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Salivary Gland Clear Cell Carcinoma

MedGen UID:
407965
•Concept ID:
C1882971
•
Neoplastic Process
Synonyms: Salivary Gland Clear Cell Carcinoma, NOS; Salivary Gland Clear Cell Carcinoma, Not Otherwise Specified

Definition

A carcinoma that arises from the salivary glands, most often the minor salivary glands. It is characterized by the presence of a monomorphic population of malignant epithelial cells with clear cytoplasm and the absence of morphologic features that define other primary neoplasms of the salivary glands. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSalivary Gland Clear Cell Carcinoma

Professional guidelines

PubMed

Current diagnosis and treatment of salivary gland-type tumors of the lung.
Horio Y, Kuroda H, Masago K, Matsushita H, Sasaki E, Fujiwara Y
Jpn J Clin Oncol 2024 Mar 9;54(3):229-247. doi: 10.1093/jjco/hyad160. PMID: 38018262
Acinic cell carcinoma of the parotid gland: from pathogenesis to management: a literature review.
Cavaliere M, De Luca P, Scarpa A, Savignano L, Cassandro C, Cassandro E, Iemma M
Eur Arch Otorhinolaryngol 2020 Oct;277(10):2673-2679. Epub 2020 May 4 doi: 10.1007/s00405-020-05998-6. PMID: 32367151
Clinical Utility of In Situ Hybridization Assays in Head and Neck Neoplasms.
Luk PP, Selinger CI, Cooper WA, Mahar A, Palme CE, O'Toole SA, Clark JR, Gupta R
Head Neck Pathol 2019 Sep;13(3):397-414. Epub 2018 Nov 22 doi: 10.1007/s12105-018-0988-1. PMID: 30467669Free PMC Article

Recent clinical studies

Etiology

Update from the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: Salivary Glands.
Skálová A, Hyrcza MD, Leivo I
Head Neck Pathol 2022 Mar;16(1):40-53. Epub 2022 Mar 21 doi: 10.1007/s12105-022-01420-1. PMID: 35312980Free PMC Article
Overview of the 2022 WHO Classification of Thyroid Neoplasms.
Baloch ZW, Asa SL, Barletta JA, Ghossein RA, Juhlin CC, Jung CK, LiVolsi VA, Papotti MG, Sobrinho-Simões M, Tallini G, Mete O
Endocr Pathol 2022 Mar;33(1):27-63. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09707-3. PMID: 35288841
Clear Cell Neoplasms of Salivary Glands: A Diagnostic Challenge.
Skalova A, Leivo I, Hellquist H, Simpson RHW, Vander Poorten V, Willems SM, Mosaieby E, Slouka D, Ferlito A
Adv Anat Pathol 2022 Jul 1;29(4):217-226. Epub 2022 Mar 7 doi: 10.1097/PAP.0000000000000339. PMID: 35249992
Molecular Pathology of Salivary Gland Neoplasms: Diagnostic, Prognostic, and Predictive Perspective.
Toper MH, Sarioglu S
Adv Anat Pathol 2021 Mar 1;28(2):81-93. doi: 10.1097/PAP.0000000000000291. PMID: 33405400
Clear cell carcinoma, not otherwise specified/hyalinising clear cell carcinoma of the salivary gland: The current nomenclature, clinical/pathological characteristics and management.
Daniele L, Nikolarakos D, Keenan J, Schaefer N, Lam AK
Crit Rev Oncol Hematol 2016 Jun;102:55-64. Epub 2016 Apr 9 doi: 10.1016/j.critrevonc.2016.03.018. PMID: 27150676

Diagnosis

Update from the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: Salivary Glands.
Skálová A, Hyrcza MD, Leivo I
Head Neck Pathol 2022 Mar;16(1):40-53. Epub 2022 Mar 21 doi: 10.1007/s12105-022-01420-1. PMID: 35312980Free PMC Article
Overview of the 2022 WHO Classification of Thyroid Neoplasms.
Baloch ZW, Asa SL, Barletta JA, Ghossein RA, Juhlin CC, Jung CK, LiVolsi VA, Papotti MG, Sobrinho-Simões M, Tallini G, Mete O
Endocr Pathol 2022 Mar;33(1):27-63. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09707-3. PMID: 35288841
Molecular Pathology of Salivary Gland Neoplasms: Diagnostic, Prognostic, and Predictive Perspective.
Toper MH, Sarioglu S
Adv Anat Pathol 2021 Mar 1;28(2):81-93. doi: 10.1097/PAP.0000000000000291. PMID: 33405400
Clear cell carcinoma, not otherwise specified/hyalinising clear cell carcinoma of the salivary gland: The current nomenclature, clinical/pathological characteristics and management.
Daniele L, Nikolarakos D, Keenan J, Schaefer N, Lam AK
Crit Rev Oncol Hematol 2016 Jun;102:55-64. Epub 2016 Apr 9 doi: 10.1016/j.critrevonc.2016.03.018. PMID: 27150676
Annexin A4 and cancer.
Wei B, Guo C, Liu S, Sun MZ
Clin Chim Acta 2015 Jul 20;447:72-8. Epub 2015 Jun 3 doi: 10.1016/j.cca.2015.05.016. PMID: 26048190

Therapy

Molecular Profiling of Clear Cell Myoepithelial Carcinoma of Salivary Glands With EWSR1 Rearrangement Identifies Frequent PLAG1 Gene Fusions But No EWSR1 Fusion Transcripts.
Skálová A, Agaimy A, Vanecek T, Baněčková M, Laco J, Ptáková N, Šteiner P, Majewska H, Biernat W, Corcione L, Eis V, Koshyk O, Vondrák J Jr, Michal M, Leivo I
Am J Surg Pathol 2021 Jan;45(1):1-13. doi: 10.1097/PAS.0000000000001591. PMID: 33027073
Acinic cell carcinoma of the parotid gland: from pathogenesis to management: a literature review.
Cavaliere M, De Luca P, Scarpa A, Savignano L, Cassandro C, Cassandro E, Iemma M
Eur Arch Otorhinolaryngol 2020 Oct;277(10):2673-2679. Epub 2020 May 4 doi: 10.1007/s00405-020-05998-6. PMID: 32367151
Salivary Gland Secretory Carcinoma With High-Grade Transformation, CDKN2A/B Loss, Distant Metastasis, and Lack of Sustained Response to Crizotinib.
Cipriani NA, Blair EA, Finkle J, Kraninger JL, Straus CM, Villaflor VM, Ginat DT
Int J Surg Pathol 2017 Oct;25(7):613-618. Epub 2017 May 12 doi: 10.1177/1066896917709350. PMID: 28497708
Hyalinizing clear cell carcinoma of the tonsil and its treatment.
Hijjawi SB, Abdullah SE, Abdelhadi K, Eyzaguirre E, Willis M, Abdulla NE
Oral Surg Oral Med Oral Pathol Oral Radiol 2012 Aug;114(2):e32-6. Epub 2012 May 30 doi: 10.1016/j.oooo.2012.02.003. PMID: 22769418
The Na/I symporter (NIS): imaging and therapeutic applications.
Dadachova E, Carrasco N
Semin Nucl Med 2004 Jan;34(1):23-31. doi: 10.1053/j.semnuclmed.2003.09.004. PMID: 14735456

Prognosis

Overview of the 2022 WHO Classification of Thyroid Neoplasms.
Baloch ZW, Asa SL, Barletta JA, Ghossein RA, Juhlin CC, Jung CK, LiVolsi VA, Papotti MG, Sobrinho-Simões M, Tallini G, Mete O
Endocr Pathol 2022 Mar;33(1):27-63. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09707-3. PMID: 35288841
Molecular Pathology of Salivary Gland Neoplasms: Diagnostic, Prognostic, and Predictive Perspective.
Toper MH, Sarioglu S
Adv Anat Pathol 2021 Mar 1;28(2):81-93. doi: 10.1097/PAP.0000000000000291. PMID: 33405400
Clear cell carcinoma, not otherwise specified/hyalinising clear cell carcinoma of the salivary gland: The current nomenclature, clinical/pathological characteristics and management.
Daniele L, Nikolarakos D, Keenan J, Schaefer N, Lam AK
Crit Rev Oncol Hematol 2016 Jun;102:55-64. Epub 2016 Apr 9 doi: 10.1016/j.critrevonc.2016.03.018. PMID: 27150676
Annexin A4 and cancer.
Wei B, Guo C, Liu S, Sun MZ
Clin Chim Acta 2015 Jul 20;447:72-8. Epub 2015 Jun 3 doi: 10.1016/j.cca.2015.05.016. PMID: 26048190
Translocation-associated salivary gland tumors: a review and update.
Weinreb I
Adv Anat Pathol 2013 Nov;20(6):367-77. doi: 10.1097/PAP.0b013e3182a92cc3. PMID: 24113307

Clinical prediction guides

EWSR1 rearrangement is not specific for hyalinizing clear cell carcinoma of salivary glands.
Aljerian K
Ann Diagn Pathol 2022 Aug;59:151946. Epub 2022 Mar 31 doi: 10.1016/j.anndiagpath.2022.151946. PMID: 35500493
Molecular Pathology of Salivary Gland Neoplasms: Diagnostic, Prognostic, and Predictive Perspective.
Toper MH, Sarioglu S
Adv Anat Pathol 2021 Mar 1;28(2):81-93. doi: 10.1097/PAP.0000000000000291. PMID: 33405400
Salivary Clear Cell Carcinoma Clinicopathologic Characteristics and Outcomes: A Population-Based Analysis.
Sharbel DD, Unsal AA, Groves MW, Albergotti WG, Byrd JK
Ann Otol Rhinol Laryngol 2019 Nov;128(11):989-996. Epub 2019 May 29 doi: 10.1177/0003489419853597. PMID: 31142129
Molecular signature of salivary gland tumors: potential use as diagnostic and prognostic marker.
Fonseca FP, Sena Filho M, Altemani A, Speight PM, Vargas PA
J Oral Pathol Med 2016 Feb;45(2):101-10. Epub 2015 May 20 doi: 10.1111/jop.12329. PMID: 25990369
Hyalinizing clear cell carcinoma: case series and comprehensive review of the literature.
Solar AA, Schmidt BL, Jordan RC
Cancer 2009 Jan 1;115(1):75-83. doi: 10.1002/cncr.23974. PMID: 18980290Free PMC Article

Recent systematic reviews

Primary pulmonary hyalinizing clear cell carcinoma with vocal-cord squamous cell carcinoma: a case report with systematic review.
Li Z, Li W, Xue L
Diagn Pathol 2023 Aug 8;18(1):90. doi: 10.1186/s13000-023-01376-y. PMID: 37553667Free PMC Article
Clinicopathological and survival profile of patients with salivary gland myoepithelial carcinoma: A systematic review.
Lavareze L, Scarini JF, de Lima-Souza RA, Kimura TC, Gondak RO, Egal ESA, Altemani A, Mariano FV
J Oral Pathol Med 2023 Feb;52(2):101-108. Epub 2023 Jan 9 doi: 10.1111/jop.13395. PMID: 36504414

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