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Abnormal liver function

MedGen UID:: 39248
•Concept ID:: C0086565
•: Finding

Synonyms:	Dysfunction, Liver; Dysfunctions, Liver; Liver Dysfunction; Liver Dysfunctions
SNOMED CT:	Abnormal liver function (75183008); Abnormal hepatic function (75183008)

Definition

A finding that indicates abnormal liver function. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVAbnormal liver function

Pathological Conditions, Signs and Symptoms
- Clinical finding
  - Finding by Site or System
    - Digestive system finding
      - Abnormal liver function
        Hepatic insufficiency
        Liver failure
        Acute liver failure
        Chronic hepatic failure
        End stage liver disease
        Fatal liver failure in infancy
        Hepatic encephalopathy
        Moderate Hepatic Insufficiency

Professional guidelines

PubMed

ACR Appropriateness Criteria® Abnormal Liver Function Tests.

Expert Panel on Gastrointestinal Imaging, Arif-Tiwari H, Porter KK, Kamel IR, Bashir MR, Fung A, Kaplan DE, McGuire BM, Russo GK, Smith EN, Solnes LB, Thakrar KH, Vij A, Wahab SA, Wardrop RM 3rd, Zaheer A, Carucci LR
J Am Coll Radiol 2023 Nov;20(11S):S302-S314. doi: 10.1016/j.jacr.2023.08.023. PMID: 38040457

Cirrhosis: Diagnosis and Management.

Smith A, Baumgartner K, Bositis C
Am Fam Physician 2019 Dec 15;100(12):759-770. PMID: 31845776

ACG clinical guidelines: diagnosis and management of celiac disease.

Rubio-Tapia A, Hill ID, Kelly CP, Calderwood AH, Murray JA; American College of Gastroenterology
Am J Gastroenterol 2013 May;108(5):656-76; quiz 677. Epub 2013 Apr 23 doi: 10.1038/ajg.2013.79. PMID: 23609613 Free PMC Article

See all (129)

Recent clinical studies

Etiology

The Emerging Role of B Cells in the Pathogenesis of NAFLD.

Barrow F, Khan S, Wang H, Revelo XS
Hepatology 2021 Oct;74(4):2277-2286. Epub 2021 Jun 18 doi: 10.1002/hep.31889. PMID: 33961302 Free PMC Article

Implications of abnormal liver function in pregnancy and non-alcoholic fatty liver disease.

Lao TT
Best Pract Res Clin Obstet Gynaecol 2020 Oct;68:2-11. Epub 2020 Mar 7 doi: 10.1016/j.bpobgyn.2020.02.011. PMID: 32312689

Cirrhosis: Diagnosis and Management.

Smith A, Baumgartner K, Bositis C
Am Fam Physician 2019 Dec 15;100(12):759-770. PMID: 31845776

Chemotherapy-induced hepatotoxicity.

Thatishetty AV, Agresti N, O'Brien CB
Clin Liver Dis 2013 Nov;17(4):671-86, ix-x. Epub 2013 Aug 22 doi: 10.1016/j.cld.2013.07.010. PMID: 24099024

Clopidogrel.

Coukell AJ, Markham A
Drugs 1997 Nov;54(5):745-50; discussion 751. doi: 10.2165/00003495-199754050-00006. PMID: 9360060

See all (1131)

Diagnosis

History!

Nayak LJ, Sondhi AR, Westerhoff M
Gastroenterology 2021 May;160(6):e5-e6. Epub 2020 Oct 8 doi: 10.1053/j.gastro.2020.09.048. PMID: 33039473

Cirrhosis: Diagnosis and Management.

Smith A, Baumgartner K, Bositis C
Am Fam Physician 2019 Dec 15;100(12):759-770. PMID: 31845776

Viral hepatitis.

Hardikar W
J Paediatr Child Health 2019 Sep;55(9):1038-1043. Epub 2019 Jul 17 doi: 10.1111/jpc.14562. PMID: 31317618

Abnormal Liver Enzymes.

Melendez-Rosado J, Alsaad A, Stancampiano FF, Palmer WC
Gastroenterol Nurs 2018 Nov/Dec;41(6):497-507. doi: 10.1097/SGA.0000000000000346. PMID: 30418344

Evaluation of abnormal liver function tests.

Agrawal S, Dhiman RK, Limdi JK
Postgrad Med J 2016 Apr;92(1086):223-34. Epub 2016 Feb 3 doi: 10.1136/postgradmedj-2015-133715. PMID: 26842972

See all (1052)

Therapy

History!

Nayak LJ, Sondhi AR, Westerhoff M
Gastroenterology 2021 May;160(6):e5-e6. Epub 2020 Oct 8 doi: 10.1053/j.gastro.2020.09.048. PMID: 33039473

Treatments for chronic inflammatory demyelinating polyradiculoneuropathy (CIDP): an overview of systematic reviews.

Oaklander AL, Lunn MP, Hughes RA, van Schaik IN, Frost C, Chalk CH
Cochrane Database Syst Rev 2017 Jan 13;1(1):CD010369. doi: 10.1002/14651858.CD010369.pub2. PMID: 28084646 Free PMC Article

Chemotherapy-induced hepatotoxicity.

Thatishetty AV, Agresti N, O'Brien CB
Clin Liver Dis 2013 Nov;17(4):671-86, ix-x. Epub 2013 Aug 22 doi: 10.1016/j.cld.2013.07.010. PMID: 24099024

ACG clinical guidelines: diagnosis and management of celiac disease.

Dabigatran versus warfarin in the treatment of acute venous thromboembolism.

Schulman S, Kearon C, Kakkar AK, Mismetti P, Schellong S, Eriksson H, Baanstra D, Schnee J, Goldhaber SZ; RE-COVER Study Group
N Engl J Med 2009 Dec 10;361(24):2342-52. doi: 10.1056/NEJMoa0906598. PMID: 19966341

See all (944)

Prognosis

Clinical Course and Characteristics of Generalized Pustular Psoriasis.

Choon SE, Navarini AA, Pinter A
Am J Clin Dermatol 2022 Jan;23(Suppl 1):21-29. Epub 2022 Jan 21 doi: 10.1007/s40257-021-00654-z. PMID: 35061227 Free PMC Article

Oxaliplatin-induced hepatic sinusoidal obstruction syndrome.

Zhu C, Ren X, Liu D, Zhang C
Toxicology 2021 Aug;460:152882. Epub 2021 Aug 2 doi: 10.1016/j.tox.2021.152882. PMID: 34352347

Obesity Predicts Liver Function Testing and Abnormal Liver Results.

Li W, Homer K, Hull S, Boomla K, Robson J, Alazawi W
Obesity (Silver Spring) 2020 Jan;28(1):132-138. Epub 2019 Dec 5 doi: 10.1002/oby.22669. PMID: 31804018

Chemotherapy-induced hepatotoxicity.

Thatishetty AV, Agresti N, O'Brien CB
Clin Liver Dis 2013 Nov;17(4):671-86, ix-x. Epub 2013 Aug 22 doi: 10.1016/j.cld.2013.07.010. PMID: 24099024

Nonalcoholic steatohepatitis.

Sheth SG, Gordon FD, Chopra S
Ann Intern Med 1997 Jan 15;126(2):137-45. doi: 10.7326/0003-4819-126-2-199701150-00008. PMID: 9005748

See all (623)

Clinical prediction guides

Oxaliplatin-induced hepatic sinusoidal obstruction syndrome.

Zhu C, Ren X, Liu D, Zhang C
Toxicology 2021 Aug;460:152882. Epub 2021 Aug 2 doi: 10.1016/j.tox.2021.152882. PMID: 34352347

Cirrhosis: Diagnosis and Management.

Smith A, Baumgartner K, Bositis C
Am Fam Physician 2019 Dec 15;100(12):759-770. PMID: 31845776

Evaluation of abnormal liver function tests.

Agrawal S, Dhiman RK, Limdi JK
Postgrad Med J 2016 Apr;92(1086):223-34. Epub 2016 Feb 3 doi: 10.1136/postgradmedj-2015-133715. PMID: 26842972

HNF1B-associated renal and extra-renal disease-an expanding clinical spectrum.

Clissold RL, Hamilton AJ, Hattersley AT, Ellard S, Bingham C
Nat Rev Nephrol 2015 Feb;11(2):102-12. Epub 2014 Dec 23 doi: 10.1038/nrneph.2014.232. PMID: 25536396

Chemotherapy-induced hepatotoxicity.

Thatishetty AV, Agresti N, O'Brien CB
Clin Liver Dis 2013 Nov;17(4):671-86, ix-x. Epub 2013 Aug 22 doi: 10.1016/j.cld.2013.07.010. PMID: 24099024

See all (604)

Recent systematic reviews

The utility of liver function tests and abdominal ultrasound in infectious mononucleosis-A systematic review.

Tan ET, Wilkinson D, Edafe O
Clin Otolaryngol 2022 Nov;47(6):611-619. Epub 2022 Jul 29 doi: 10.1111/coa.13965. PMID: 35834363

Crimean-Congo haemorrhagic fever-induced liver injury: A systematic review and meta-analysis.

Rathore SS, Manju AH, Wen Q, Sondhi M, Pydi R, Haddad I, Hasan J, Ali MA, Tousif S, Singh R, Muhammed AA, Ahmed NK, Patel DM
Int J Clin Pract 2021 Nov;75(11):e14775. Epub 2021 Sep 12 doi: 10.1111/ijcp.14775. PMID: 34480502

Treatments for chronic inflammatory demyelinating polyradiculoneuropathy (CIDP): an overview of systematic reviews.

Oaklander AL, Lunn MP, Hughes RA, van Schaik IN, Frost C, Chalk CH
Cochrane Database Syst Rev 2017 Jan 13;1(1):CD010369. doi: 10.1002/14651858.CD010369.pub2. PMID: 28084646 Free PMC Article

A systematic review of the prevalence of mildly abnormal liver function tests and associated health outcomes.

Radcke S, Dillon JF, Murray AL
Eur J Gastroenterol Hepatol 2015 Jan;27(1):1-7. doi: 10.1097/MEG.0000000000000233. PMID: 25380394

Antipsychotics and abnormal liver function tests: systematic review.

Marwick KF, Taylor M, Walker SW
Clin Neuropharmacol 2012 Sep-Oct;35(5):244-53. doi: 10.1097/WNF.0b013e31826818b6. PMID: 22986798

See all (36)

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Abnormal liver function

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Practice guidelines

Related information

Recent activity