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Melanoma, cutaneous malignant, susceptibility to, 4(CMM4)

MedGen UID:
334129
Concept ID:
C1842643
Finding
Synonyms: CMM4; Cutaneous malignant melanoma 4
 
Monarch Initiative: MONDO:0011954
OMIM®: 608035

Definition

Malignant melanoma is a neoplasm of pigment-producing cells called melanocytes that occurs most often in the skin, but may also occur in the eyes, ears, gastrointestinal tract, leptomeninges, and oral and genital mucous membranes (summary by Habif, 2010). For a discussion of genetic heterogeneity of cutaneous malignant melanoma (CMM), see 155600. [from OMIM]

Professional guidelines

PubMed

Primiero CA, Maas EJ, Wallingford CK, Soyer HP, McInerney-Leo AM
Ital J Dermatol Venerol 2024 Feb;159(1):34-42. Epub 2024 Jan 29 doi: 10.23736/S2784-8671.23.07761-7. PMID: 38287743
Gabree M, Seidel M
Cancer J 2012 Jul-Aug;18(4):372-80. doi: 10.1097/PPO.0b013e3182624664. PMID: 22846740
Gerstenblith MR, Goldstein AM, Tucker MA, Fraser MC
Cancer Nurs 2007 Nov-Dec;30(6):452-9; quiz 462-3. doi: 10.1097/01.NCC.0000300165.98391.e7. PMID: 18025917

Recent clinical studies

Etiology

Bruno W, Dalmasso B, Barile M, Andreotti V, Elefanti L, Colombino M, Vanni I, Allavena E, Barbero F, Passoni E, Merelli B, Pellegrini S, Morgese F, Danesi R, Calò V, Bazan V, D'Elia AV, Molica C, Gensini F, Sala E, Uliana V, Soma PF, Genuardi M, Ballestrero A, Spagnolo F, Tanda E, Queirolo P, Mandalà M, Stanganelli I, Palmieri G, Menin C; Italian Melanoma Intergroup (IMI), Pastorino L, Ghiorzo P
ESMO Open 2022 Aug;7(4):100525. Epub 2022 Jun 28 doi: 10.1016/j.esmoop.2022.100525. PMID: 35777164Free PMC Article
Goldstein AM, Stidd KC, Yang XR, Fraser MC, Tucker MA
Cancer 2018 Sep 15;124(18):3715-3723. Epub 2018 Sep 12 doi: 10.1002/cncr.31641. PMID: 30207590Free PMC Article
Aoude LG, Heitzer E, Johansson P, Gartside M, Wadt K, Pritchard AL, Palmer JM, Symmons J, Gerdes AM, Montgomery GW, Martin NG, Tomlinson I, Kearsey S, Hayward NK
Fam Cancer 2015 Dec;14(4):621-8. doi: 10.1007/s10689-015-9826-8. PMID: 26251183
Bastuji-Garin S, Diepgen TL
Br J Dermatol 2002 Apr;146 Suppl 61:24-30. doi: 10.1046/j.1365-2133.146.s61.9.x. PMID: 11966729
Bressac-de-Paillerets B, Avril MF, Chompret A, Demenais F
Biochimie 2002 Jan;84(1):67-74. doi: 10.1016/s0300-9084(01)01360-8. PMID: 11900878

Diagnosis

Primiero CA, Maas EJ, Wallingford CK, Soyer HP, McInerney-Leo AM
Ital J Dermatol Venerol 2024 Feb;159(1):34-42. Epub 2024 Jan 29 doi: 10.23736/S2784-8671.23.07761-7. PMID: 38287743
Goldstein AM, Stidd KC, Yang XR, Fraser MC, Tucker MA
Cancer 2018 Sep 15;124(18):3715-3723. Epub 2018 Sep 12 doi: 10.1002/cncr.31641. PMID: 30207590Free PMC Article
Wang LE, Li C, Xiong P, Gershenwald JE, Prieto VG, Duvic M, Lee JE, Grimm EA, Hsu TC, Wei Q
Melanoma Res 2016 Apr;26(2):181-7. doi: 10.1097/CMR.0000000000000106. PMID: 24977319Free PMC Article
Gabree M, Seidel M
Cancer J 2012 Jul-Aug;18(4):372-80. doi: 10.1097/PPO.0b013e3182624664. PMID: 22846740
Slutsky JB, Jones EC
Dermatol Surg 2012 Apr;38(4):552-69. Epub 2012 Mar 8 doi: 10.1111/j.1524-4725.2012.02367.x. PMID: 22404129

Therapy

Goldstein AM, Stidd KC, Yang XR, Fraser MC, Tucker MA
Cancer 2018 Sep 15;124(18):3715-3723. Epub 2018 Sep 12 doi: 10.1002/cncr.31641. PMID: 30207590Free PMC Article
Herraiz C, Jiménez-Cervantes C, Sánchez-Laorden B, García-Borrón JC
Semin Cell Dev Biol 2018 Jun;78:73-84. Epub 2017 Jul 1 doi: 10.1016/j.semcdb.2017.06.021. PMID: 28676423
Mohania D, Chandel S, Kumar P, Verma V, Digvijay K, Tripathi D, Choudhury K, Mitten SK, Shah D
Adv Exp Med Biol 2017;996:71-87. doi: 10.1007/978-3-319-56017-5_7. PMID: 29124692
Gandini S, Raimondi S, Gnagnarella P, Doré JF, Maisonneuve P, Testori A
Eur J Cancer 2009 Mar;45(4):634-41. Epub 2008 Nov 12 doi: 10.1016/j.ejca.2008.10.003. PMID: 19008093
Bastuji-Garin S, Diepgen TL
Br J Dermatol 2002 Apr;146 Suppl 61:24-30. doi: 10.1046/j.1365-2133.146.s61.9.x. PMID: 11966729

Prognosis

Bruno W, Dalmasso B, Barile M, Andreotti V, Elefanti L, Colombino M, Vanni I, Allavena E, Barbero F, Passoni E, Merelli B, Pellegrini S, Morgese F, Danesi R, Calò V, Bazan V, D'Elia AV, Molica C, Gensini F, Sala E, Uliana V, Soma PF, Genuardi M, Ballestrero A, Spagnolo F, Tanda E, Queirolo P, Mandalà M, Stanganelli I, Palmieri G, Menin C; Italian Melanoma Intergroup (IMI), Pastorino L, Ghiorzo P
ESMO Open 2022 Aug;7(4):100525. Epub 2022 Jun 28 doi: 10.1016/j.esmoop.2022.100525. PMID: 35777164Free PMC Article
Torricelli C, Carron J, Carvalho BF, Macedo LT, Rinck-Junior JA, Lima CSP, Lourenço GJ
Melanoma Res 2021 Oct 1;31(5):476-481. doi: 10.1097/CMR.0000000000000763. PMID: 34284461
Aoude LG, Heitzer E, Johansson P, Gartside M, Wadt K, Pritchard AL, Palmer JM, Symmons J, Gerdes AM, Montgomery GW, Martin NG, Tomlinson I, Kearsey S, Hayward NK
Fam Cancer 2015 Dec;14(4):621-8. doi: 10.1007/s10689-015-9826-8. PMID: 26251183
Yaman B, Akalin T, Kandiloğlu G
Am J Dermatopathol 2015 May;37(5):389-97. doi: 10.1097/DAD.0000000000000241. PMID: 25357015
Howell WM, Turner SJ, Theaker JM, Bateman AC
Eur J Immunogenet 2003 Dec;30(6):409-14. doi: 10.1111/j.1365-2370.2003.00425.x. PMID: 14675394

Clinical prediction guides

Bruno W, Dalmasso B, Barile M, Andreotti V, Elefanti L, Colombino M, Vanni I, Allavena E, Barbero F, Passoni E, Merelli B, Pellegrini S, Morgese F, Danesi R, Calò V, Bazan V, D'Elia AV, Molica C, Gensini F, Sala E, Uliana V, Soma PF, Genuardi M, Ballestrero A, Spagnolo F, Tanda E, Queirolo P, Mandalà M, Stanganelli I, Palmieri G, Menin C; Italian Melanoma Intergroup (IMI), Pastorino L, Ghiorzo P
ESMO Open 2022 Aug;7(4):100525. Epub 2022 Jun 28 doi: 10.1016/j.esmoop.2022.100525. PMID: 35777164Free PMC Article
Goldstein AM, Stidd KC, Yang XR, Fraser MC, Tucker MA
Cancer 2018 Sep 15;124(18):3715-3723. Epub 2018 Sep 12 doi: 10.1002/cncr.31641. PMID: 30207590Free PMC Article
Aoude LG, Heitzer E, Johansson P, Gartside M, Wadt K, Pritchard AL, Palmer JM, Symmons J, Gerdes AM, Montgomery GW, Martin NG, Tomlinson I, Kearsey S, Hayward NK
Fam Cancer 2015 Dec;14(4):621-8. doi: 10.1007/s10689-015-9826-8. PMID: 26251183
Yaman B, Akalin T, Kandiloğlu G
Am J Dermatopathol 2015 May;37(5):389-97. doi: 10.1097/DAD.0000000000000241. PMID: 25357015
Bale SJ, Greene MH, Murray C, Goldin LR, Johnson AH, Mann D
Int J Cancer 1985 Oct 15;36(4):439-43. doi: 10.1002/ijc.2910360405. PMID: 4044054

Recent systematic reviews

Peng H, He Q, Zhu J, Peng C
Tumour Biol 2013 Apr;34(2):675-81. Epub 2012 Nov 27 doi: 10.1007/s13277-012-0595-9. PMID: 23184764

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