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Anaplastic cancer

MedGen UID:
231373
•Concept ID:
C1332287
•
Neoplastic Process
Synonyms: anaplastic cancer; Anaplastic Malignant Neoplasm; anaplastic malignant neoplasm
 
Monarch Initiative: MONDO:0020633

Definition

A malignant neoplasm characterized by the presence of poorly differentiated, often large neoplastic cells with bizarre morphologic characteristics, associated with high mitotic activity and necrotic changes. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAnaplastic cancer

Professional guidelines

PubMed

Management of acute clinical presentation of anaplastic thyroid cancer. A difficult choice.
Biffoni M, Garritano S, Scipioni P, Colangelo M, De Meo D, Monti M
Ann Ital Chir 2013 Mar-Apr;84(2):187-91. PMID: 23698085
Treatment of recurrent thyroid cancers--is there a light in the horizon?
Rovere RK, Awada A
Curr Opin Oncol 2008 May;20(3):245-8. doi: 10.1097/CCO.0b013e3282fb289a. PMID: 18391621
Prognosis and treatment of brain metastases in thyroid carcinoma.
Chiu AC, Delpassand ES, Sherman SI
J Clin Endocrinol Metab 1997 Nov;82(11):3637-42. doi: 10.1210/jcem.82.11.4386. PMID: 9360519

Recent clinical studies

Etiology

External beam radiotherapy for thyroid cancer: Patients, complications, and survival.
Goodsell K, Ermer J, Amjad W, Swisher-McClure S, Wachtel H
Am J Surg 2023 Jun;225(6):994-999. Epub 2023 Jan 11 doi: 10.1016/j.amjsurg.2023.01.009. PMID: 36707300
Five-year relative survival and determinants of excess mortality in patients with head and neck and thyroid cancers: A population-based study from Golestan province, Northern Iran.
Taziki M, Rajaei S, Firouzei G, Hashemzadeh F, Rajabalian M, Mansoury M, Sedaghat S, Ghahraman F, Ghasemi-Kebria F, Weiderpass E, Roshandel G
Cancer Epidemiol 2022 Oct;80:102247. Epub 2022 Sep 5 doi: 10.1016/j.canep.2022.102247. PMID: 36081275
Anaplastic cancer, lymphoma, and metastases of the thyroid gland.
Pasieka JL
Surg Oncol Clin N Am 1998 Oct;7(4):707-20. PMID: 9735130
Predictors of thyroid tumor aggressiveness.
Clark OH
West J Med 1996 Sep;165(3):131-8. PMID: 8909165Free PMC Article
Thyroid cancer: a lethal endocrine neoplasm.
Robbins J, Merino MJ, Boice JD Jr, Ron E, Ain KB, Alexander HR, Norton JA, Reynolds J
Ann Intern Med 1991 Jul 15;115(2):133-47. doi: 10.7326/0003-4819-115-2-133. PMID: 2058861

Diagnosis

Thyroid cancer in the Democratic Republic of the Congo: Frequency and risk factors.
Bukasa Kakamba J, Sabbah N, Bayauli P, Massicard M, Bidingija J, Nkodila A, Mbunga B, Ditu S, Beckers A, Potorac I
Ann Endocrinol (Paris) 2021 Dec;82(6):606-612. Epub 2021 Oct 5 doi: 10.1016/j.ando.2021.09.002. PMID: 34624256
The mutation profile of differentiated thyroid cancer coexisting with undifferentiated anaplastic cancer resembles that of anaplastic thyroid cancer but not that of archetypal differentiated thyroid cancer.
Mika J, Łabaj W, Chekan M, Abramowicz A, Pietrowska M, Polański A, Widłak P
J Appl Genet 2021 Feb;62(1):115-120. doi: 10.1007/s13353-020-00594-0. PMID: 33222100Free PMC Article
Merkel cell carcinoma.
Swann MH, Yoon J
Semin Oncol 2007 Feb;34(1):51-6. doi: 10.1053/j.seminoncol.2006.10.021. PMID: 17270666
Predictors of thyroid tumor aggressiveness.
Clark OH
West J Med 1996 Sep;165(3):131-8. PMID: 8909165Free PMC Article
Thyroid cancer: a lethal endocrine neoplasm.
Robbins J, Merino MJ, Boice JD Jr, Ron E, Ain KB, Alexander HR, Norton JA, Reynolds J
Ann Intern Med 1991 Jul 15;115(2):133-47. doi: 10.7326/0003-4819-115-2-133. PMID: 2058861

Therapy

Effects of metformin and pioglitazone combination on apoptosis and AMPK/mTOR signaling pathway in human anaplastic thyroid cancer cells.
Ozdemir Kutbay N, Biray Avci C, Sarer Yurekli B, Caliskan Kurt C, Shademan B, Gunduz C, Erdogan M
J Biochem Mol Toxicol 2020 Oct;34(10):e22547. Epub 2020 Jun 26 doi: 10.1002/jbt.22547. PMID: 32589349
Merkel cell carcinoma.
Swann MH, Yoon J
Semin Oncol 2007 Feb;34(1):51-6. doi: 10.1053/j.seminoncol.2006.10.021. PMID: 17270666
Efficacy of epidermal growth factor receptor-targeted molecular therapy in anaplastic thyroid cancer cell lines.
Nobuhara Y, Onoda N, Yamashita Y, Yamasaki M, Ogisawa K, Takashima T, Ishikawa T, Hirakawa K
Br J Cancer 2005 Mar 28;92(6):1110-6. doi: 10.1038/sj.bjc.6602461. PMID: 15785737Free PMC Article
Epidemiology of thyroid diseases in iodine sufficiency.
Lind P, Langsteger W, Molnar M, Gallowitsch HJ, Mikosch P, Gomez I
Thyroid 1998 Dec;8(12):1179-83. doi: 10.1089/thy.1998.8.1179. PMID: 9920375
Thyroid cancer.
Leeper RD
Med Clin North Am 1985 Sep;69(5):1079-96. doi: 10.1016/s0025-7125(16)31007-0. PMID: 4058094

Prognosis

Merkel cell carcinoma.
Swann MH, Yoon J
Semin Oncol 2007 Feb;34(1):51-6. doi: 10.1053/j.seminoncol.2006.10.021. PMID: 17270666
The management of advanced thyroid cancer.
Wilson PC, Millar BM, Brierley JD
Clin Oncol (R Coll Radiol) 2004 Dec;16(8):561-8. doi: 10.1016/j.clon.2004.08.009. PMID: 15630850
Anaplastic cancer, lymphoma, and metastases of the thyroid gland.
Pasieka JL
Surg Oncol Clin N Am 1998 Oct;7(4):707-20. PMID: 9735130
Predictors of thyroid tumor aggressiveness.
Clark OH
West J Med 1996 Sep;165(3):131-8. PMID: 8909165Free PMC Article
Thyroid cancer.
Leeper RD
Med Clin North Am 1985 Sep;69(5):1079-96. doi: 10.1016/s0025-7125(16)31007-0. PMID: 4058094

Clinical prediction guides

Early mortality critically impedes improvements in thyroid cancer survival through a half century.
Tichanek F, Försti A, Liska V, Hemminki O, Koskinen A, Hemminki A, Hemminki K
Eur J Endocrinol 2023 Sep 1;189(3):355-362. doi: 10.1093/ejendo/lvad117. PMID: 37675794
The mutation profile of differentiated thyroid cancer coexisting with undifferentiated anaplastic cancer resembles that of anaplastic thyroid cancer but not that of archetypal differentiated thyroid cancer.
Mika J, Łabaj W, Chekan M, Abramowicz A, Pietrowska M, Polański A, Widłak P
J Appl Genet 2021 Feb;62(1):115-120. doi: 10.1007/s13353-020-00594-0. PMID: 33222100Free PMC Article
Inhibition of gap junction transfer sensitizes thyroid cancer cells to anoikis.
Jensen K, Patel A, Klubo-Gwiezdzinska J, Bauer A, Vasko V
Endocr Relat Cancer 2011 Oct;18(5):613-26. Epub 2011 Sep 20 doi: 10.1530/ERC-10-0289. PMID: 21813730
Predictors of thyroid tumor aggressiveness.
Clark OH
West J Med 1996 Sep;165(3):131-8. PMID: 8909165Free PMC Article
Thyroid cancer.
Leeper RD
Med Clin North Am 1985 Sep;69(5):1079-96. doi: 10.1016/s0025-7125(16)31007-0. PMID: 4058094

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