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Hepatitis D virus infection

MedGen UID:
4182
•Concept ID:
C0011226
•
Disease or Syndrome
Synonyms: Delta Hepatitis; Delta Infection; Hepatitides, Delta; Hepatitis D; Hepatitis, Delta; Infection, Delta; Infections, Delta
SNOMED CT: Viral hepatitis type D (707341005); Viral hepatitis D (707341005); Hepatitis D virus infection (707341005); Hepatitis D (707341005)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
Monarch Initiative: MONDO:0005789
Orphanet: ORPHA402823

Definition

Hepatitis delta is a rare hepatic disease characterized by variable degrees of acute hepatitis resulting from infection with the hepatitis delta virus. Occasionally it may present a benign course, but most frequently it manifests with severe liver disease that may include fulminant liver failure, hepatic decompensation and rapid progression to cirrhosis. All patients present concomitant hepatitis B virus infection and an increased risk of developing hepatocellular carcinoma has been reported. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHepatitis D virus infection

Professional guidelines

PubMed

Effectiveness of pegylated interferon monotherapy in the treatment of chronic hepatitis D virus infection: A meta-analysis.
Abdrakhman A, Ashimkhanova A, Almawi WY
Antiviral Res 2021 Jan;185:104995. Epub 2020 Dec 13 doi: 10.1016/j.antiviral.2020.104995. PMID: 33321155
Natural course and treatment of hepatitis D virus infection.
Hsieh TH, Liu CJ, Chen DS, Chen PJ
J Formos Med Assoc 2006 Nov;105(11):869-81. doi: 10.1016/S0929-6646(09)60172-8. PMID: 17098688
A meta-analysis of interferon-alpha treatment of hepatitis D virus infection.
Malaguarnera M, Restuccia S, Pistone G, Ruello P, Giugno I, Trovato BA
Pharmacotherapy 1996 Jul-Aug;16(4):609-14. PMID: 8840366

Recent clinical studies

Etiology

Safety and efficacy of bulevirtide in combination with tenofovir disoproxil fumarate in patients with hepatitis B virus and hepatitis D virus coinfection (MYR202): a multicentre, randomised, parallel-group, open-label, phase 2 trial.
Wedemeyer H, Schöneweis K, Bogomolov P, Blank A, Voronkova N, Stepanova T, Sagalova O, Chulanov V, Osipenko M, Morozov V, Geyvandova N, Sleptsova S, Bakulin IG, Khaertynova I, Rusanova M, Pathil A, Merle U, Bremer B, Allweiss L, Lempp FA, Port K, Haag M, Schwab M, Zur Wiesch JS, Cornberg M, Haefeli WE, Dandri M, Alexandrov A, Urban S
Lancet Infect Dis 2023 Jan;23(1):117-129. Epub 2022 Sep 13 doi: 10.1016/S1473-3099(22)00318-8. PMID: 36113537
Seroprevalence and clinical outcome of hepatitis D infection in Qatar.
Abdallah T, Ibrahim T, Hajmusa M, Abdulgayoom M, Elhassan A, Abusabeib A, Babikir M, Abdelrahim S, Daghfal J, Derbala M
East Mediterr Health J 2022 Nov 30;28(11):840-846. doi: 10.26719/emhj.22.081. PMID: 36515449
Innate immune recognition and modulation in hepatitis D virus infection.
Jung S, Altstetter SM, Protzer U
World J Gastroenterol 2020 Jun 7;26(21):2781-2791. doi: 10.3748/wjg.v26.i21.2781. PMID: 32550754Free PMC Article
Hepatitis D virus infection, cirrhosis and hepatocellular carcinoma in The Gambia.
Mahale P, Aka P, Chen X, Pfeiffer RM, Liu P, Groover S, Mendy M, Njie R, Goedert JJ, Kirk GD, Glenn JS, O'Brien TR
J Viral Hepat 2019 Jun;26(6):738-749. Epub 2019 Feb 14 doi: 10.1111/jvh.13065. PMID: 30661282Free PMC Article
Prevalence of hepatitis D virus infection in sub-Saharan Africa: a systematic review and meta-analysis.
Stockdale AJ, Chaponda M, Beloukas A, Phillips RO, Matthews PC, Papadimitropoulos A, King S, Bonnett L, Geretti AM
Lancet Glob Health 2017 Oct;5(10):e992-e1003. doi: 10.1016/S2214-109X(17)30298-X. PMID: 28911765Free PMC Article

Diagnosis

Epidemiology of hepatitis D virus infection in Europe: Is it vanishing?
Demirel A, Uraz S, Deniz Z, Daglilar E, Basar O, Tahan V, Ozaras R
J Viral Hepat 2024 Feb;31(2):120-128. Epub 2023 Nov 14 doi: 10.1111/jvh.13899. PMID: 37964693
Hepatitis D Virus Infection.
Asselah T, Rizzetto M
N Engl J Med 2023 Jul 6;389(1):58-70. doi: 10.1056/NEJMra2212151. PMID: 37407002
Hepatitis delta virus: Disease assessment and stratification.
Koffas A, Mak LY, Kennedy PTF
J Viral Hepat 2023 Apr;30 Suppl 1:11-20. Epub 2023 Jan 4 doi: 10.1111/jvh.13777. PMID: 36458851
The medical impact of hepatitis D virus infection in Asia and Africa; time for a reappraisal.
Rizzetto M, Hamid S
Liver Int 2021 Jan;41(1):16-19. Epub 2020 Nov 23 doi: 10.1111/liv.14729. PMID: 33179354
Hepatitis D virus infection.
Poss JE
Nurse Pract 1989 Aug;14(8):12, 14-5, 18. PMID: 2671823

Therapy

Hepatitis D virus infection: Progress on the path toward disease control and cure.
Sulkowski MS
J Viral Hepat 2023 Apr;30 Suppl 1:39-42. Epub 2023 Apr 7 doi: 10.1111/jvh.13825. PMID: 36856472
Safety and efficacy of bulevirtide in combination with tenofovir disoproxil fumarate in patients with hepatitis B virus and hepatitis D virus coinfection (MYR202): a multicentre, randomised, parallel-group, open-label, phase 2 trial.
Wedemeyer H, Schöneweis K, Bogomolov P, Blank A, Voronkova N, Stepanova T, Sagalova O, Chulanov V, Osipenko M, Morozov V, Geyvandova N, Sleptsova S, Bakulin IG, Khaertynova I, Rusanova M, Pathil A, Merle U, Bremer B, Allweiss L, Lempp FA, Port K, Haag M, Schwab M, Zur Wiesch JS, Cornberg M, Haefeli WE, Dandri M, Alexandrov A, Urban S
Lancet Infect Dis 2023 Jan;23(1):117-129. Epub 2022 Sep 13 doi: 10.1016/S1473-3099(22)00318-8. PMID: 36113537
New Treatments for Chronic Hepatitis B Virus/Hepatitis D Virus Infection.
Sandmann L, Wedemeyer H
Clin Liver Dis 2021 Nov;25(4):831-839. Epub 2021 Aug 8 doi: 10.1016/j.cld.2021.06.011. PMID: 34593156
The global prevalence of hepatitis D virus infection: Systematic review and meta-analysis.
Stockdale AJ, Kreuels B, Henrion MYR, Giorgi E, Kyomuhangi I, de Martel C, Hutin Y, Geretti AM
J Hepatol 2020 Sep;73(3):523-532. Epub 2020 Apr 23 doi: 10.1016/j.jhep.2020.04.008. PMID: 32335166Free PMC Article
Prevalence of hepatitis D virus infection in sub-Saharan Africa: a systematic review and meta-analysis.
Stockdale AJ, Chaponda M, Beloukas A, Phillips RO, Matthews PC, Papadimitropoulos A, King S, Bonnett L, Geretti AM
Lancet Glob Health 2017 Oct;5(10):e992-e1003. doi: 10.1016/S2214-109X(17)30298-X. PMID: 28911765Free PMC Article

Prognosis

Hepatitis delta virus: Disease assessment and stratification.
Koffas A, Mak LY, Kennedy PTF
J Viral Hepat 2023 Apr;30 Suppl 1:11-20. Epub 2023 Jan 4 doi: 10.1111/jvh.13777. PMID: 36458851
Role of hepatitis D virus infection in development of hepatocellular carcinoma among chronic hepatitis B patients treated with nucleotide/nucleoside analogues.
Jang TY, Wei YJ, Liu TW, Yeh ML, Liu SF, Hsu CT, Hsu PY, Lin YH, Liang PC, Hsieh MH, Ko YM, Tsai YS, Chen KY, Lin CC, Tsai PC, Wang SC, Huang CI, Lin ZY, Chen SC, Chuang WL, Huang JF, Dai CY, Huang CF, Yu ML
Sci Rep 2021 Apr 14;11(1):8184. doi: 10.1038/s41598-021-87679-w. PMID: 33854160Free PMC Article
Hepatitis D virus infection, cirrhosis and hepatocellular carcinoma in The Gambia.
Mahale P, Aka P, Chen X, Pfeiffer RM, Liu P, Groover S, Mendy M, Njie R, Goedert JJ, Kirk GD, Glenn JS, O'Brien TR
J Viral Hepat 2019 Jun;26(6):738-749. Epub 2019 Feb 14 doi: 10.1111/jvh.13065. PMID: 30661282Free PMC Article
Natural course and treatment of hepatitis D virus infection.
Hsieh TH, Liu CJ, Chen DS, Chen PJ
J Formos Med Assoc 2006 Nov;105(11):869-81. doi: 10.1016/S0929-6646(09)60172-8. PMID: 17098688
Epidemiology of hepatitis D virus infection: changes in the last 14 years.
Navascués CA, Rodríguez M, Sotorrío NG, Sala P, Linares A, Suárez A, Rodrigo L
Am J Gastroenterol 1995 Nov;90(11):1981-4. PMID: 7485005

Clinical prediction guides

Hepatitis delta virus: Disease assessment and stratification.
Koffas A, Mak LY, Kennedy PTF
J Viral Hepat 2023 Apr;30 Suppl 1:11-20. Epub 2023 Jan 4 doi: 10.1111/jvh.13777. PMID: 36458851
Liver-Resident Bystander CD8(+) T Cells Contribute to Liver Disease Pathogenesis in Chronic Hepatitis D Virus Infection.
Kefalakes H, Horgan XJ, Jung MK, Amanakis G, Kapuria D, Bolte FJ, Kleiner DE, Koh C, Heller T, Rehermann B
Gastroenterology 2021 Nov;161(5):1567-1583.e9. Epub 2021 Jul 21 doi: 10.1053/j.gastro.2021.07.027. PMID: 34302839Free PMC Article
The medical impact of hepatitis D virus infection in Uzbekistan.
Khodjaeva M, Ibadullaeva N, Khikmatullaeva A, Joldasova E, Ismoilov U, Colombo M, Caviglia GP, Rizzetto M, Musabaev E
Liver Int 2019 Nov;39(11):2077-2081. Epub 2019 Sep 20 doi: 10.1111/liv.14243. PMID: 31505080
Hepatitis D virus infection, cirrhosis and hepatocellular carcinoma in The Gambia.
Mahale P, Aka P, Chen X, Pfeiffer RM, Liu P, Groover S, Mendy M, Njie R, Goedert JJ, Kirk GD, Glenn JS, O'Brien TR
J Viral Hepat 2019 Jun;26(6):738-749. Epub 2019 Feb 14 doi: 10.1111/jvh.13065. PMID: 30661282Free PMC Article
Natural course and treatment of hepatitis D virus infection.
Hsieh TH, Liu CJ, Chen DS, Chen PJ
J Formos Med Assoc 2006 Nov;105(11):869-81. doi: 10.1016/S0929-6646(09)60172-8. PMID: 17098688

Recent systematic reviews

The global prevalence of hepatitis D virus infection: Systematic review and meta-analysis.
Stockdale AJ, Kreuels B, Henrion MYR, Giorgi E, Kyomuhangi I, de Martel C, Hutin Y, Geretti AM
J Hepatol 2020 Sep;73(3):523-532. Epub 2020 Apr 23 doi: 10.1016/j.jhep.2020.04.008. PMID: 32335166Free PMC Article
Chronic hepatitis D and hepatocellular carcinoma: A systematic review and meta-analysis of observational studies.
Alfaiate D, Clément S, Gomes D, Goossens N, Negro F
J Hepatol 2020 Sep;73(3):533-539. Epub 2020 Mar 6 doi: 10.1016/j.jhep.2020.02.030. PMID: 32151618
Prevalence and burden of hepatitis D virus infection in the global population: a systematic review and meta-analysis.
Chen HY, Shen DT, Ji DZ, Han PC, Zhang WM, Ma JF, Chen WS, Goyal H, Pan S, Xu HG
Gut 2019 Mar;68(3):512-521. Epub 2018 Sep 18 doi: 10.1136/gutjnl-2018-316601. PMID: 30228220
Prevalence of hepatitis D virus infection in sub-Saharan Africa: a systematic review and meta-analysis.
Stockdale AJ, Chaponda M, Beloukas A, Phillips RO, Matthews PC, Papadimitropoulos A, King S, Bonnett L, Geretti AM
Lancet Glob Health 2017 Oct;5(10):e992-e1003. doi: 10.1016/S2214-109X(17)30298-X. PMID: 28911765Free PMC Article

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