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Neoplastic meningitis

MedGen UID:
352817
•Concept ID:
C1704231
•
Neoplastic Process
Synonyms: carcinomatous meningitis; leptomeningeal carcinoma; leptomeningeal carcinomatosis; Leptomeningeal Metastases; Leptomeningeal Metastasis; leptomeningeal metastasis; Lymphomatous meningitis; meningeal carcinomatosis; Meningeal Metastasis; meningeal metastasis; Metastasis to the Leptomeninges; Metastatic cancer to leptomeninges; Metastatic Malignant Neoplasm in the Leptomeninges; metastatic malignant neoplasm in the leptomeninges; Metastatic Malignant Neoplasm in the Meninges; Metastatic malignant neoplasm of leptomeninges; Metastatic malignant neoplasm to leptomeninges; Metastatic Malignant Neoplasm to the Leptomeninges; Metastatic Neoplasm to the Leptomeninges; Metastatic Neoplasm to the Meninges; Metastatic Tumor to the Leptomeninges; neoplastic meningitis; Secondary malignant neoplasm of leptomeninges
SNOMED CT: Lymphomatous meningitis (426128009); Neoplastic meningitis (230156002); Secondary malignant neoplasm of leptomeninges (1155991005); Metastatic malignant neoplasm of leptomeninges (1155991005); Metastatic cancer to leptomeninges (1155991005); Metastatic malignant neoplasm to leptomeninges (1155991005)
 
Monarch Initiative: MONDO:0700219

Definition

A malignant neoplasm that has spread from its original site of growth to the leptomeninges. [from NCI]

Professional guidelines

PubMed

Neoplastic meningitis in solid tumours: updated review of diagnosis, prognosis, therapeutic management, and future directions.
García Molina E, Penas-Prado M
Neurologia (Engl Ed) 2022 Nov-Dec;37(9):794-805. Epub 2021 Oct 15 doi: 10.1016/j.nrleng.2019.10.009. PMID: 34663545
Management of neoplastic meningitis.
Roth P, Weller M
Chin Clin Oncol 2015 Jun;4(2):26. doi: 10.3978/j.issn.2304-3865.2015.05.02. PMID: 26112812
Leukemic and lymphomatous meningitis: incidence, prognosis and treatment.
Chamberlain MC, Nolan C, Abrey LE
J Neurooncol 2005 Oct;75(1):71-83. doi: 10.1007/s11060-004-8100-y. PMID: 16215818

Recent clinical studies

Etiology

Neoplastic Meningitis and Paraneoplastic Syndromes.
Kanekar S, Zacharia T, Agarwal A
Radiol Clin North Am 2021 May;59(3):409-423. doi: 10.1016/j.rcl.2021.01.007. PMID: 33926686
Aseptic meningitis.
Tattevin P, Tchamgoué S, Belem A, Bénézit F, Pronier C, Revest M
Rev Neurol (Paris) 2019 Sep-Oct;175(7-8):475-480. Epub 2019 Jul 30 doi: 10.1016/j.neurol.2019.07.005. PMID: 31375286
Management of neoplastic meningitis.
Roth P, Weller M
Chin Clin Oncol 2015 Jun;4(2):26. doi: 10.3978/j.issn.2304-3865.2015.05.02. PMID: 26112812
Neoplastic meningitis.
Van Horn A, Chamberlain MC
J Support Oncol 2012 Mar-Apr;10(2):45-53. Epub 2011 Sep 23 doi: 10.1016/j.suponc.2011.06.002. PMID: 22005214
Neoplastic meningitis.
Kim L, Glantz MJ
Curr Treat Options Oncol 2001 Dec;2(6):517-27. doi: 10.1007/s11864-001-0073-x. PMID: 12057097

Diagnosis

Neoplastic Meningitis and Paraneoplastic Syndromes.
Kanekar S, Zacharia T, Agarwal A
Radiol Clin North Am 2021 May;59(3):409-423. doi: 10.1016/j.rcl.2021.01.007. PMID: 33926686
Aseptic meningitis.
Tattevin P, Tchamgoué S, Belem A, Bénézit F, Pronier C, Revest M
Rev Neurol (Paris) 2019 Sep-Oct;175(7-8):475-480. Epub 2019 Jul 30 doi: 10.1016/j.neurol.2019.07.005. PMID: 31375286
Overview of cerebrospinal fluid cytology.
Rahimi J, Woehrer A
Handb Clin Neurol 2017;145:563-571. doi: 10.1016/B978-0-12-802395-2.00035-3. PMID: 28987194
Neoplastic meningitis.
Van Horn A, Chamberlain MC
J Support Oncol 2012 Mar-Apr;10(2):45-53. Epub 2011 Sep 23 doi: 10.1016/j.suponc.2011.06.002. PMID: 22005214
Neoplastic meningitis.
Gleissner B, Chamberlain MC
Lancet Neurol 2006 May;5(5):443-52. doi: 10.1016/S1474-4422(06)70443-4. PMID: 16632315

Therapy

Leptomeningeal metastasis.
Taillibert S, Chamberlain MC
Handb Clin Neurol 2018;149:169-204. doi: 10.1016/B978-0-12-811161-1.00013-X. PMID: 29307353
Neoplastic meningitis.
Van Horn A, Chamberlain MC
J Support Oncol 2012 Mar-Apr;10(2):45-53. Epub 2011 Sep 23 doi: 10.1016/j.suponc.2011.06.002. PMID: 22005214
Diagnosis and individualized therapy of neoplastic meningitis.
Strik H, Prömmel P
Expert Rev Anticancer Ther 2010 Jul;10(7):1137-48. doi: 10.1586/era.10.86. PMID: 20645702
Neoplastic meningitis.
Kim L, Glantz MJ
Curr Treat Options Oncol 2001 Dec;2(6):517-27. doi: 10.1007/s11864-001-0073-x. PMID: 12057097
Intrathecal chemotherapy.
Kerr JZ, Berg S, Blaney SM
Crit Rev Oncol Hematol 2001 Mar;37(3):227-36. doi: 10.1016/s1040-8428(00)00115-3. PMID: 11248578

Prognosis

Leptomeningeal metastasis from solid tumors.
Thakkar JP, Kumthekar P, Dixit KS, Stupp R, Lukas RV
J Neurol Sci 2020 Apr 15;411:116706. Epub 2020 Jan 23 doi: 10.1016/j.jns.2020.116706. PMID: 32007755
Management of neoplastic meningitis.
Roth P, Weller M
Chin Clin Oncol 2015 Jun;4(2):26. doi: 10.3978/j.issn.2304-3865.2015.05.02. PMID: 26112812
Neoplastic meningitis.
Van Horn A, Chamberlain MC
J Support Oncol 2012 Mar-Apr;10(2):45-53. Epub 2011 Sep 23 doi: 10.1016/j.suponc.2011.06.002. PMID: 22005214
Neoplastic meningitis.
Gleissner B, Chamberlain MC
Lancet Neurol 2006 May;5(5):443-52. doi: 10.1016/S1474-4422(06)70443-4. PMID: 16632315
Neoplastic meningitis.
Kim L, Glantz MJ
Curr Treat Options Oncol 2001 Dec;2(6):517-27. doi: 10.1007/s11864-001-0073-x. PMID: 12057097

Clinical prediction guides

Management of neoplastic meningitis.
Roth P, Weller M
Chin Clin Oncol 2015 Jun;4(2):26. doi: 10.3978/j.issn.2304-3865.2015.05.02. PMID: 26112812
Neoplastic meningitis.Review of a clinical series.
Jiménez Mateos A, Cabrera Naranjo F, González Hernández A, Fabre Pi O, Díaz Nicolás S, López Fernández JC
Neurologia 2011 May;26(4):227-32. Epub 2010 Oct 2 doi: 10.1016/j.nrl.2010.07.020. PMID: 21163194
Diagnostic tools for neoplastic meningitis: detecting disease, identifying patient risk, and determining benefit of treatment.
Chamberlain MC, Glantz M, Groves MD, Wilson WH
Semin Oncol 2009 Aug;36(4 Suppl 2):S35-45. doi: 10.1053/j.seminoncol.2009.05.005. PMID: 19660682
Liposomal cytarabine (DepoCyte) for the treatment of neoplastic meningitis.
Rueda Domínguez A, Olmos Hidalgo D, Viciana Garrido R, Torres Sánchez E
Clin Transl Oncol 2005 Jul;7(6):232-8. doi: 10.1007/BF02710168. PMID: 16131445
Neoplastic meningitis-related encephalopathy.
Chamberlain MC, Tsao-Wei D, Groshen S
J Neurooncol 2005 Apr;72(2):185-9. doi: 10.1007/s11060-004-2062-y. PMID: 15926000

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