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Vulvar Non-Neoplastic Disorder

MedGen UID:
277873
•Concept ID:
C1336980
•
Disease or Syndrome
Synonym: Vulvar Non-Neoplastic Disease

Definition

A non-neoplastic disorder that affects the vulva. Representative examples include infection and fibroepithelial polyp. [from NCI]

Professional guidelines

PubMed

High intensity focused ultrasound treatment for non-neoplastic epithelial disorders of the vulva: Factors affecting effectiveness and recurrence.
Ye M, Deng X, Mao S, Xue M
Int J Hyperthermia 2015;31(7):771-6. Epub 2015 Sep 14 doi: 10.3109/02656736.2015.1053101. PMID: 26367074
Recent trends in surgical and reconstructive management of vulvar cancer: review of literature.
Vitale SG, Valenti G, Biondi A, Rossetti D, Frigerio L
Updates Surg 2015 Dec;67(4):367-71. Epub 2015 Jun 13 doi: 10.1007/s13304-015-0303-6. PMID: 26070991
Medical treatment of squamous hyperplasia and lichen sclerosus of the vulva.
Zorlu CG, Cobanoglu O
Int J Gynaecol Obstet 1995 Dec;51(3):235-8. doi: 10.1016/0020-7292(95)80012-3. PMID: 8745089

Recent clinical studies

Etiology

Prospective observational study of the efficacy of mixed methylene blue compound injection for treatment of vulvar non-neoplastic epithelial disorders.
Li Y, Shi J, Tan W, Ma Q, Wu X, Gao H
Int J Gynaecol Obstet 2020 Feb;148(2):157-161. Epub 2019 Nov 19 doi: 10.1002/ijgo.13007. PMID: 31628667
Short- and long-term efficacy of focused ultrasound therapy for non-neoplastic epithelial disorders of the vulva.
Wu C, Zou M, Xiong Y, Wang L, Chen H, Fan Y, Li C
BJOG 2017 Aug;124 Suppl 3:87-92. doi: 10.1111/1471-0528.14747. PMID: 28856863
Current insights into the aetiology, pathobiology, and management of local disease recurrence in squamous cell carcinoma of the vulva.
Yap J, O'Neill D, Nagenthiran S, Dawson CW, Luesley DM
BJOG 2017 May;124(6):946-954. Epub 2017 Mar 9 doi: 10.1111/1471-0528.14560. PMID: 28081287
Efficacy of chlortetracycline treatment on vulvar non-neoplastic epithelial disorders.
Li GT, Li GR, Liu YJ, Li XF, Guo SZ
Clin Exp Obstet Gynecol 2015;42(2):199-201. PMID: 26054119
Non-neoplastic epithelial disorders of the vulva.
O'Connell TX, Nathan LS, Satmary WA, Goldstein AT
Am Fam Physician 2008 Feb 1;77(3):321-6. PMID: 18297956

Diagnosis

TRPS1 expression is sensitive and specific for primary extramammary Paget disease.
Cook EE, Harrison BT, Hirsch MS
Histopathology 2023 Jul;83(1):104-108. Epub 2023 Mar 27 doi: 10.1111/his.14908. PMID: 36971374
Recent trends in surgical and reconstructive management of vulvar cancer: review of literature.
Vitale SG, Valenti G, Biondi A, Rossetti D, Frigerio L
Updates Surg 2015 Dec;67(4):367-71. Epub 2015 Jun 13 doi: 10.1007/s13304-015-0303-6. PMID: 26070991
Non-neoplastic epithelial disorders of the vulva.
O'Connell TX, Nathan LS, Satmary WA, Goldstein AT
Am Fam Physician 2008 Feb 1;77(3):321-6. PMID: 18297956
Inflammatory dermatoses of the vulva.
Hammock LA, Barrett TL
J Cutan Pathol 2005 Oct;32(9):604-11. doi: 10.1111/j.0303-6987.2005.00385.x. PMID: 16176297
Vulvar cancer.
Canavan TP, Cohen D
Am Fam Physician 2002 Oct 1;66(7):1269-74. PMID: 12387439

Therapy

Prospective observational study of the efficacy of mixed methylene blue compound injection for treatment of vulvar non-neoplastic epithelial disorders.
Li Y, Shi J, Tan W, Ma Q, Wu X, Gao H
Int J Gynaecol Obstet 2020 Feb;148(2):157-161. Epub 2019 Nov 19 doi: 10.1002/ijgo.13007. PMID: 31628667
Efficacy of chlortetracycline treatment on vulvar non-neoplastic epithelial disorders.
Li GT, Li GR, Liu YJ, Li XF, Guo SZ
Clin Exp Obstet Gynecol 2015;42(2):199-201. PMID: 26054119
High-intensity focused ultrasound treatment for non-neoplastic epithelial disorders of the vulva.
Ruan L, Xie Z, Wang H, Jiang J, Shi H, Xu J
Int J Gynaecol Obstet 2010 May;109(2):167-70. Epub 2010 Feb 13 doi: 10.1016/j.ijgo.2009.12.014. PMID: 20153858
Non-neoplastic epithelial disorders of the vulva.
O'Connell TX, Nathan LS, Satmary WA, Goldstein AT
Am Fam Physician 2008 Feb 1;77(3):321-6. PMID: 18297956
Vulvar cancer.
Canavan TP, Cohen D
Am Fam Physician 2002 Oct 1;66(7):1269-74. PMID: 12387439

Prognosis

The efficacy and safety of secondary focused ultrasound therapy for recurrence of non-neoplastic epithelial disorders of the vulva.
Li R, Jiang J
Int J Hyperthermia 2022;39(1):1310-1314. doi: 10.1080/02656736.2022.2131000. PMID: 36202394
Short- and long-term efficacy of focused ultrasound therapy for non-neoplastic epithelial disorders of the vulva.
Wu C, Zou M, Xiong Y, Wang L, Chen H, Fan Y, Li C
BJOG 2017 Aug;124 Suppl 3:87-92. doi: 10.1111/1471-0528.14747. PMID: 28856863
Current insights into the aetiology, pathobiology, and management of local disease recurrence in squamous cell carcinoma of the vulva.
Yap J, O'Neill D, Nagenthiran S, Dawson CW, Luesley DM
BJOG 2017 May;124(6):946-954. Epub 2017 Mar 9 doi: 10.1111/1471-0528.14560. PMID: 28081287
Expression of cyclooxygenase-2 (COX-2) in non-neoplastic and neoplastic vulvar epithelial lesions.
Ferrandina G, Ranelletti FO, Salutari V, Gessi M, Legge F, Zannoni GF, Scambia G, Lauriola L
Gynecol Oncol 2004 Feb;92(2):537-44. doi: 10.1016/j.ygyno.2003.10.054. PMID: 14766245
Vulvar cancer.
Canavan TP, Cohen D
Am Fam Physician 2002 Oct 1;66(7):1269-74. PMID: 12387439

Clinical prediction guides

TRPS1 expression is sensitive and specific for primary extramammary Paget disease.
Cook EE, Harrison BT, Hirsch MS
Histopathology 2023 Jul;83(1):104-108. Epub 2023 Mar 27 doi: 10.1111/his.14908. PMID: 36971374
Factors influencing the clinical efficacy of high-intensity focused ultrasound in the treatment of non-neoplastic epithelial disorders of the vulva: a retrospective observational study.
Feng T, Wang L, Zhu D, Wu Y, Xie J, Fang L, Du X
Int J Hyperthermia 2021;38(1):1457-1461. doi: 10.1080/02656736.2021.1985628. PMID: 34620032
Prospective observational study of the efficacy of mixed methylene blue compound injection for treatment of vulvar non-neoplastic epithelial disorders.
Li Y, Shi J, Tan W, Ma Q, Wu X, Gao H
Int J Gynaecol Obstet 2020 Feb;148(2):157-161. Epub 2019 Nov 19 doi: 10.1002/ijgo.13007. PMID: 31628667
Short- and long-term efficacy of focused ultrasound therapy for non-neoplastic epithelial disorders of the vulva.
Wu C, Zou M, Xiong Y, Wang L, Chen H, Fan Y, Li C
BJOG 2017 Aug;124 Suppl 3:87-92. doi: 10.1111/1471-0528.14747. PMID: 28856863
Efficacy of chlortetracycline treatment on vulvar non-neoplastic epithelial disorders.
Li GT, Li GR, Liu YJ, Li XF, Guo SZ
Clin Exp Obstet Gynecol 2015;42(2):199-201. PMID: 26054119

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