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Meningeal Chronic Myelogenous Leukemia, BCR-ABL1 Positive

MedGen UID:
78930
•Concept ID:
C0279083
•
Neoplastic Process
Synonyms: Meningeal Chronic Myelogenous Leukemia; Meningeal Chronic Myelogenous Leukemia, BCR::ABL1 Positive

Definition

Infiltration of the meninges by chronic myelogenous leukemia, BCR-ABL1 positive. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMeningeal Chronic Myelogenous Leukemia, BCR-ABL1 Positive

Professional guidelines

PubMed

Treatment of pediatric acute lymphoblastic leukemia.
Tucci F, Aricò M
Haematologica 2008 Aug;93(8):1124-8. doi: 10.3324/haematol.13517. PMID: 18669975

Recent clinical studies

Etiology

Miniaturized flow cytometry-based BCR-ABL immunoassay in detecting leptomeningeal disease.
D'Alessio F, Mirabelli P, Mariotti E, Raia M, Di Noto R, Fortunato G, Camera A, Del Vecchio L
Leuk Res 2011 Oct;35(10):1290-3. Epub 2011 Jun 11 doi: 10.1016/j.leukres.2011.05.016. PMID: 21658767
Central nervous system is a sanctuary site for chronic myelogenous leukaemia treated with imatinib mesylate.
Isobe Y, Sugimoto K, Masuda A, Hamano Y, Oshimi K
Intern Med J 2009 Jun;39(6):408-11. doi: 10.1111/j.1445-5994.2009.01947.x. PMID: 19580620
Risk and prognosis of central nervous system leukemia in patients with Philadelphia chromosome-positive acute leukemias treated with imatinib mesylate.
Pfeifer H, Wassmann B, Hofmann WK, Komor M, Scheuring U, Brück P, Binckebanck A, Schleyer E, Gökbuget N, Wolff T, Lübbert M, Leimer L, Gschaidmeier H, Hoelzer D, Ottmann OG
Clin Cancer Res 2003 Oct 15;9(13):4674-81. PMID: 14581336
Penicillin-resistant Streptococcus pneumoniae septic shock and meningitis complicating chronic graft versus host disease: a case report and review of the literature.
Haddad PA, Repka TL, Weisdorf DJ
Am J Med 2002 Aug 1;113(2):152-5. doi: 10.1016/s0002-9343(02)01154-3. PMID: 12133754
Thiotepa, busulfan and cyclophosphamide as a preparative regimen for allogeneic transplantation for advanced chronic myelogenous leukemia.
Przepiorka D, Khouri I, Thall P, Mehra R, Lee MS, Ippoliti C, Giralt S, Gajewski J, van Besien K, Andersson B, Körbling M, Deisseroth AB, Champlin R
Bone Marrow Transplant 1999 May;23(10):977-81. doi: 10.1038/sj.bmt.1701764. PMID: 10373061

Diagnosis

Central nervous system blast crisis of chronic myeloid leukaemia misdiagnosed as tubercular meningitis.
Kumawat BL, Sharma CM, Saini PK, Garg A
BMJ Case Rep 2018 Jun 12;2018 doi: 10.1136/bcr-2017-223923. PMID: 29895576Free PMC Article
Intracerebral granulocytic sarcoma.
Alvarez M
J Neurosci Nurs 2007 Oct;39(5):297-304. doi: 10.1097/01376517-200710000-00007. PMID: 17966297
Risk and prognosis of central nervous system leukemia in patients with Philadelphia chromosome-positive acute leukemias treated with imatinib mesylate.
Pfeifer H, Wassmann B, Hofmann WK, Komor M, Scheuring U, Brück P, Binckebanck A, Schleyer E, Gökbuget N, Wolff T, Lübbert M, Leimer L, Gschaidmeier H, Hoelzer D, Ottmann OG
Clin Cancer Res 2003 Oct 15;9(13):4674-81. PMID: 14581336
Cleaved L-selectin concentrations in meningeal leukaemia.
Stucki A, Cordey AS, Monai N, de Flaugergues JC, Schapira M, Spertini O
Lancet 1995 Feb 4;345(8945):286-9. doi: 10.1016/s0140-6736(95)90276-7. PMID: 7530792
Simultaneous meningeal and testicular lymphoblastic transformation of Ph1-positive chronic myelocytic leukaemia in a three-year-old boy.
Carlsen NL, Erichsen G, Lisse I
Anticancer Res 1990 Nov-Dec;10(6):1739-41. PMID: 2285252

Therapy

Efficacy and pharmacologic data of second-generation tyrosine kinase inhibitor nilotinib in BCR-ABL-positive leukemia patients with central nervous system relapse after allogeneic stem cell transplantation.
Reinwald M, Schleyer E, Kiewe P, Blau IW, Burmeister T, Pursche S, Neumann M, Notter M, Thiel E, Hofmann WK, Kolb HJ, Burdach S, Bender HU
Biomed Res Int 2014;2014:637059. Epub 2014 Jun 15 doi: 10.1155/2014/637059. PMID: 25025064Free PMC Article
Intracerebral granulocytic sarcoma.
Alvarez M
J Neurosci Nurs 2007 Oct;39(5):297-304. doi: 10.1097/01376517-200710000-00007. PMID: 17966297
Risk and prognosis of central nervous system leukemia in patients with Philadelphia chromosome-positive acute leukemias treated with imatinib mesylate.
Pfeifer H, Wassmann B, Hofmann WK, Komor M, Scheuring U, Brück P, Binckebanck A, Schleyer E, Gökbuget N, Wolff T, Lübbert M, Leimer L, Gschaidmeier H, Hoelzer D, Ottmann OG
Clin Cancer Res 2003 Oct 15;9(13):4674-81. PMID: 14581336
Thiotepa, busulfan and cyclophosphamide as a preparative regimen for allogeneic transplantation for advanced chronic myelogenous leukemia.
Przepiorka D, Khouri I, Thall P, Mehra R, Lee MS, Ippoliti C, Giralt S, Gajewski J, van Besien K, Andersson B, Körbling M, Deisseroth AB, Champlin R
Bone Marrow Transplant 1999 May;23(10):977-81. doi: 10.1038/sj.bmt.1701764. PMID: 10373061
High incidence of meningeal leukemia in lymphoid blast crisis of chronic myelogenous leukemia.
Saikia TK, Dhabhar B, Iyer RS, Nanjangud G, Gopal R, Nair CN, Nadkarni KS, Ashokkumar MS, Dhond SR, Advani SH
Am J Hematol 1993 May;43(1):10-3. doi: 10.1002/ajh.2830430104. PMID: 8317457

Prognosis

Intracerebral granulocytic sarcoma.
Alvarez M
J Neurosci Nurs 2007 Oct;39(5):297-304. doi: 10.1097/01376517-200710000-00007. PMID: 17966297
Risk and prognosis of central nervous system leukemia in patients with Philadelphia chromosome-positive acute leukemias treated with imatinib mesylate.
Pfeifer H, Wassmann B, Hofmann WK, Komor M, Scheuring U, Brück P, Binckebanck A, Schleyer E, Gökbuget N, Wolff T, Lübbert M, Leimer L, Gschaidmeier H, Hoelzer D, Ottmann OG
Clin Cancer Res 2003 Oct 15;9(13):4674-81. PMID: 14581336
Penicillin-resistant Streptococcus pneumoniae septic shock and meningitis complicating chronic graft versus host disease: a case report and review of the literature.
Haddad PA, Repka TL, Weisdorf DJ
Am J Med 2002 Aug 1;113(2):152-5. doi: 10.1016/s0002-9343(02)01154-3. PMID: 12133754
High incidence of meningeal leukemia in lymphoid blast crisis of chronic myelogenous leukemia.
Saikia TK, Dhabhar B, Iyer RS, Nanjangud G, Gopal R, Nair CN, Nadkarni KS, Ashokkumar MS, Dhond SR, Advani SH
Am J Hematol 1993 May;43(1):10-3. doi: 10.1002/ajh.2830430104. PMID: 8317457
Simultaneous meningeal and testicular lymphoblastic transformation of Ph1-positive chronic myelocytic leukaemia in a three-year-old boy.
Carlsen NL, Erichsen G, Lisse I
Anticancer Res 1990 Nov-Dec;10(6):1739-41. PMID: 2285252

Clinical prediction guides

Efficacy and pharmacologic data of second-generation tyrosine kinase inhibitor nilotinib in BCR-ABL-positive leukemia patients with central nervous system relapse after allogeneic stem cell transplantation.
Reinwald M, Schleyer E, Kiewe P, Blau IW, Burmeister T, Pursche S, Neumann M, Notter M, Thiel E, Hofmann WK, Kolb HJ, Burdach S, Bender HU
Biomed Res Int 2014;2014:637059. Epub 2014 Jun 15 doi: 10.1155/2014/637059. PMID: 25025064Free PMC Article
Peripheral blast counts at diagnosis of late isolated bone marrow relapse of childhood acute lymphoblastic leukemia predict response to salvage chemotherapy and outcome. Berlin-Frankfurt-Münster Relapse Study Group.
Bührer C, Hartmann R, Fengler R, Rath B, Schrappe M, Janka-Schaub G, Henze G
J Clin Oncol 1996 Oct;14(10):2812-7. doi: 10.1200/JCO.1996.14.10.2812. PMID: 8874343
Clinical pharmacology of 1-beta-D-arabinofuranosylcytosine-5'-stearylphosphate, an orally administered long-acting derivative of low-dose 1-beta-D-arabinofuranosylcytosine.
Ueda T, Kamiya K, Urasaki Y, Wataya S, Kawai Y, Tsutani H, Sugiyama M, Nakamura T
Cancer Res 1994 Jan 1;54(1):109-13. PMID: 8261429
Fatal encephalitis in a patient with chronic graft-versus-host disease.
Marosi C, Budka H, Grimm G, Zeitlhofer J, Sluga E, Brunner C, Schneeweiss B, Volc B, Bettelheim P, Panzer S
Bone Marrow Transplant 1990 Jul;6(1):53-7. PMID: 2390633
Simultaneous meningeal and testicular lymphoblastic transformation of Ph1-positive chronic myelocytic leukaemia in a three-year-old boy.
Carlsen NL, Erichsen G, Lisse I
Anticancer Res 1990 Nov-Dec;10(6):1739-41. PMID: 2285252

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