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Buruli ulcer(BUD)

MedGen UID:
43206
•Concept ID:
C0085568
•
Disease or Syndrome
Synonyms: BUD; Buruli ulcer disease
SNOMED CT: Buruli ulcer (15845006); Infection due to Mycobacterium ulcerans (15845006); Searles's ulcer (15845006); Cutaneous mycobacterium ulcerans infection (15845006)
 
Monarch Initiative: MONDO:0000327

Definition

A cutaneous infection caused by Mycobacterium ulcerans. It presents with painless nodular swelling of the skin, leading to the formation of necrotizing ulcers. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBuruli ulcer

Professional guidelines

PubMed

Pharmacologic management of Mycobacterium ulcerans infection.
Van Der Werf TS, Barogui YT, Converse PJ, Phillips RO, Stienstra Y
Expert Rev Clin Pharmacol 2020 Apr;13(4):391-401. Epub 2020 Apr 20 doi: 10.1080/17512433.2020.1752663. PMID: 32310683Free PMC Article
Lipid-Based Nanocarriers for Cutaneous Leishmaniais and Buruli Ulcer Management.
Simoes S, Carvalheiro M, Gaspar MM
Curr Pharm Des 2016;22(43):6577-6586. doi: 10.2174/1381612822666160701083812. PMID: 27396598
Epidemiology and management of Buruli ulcer.
Huang GK, Johnson PD
Expert Rev Anti Infect Ther 2014 Jul;12(7):855-65. doi: 10.1586/14787210.2014.910113. PMID: 24918117

Recent clinical studies

Etiology

Mycobacterial skin infection.
Gardini G, Gregori N, Matteelli A, Castelli F
Curr Opin Infect Dis 2022 Apr 1;35(2):79-87. doi: 10.1097/QCO.0000000000000820. PMID: 35067521Free PMC Article
Proteomics of Select Neglected Tropical Diseases.
Saviola AJ, Negrão F, Yates JR 3rd
Annu Rev Anal Chem (Palo Alto Calif) 2020 Jun 12;13(1):315-336. Epub 2020 Feb 28 doi: 10.1146/annurev-anchem-091619-093003. PMID: 32109150
Cutaneous Mycobacterial Infections.
Franco-Paredes C, Marcos LA, Henao-Martínez AF, Rodríguez-Morales AJ, Villamil-Gómez WE, Gotuzzo E, Bonifaz A
Clin Microbiol Rev 2018 Jan;32(1) Epub 2018 Nov 14 doi: 10.1128/CMR.00069-18. PMID: 30429139Free PMC Article
Ecohealth research in Africa: Where from-Where to?
Bergquist R, Brattig NW, Chimbari MJ, Zinsstag J, Utzinger J
Acta Trop 2017 Nov;175:1-8. Epub 2017 Jul 18 doi: 10.1016/j.actatropica.2017.07.015. PMID: 28733024
Revisiting Buruli ulcer.
Yotsu RR, Murase C, Sugawara M, Suzuki K, Nakanaga K, Ishii N, Asiedu K
J Dermatol 2015 Nov;42(11):1033-41. Epub 2015 Sep 1 doi: 10.1111/1346-8138.13049. PMID: 26332541

Diagnosis

Mycobacterial skin infection.
Gardini G, Gregori N, Matteelli A, Castelli F
Curr Opin Infect Dis 2022 Apr 1;35(2):79-87. doi: 10.1097/QCO.0000000000000820. PMID: 35067521Free PMC Article
Cutaneous Mycobacterial Infections.
Franco-Paredes C, Marcos LA, Henao-Martínez AF, Rodríguez-Morales AJ, Villamil-Gómez WE, Gotuzzo E, Bonifaz A
Clin Microbiol Rev 2018 Jan;32(1) Epub 2018 Nov 14 doi: 10.1128/CMR.00069-18. PMID: 30429139Free PMC Article
Revisiting Buruli ulcer.
Yotsu RR, Murase C, Sugawara M, Suzuki K, Nakanaga K, Ishii N, Asiedu K
J Dermatol 2015 Nov;42(11):1033-41. Epub 2015 Sep 1 doi: 10.1111/1346-8138.13049. PMID: 26332541
Buruli ulcer.
Boleira M, Lupi O, Lehman L, Asiedu KB, Kiszewski AE
An Bras Dermatol 2010 May-Jun;85(3):281-298; quiz 299-301. doi: 10.1590/s0365-05962010000300002. PMID: 20676462
Buruli ulcer.
Portaels F, Silva MT, Meyers WM
Clin Dermatol 2009 May-Jun;27(3):291-305. doi: 10.1016/j.clindermatol.2008.09.021. PMID: 19362692

Therapy

Mycobacterial skin infection.
Gardini G, Gregori N, Matteelli A, Castelli F
Curr Opin Infect Dis 2022 Apr 1;35(2):79-87. doi: 10.1097/QCO.0000000000000820. PMID: 35067521Free PMC Article
Pharmacologic management of Mycobacterium ulcerans infection.
Van Der Werf TS, Barogui YT, Converse PJ, Phillips RO, Stienstra Y
Expert Rev Clin Pharmacol 2020 Apr;13(4):391-401. Epub 2020 Apr 20 doi: 10.1080/17512433.2020.1752663. PMID: 32310683Free PMC Article
Management of BU-HIV co-infection.
O'Brien DP, Ford N, Vitoria M, Christinet V, Comte E, Calmy A, Stienstra Y, Eholie S, Asiedu K
Trop Med Int Health 2014 Sep;19(9):1040-7. Epub 2014 Jun 20 doi: 10.1111/tmi.12342. PMID: 24946829
Epidemiology and management of Buruli ulcer.
Huang GK, Johnson PD
Expert Rev Anti Infect Ther 2014 Jul;12(7):855-65. doi: 10.1586/14787210.2014.910113. PMID: 24918117
Buruli ulcer disease.
Ofori-Adjei D
Ghana Med J 2011 Mar;45(1):1. PMID: 21572816Free PMC Article

Prognosis

Mycobacterial skin infection.
Gardini G, Gregori N, Matteelli A, Castelli F
Curr Opin Infect Dis 2022 Apr 1;35(2):79-87. doi: 10.1097/QCO.0000000000000820. PMID: 35067521Free PMC Article
Methods and Approaches for Buruli Ulcer Surveillance in Africa: Lessons Learnt and Future Directions.
Timothy JWS, Pullan RL, Yotsu RR
Methods Mol Biol 2022;2387:87-102. doi: 10.1007/978-1-0716-1779-3_10. PMID: 34643905
Hand Infections: Epidemiology and Public Health Burden.
Gundlach BK, Sasor SE, Chung KC
Hand Clin 2020 Aug;36(3):275-283. doi: 10.1016/j.hcl.2020.03.001. PMID: 32586453Free PMC Article
The Buruli Ulcer.
Kumar S, Basu S, Bhartiya SK, Shukla VK
Int J Low Extrem Wounds 2015 Sep;14(3):217-23. Epub 2015 Aug 18 doi: 10.1177/1534734615599653. PMID: 26286931
Buruli ulcer disease.
Ofori-Adjei D
Ghana Med J 2011 Mar;45(1):1. PMID: 21572816Free PMC Article

Clinical prediction guides

Pharmacologic management of Mycobacterium ulcerans infection.
Van Der Werf TS, Barogui YT, Converse PJ, Phillips RO, Stienstra Y
Expert Rev Clin Pharmacol 2020 Apr;13(4):391-401. Epub 2020 Apr 20 doi: 10.1080/17512433.2020.1752663. PMID: 32310683Free PMC Article
Mycobacterium ulcerans mycolactones-fungi crosstalking.
Hammoudi N, Cassagne C, Armstrong N, Ranque S, Henrissat B, Drancourt M, Bouam A
Sci Rep 2019 Feb 28;9(1):3028. doi: 10.1038/s41598-019-39927-3. PMID: 30816261Free PMC Article
Human genetics of mycobacterial disease.
Dallmann-Sauer M, Correa-Macedo W, Schurr E
Mamm Genome 2018 Aug;29(7-8):523-538. Epub 2018 Aug 16 doi: 10.1007/s00335-018-9765-4. PMID: 30116885Free PMC Article
Improving clinical and epidemiological predictors of Buruli ulcer.
Ayelo GA, Sopoh GE, Houezo JG, Fiodessihoue R, Affolabi D, Dossou AD, Barogui YT, Wadagni AAC, Agossadou DC, Hasker E, Portaels F, de Jong BC, Eddyani M
PLoS Negl Trop Dis 2018 Aug;12(8):e0006713. Epub 2018 Aug 6 doi: 10.1371/journal.pntd.0006713. PMID: 30080870Free PMC Article
Buruli ulcer and mycolactone-producing mycobacteria.
Nakanaga K, Yotsu RR, Hoshino Y, Suzuki K, Makino M, Ishii N
Jpn J Infect Dis 2013;66(2):83-8. doi: 10.7883/yoken.66.83. PMID: 23514902

Recent systematic reviews

Mapping the global distribution of Buruli ulcer: a systematic review with evidence consensus.
Simpson H, Deribe K, Tabah EN, Peters A, Maman I, Frimpong M, Ampadu E, Phillips R, Saunderson P, Pullan RL, Cano J
Lancet Glob Health 2019 Jul;7(7):e912-e922. doi: 10.1016/S2214-109X(19)30171-8. PMID: 31200890Free PMC Article
Effectiveness of rifampicin-streptomycin for treatment of Buruli ulcer: a systematic review.
Tanywe A, Fernandez RS
JBI Database System Rev Implement Rep 2017 Jan;15(1):119-139. doi: 10.11124/JBISRIR-2016-003235. PMID: 28085731
The impact of community health workers (CHWs) on Buruli ulcer in sub-Saharan Africa: a systematic review.
Vouking MZ, Tamo VC, Mbuagbaw L
Pan Afr Med J 2013;15:19. Epub 2013 May 10 doi: 10.11604/pamj.2013.15.19.1991. PMID: 24009795Free PMC Article
Neglected tropical diseases: survey and geometry of randomised evidence.
Kappagoda S, Ioannidis JP
BMJ 2012 Oct 22;345:e6512. doi: 10.1136/bmj.e6512. PMID: 23089149Free PMC Article
Ecology and transmission of Buruli ulcer disease: a systematic review.
Merritt RW, Walker ED, Small PL, Wallace JR, Johnson PD, Benbow ME, Boakye DA
PLoS Negl Trop Dis 2010 Dec 14;4(12):e911. doi: 10.1371/journal.pntd.0000911. PMID: 21179505Free PMC Article

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