrajan R, Mehta R, Mackay A, Savage K, Parry S, Ashworth A, Badve S, Reis-Filho JS
Mod Pathol 2010 Jul;23(7):951-60. Epub 2010 May 7 doi: 10.1038/modpathol.2010.82. PMID: 20453835
Metaplastic breast carcinoma: clinical-pathologic characteristics and HER2/neu expression.
Barnes PJ, Boutilier R, Chiasson D, Rayson D
Breast Cancer Res Treat 2005 May;91(2):173-8. doi: 10.1007/s10549-004-7260-y. PMID: 15868445

Diagnosis

Adenomyoepithelioma of the breast: a proposal for classification.
Rakha E, Tan PH, Ellis I, Quinn C
Histopathology 2021 Oct;79(4):465-479. Epub 2021 Jun 13 doi: 10.1111/his.14380. PMID: 33829532
Best Practice (Efficient) Immunohistologic Panel for Diagnosing Metaplastic Breast Carcinoma.
Han M, Zhang H, Dabbs DJ
Appl Immunohistochem Mol Morphol 2021 Apr 1;29(4):265-269. doi: 10.1097/PAI.0000000000000873. PMID: 32858538
Rare variant of metaplastic carcinoma of the breast: a case report and review of the literature.
Alaoui M'hamdi H, Abbad F, Rais H, Asmouki H, Soumani A, Khouchani M, Belbaraka R
J Med Case Rep 2018 Feb 21;12(1):43. doi: 10.1186/s13256-017-1553-3. PMID: 29463294Free PMC Article
Low-grade fibromatosis-like spindle cell carcinoma of the breast.
Dwyer JB, Clark BZ
Arch Pathol Lab Med 2015 Apr;139(4):552-7. doi: 10.5858/arpa.2013-0555-RS. PMID: 25822766
Low-grade (fibromatosis-like) spindle cell carcinoma of the breast.
Sneige N, Yaziji H, Mandavilli SR, Perez ER, Ordonez NG, Gown AM, Ayala A
Am J Surg Pathol 2001 Aug;25(8):1009-16. doi: 10.1097/00000478-200108000-00004. PMID: 11474284

Therapy

Best Practice (Efficient) Immunohistologic Panel for Diagnosing Metaplastic Breast Carcinoma.
Han M, Zhang H, Dabbs DJ
Appl Immunohistochem Mol Morphol 2021 Apr 1;29(4):265-269. doi: 10.1097/PAI.0000000000000873. PMID: 32858538
Fine needle aspiration cytology presentation of a cellular variant of breast myofibroblastoma. Report of a case with immunohistochemical studies.
Schmitt FC, AC Mera A
Acta Cytol 1998 May-Jun;42(3):721-4. doi: 10.1159/000331833. PMID: 9622694

Prognosis

Rare variant of metaplastic carcinoma of the breast: a case report and review of the literature.
Alaoui M'hamdi H, Abbad F, Rais H, Asmouki H, Soumani A, Khouchani M, Belbaraka R
J Med Case Rep 2018 Feb 21;12(1):43. doi: 10.1186/s13256-017-1553-3. PMID: 29463294Free PMC Article
A case of matrix-producing carcinoma of the breast with micoglandular adenosis and review of literature.
Liu LY, Sheng SH, Zhang ZY, Xu JH
Int J Clin Exp Pathol 2015;8(7):8568-72. Epub 2015 Jul 1 PMID: 26339435Free PMC Article
Low-grade fibromatosis-like spindle cell carcinoma of the breast.
Dwyer JB, Clark BZ
Arch Pathol Lab Med 2015 Apr;139(4):552-7. doi: 10.5858/arpa.2013-0555-RS. PMID: 25822766
Low-grade (fibromatosis-like) spindle cell carcinoma of the breast.
Sneige N, Yaziji H, Mandavilli SR, Perez ER, Ordonez NG, Gown AM, Ayala A
Am J Surg Pathol 2001 Aug;25(8):1009-16. doi: 10.1097/00000478-200108000-00004. PMID: 11474284
Spindle cell carcinoma of the breast, a mimicker of benign lesions: case report and review of the literature.
Al-Bozom IA, Abrams J
Arch Pathol Lab Med 1996 Nov;120(11):1066-8. PMID: 12049111

Clinical prediction guides

High rate of PIK3CA mutations but no TP53 mutations in low-grade adenosquamous carcinoma of the breast.
Bataillon G, Fuhrmann L, Girard E, Menet E, Laé M, Capovilla M, Treilleux I, Arnould L, Penault-Llorca F, Rouzier R, Marchiò C, Bieche I, Vincent-Salomon A
Histopathology 2018 Aug;73(2):273-283. Epub 2018 May 7 doi: 10.1111/his.13514. PMID: 29537649
Mammary NOS-type sarcoma with CD10 expression: a rare entity with features of myoepithelial differentiation.
Leibl S, Moinfar F
Am J Surg Pathol 2006 Apr;30(4):450-6. doi: 10.1097/00000478-200604000-00004. PMID: 16625090
Low-grade (fibromatosis-like) spindle cell carcinoma of the breast.
Sneige N, Yaziji H, Mandavilli SR, Perez ER, Ordonez NG, Gown AM, Ayala A
Am J Surg Pathol 2001 Aug;25(8):1009-16. doi: 10.1097/00000478-200108000-00004. PMID: 11474284
Fine needle aspiration cytology presentation of a cellular variant of breast myofibroblastoma. Report of a case with immunohistochemical studies.
Schmitt FC, AC Mera A
Acta Cytol 1998 May-Jun;42(3):721-4. doi: 10.1159/000331833. PMID: 9622694

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