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Hypoactive sexual desire disorder

MedGen UID:
43792
•Concept ID:
C0020594
•
Mental or Behavioral Dysfunction
Synonym: Hypoactive Sexual Desire Disorder
SNOMED CT: Lack or loss of sexual desire (270903007); Hypoactive sexual desire disorder (270903007)
 
Monarch Initiative: MONDO:0001821

Definition

A disorder characterized by a recurrent or persistent lack of desire for sexual activity. The lack of sexual desire is not attributable to another psychiatric disorder or to the physiological effects of substance use or a general medical condition. [from NCI]

Professional guidelines

PubMed

Medical Treatment of Female Sexual Dysfunction.
Nappi RE, Tiranini L, Martini E, Bosoni D, Righi A, Cucinella L
Urol Clin North Am 2022 May;49(2):299-307. doi: 10.1016/j.ucl.2022.02.001. PMID: 35428435
Hypoactive Sexual Desire Disorder in Women: Physiology, Assessment, Diagnosis, and Treatment.
Pettigrew JA, Novick AM
J Midwifery Womens Health 2021 Nov;66(6):740-748. Epub 2021 Sep 12 doi: 10.1111/jmwh.13283. PMID: 34510696Free PMC Article
International Society for the Study of Women's Sexual Health Clinical Practice Guideline for the Use of Systemic Testosterone for Hypoactive Sexual Desire Disorder in Women.
Parish SJ, Simon JA, Davis SR, Giraldi A, Goldstein I, Goldstein SW, Kim NN, Kingsberg SA, Morgentaler A, Nappi RE, Park K, Stuenkel CA, Traish AM, Vignozzi L
J Sex Med 2021 May;18(5):849-867. Epub 2021 Apr 1 doi: 10.1016/j.jsxm.2020.10.009. PMID: 33814355

Recent clinical studies

Etiology

The clinical management of testosterone replacement therapy in postmenopausal women with hypoactive sexual desire disorder: a review.
Uloko M, Rahman F, Puri LI, Rubin RS
Int J Impot Res 2022 Nov;34(7):635-641. Epub 2022 Oct 5 doi: 10.1038/s41443-022-00613-0. PMID: 36198811Free PMC Article
International Society for the Study of Women's Sexual Health Clinical Practice Guideline for the Use of Systemic Testosterone for Hypoactive Sexual Desire Disorder in Women.
Parish SJ, Simon JA, Davis SR, Giraldi A, Goldstein I, Goldstein SW, Kim NN, Kingsberg SA, Morgentaler A, Nappi RE, Park K, Stuenkel CA, Traish AM, Vignozzi L
J Sex Med 2021 May;18(5):849-867. Epub 2021 Apr 1 doi: 10.1016/j.jsxm.2020.10.009. PMID: 33814355
Risks of Testosterone for Postmenopausal Women.
Pinkerton JV, Blackman I, Conner EA, Kaunitz AM
Endocrinol Metab Clin North Am 2021 Mar;50(1):139-150. Epub 2021 Jan 11 doi: 10.1016/j.ecl.2020.10.007. PMID: 33518182
Evaluation of safety for flibanserin.
Clayton AH, Brown L, Kim NN
Expert Opin Drug Saf 2020 Jan;19(1):1-8. Epub 2019 Dec 23 doi: 10.1080/14740338.2020.1707804. PMID: 31855607
Androgen Therapy in Women.
Vegunta S, Kling JM, Kapoor E
J Womens Health (Larchmt) 2020 Jan;29(1):57-64. Epub 2019 Nov 5 doi: 10.1089/jwh.2018.7494. PMID: 31687883

Diagnosis

Medical Treatment of Female Sexual Dysfunction.
Nappi RE, Tiranini L, Martini E, Bosoni D, Righi A, Cucinella L
Urol Clin North Am 2022 May;49(2):299-307. doi: 10.1016/j.ucl.2022.02.001. PMID: 35428435
Hypoactive Sexual Desire Disorder in Women: Physiology, Assessment, Diagnosis, and Treatment.
Pettigrew JA, Novick AM
J Midwifery Womens Health 2021 Nov;66(6):740-748. Epub 2021 Sep 12 doi: 10.1111/jmwh.13283. PMID: 34510696Free PMC Article
International Society for the Study of Women's Sexual Health Clinical Practice Guideline for the Use of Systemic Testosterone for Hypoactive Sexual Desire Disorder in Women.
Parish SJ, Simon JA, Davis SR, Giraldi A, Goldstein I, Goldstein SW, Kim NN, Kingsberg SA, Morgentaler A, Nappi RE, Park K, Stuenkel CA, Traish AM, Vignozzi L
J Sex Med 2021 May;18(5):849-867. Epub 2021 Apr 1 doi: 10.1016/j.jsxm.2020.10.009. PMID: 33814355
Female Sexual Dysfunction.
Clayton AH, Valladares Juarez EM
Med Clin North Am 2019 Jul;103(4):681-698. doi: 10.1016/j.mcna.2019.02.008. PMID: 31078200
Hypoactive Sexual Desire Disorder: International Society for the Study of Women's Sexual Health (ISSWSH) Expert Consensus Panel Review.
Goldstein I, Kim NN, Clayton AH, DeRogatis LR, Giraldi A, Parish SJ, Pfaus J, Simon JA, Kingsberg SA, Meston C, Stahl SM, Wallen K, Worsley R
Mayo Clin Proc 2017 Jan;92(1):114-128. Epub 2016 Dec 1 doi: 10.1016/j.mayocp.2016.09.018. PMID: 27916394

Therapy

The clinical management of testosterone replacement therapy in postmenopausal women with hypoactive sexual desire disorder: a review.
Uloko M, Rahman F, Puri LI, Rubin RS
Int J Impot Res 2022 Nov;34(7):635-641. Epub 2022 Oct 5 doi: 10.1038/s41443-022-00613-0. PMID: 36198811Free PMC Article
International Society for the Study of Women's Sexual Health Clinical Practice Guideline for the Use of Systemic Testosterone for Hypoactive Sexual Desire Disorder in Women.
Parish SJ, Simon JA, Davis SR, Giraldi A, Goldstein I, Goldstein SW, Kim NN, Kingsberg SA, Morgentaler A, Nappi RE, Park K, Stuenkel CA, Traish AM, Vignozzi L
J Sex Med 2021 May;18(5):849-867. Epub 2021 Apr 1 doi: 10.1016/j.jsxm.2020.10.009. PMID: 33814355
Androgen Therapy in Women.
Vegunta S, Kling JM, Kapoor E
J Womens Health (Larchmt) 2020 Jan;29(1):57-64. Epub 2019 Nov 5 doi: 10.1089/jwh.2018.7494. PMID: 31687883
Sexual Health in Menopause.
Scavello I, Maseroli E, Di Stasi V, Vignozzi L
Medicina (Kaunas) 2019 Sep 2;55(9) doi: 10.3390/medicina55090559. PMID: 31480774Free PMC Article
Hypoactive Sexual Desire Disorder: International Society for the Study of Women's Sexual Health (ISSWSH) Expert Consensus Panel Review.
Goldstein I, Kim NN, Clayton AH, DeRogatis LR, Giraldi A, Parish SJ, Pfaus J, Simon JA, Kingsberg SA, Meston C, Stahl SM, Wallen K, Worsley R
Mayo Clin Proc 2017 Jan;92(1):114-128. Epub 2016 Dec 1 doi: 10.1016/j.mayocp.2016.09.018. PMID: 27916394

Prognosis

Low prolactin level identifies hypoactive sexual desire disorder women with a reduced inhibition profile.
Maseroli E, Verde N, Cipriani S, Rastrelli G, Alfaroli C, Ravelli SA, Costeniero D, Scairati R, Minnetti M, Petraglia F, Auriemma RS, Nappi RE, Maggi M, Vignozzi L
J Endocrinol Invest 2023 Dec;46(12):2481-2492. Epub 2023 May 18 doi: 10.1007/s40618-023-02101-8. PMID: 37204690Free PMC Article
Low Sexual Desire in Breast Cancer Survivors and Patients: A Review.
Luo F, Link M, Grabenhorst C, Lynn B
Sex Med Rev 2022 Jul;10(3):367-375. Epub 2022 Apr 8 doi: 10.1016/j.sxmr.2022.02.001. PMID: 35410784
Efficacy of metacognitive therapy for hypoactive sexual desire disorder among Iranian couples.
Ramezani MA, Ahmadi K, Besharat M, Noohi S, Ghaemmaghami A
Psychother Res 2018 Nov;28(6):902-908. Epub 2017 Mar 24 doi: 10.1080/10503307.2017.1301690. PMID: 28337949
Hypoactive sexual desire disorder: inventing a disease to sell low libido.
Meixel A, Yanchar E, Fugh-Berman A
J Med Ethics 2015 Oct;41(10):859-62. Epub 2015 Jun 29 doi: 10.1136/medethics-2014-102596. PMID: 26124287
Hypoactive sexual desire disorder.
Davison SL
Curr Opin Obstet Gynecol 2012 Aug;24(4):215-20. doi: 10.1097/GCO.0b013e328355847e. PMID: 22729093

Clinical prediction guides

Low Sexual Desire in Breast Cancer Survivors and Patients: A Review.
Luo F, Link M, Grabenhorst C, Lynn B
Sex Med Rev 2022 Jul;10(3):367-375. Epub 2022 Apr 8 doi: 10.1016/j.sxmr.2022.02.001. PMID: 35410784
Women's Sexual Desire, Trauma Exposure, and Posttraumatic Stress Disorder.
O'Loughlin JI, Brotto LA
J Trauma Stress 2020 Jun;33(3):238-247. Epub 2020 Mar 26 doi: 10.1002/jts.22485. PMID: 32216146
Flibanserin for Hypoactive Sexual Desire Disorder: An Open-Label Safety Study.
Simon JA, Derogatis L, Portman D, Brown L, Yuan J, Kissling R
J Sex Med 2018 Mar;15(3):387-395. doi: 10.1016/j.jsxm.2017.12.016. PMID: 29502984
Flibanserin.
Vallejos X, Wu C
J Pharm Pract 2017 Apr;30(2):256-260. Epub 2016 Jul 9 doi: 10.1177/0897190016630409. PMID: 26873507
Flibanserin for the treatment of hypoactive sexual desire disorder in premenopausal women.
Dhanuka I, Simon JA
Expert Opin Pharmacother 2015;16(16):2523-9. Epub 2015 Sep 22 doi: 10.1517/14656566.2015.1090426. PMID: 26395164

Recent systematic reviews

Sexual dysfunction and disorders as a consequence of infertility: a systematic review and meta-analysis.
Leeners B, Tschudin S, Wischmann T, Kalaitzopoulos DR
Hum Reprod Update 2023 Jan 5;29(1):95-125. doi: 10.1093/humupd/dmac030. PMID: 35900268
A Systematic Literature Review of Health-related Quality of Life Measures for Women with Hypoactive Sexual Desire Disorder and Female Sexual Interest/Arousal Disorder.
Lim-Watson MZ, Hays RD, Kingsberg S, Kallich JD, Murimi-Worstell IB
Sex Med Rev 2022 Jan;10(1):23-41. Epub 2021 Sep 1 doi: 10.1016/j.sxmr.2021.07.003. PMID: 34481749
Bremelanotide: New Drug Approved for Treating Hypoactive Sexual Desire Disorder.
Mayer D, Lynch SE
Ann Pharmacother 2020 Jul;54(7):684-690. Epub 2020 Jan 1 doi: 10.1177/1060028019899152. PMID: 31893927
Neuroimaging of Female Sexual Desire and Hypoactive Sexual Desire Disorder.
Cacioppo S
Sex Med Rev 2017 Oct;5(4):434-444. Epub 2017 Aug 31 doi: 10.1016/j.sxmr.2017.07.006. PMID: 28865901
Efficacy of psychological interventions for sexual dysfunction: a systematic review and meta-analysis.
Frühauf S, Gerger H, Schmidt HM, Munder T, Barth J
Arch Sex Behav 2013 Aug;42(6):915-33. Epub 2013 Apr 5 doi: 10.1007/s10508-012-0062-0. PMID: 23559141

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