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Mycobacterial infection (excluding tuberculosis AND leprosy)

MedGen UID:
44537
•Concept ID:
C0026919
•
Disease or Syndrome
Synonyms: Atypical Mycobacterium Infection; Atypical Mycobacterium Infections; Infections, Atypical Mycobacterium; Mycobacterium Infection, Atypical; Mycobacterium Infection, Nontuberculous; Mycobacterium Infections, Atypical; Mycobacterium Infections, Nontuberculous; Nontuberculous Mycobacterium Infection; Nontuberculous Mycobacterium Infections
SNOMED CT: Atypical mycobacterial disease (111812000); Mycobacterial infection (excluding tuberculosis AND leprosy) (111811007); Atypical mycobacterial infection (111812000); Infection due to mycobacterium, non-TB (111812000)

Definition

Infections with nontuberculous mycobacteria (atypical mycobacteria): M. kansasii, M. marinum, M. scrofulaceum, M. flavescens, M. gordonae, M. obuense, M. gilvum, M. duvali, M. szulgai, M. intracellulare (see MYCOBACTERIUM AVIUM COMPLEX;), M. xenopi (littorale), M. ulcerans, M. buruli, M. terrae, M. fortuitum (minetti, giae), M. chelonae, M. leprae. [from MeSH]

Recent clinical studies

Etiology

Assessment of the tuberculosis case-finding and prevention cascade among people living with HIV in Zambia - 2018: a cross-sectional cluster survey.
Melgar M, Shiraishi RW, Tende C, Mwanza S, Mulenga J, Khondowe S, Mwakazanga D, Kapungu K, Tembo M, Nota A, Lungu P, Moore B, Podewils LJ
BMC Public Health 2021 May 4;21(1):859. doi: 10.1186/s12889-021-10929-z. PMID: 33947361Free PMC Article
SARS-CoV-2 antibody seroprevalence in India, August-September, 2020: findings from the second nationwide household serosurvey.
Murhekar MV, Bhatnagar T, Selvaraju S, Saravanakumar V, Thangaraj JWV, Shah N, Kumar MS, Rade K, Sabarinathan R, Asthana S, Balachandar R, Bangar SD, Bansal AK, Bhat J, Chopra V, Das D, Deb AK, Devi KR, Dwivedi GR, Khan SMS, Kumar CPG, Kumar MS, Laxmaiah A, Madhukar M, Mahapatra A, Mohanty SS, Rangaraju C, Turuk A, Baradwaj DK, Chahal AS, Debnath F, Haq I, Kalliath A, Kanungo S, Kshatri JS, Lakshmi GGJN, Mitra A, Nirmala AR, Prasad GV, Qurieshi MA, Sahay S, Sangwan RK, Sekar K, Shukla VK, Singh PK, Singh P, Singh R, Varma DS, Viramgami A, Panda S, Reddy DCS, Bhargava B; ICMR Serosurveillance Group
Lancet Glob Health 2021 Mar;9(3):e257-e266. Epub 2021 Jan 27 doi: 10.1016/S2214-109X(20)30544-1. PMID: 33515512Free PMC Article
Possible cases of leprosy from the Late Copper Age (3780-3650 cal BC) in Hungary.
Köhler K, Marcsik A, Zádori P, Biro G, Szeniczey T, Fábián S, Serlegi G, Marton T, Donoghue HD, Hajdu T
PLoS One 2017;12(10):e0185966. Epub 2017 Oct 12 doi: 10.1371/journal.pone.0185966. PMID: 29023477Free PMC Article
Variation and risk factors of drug resistant tuberculosis in sub-Saharan Africa: a systematic review and meta-analysis.
Lukoye D, Ssengooba W, Musisi K, Kasule GW, Cobelens FG, Joloba M, Gomez GB
BMC Public Health 2015 Mar 25;15:291. doi: 10.1186/s12889-015-1614-8. PMID: 25880829Free PMC Article
Effectiveness of BCG vaccination among leprosy contacts: a cohort study.
Düppre NC, Camacho LA, da Cunha SS, Struchiner CJ, Sales AM, Nery JA, Sarno EN
Trans R Soc Trop Med Hyg 2008 Jul;102(7):631-8. Epub 2008 Jun 2 doi: 10.1016/j.trstmh.2008.04.015. PMID: 18514242

Diagnosis

Concurrent pulmonary tuberculosis and lepromatous leprosy in a newly diagnosed HIV positive patient: a case report.
Masuka JT, Mkhize Z, Pillay S, Mosam A
BMC Pulm Med 2021 Jun 30;21(1):207. doi: 10.1186/s12890-021-01572-w. PMID: 34193098Free PMC Article
Assessment of the tuberculosis case-finding and prevention cascade among people living with HIV in Zambia - 2018: a cross-sectional cluster survey.
Melgar M, Shiraishi RW, Tende C, Mwanza S, Mulenga J, Khondowe S, Mwakazanga D, Kapungu K, Tembo M, Nota A, Lungu P, Moore B, Podewils LJ
BMC Public Health 2021 May 4;21(1):859. doi: 10.1186/s12889-021-10929-z. PMID: 33947361Free PMC Article
Diagnostic Utility of Biplex/Multiplex Polymerase Chain Reaction in Infectious Granulomatous Dermatitis in North Indian Population.
Parkhi M, Kumar S M, De D, Yadav R, Sethi S, Radotra BD, Saikia UN
Am J Dermatopathol 2021 Aug 1;43(8):567-573. doi: 10.1097/DAD.0000000000001878. PMID: 33395043
Leprosy post-exposure prophylaxis with single-dose rifampicin (LPEP): an international feasibility programme.
Richardus JH, Tiwari A, Barth-Jaeggi T, Arif MA, Banstola NL, Baskota R, Blaney D, Blok DJ, Bonenberger M, Budiawan T, Cavaliero A, Gani Z, Greter H, Ignotti E, Kamara DV, Kasang C, Manglani PR, Mieras L, Njako BF, Pakasi T, Pandey BD, Saunderson P, Singh R, Smith WCS, Stäheli R, Suriyarachchi ND, Tin Maung A, Shwe T, van Berkel J, van Brakel WH, Vander Plaetse B, Virmond M, Wijesinghe MSD, Aerts A, Steinmann P
Lancet Glob Health 2021 Jan;9(1):e81-e90. Epub 2020 Oct 29 doi: 10.1016/S2214-109X(20)30396-X. PMID: 33129378
Possible cases of leprosy from the Late Copper Age (3780-3650 cal BC) in Hungary.
Köhler K, Marcsik A, Zádori P, Biro G, Szeniczey T, Fábián S, Serlegi G, Marton T, Donoghue HD, Hajdu T
PLoS One 2017;12(10):e0185966. Epub 2017 Oct 12 doi: 10.1371/journal.pone.0185966. PMID: 29023477Free PMC Article

Therapy

Assessment of the tuberculosis case-finding and prevention cascade among people living with HIV in Zambia - 2018: a cross-sectional cluster survey.
Melgar M, Shiraishi RW, Tende C, Mwanza S, Mulenga J, Khondowe S, Mwakazanga D, Kapungu K, Tembo M, Nota A, Lungu P, Moore B, Podewils LJ
BMC Public Health 2021 May 4;21(1):859. doi: 10.1186/s12889-021-10929-z. PMID: 33947361Free PMC Article
SARS-CoV-2 antibody seroprevalence in India, August-September, 2020: findings from the second nationwide household serosurvey.
Murhekar MV, Bhatnagar T, Selvaraju S, Saravanakumar V, Thangaraj JWV, Shah N, Kumar MS, Rade K, Sabarinathan R, Asthana S, Balachandar R, Bangar SD, Bansal AK, Bhat J, Chopra V, Das D, Deb AK, Devi KR, Dwivedi GR, Khan SMS, Kumar CPG, Kumar MS, Laxmaiah A, Madhukar M, Mahapatra A, Mohanty SS, Rangaraju C, Turuk A, Baradwaj DK, Chahal AS, Debnath F, Haq I, Kalliath A, Kanungo S, Kshatri JS, Lakshmi GGJN, Mitra A, Nirmala AR, Prasad GV, Qurieshi MA, Sahay S, Sangwan RK, Sekar K, Shukla VK, Singh PK, Singh P, Singh R, Varma DS, Viramgami A, Panda S, Reddy DCS, Bhargava B; ICMR Serosurveillance Group
Lancet Glob Health 2021 Mar;9(3):e257-e266. Epub 2021 Jan 27 doi: 10.1016/S2214-109X(20)30544-1. PMID: 33515512Free PMC Article
Leprosy post-exposure prophylaxis with single-dose rifampicin (LPEP): an international feasibility programme.
Richardus JH, Tiwari A, Barth-Jaeggi T, Arif MA, Banstola NL, Baskota R, Blaney D, Blok DJ, Bonenberger M, Budiawan T, Cavaliero A, Gani Z, Greter H, Ignotti E, Kamara DV, Kasang C, Manglani PR, Mieras L, Njako BF, Pakasi T, Pandey BD, Saunderson P, Singh R, Smith WCS, Stäheli R, Suriyarachchi ND, Tin Maung A, Shwe T, van Berkel J, van Brakel WH, Vander Plaetse B, Virmond M, Wijesinghe MSD, Aerts A, Steinmann P
Lancet Glob Health 2021 Jan;9(1):e81-e90. Epub 2020 Oct 29 doi: 10.1016/S2214-109X(20)30396-X. PMID: 33129378
Variation and risk factors of drug resistant tuberculosis in sub-Saharan Africa: a systematic review and meta-analysis.
Lukoye D, Ssengooba W, Musisi K, Kasule GW, Cobelens FG, Joloba M, Gomez GB
BMC Public Health 2015 Mar 25;15:291. doi: 10.1186/s12889-015-1614-8. PMID: 25880829Free PMC Article
Safety and efficacy assessment of two new leprosy skin test antigens: randomized double blind clinical study.
Rivoire BL, Groathouse NA, TerLouw S, Neupane KD, Ranjit C, Sapkota BR, Khadge S, Kunwar CB, Macdonald M, Hawksworth R, Thapa MB, Hagge DA, Tibbals M, Smith C, Dube T, She D, Wolff M, Zhou E, Makhene M, Mason R, Sizemore C, Brennan PJ
PLoS Negl Trop Dis 2014;8(5):e2811. Epub 2014 May 29 doi: 10.1371/journal.pntd.0002811. PMID: 24874401Free PMC Article

Prognosis

Co-infection leprosy and tuberculosis: a systematic review.
Cavalcante Trindade L, Da Silveira Mendes M, Conceição Martins L, Carlos Evangelista de A Bonfim A, Fonseca FLA
J Infect Dev Ctries 2021 Nov 30;15(11):1569-1577. doi: 10.3855/jidc.14308. PMID: 34898480
Assessment of the tuberculosis case-finding and prevention cascade among people living with HIV in Zambia - 2018: a cross-sectional cluster survey.
Melgar M, Shiraishi RW, Tende C, Mwanza S, Mulenga J, Khondowe S, Mwakazanga D, Kapungu K, Tembo M, Nota A, Lungu P, Moore B, Podewils LJ
BMC Public Health 2021 May 4;21(1):859. doi: 10.1186/s12889-021-10929-z. PMID: 33947361Free PMC Article
Evaluation of the performance of clinical predictors in estimating the probability of pulmonary tuberculosis among smear-negative cases in Northern Ethiopia: a cross-sectional study.
George M, Dinant GJ, Kentiba E, Teshome T, Teshome A, Tsegaye B, Spigt M
BMJ Open 2020 Nov 3;10(11):e037913. doi: 10.1136/bmjopen-2020-037913. PMID: 33148731Free PMC Article

Clinical prediction guides

Evaluation of the performance of clinical predictors in estimating the probability of pulmonary tuberculosis among smear-negative cases in Northern Ethiopia: a cross-sectional study.
George M, Dinant GJ, Kentiba E, Teshome T, Teshome A, Tsegaye B, Spigt M
BMJ Open 2020 Nov 3;10(11):e037913. doi: 10.1136/bmjopen-2020-037913. PMID: 33148731Free PMC Article
Pleural fluid ADA activity in tuberculous pleurisy can be low in elderly, critically ill patients with multi-organ failure.
Kim SB, Shin B, Lee JH, Lee SJ, Lee MK, Lee WY, Yong SJ, Kim SH
BMC Pulm Med 2020 Jan 14;20(1):13. doi: 10.1186/s12890-020-1049-6. PMID: 31937286Free PMC Article
Possible cases of leprosy from the Late Copper Age (3780-3650 cal BC) in Hungary.
Köhler K, Marcsik A, Zádori P, Biro G, Szeniczey T, Fábián S, Serlegi G, Marton T, Donoghue HD, Hajdu T
PLoS One 2017;12(10):e0185966. Epub 2017 Oct 12 doi: 10.1371/journal.pone.0185966. PMID: 29023477Free PMC Article
An RFLP map for 2q33-q37 from multicase mycobacterial and leishmanial disease families: no evidence for an Lsh/Ity/Bcg gene homologue influencing susceptibility to leprosy.
Shaw MA, Atkinson S, Dockrell H, Hussain R, Lins-Lainson Z, Shaw J, Ramos F, Silveira F, Mehdi SQ, Kaukab F
Ann Hum Genet 1993 Oct;57(4):251-71. doi: 10.1111/j.1469-1809.1993.tb00899.x. PMID: 7910002
T cell reactivity to the purified mycobacterial antigens p65 and p70 in leprosy patients and their household contacts.
Adams E, Garsia RJ, Hellqvist L, Holt P, Basten A
Clin Exp Immunol 1990 May;80(2):206-12. doi: 10.1111/j.1365-2249.1990.tb05235.x. PMID: 2192825Free PMC Article

Recent systematic reviews

Co-infection leprosy and tuberculosis: a systematic review.
Cavalcante Trindade L, Da Silveira Mendes M, Conceição Martins L, Carlos Evangelista de A Bonfim A, Fonseca FLA
J Infect Dev Ctries 2021 Nov 30;15(11):1569-1577. doi: 10.3855/jidc.14308. PMID: 34898480
Mapping the global distribution of Buruli ulcer: a systematic review with evidence consensus.
Simpson H, Deribe K, Tabah EN, Peters A, Maman I, Frimpong M, Ampadu E, Phillips R, Saunderson P, Pullan RL, Cano J
Lancet Glob Health 2019 Jul;7(7):e912-e922. doi: 10.1016/S2214-109X(19)30171-8. PMID: 31200890Free PMC Article
Variation and risk factors of drug resistant tuberculosis in sub-Saharan Africa: a systematic review and meta-analysis.
Lukoye D, Ssengooba W, Musisi K, Kasule GW, Cobelens FG, Joloba M, Gomez GB
BMC Public Health 2015 Mar 25;15:291. doi: 10.1186/s12889-015-1614-8. PMID: 25880829Free PMC Article

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