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Ovarian Tumor of the Thecoma/Fibroma Group

MedGen UID:
277816
•Concept ID:
C1336734
•
Neoplastic Process
Synonym: Thecoma/Fibroma Group Ovarian Tumor

Definition

A group of neoplasms that arise from the ovary and represent a spectrum of tumors ranging from neoplasms that are composed entirely of fibroblasts to those that are composed predominantly of theca cells. [from NCI]

Recent clinical studies

Etiology

Diagnostic utility of a conventional MRI-based analysis and texture analysis for discriminating between ovarian thecoma-fibroma groups and ovarian granulosa cell tumors.
Nagawa K, Kishigami T, Yokoyama F, Murakami S, Yasugi T, Takaki Y, Inoue K, Tsuchihashi S, Seki S, Okada Y, Baba Y, Hasegawa K, Yasuda M, Kozawa E
J Ovarian Res 2022 May 25;15(1):65. doi: 10.1186/s13048-022-00989-z. PMID: 35610706Free PMC Article
Pelvic effusion in patients with ovarian thecoma-fibroma associated with the tumor size and plaste CA-125 level: A retrospective magnetic resonance imaging study.
Zhang S, Li Y, Wang M, Liu H, Meng F, Hua G, Hu Q, Zhao X
Clin Imaging 2022 Jan;81:62-66. Epub 2021 Aug 3 doi: 10.1016/j.clinimag.2021.06.007. PMID: 34607094
Ovarian thecoma-fibroma groups: clinical and sonographic features with pathological comparison.
Chen H, Liu Y, Shen LF, Jiang MJ, Yang ZF, Fang GP
J Ovarian Res 2016 Nov 22;9(1):81. doi: 10.1186/s13048-016-0291-2. PMID: 27876070Free PMC Article
CT diagnosis in the thecoma-fibroma group of the ovarian stromal tumors.
Zhang Z, Wu Y, Gao J
Cell Biochem Biophys 2015 Mar;71(2):937-43. doi: 10.1007/s12013-014-0288-7. PMID: 25315640
Tetrasomy 12 in ovarian tumors of thecoma-fibroma group: A fluorescence in situ hybridization analysis using paraffin sections.
Liang SB, Sonobe H, Taguchi T, Takeuchi T, Furihata M, Yuri K, Ohtsuki Y
Pathol Int 2001 Jan;51(1):37-42. doi: 10.1046/j.1440-1827.2001.01168.x. PMID: 11148462

Diagnosis

Diagnostic utility of a conventional MRI-based analysis and texture analysis for discriminating between ovarian thecoma-fibroma groups and ovarian granulosa cell tumors.
Nagawa K, Kishigami T, Yokoyama F, Murakami S, Yasugi T, Takaki Y, Inoue K, Tsuchihashi S, Seki S, Okada Y, Baba Y, Hasegawa K, Yasuda M, Kozawa E
J Ovarian Res 2022 May 25;15(1):65. doi: 10.1186/s13048-022-00989-z. PMID: 35610706Free PMC Article
Pelvic effusion in patients with ovarian thecoma-fibroma associated with the tumor size and plaste CA-125 level: A retrospective magnetic resonance imaging study.
Zhang S, Li Y, Wang M, Liu H, Meng F, Hua G, Hu Q, Zhao X
Clin Imaging 2022 Jan;81:62-66. Epub 2021 Aug 3 doi: 10.1016/j.clinimag.2021.06.007. PMID: 34607094
Clinical laboratory features of Meigs' syndrome: a retrospective study from 2009 to 2018.
Shang W, Wu L, Xu R, Chen X, Yao S, Huang P, Wang F
Front Med 2021 Feb;15(1):116-124. Epub 2020 Jul 10 doi: 10.1007/s11684-019-0732-6. PMID: 32651935
Ovarian thecoma-fibroma groups: clinical and sonographic features with pathological comparison.
Chen H, Liu Y, Shen LF, Jiang MJ, Yang ZF, Fang GP
J Ovarian Res 2016 Nov 22;9(1):81. doi: 10.1186/s13048-016-0291-2. PMID: 27876070Free PMC Article
CT diagnosis in the thecoma-fibroma group of the ovarian stromal tumors.
Zhang Z, Wu Y, Gao J
Cell Biochem Biophys 2015 Mar;71(2):937-43. doi: 10.1007/s12013-014-0288-7. PMID: 25315640

Therapy

Hypoxia is important in F‑18 FDG accumulation in thecoma‑fibroma tumors on F‑18 FDG PET/CT scans.
Seino H, Ono S, Miura H, Morohashi S, Wu Y, Tsushima F, Takai Y, Kijima H
Mol Med Rep 2016 May;13(5):3821-7. Epub 2016 Mar 21 doi: 10.3892/mmr.2016.5016. PMID: 27035330Free PMC Article

Prognosis

MRI combined with clinical features to differentiate ovarian thecoma-fibroma with cystic degeneration from ovary adenofibroma.
Bo J, Sun M, Wei C, Wei L, Fu B, Shi B, Fang X, Dong J
Br J Radiol 2024 May 7;97(1157):1057-1065. doi: 10.1093/bjr/tqae046. PMID: 38402483Free PMC Article
Coexisting ovarian serous cystadenoma with fibroma: A very unusual combination.
Balhara K, Mallya V, Khurana N, Tempe A
J Cancer Res Ther 2023 Jul-Sep;19(5):1474-1476. doi: 10.4103/jcrt.jcrt_2319_21. PMID: 37787335
Testicular thecoma in an 11-year-old boy with nevoid basal-cell carcinoma syndrome (Gorlin syndrome).
Ueda M, Kanematsu A, Nishiyama H, Yoshimura K, Watanabe K, Yorifuji T, Mikami Y, Kamoto T, Ogawa O
J Pediatr Surg 2010 Mar;45(3):E1-3. doi: 10.1016/j.jpedsurg.2009.12.005. PMID: 20223301

Clinical prediction guides

MRI combined with clinical features to differentiate ovarian thecoma-fibroma with cystic degeneration from ovary adenofibroma.
Bo J, Sun M, Wei C, Wei L, Fu B, Shi B, Fang X, Dong J
Br J Radiol 2024 May 7;97(1157):1057-1065. doi: 10.1093/bjr/tqae046. PMID: 38402483Free PMC Article
Hypoxia is important in F‑18 FDG accumulation in thecoma‑fibroma tumors on F‑18 FDG PET/CT scans.
Seino H, Ono S, Miura H, Morohashi S, Wu Y, Tsushima F, Takai Y, Kijima H
Mol Med Rep 2016 May;13(5):3821-7. Epub 2016 Mar 21 doi: 10.3892/mmr.2016.5016. PMID: 27035330Free PMC Article
Is loss of heterozygosity at 9q22.3 (PTCH gene) and 19p13.3 (STK11 gene) involved in the pathogenesis of ovarian stromal tumors?
Tsuji T, Catasus L, Prat J
Hum Pathol 2005 Jul;36(7):792-6. doi: 10.1016/j.humpath.2005.05.009. PMID: 16084949

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