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Vulvar Soft Tissue Neoplasm

MedGen UID:
276997
•Concept ID:
C1520095
•
Neoplastic Process
Synonym: Vulvar Soft Tissue Tumor

Definition

A benign or malignant mesenchymal neoplasm of the vulva. Representative examples include leiomyoma, cellular angiofibroma, angiomyxoma, leiomyosarcoma, liposarcoma, and childhood botryoid-type embryonal rhabdomyosarcoma. [from NCI]

Professional guidelines

PubMed

Dilemmas in the management of patients with vulval epithelioid sarcoma: a literature review.
Iavazzo C, Gkegkes ID, Vrachnis N
Eur J Obstet Gynecol Reprod Biol 2014 May;176:1-4. Epub 2014 Feb 20 doi: 10.1016/j.ejogrb.2014.02.013. PMID: 24636595
Management of congenital venous malformations of the vulva.
Marrocco-Trischitta MM, Nicodemi EM, Nater C, Stillo F
Obstet Gynecol 2001 Nov;98(5 Pt 1):789-93. PMID: 11704170
The role of fine needle aspiration cytology in the management of gynecologic malignancies.
Moriarty AT, Glant MD, Stehman FB
Acta Cytol 1986 Jan-Feb;30(1):59-64. PMID: 3456185

Recent clinical studies

Etiology

Mesenchymal lesions of the vulva.
Chapel DB, Cipriani NA, Bennett JA
Semin Diagn Pathol 2021 Jan;38(1):85-98. Epub 2020 Sep 6 doi: 10.1053/j.semdp.2020.09.003. PMID: 32958293
Vulvar leiomyoma: a case report.
Ammouri S, Elkarkri C, Zeraidi N, Lakhdar A, Baydada A
Pan Afr Med J 2019;32:208. Epub 2019 Apr 29 doi: 10.11604/pamj.2019.32.208.18480. PMID: 31312320Free PMC Article
A contemporary review of myxoid adipocytic tumors.
Creytens D
Semin Diagn Pathol 2019 Mar;36(2):129-141. Epub 2019 Feb 28 doi: 10.1053/j.semdp.2019.02.008. PMID: 30853315
Outcome of vulvar reconstruction in patients with advanced and recurrent vulvar malignancies.
Zhang W, Zeng A, Yang J, Cao D, He X, Wang X, You Y, Chen J, Lang J, Shen K
BMC Cancer 2015 Nov 5;15:851. doi: 10.1186/s12885-015-1792-x. PMID: 26542779Free PMC Article
Vulvar soft tissue tumors.
Behranwala KA, Latifaj B, Blake P, Barton DP, Shepherd JH, Thomas JM
Int J Gynecol Cancer 2004 Jan-Feb;14(1):94-9. doi: 10.1111/j.1048-891x.2004.14946.x. PMID: 14764035

Diagnosis

Mesenchymal lesions of the vulva.
Chapel DB, Cipriani NA, Bennett JA
Semin Diagn Pathol 2021 Jan;38(1):85-98. Epub 2020 Sep 6 doi: 10.1053/j.semdp.2020.09.003. PMID: 32958293
A contemporary review of myxoid adipocytic tumors.
Creytens D
Semin Diagn Pathol 2019 Mar;36(2):129-141. Epub 2019 Feb 28 doi: 10.1053/j.semdp.2019.02.008. PMID: 30853315
Imaging of the female perineum in adults.
Hosseinzadeh K, Heller MT, Houshmand G
Radiographics 2012 Jul-Aug;32(4):E129-68. doi: 10.1148/rg.324115134. PMID: 22787005
Mesenchymal lesions of the vulva.
Fitzhugh VA, Heller DS
J Low Genit Tract Dis 2011 Apr;15(2):134-45. doi: 10.1097/LGT.0b013e3181f6f2d0. PMID: 21478700
Vulvar soft tissue tumors.
Behranwala KA, Latifaj B, Blake P, Barton DP, Shepherd JH, Thomas JM
Int J Gynecol Cancer 2004 Jan-Feb;14(1):94-9. doi: 10.1111/j.1048-891x.2004.14946.x. PMID: 14764035

Therapy

High-dose intensity-modulated chemoradiotherapy in vulvar squamous cell carcinoma: Outcome and toxicity.
Rishi A, Rollins M, Ahmed KA, Hunt DC, Sarkar P, Fernandez DC, Hoffman MS, Apte SM, Shahzad MMK, Chon HS, Chern JY, Wenham RM, Montejo ME
Gynecol Oncol 2020 Feb;156(2):349-356. Epub 2019 Nov 23 doi: 10.1016/j.ygyno.2019.11.027. PMID: 31771865
Cancer Risk After Pediatric Solid Organ Transplantation.
Yanik EL, Smith JM, Shiels MS, Clarke CA, Lynch CF, Kahn AR, Koch L, Pawlish KS, Engels EA
Pediatrics 2017 May;139(5) doi: 10.1542/peds.2016-3893. PMID: 28557749Free PMC Article
Outcome of vulvar reconstruction in patients with advanced and recurrent vulvar malignancies.
Zhang W, Zeng A, Yang J, Cao D, He X, Wang X, You Y, Chen J, Lang J, Shen K
BMC Cancer 2015 Nov 5;15:851. doi: 10.1186/s12885-015-1792-x. PMID: 26542779Free PMC Article
Groin angiosarcoma following radiotherapy for vulvar cancer.
Sanz C, Moreno F, Armas A, Casado A, Castillo MC
Gynecol Oncol 2005 May;97(2):677-80. doi: 10.1016/j.ygyno.2004.12.061. PMID: 15863181
Management of congenital venous malformations of the vulva.
Marrocco-Trischitta MM, Nicodemi EM, Nater C, Stillo F
Obstet Gynecol 2001 Nov;98(5 Pt 1):789-93. PMID: 11704170

Prognosis

Myxoepithelioid tumour with chordoid features: a clinicopathological, immunohistochemical and genetic study of 14 cases of SMARCB1/INI1-deficient soft-tissue neoplasm.
Kinoshita I, Kohashi K, Yamamoto H, Yamada Y, Inoue T, Higaki K, Teramoto N, Oshiro Y, Nakashima Y, Oda Y
Histopathology 2021 Oct;79(4):629-641. Epub 2021 Jul 5 doi: 10.1111/his.14393. PMID: 33932047
Myoepithelioma of soft tissue and bone, and myoepithelioma-like tumors of the vulvar region: Clinicopathological study of 15 cases by PLAG1 immunohistochemistry.
Segawa K, Sugita S, Aoyama T, Takenami T, Asanuma H, Kojima Y, Inayama Y, Hasegawa T
Pathol Int 2020 Dec;70(12):965-974. Epub 2020 Sep 17 doi: 10.1111/pin.13017. PMID: 32940946
Outcome of vulvar reconstruction in patients with advanced and recurrent vulvar malignancies.
Zhang W, Zeng A, Yang J, Cao D, He X, Wang X, You Y, Chen J, Lang J, Shen K
BMC Cancer 2015 Nov 5;15:851. doi: 10.1186/s12885-015-1792-x. PMID: 26542779Free PMC Article
Vulvar soft tissue tumors.
Behranwala KA, Latifaj B, Blake P, Barton DP, Shepherd JH, Thomas JM
Int J Gynecol Cancer 2004 Jan-Feb;14(1):94-9. doi: 10.1111/j.1048-891x.2004.14946.x. PMID: 14764035
Vulvovaginal soft tissue tumours: update and review.
Nucci MR, Fletcher CD
Histopathology 2000 Feb;36(2):97-108. doi: 10.1046/j.1365-2559.2000.00865.x. PMID: 10672053

Clinical prediction guides

Myoepithelioma-like tumors of the vulvar region: A case report and review of the literature.
Liu X, Chen L, Zhou Q, Liu J, Hu Y
J Obstet Gynaecol Res 2022 Jul;48(7):2015-2020. Epub 2022 May 17 doi: 10.1111/jog.15286. PMID: 35581677
Myoepithelioma of soft tissue and bone, and myoepithelioma-like tumors of the vulvar region: Clinicopathological study of 15 cases by PLAG1 immunohistochemistry.
Segawa K, Sugita S, Aoyama T, Takenami T, Asanuma H, Kojima Y, Inayama Y, Hasegawa T
Pathol Int 2020 Dec;70(12):965-974. Epub 2020 Sep 17 doi: 10.1111/pin.13017. PMID: 32940946
Outcome of vulvar reconstruction in patients with advanced and recurrent vulvar malignancies.
Zhang W, Zeng A, Yang J, Cao D, He X, Wang X, You Y, Chen J, Lang J, Shen K
BMC Cancer 2015 Nov 5;15:851. doi: 10.1186/s12885-015-1792-x. PMID: 26542779Free PMC Article
Vulvar soft tissue tumors.
Behranwala KA, Latifaj B, Blake P, Barton DP, Shepherd JH, Thomas JM
Int J Gynecol Cancer 2004 Jan-Feb;14(1):94-9. doi: 10.1111/j.1048-891x.2004.14946.x. PMID: 14764035
Vulvovaginal soft tissue tumours: update and review.
Nucci MR, Fletcher CD
Histopathology 2000 Feb;36(2):97-108. doi: 10.1046/j.1365-2559.2000.00865.x. PMID: 10672053

Recent systematic reviews

Prognostic implications of extranodal extension in node-positive squamous cell carcinoma of the vulva: A systematic review and meta-analysis.
Luchini C, Nottegar A, Solmi M, Sergi G, Manzato E, Capelli P, Scarpa A, Veronese N
Surg Oncol 2016 Mar;25(1):60-5. Epub 2015 Sep 14 doi: 10.1016/j.suronc.2015.09.005. PMID: 26394825
Benign granular cell tumor of the vulva: first report of multiple cases in a family.
Kardhashi A, Assunta Deliso M, Renna A, Trojano G, Zito FA, Trojano V
Gynecol Obstet Invest 2012;73(4):341-8. Epub 2012 Apr 20 doi: 10.1159/000336256. PMID: 22517025

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