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Proximal Left Anterior Descending Coronary Artery Stenosis

MedGen UID:
414587
•Concept ID:
C2825180
•
Finding

Definition

A narrowing of the proximal portion of the left main coronary artery, usually considered significant if the stenosis is 70% or greater. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVProximal Left Anterior Descending Coronary Artery Stenosis

Professional guidelines

PubMed

Hybrid coronary revascularization for the treatment of left main coronary artery disease in high-risk patients.
Fedakar A, Taşar M, Rabus MB, Alsalehi S, Toker ME, Balkanay M
Heart Surg Forum 2012 Feb;15(1):E51-5. doi: 10.1532/HSF98.20111116. PMID: 22360908
Long-term follow-up after fractional flow reserve-guided treatment strategy in patients with an isolated proximal left anterior descending coronary artery stenosis.
Muller O, Mangiacapra F, Ntalianis A, Verhamme KM, Trana C, Hamilos M, Bartunek J, Vanderheyden M, Wyffels E, Heyndrickx GR, van Rooij FJ, Witteman JC, Hofman A, Wijns W, Barbato E, De Bruyne B
JACC Cardiovasc Interv 2011 Nov;4(11):1175-82. Epub 2011 Oct 26 doi: 10.1016/j.jcin.2011.09.007. PMID: 22035875

Recent clinical studies

Etiology

Risk of coronary stenosis after adjuvant radiotherapy for breast cancer.
Wennstig AK, Garmo H, Wadsten L, Lagerqvist B, Fredriksson I, Holmberg L, Blomqvist C, Nilsson G, Sund M
Strahlenther Onkol 2022 Jul;198(7):630-638. Epub 2022 Apr 7 doi: 10.1007/s00066-022-01927-0. PMID: 35389076Free PMC Article
Atrial branch coronary artery stenosis as a mechanism for atrial fibrillation.
Pokorney SD, Berchuck SI, Chiswell K, Sun JL, Thomas L, Jones WS, Patel MR, Piccini JP
Heart Rhythm 2022 Aug;19(8):1237-1244. Epub 2021 Dec 24 doi: 10.1016/j.hrthm.2021.12.020. PMID: 34958941
Review of coronary subclavian steal syndrome.
Cua B, Mamdani N, Halpin D, Jhamnani S, Jayasuriya S, Mena-Hurtado C
J Cardiol 2017 Nov;70(5):432-437. Epub 2017 Apr 14 doi: 10.1016/j.jjcc.2017.02.012. PMID: 28416323
Audible Coronary Artery Stenosis.
Azimpour F, Caldwell E, Tawfik P, Duval S, Wilson RF
Am J Med 2016 May;129(5):515-521.e3. Epub 2016 Feb 2 doi: 10.1016/j.amjmed.2016.01.015. PMID: 26841299
Percutaneous transluminal angioplasty.
Ann Intern Med 1983 Dec;99(6):864-9. doi: 10.7326/0003-4819-99-6-864. PMID: 6228175

Diagnosis

Angiographic predictors of coronary hemodynamics.
Nour D, Allahwala U, Hansen P, Figtree GA, Nelson G, Ward M, Bhindi R
Future Cardiol 2022 Apr;18(4):299-308. Epub 2022 Feb 22 doi: 10.2217/fca-2020-0090. PMID: 35189697
Atrial branch coronary artery stenosis as a mechanism for atrial fibrillation.
Pokorney SD, Berchuck SI, Chiswell K, Sun JL, Thomas L, Jones WS, Patel MR, Piccini JP
Heart Rhythm 2022 Aug;19(8):1237-1244. Epub 2021 Dec 24 doi: 10.1016/j.hrthm.2021.12.020. PMID: 34958941
Review of coronary subclavian steal syndrome.
Cua B, Mamdani N, Halpin D, Jhamnani S, Jayasuriya S, Mena-Hurtado C
J Cardiol 2017 Nov;70(5):432-437. Epub 2017 Apr 14 doi: 10.1016/j.jjcc.2017.02.012. PMID: 28416323
Audible Coronary Artery Stenosis.
Azimpour F, Caldwell E, Tawfik P, Duval S, Wilson RF
Am J Med 2016 May;129(5):515-521.e3. Epub 2016 Feb 2 doi: 10.1016/j.amjmed.2016.01.015. PMID: 26841299
Percutaneous transluminal angioplasty.
Ann Intern Med 1983 Dec;99(6):864-9. doi: 10.7326/0003-4819-99-6-864. PMID: 6228175

Therapy

Atrial branch coronary artery stenosis as a mechanism for atrial fibrillation.
Pokorney SD, Berchuck SI, Chiswell K, Sun JL, Thomas L, Jones WS, Patel MR, Piccini JP
Heart Rhythm 2022 Aug;19(8):1237-1244. Epub 2021 Dec 24 doi: 10.1016/j.hrthm.2021.12.020. PMID: 34958941
Prevalence of Subclinical Coronary Artery Atherosclerosis in the General Population.
Bergström G, Persson M, Adiels M, Björnson E, Bonander C, Ahlström H, Alfredsson J, Angerås O, Berglund G, Blomberg A, Brandberg J, Börjesson M, Cederlund K, de Faire U, Duvernoy O, Ekblom Ö, Engström G, Engvall JE, Fagman E, Eriksson M, Erlinge D, Fagerberg B, Flinck A, Gonçalves I, Hagström E, Hjelmgren O, Lind L, Lindberg E, Lindqvist P, Ljungberg J, Magnusson M, Mannila M, Markstad H, Mohammad MA, Nystrom FH, Ostenfeld E, Persson A, Rosengren A, Sandström A, Själander A, Sköld MC, Sundström J, Swahn E, Söderberg S, Torén K, Östgren CJ, Jernberg T
Circulation 2021 Sep 21;144(12):916-929. Epub 2021 Sep 20 doi: 10.1161/CIRCULATIONAHA.121.055340. PMID: 34543072Free PMC Article
Left coronary artery calcification patterns after coronary bypass graft surgery: An in-vivo optical coherence tomography study.
Wolny R, Mintz GS, Matsumura M, Kim SY, Ishida M, Fujino A, Lee T, Shlofmitz E, Goldberg A, Liu Y, Zhang Z, Zhang M, Hu X, Jeremias A, Petrossian G, Shlofmitz RA, Maehara A
Catheter Cardiovasc Interv 2021 Sep;98(3):483-491. Epub 2020 Sep 11 doi: 10.1002/ccd.29220. PMID: 32915510
Audible Coronary Artery Stenosis.
Azimpour F, Caldwell E, Tawfik P, Duval S, Wilson RF
Am J Med 2016 May;129(5):515-521.e3. Epub 2016 Feb 2 doi: 10.1016/j.amjmed.2016.01.015. PMID: 26841299
Revascularization for Left Anterior Descending Artery Stenosis: A Review of the Evidence That Supports Practice.
Kinnaird T, Anderson R, Ossei-Gerning N, Mamas MA, Ludman P, Moat N
Cardiol Rev 2016 May-Jun;24(3):136-40. doi: 10.1097/CRD.0000000000000097. PMID: 26751264

Prognosis

Angiographic predictors of coronary hemodynamics.
Nour D, Allahwala U, Hansen P, Figtree GA, Nelson G, Ward M, Bhindi R
Future Cardiol 2022 Apr;18(4):299-308. Epub 2022 Feb 22 doi: 10.2217/fca-2020-0090. PMID: 35189697
Left coronary artery calcification patterns after coronary bypass graft surgery: An in-vivo optical coherence tomography study.
Wolny R, Mintz GS, Matsumura M, Kim SY, Ishida M, Fujino A, Lee T, Shlofmitz E, Goldberg A, Liu Y, Zhang Z, Zhang M, Hu X, Jeremias A, Petrossian G, Shlofmitz RA, Maehara A
Catheter Cardiovasc Interv 2021 Sep;98(3):483-491. Epub 2020 Sep 11 doi: 10.1002/ccd.29220. PMID: 32915510
Prevalence and characteristics of dual left anterior descending artery in adult patients undergoing coronary angiography.
Sidhu NS, Wander GS
Future Cardiol 2019 Nov;15(6):425-435. Epub 2019 Oct 3 doi: 10.2217/fca-2019-0052. PMID: 31580149
Coronary Artery Imaging with Transthoracic Doppler Echocardiography.
Takeuchi M, Nakazono A
Curr Cardiol Rep 2016 Jul;18(7):63. doi: 10.1007/s11886-016-0740-y. PMID: 27216843
Audible Coronary Artery Stenosis.
Azimpour F, Caldwell E, Tawfik P, Duval S, Wilson RF
Am J Med 2016 May;129(5):515-521.e3. Epub 2016 Feb 2 doi: 10.1016/j.amjmed.2016.01.015. PMID: 26841299

Clinical prediction guides

Angiographic predictors of coronary hemodynamics.
Nour D, Allahwala U, Hansen P, Figtree GA, Nelson G, Ward M, Bhindi R
Future Cardiol 2022 Apr;18(4):299-308. Epub 2022 Feb 22 doi: 10.2217/fca-2020-0090. PMID: 35189697
Prevalence of Subclinical Coronary Artery Atherosclerosis in the General Population.
Bergström G, Persson M, Adiels M, Björnson E, Bonander C, Ahlström H, Alfredsson J, Angerås O, Berglund G, Blomberg A, Brandberg J, Börjesson M, Cederlund K, de Faire U, Duvernoy O, Ekblom Ö, Engström G, Engvall JE, Fagman E, Eriksson M, Erlinge D, Fagerberg B, Flinck A, Gonçalves I, Hagström E, Hjelmgren O, Lind L, Lindberg E, Lindqvist P, Ljungberg J, Magnusson M, Mannila M, Markstad H, Mohammad MA, Nystrom FH, Ostenfeld E, Persson A, Rosengren A, Sandström A, Själander A, Sköld MC, Sundström J, Swahn E, Söderberg S, Torén K, Östgren CJ, Jernberg T
Circulation 2021 Sep 21;144(12):916-929. Epub 2021 Sep 20 doi: 10.1161/CIRCULATIONAHA.121.055340. PMID: 34543072Free PMC Article
Left coronary artery calcification patterns after coronary bypass graft surgery: An in-vivo optical coherence tomography study.
Wolny R, Mintz GS, Matsumura M, Kim SY, Ishida M, Fujino A, Lee T, Shlofmitz E, Goldberg A, Liu Y, Zhang Z, Zhang M, Hu X, Jeremias A, Petrossian G, Shlofmitz RA, Maehara A
Catheter Cardiovasc Interv 2021 Sep;98(3):483-491. Epub 2020 Sep 11 doi: 10.1002/ccd.29220. PMID: 32915510
Audible Coronary Artery Stenosis.
Azimpour F, Caldwell E, Tawfik P, Duval S, Wilson RF
Am J Med 2016 May;129(5):515-521.e3. Epub 2016 Feb 2 doi: 10.1016/j.amjmed.2016.01.015. PMID: 26841299
Revascularization for Left Anterior Descending Artery Stenosis: A Review of the Evidence That Supports Practice.
Kinnaird T, Anderson R, Ossei-Gerning N, Mamas MA, Ludman P, Moat N
Cardiol Rev 2016 May-Jun;24(3):136-40. doi: 10.1097/CRD.0000000000000097. PMID: 26751264

Recent systematic reviews

Minimally invasive direct coronary artery bypass graft surgery or percutaneous coronary intervention for proximal left anterior descending artery stenosis: a meta-analysis.
Deo SV, Sharma V, Shah IK, Erwin PJ, Joyce LD, Park SJ
Ann Thorac Surg 2014 Jun;97(6):2056-65. Epub 2014 Apr 26 doi: 10.1016/j.athoracsur.2014.01.086. PMID: 24775802

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