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Vulvar non-keratinizing squamous cell carcinoma

MedGen UID:
311488
•Concept ID:
C1520092
•
Neoplastic Process
Synonyms: Vulvar Non-Keratinizing Squamous Cell Carcinoma; vulvar non-keratinizing squamous cell carcinoma
 
Monarch Initiative: MONDO:0004213

Definition

A squamous cell carcinoma that arises from the vulva and is characterized by the absence of keratin pearls. [from NCI]

Recent clinical studies

Etiology

Characteristics of vulvar squamous cell carcinoma in Japanese women.
Osakabe M, Hayashi M, Katayama Y, Emura I, Nemoto K, Umezu H, Saitoh K, Motoyama T
Pathol Int 2007 Jun;57(6):322-7. doi: 10.1111/j.1440-1827.2007.02103.x. PMID: 17539962
Vulvar carcinoma at Srinagarind Hospital, Khon Kaen, Thailand.
Pengsaa P, Pothinam S, Udomthavornsuk B
Eur J Gynaecol Oncol 1993;14(1):56-62. PMID: 8472734

Diagnosis

Trends in HPV- and non-HPV-associated vulvar cancer incidence, United States, 2001-2017.
Mix JM, Gopalani SV, Simko S, Saraiya M
Prev Med 2022 Nov;164:107302. Epub 2022 Oct 12 doi: 10.1016/j.ypmed.2022.107302. PMID: 36240909Free PMC Article
Primary squamous cell carcinoma of the vagina: human papillomavirus detection, p16(INK4A) overexpression and clinicopathological correlations.
Fuste V, del Pino M, Perez A, Garcia A, Torne A, Pahisa J, Ordi J
Histopathology 2010 Dec;57(6):907-16. doi: 10.1111/j.1365-2559.2010.03727.x. PMID: 21166704
Squamous cell carcinoma of the vulva and adjacent lesions treated at Nagoya University Hospital from 1965 to 1997.
Akashi K, Nagasaka T, Nakashim N, Harada T, Okamoto T, Mizutani S, Ishiko H
Nagoya J Med Sci 2001 Nov;64(3-4):109-21. PMID: 11820332
Vulvar carcinoma at Srinagarind Hospital, Khon Kaen, Thailand.
Pengsaa P, Pothinam S, Udomthavornsuk B
Eur J Gynaecol Oncol 1993;14(1):56-62. PMID: 8472734
Carcinoma of the vulva.
Hohlweg-Majert P, Bauknecht H, Ubl A, Czernobilsky B
Eur J Gynaecol Oncol 1983;4(1):1-5. PMID: 6861772

Prognosis

MTA1 as negative prognostic marker in vulvar carcinoma.
Wanka G, Jueckstock J, Wild CM, Vattai A, Fürst S, Heidegger HH, Kuhn C, Schmoeckel E, Jeschke U, Dannecker C
J Cancer Res Clin Oncol 2023 Aug;149(9):6191-6201. Epub 2023 Jan 23 doi: 10.1007/s00432-023-04579-4. PMID: 36689059Free PMC Article
Trends in HPV- and non-HPV-associated vulvar cancer incidence, United States, 2001-2017.
Mix JM, Gopalani SV, Simko S, Saraiya M
Prev Med 2022 Nov;164:107302. Epub 2022 Oct 12 doi: 10.1016/j.ypmed.2022.107302. PMID: 36240909Free PMC Article
Vulvar carcinoma at Srinagarind Hospital, Khon Kaen, Thailand.
Pengsaa P, Pothinam S, Udomthavornsuk B
Eur J Gynaecol Oncol 1993;14(1):56-62. PMID: 8472734

Clinical prediction guides

MTA1 as negative prognostic marker in vulvar carcinoma.
Wanka G, Jueckstock J, Wild CM, Vattai A, Fürst S, Heidegger HH, Kuhn C, Schmoeckel E, Jeschke U, Dannecker C
J Cancer Res Clin Oncol 2023 Aug;149(9):6191-6201. Epub 2023 Jan 23 doi: 10.1007/s00432-023-04579-4. PMID: 36689059Free PMC Article

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