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Lipedema

MedGen UID:
451048
Concept ID:
C0398370
Disease or Syndrome
Synonyms: Lipedemas; Lipoedema; Lipoedemas
SNOMED CT: Lipedema (234102003)
 
HPO: HP:0100695
Monarch Initiative: MONDO:0013577
OMIM®: 614103

Definition

Excess deposit and expansion of adipose tissue in an unusual pattern which cannot be lost through diet and exercise . [from HPO]

Clinical features

From HPO
Lipedema
MedGen UID:
451048
Concept ID:
C0398370
Disease or Syndrome
Excess deposit and expansion of adipose tissue in an unusual pattern which cannot be lost through diet and exercise .
Edema
MedGen UID:
4451
Concept ID:
C0013604
Pathologic Function
An abnormal accumulation of fluid beneath the skin, or in one or more cavities of the body.
  • Abnormality of metabolism/homeostasis
  • Abnormality of the musculoskeletal system

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • Lipedema
Follow this link to review classifications for Lipedema in Orphanet.

Conditions with this feature

Lipedema
MedGen UID:
451048
Concept ID:
C0398370
Disease or Syndrome
Excess deposit and expansion of adipose tissue in an unusual pattern which cannot be lost through diet and exercise .

Professional guidelines

PubMed

Forner-Cordero I, Forner-Cordero A, Szolnoky G
Int Angiol 2021 Aug;40(4):345-357. Epub 2021 Apr 19 doi: 10.23736/S0392-9590.21.04604-6. PMID: 33870676
Aksoy H, Karadag AS, Wollina U
Dermatol Ther 2021 Jan;34(1):e14364. Epub 2020 Oct 12 doi: 10.1111/dth.14364. PMID: 33001552
Kruppa P, Georgiou I, Biermann N, Prantl L, Klein-Weigel P, Ghods M
Dtsch Arztebl Int 2020 Jun 1;117(22-23):396-403. doi: 10.3238/arztebl.2020.0396. PMID: 32762835Free PMC Article

Recent clinical studies

Etiology

Kiani AK, Pheby D, Henehan G, Brown R, Sieving P, Sykora P, Marks R, Falsini B, Capodicasa N, Miertus S, Lorusso L, Dondossola D, Tartaglia GM, Ergoren MC, Dundar M, Michelini S, Malacarne D, Bonetti G, Dautaj A, Donato K, Medori MC, Beccari T, Samaja M, Connelly ST, Martin D, Morresi A, Bacu A, Herbst KL, Kapustin M, Stuppia L, Lumer L, Farronato G, Bertelli M; INTERNATIONAL BIOETHICS STUDY GROUP
J Prev Med Hyg 2022 Jun;63(2 Suppl 3):E255-E266. Epub 2022 Oct 17 doi: 10.15167/2421-4248/jpmh2022.63.2S3.2768. PMID: 36479489Free PMC Article
Dhuli K, Naureen Z, Medori MC, Fioretti F, Caruso P, Perrone MA, Nodari S, Manganotti P, Xhufi S, Bushati M, Bozo D, Connelly ST, Herbst KL, Bertelli M
J Prev Med Hyg 2022 Jun;63(2 Suppl 3):E150-E159. Epub 2022 Oct 17 doi: 10.15167/2421-4248/jpmh2022.63.2S3.2756. PMID: 36479484Free PMC Article
Kiani AK, Bonetti G, Donato K, Kaftalli J, Herbst KL, Stuppia L, Fioretti F, Nodari S, Perrone M, Chiurazzi P, Bellinato F, Gisondi P, Bertelli M
J Prev Med Hyg 2022 Jun;63(2 Suppl 3):E125-E141. Epub 2022 Oct 17 doi: 10.15167/2421-4248/jpmh2022.63.2S3.2754. PMID: 36479483Free PMC Article
Kiani AK, Naureen Z, Pheby D, Henehan G, Brown R, Sieving P, Sykora P, Marks R, Falsini B, Capodicasa N, Miertus S, Lorusso L, Dondossola D, Tartaglia GM, Ergoren MC, Dundar M, Michelini S, Malacarne D, Bonetti G, Donato K, Medori MC, Beccari T, Samaja M, Connelly ST, Martin D, Morresi A, Bacu A, Herbst KL, Kapustin M, Stuppia L, Lumer L, Farronato G, Bertelli M; INTERNATIONAL BIOETHICS STUDY GROUP
J Prev Med Hyg 2022 Jun;63(2 Suppl 3):E267-E278. Epub 2022 Oct 17 doi: 10.15167/2421-4248/jpmh2022.63.2S3.2769. PMID: 36479476Free PMC Article
Forner-Cordero I, Forner-Cordero A, Szolnoky G
Int Angiol 2021 Aug;40(4):345-357. Epub 2021 Apr 19 doi: 10.23736/S0392-9590.21.04604-6. PMID: 33870676

Diagnosis

van la Parra RFD, Deconinck C, Pirson G, Servaes M, Fosseprez P
J Plast Reconstr Aesthet Surg 2023 Sep;84:302-312. Epub 2023 May 30 doi: 10.1016/j.bjps.2023.05.056. PMID: 37390539
Herbst KL, Kahn LA, Iker E, Ehrlich C, Wright T, McHutchison L, Schwartz J, Sleigh M, Donahue PM, Lisson KH, Faris T, Miller J, Lontok E, Schwartz MS, Dean SM, Bartholomew JR, Armour P, Correa-Perez M, Pennings N, Wallace EL, Larson E
Phlebology 2021 Dec;36(10):779-796. Epub 2021 May 28 doi: 10.1177/02683555211015887. PMID: 34049453Free PMC Article
Forner-Cordero I, Forner-Cordero A, Szolnoky G
Int Angiol 2021 Aug;40(4):345-357. Epub 2021 Apr 19 doi: 10.23736/S0392-9590.21.04604-6. PMID: 33870676
Aksoy H, Karadag AS, Wollina U
Dermatol Ther 2021 Jan;34(1):e14364. Epub 2020 Oct 12 doi: 10.1111/dth.14364. PMID: 33001552
Kruppa P, Georgiou I, Biermann N, Prantl L, Klein-Weigel P, Ghods M
Dtsch Arztebl Int 2020 Jun 1;117(22-23):396-403. doi: 10.3238/arztebl.2020.0396. PMID: 32762835Free PMC Article

Therapy

Di Renzo L, Gualtieri P, Zomparelli S, De Santis GL, Seraceno S, Zuena C, Frank G, Cianci R, Centofanti D, De Lorenzo A
Nutrients 2023 Aug 20;15(16) doi: 10.3390/nu15163654. PMID: 37630844Free PMC Article
Seefeldt T, Aitzetmüller-Klietz ML, Kückelhaus M, Wiebringhaus P, Hirsch T, Harati K, Aitzetmüller-Klietz MM
J Dtsch Dermatol Ges 2023 Jun;21(6):601-609. Epub 2023 May 15 doi: 10.1111/ddg.15064. PMID: 37190925
Forner-Cordero I, Forner-Cordero A, Szolnoky G
Int Angiol 2021 Aug;40(4):345-357. Epub 2021 Apr 19 doi: 10.23736/S0392-9590.21.04604-6. PMID: 33870676
Shavit E, Wollina U, Alavi A
Int Wound J 2018 Dec;15(6):921-928. Epub 2018 Jun 29 doi: 10.1111/iwj.12949. PMID: 29956468Free PMC Article
Okhovat JP, Alavi A
Int J Low Extrem Wounds 2015 Sep;14(3):262-7. Epub 2014 Oct 17 doi: 10.1177/1534734614554284. PMID: 25326446

Prognosis

Kempa S, Buechler C, Föh B, Felthaus O, Prantl L, Günther UL, Müller M, Derer-Petersen S, Sina C, Schmelter F, Tews HC
Int J Mol Sci 2023 Dec 13;24(24) doi: 10.3390/ijms242417437. PMID: 38139266Free PMC Article
Duhon BH, Phan TT, Taylor SL, Crescenzi RL, Rutkowski JM
Int J Mol Sci 2022 Jun 14;23(12) doi: 10.3390/ijms23126621. PMID: 35743063Free PMC Article
Reich-Schupke S, Schmeller W, Brauer WJ, Cornely ME, Faerber G, Ludwig M, Lulay G, Miller A, Rapprich S, Richter DF, Schacht V, Schrader K, Stücker M, Ure C
J Dtsch Dermatol Ges 2017 Jul;15(7):758-767. doi: 10.1111/ddg.13036. PMID: 28677175
Okhovat JP, Alavi A
Int J Low Extrem Wounds 2015 Sep;14(3):262-7. Epub 2014 Oct 17 doi: 10.1177/1534734614554284. PMID: 25326446
Reich-Schupke S, Altmeyer P, Stücker M
J Dtsch Dermatol Ges 2013 Mar;11(3):225-33. Epub 2012 Dec 11 doi: 10.1111/ddg.12024. PMID: 23231593

Clinical prediction guides

Kempa S, Buechler C, Föh B, Felthaus O, Prantl L, Günther UL, Müller M, Derer-Petersen S, Sina C, Schmelter F, Tews HC
Int J Mol Sci 2023 Dec 13;24(24) doi: 10.3390/ijms242417437. PMID: 38139266Free PMC Article
Di Renzo L, Gualtieri P, Zomparelli S, De Santis GL, Seraceno S, Zuena C, Frank G, Cianci R, Centofanti D, De Lorenzo A
Nutrients 2023 Aug 20;15(16) doi: 10.3390/nu15163654. PMID: 37630844Free PMC Article
Kiani AK, Naureen Z, Pheby D, Henehan G, Brown R, Sieving P, Sykora P, Marks R, Falsini B, Capodicasa N, Miertus S, Lorusso L, Dondossola D, Tartaglia GM, Ergoren MC, Dundar M, Michelini S, Malacarne D, Bonetti G, Donato K, Medori MC, Beccari T, Samaja M, Connelly ST, Martin D, Morresi A, Bacu A, Herbst KL, Kapustin M, Stuppia L, Lumer L, Farronato G, Bertelli M; INTERNATIONAL BIOETHICS STUDY GROUP
J Prev Med Hyg 2022 Jun;63(2 Suppl 3):E267-E278. Epub 2022 Oct 17 doi: 10.15167/2421-4248/jpmh2022.63.2S3.2769. PMID: 36479476Free PMC Article
Di Renzo L, Cinelli G, Romano L, Zomparelli S, Lou De Santis G, Nocerino P, Bigioni G, Arsini L, Cenname G, Pujia A, Chiricolo G, De Lorenzo A
Nutrients 2021 Jan 25;13(2) doi: 10.3390/nu13020358. PMID: 33504026Free PMC Article
Kruppa P, Georgiou I, Biermann N, Prantl L, Klein-Weigel P, Ghods M
Dtsch Arztebl Int 2020 Jun 1;117(22-23):396-403. doi: 10.3238/arztebl.2020.0396. PMID: 32762835Free PMC Article

Recent systematic reviews

van la Parra RFD, Deconinck C, Krug B
Obes Rev 2024 Jan;25(1):e13648. Epub 2023 Oct 3 doi: 10.1111/obr.13648. PMID: 37789512
Czerwińska M, Ostrowska P, Hansdorfer-Korzon R
Int J Environ Res Public Health 2021 Sep 28;18(19) doi: 10.3390/ijerph181910223. PMID: 34639524Free PMC Article
Schmidt J, Kruppa P, Georgiou I, Ghods M
Clin Hemorheol Microcirc 2021;78(3):311-324. doi: 10.3233/CH-201063. PMID: 33814418
Halk AB, Damstra RJ
Phlebology 2017 Apr;32(3):152-159. Epub 2016 Jul 9 doi: 10.1177/0268355516639421. PMID: 27075680

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