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Melanoma, cutaneous malignant, susceptibility to, 6(CMM6)

MedGen UID:
462767
Concept ID:
C3151417
Finding
Synonym: Cutaneous malignant melanoma 6
 
Gene (location): XRCC3 (14q32.33)
 
Monarch Initiative: MONDO:0013510
OMIM®: 613972

Definition

Malignant melanoma is a neoplasm of pigment-producing cells called melanocytes that occurs most often in the skin, but may also occur in the eyes, ears, gastrointestinal tract, leptomeninges, and oral and genital mucous membranes (summary by Habif, 2010). For a discussion of genetic heterogeneity of cutaneous malignant melanoma, see 155600. [from OMIM]

Professional guidelines

PubMed

Gerstenblith MR, Goldstein AM, Tucker MA, Fraser MC
Cancer Nurs 2007 Nov-Dec;30(6):452-9; quiz 462-3. doi: 10.1097/01.NCC.0000300165.98391.e7. PMID: 18025917

Recent clinical studies

Etiology

Zhang Y, Lan S, Wu D
Curr Treat Options Oncol 2022 Oct;23(10):1405-1427. Epub 2022 Sep 20 doi: 10.1007/s11864-022-01007-6. PMID: 36125617Free PMC Article
Strashilov S, Yordanov A
Int J Mol Sci 2021 Jun 15;22(12) doi: 10.3390/ijms22126395. PMID: 34203771Free PMC Article
Goldstein AM, Stidd KC, Yang XR, Fraser MC, Tucker MA
Cancer 2018 Sep 15;124(18):3715-3723. Epub 2018 Sep 12 doi: 10.1002/cncr.31641. PMID: 30207590Free PMC Article
Inzelberg R, Flash S, Friedman E, Azizi E
Ann Neurol 2016 Dec;80(6):811-820. Epub 2016 Nov 14 doi: 10.1002/ana.24802. PMID: 27761938
Conrad N, Leis P, Orengo I, Medrano EE, Hayes TG, Baer S, Rosen T
Dermatol Surg 1999 Jul;25(7):576-81. doi: 10.1046/j.1524-4725.1999.98050.x. PMID: 10469118

Diagnosis

Seviiri M, Scolyer RA, Bishop DT, Newton-Bishop JA, Iles MM, Lo SN, Stretch JR, Saw RPM, Nieweg OE, Shannon KF, Spillane AJ, Gordon SD, Olsen CM, Whiteman DC, Landi MT, Thompson JF, Long GV, MacGregor S, Law MH
J Transl Med 2022 Sep 5;20(1):403. doi: 10.1186/s12967-022-03613-2. PMID: 36064556Free PMC Article
Goldstein AM, Stidd KC, Yang XR, Fraser MC, Tucker MA
Cancer 2018 Sep 15;124(18):3715-3723. Epub 2018 Sep 12 doi: 10.1002/cncr.31641. PMID: 30207590Free PMC Article
Belbasis L, Stefanaki I, Stratigos AJ, Evangelou E
J Dermatol Sci 2016 Dec;84(3):330-339. Epub 2016 Sep 13 doi: 10.1016/j.jdermsci.2016.09.003. PMID: 27663092
Yaman B, Akalin T, Kandiloğlu G
Am J Dermatopathol 2015 May;37(5):389-97. doi: 10.1097/DAD.0000000000000241. PMID: 25357015
Jovanovic P, Mihajlovic M, Djordjevic-Jocic J, Vlajkovic S, Cekic S, Stefanovic V
Int J Clin Exp Pathol 2013;6(7):1230-44. Epub 2013 Jun 15 PMID: 23826405Free PMC Article

Therapy

Zhang Y, Lan S, Wu D
Curr Treat Options Oncol 2022 Oct;23(10):1405-1427. Epub 2022 Sep 20 doi: 10.1007/s11864-022-01007-6. PMID: 36125617Free PMC Article
Goldstein AM, Stidd KC, Yang XR, Fraser MC, Tucker MA
Cancer 2018 Sep 15;124(18):3715-3723. Epub 2018 Sep 12 doi: 10.1002/cncr.31641. PMID: 30207590Free PMC Article
Arnold M, de Vries E, Whiteman DC, Jemal A, Bray F, Parkin DM, Soerjomataram I
Int J Cancer 2018 Sep 15;143(6):1305-1314. Epub 2018 May 7 doi: 10.1002/ijc.31527. PMID: 29659012
Belbasis L, Stefanaki I, Stratigos AJ, Evangelou E
J Dermatol Sci 2016 Dec;84(3):330-339. Epub 2016 Sep 13 doi: 10.1016/j.jdermsci.2016.09.003. PMID: 27663092
Kim SY, Kim SN, Hahn HJ, Lee YW, Choe YB, Ahn KJ
J Am Acad Dermatol 2015 Jun;72(6):1036-46.e2. Epub 2015 Mar 25 doi: 10.1016/j.jaad.2015.02.1113. PMID: 25819940

Prognosis

Arnold M, de Vries E, Whiteman DC, Jemal A, Bray F, Parkin DM, Soerjomataram I
Int J Cancer 2018 Sep 15;143(6):1305-1314. Epub 2018 May 7 doi: 10.1002/ijc.31527. PMID: 29659012
Belbasis L, Stefanaki I, Stratigos AJ, Evangelou E
J Dermatol Sci 2016 Dec;84(3):330-339. Epub 2016 Sep 13 doi: 10.1016/j.jdermsci.2016.09.003. PMID: 27663092
Kim SY, Kim SN, Hahn HJ, Lee YW, Choe YB, Ahn KJ
J Am Acad Dermatol 2015 Jun;72(6):1036-46.e2. Epub 2015 Mar 25 doi: 10.1016/j.jaad.2015.02.1113. PMID: 25819940
Jovanovic P, Mihajlovic M, Djordjevic-Jocic J, Vlajkovic S, Cekic S, Stefanovic V
Int J Clin Exp Pathol 2013;6(7):1230-44. Epub 2013 Jun 15 PMID: 23826405Free PMC Article
Howell WM, Turner SJ, Theaker JM, Bateman AC
Eur J Immunogenet 2003 Dec;30(6):409-14. doi: 10.1111/j.1365-2370.2003.00425.x. PMID: 14675394

Clinical prediction guides

Liyanage UE, MacGregor S, Bishop DT, Shi J, An J, Ong JS, Han X, Scolyer RA, Martin NG, Medland SE, Byrne EM, Green AC, Saw RPM, Thompson JF, Stretch J, Spillane A, Jiang Y, Tian C; 23andMe Research Team, Gordon SG, Duffy DL, Olsen CM, Whiteman DC, Long GV, Iles MM, Landi MT, Law MH
J Invest Dermatol 2022 Jun;142(6):1607-1616. Epub 2021 Nov 20 doi: 10.1016/j.jid.2021.08.449. PMID: 34813871
Goldstein AM, Stidd KC, Yang XR, Fraser MC, Tucker MA
Cancer 2018 Sep 15;124(18):3715-3723. Epub 2018 Sep 12 doi: 10.1002/cncr.31641. PMID: 30207590Free PMC Article
Arnold M, de Vries E, Whiteman DC, Jemal A, Bray F, Parkin DM, Soerjomataram I
Int J Cancer 2018 Sep 15;143(6):1305-1314. Epub 2018 May 7 doi: 10.1002/ijc.31527. PMID: 29659012
Belbasis L, Stefanaki I, Stratigos AJ, Evangelou E
J Dermatol Sci 2016 Dec;84(3):330-339. Epub 2016 Sep 13 doi: 10.1016/j.jdermsci.2016.09.003. PMID: 27663092
Yaman B, Akalin T, Kandiloğlu G
Am J Dermatopathol 2015 May;37(5):389-97. doi: 10.1097/DAD.0000000000000241. PMID: 25357015

Recent systematic reviews

Kim SY, Kim SN, Hahn HJ, Lee YW, Choe YB, Ahn KJ
J Am Acad Dermatol 2015 Jun;72(6):1036-46.e2. Epub 2015 Mar 25 doi: 10.1016/j.jaad.2015.02.1113. PMID: 25819940

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