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Malignant Gastrointestinal Stromal Tumor

MedGen UID:
465816
•Concept ID:
C3179349
•
Neoplastic Process
Synonym: Gastrointestinal Stromal Sarcoma
SNOMED CT: Gastrointestinal stromal tumor, malignant (128756002); Gastrointestinal stromal sarcoma (128756002); Gastrointestinal stromal sarcoma (420120006); Malignant GIST (gastrointestinal stromal tumor) (128756002)

Definition

A gastrointestinal stromal tumor that is characterized by large size (diameter greater than 10 cm for gastric localization and greater than 5 cm for intestinal localization) or more than 5 mitotic figures per 50 high power fields. [from NCI]

Professional guidelines

PubMed

Giant malignant gastrointestinal stromal tumors: recurrence and effects of treatment with STI-571.
Chen TW, Liu HD, Shyu RY, Yu JC, Shih ML, Chang TM, Hsieh CB
World J Gastroenterol 2005 Jan 14;11(2):260-3. doi: 10.3748/wjg.v11.i2.260. PMID: 15633227Free PMC Article

Recent clinical studies

Etiology

The radiology of gastrointestinal stromal tumours (GIST).
King DM
Cancer Imaging 2005 Dec 15;5(1):150-6. doi: 10.1102/1470-7330.2005.0109. PMID: 16361144Free PMC Article
Giant malignant gastrointestinal stromal tumors: recurrence and effects of treatment with STI-571.
Chen TW, Liu HD, Shyu RY, Yu JC, Shih ML, Chang TM, Hsieh CB
World J Gastroenterol 2005 Jan 14;11(2):260-3. doi: 10.3748/wjg.v11.i2.260. PMID: 15633227Free PMC Article
Malignant gastrointestinal stromal tumor of the gallbladder.
Park JK, Choi SH, Lee S, Min KO, Yun SS, Jeon HM
J Korean Med Sci 2004 Oct;19(5):763-7. doi: 10.3346/jkms.2004.19.5.763. PMID: 15483360Free PMC Article
Malignant gastrointestinal leiomyosarcoma and gastrointestinal stromal tumor with prominent osteoclast-like giant cells.
Insabato L, Di Vizio D, Ciancia G, Pettinato G, Tornillo L, Terracciano L
Arch Pathol Lab Med 2004 Apr;128(4):440-3. doi: 10.5858/2004-128-440-MGLAGS. PMID: 15043462
Malignant gastrointestinal stromal tumor: distribution, imaging features, and pattern of metastatic spread.
Burkill GJ, Badran M, Al-Muderis O, Meirion Thomas J, Judson IR, Fisher C, Moskovic EC
Radiology 2003 Feb;226(2):527-32. doi: 10.1148/radiol.2262011880. PMID: 12563150

Diagnosis

Malignant gastrointestinal stromal tumor in association with Russell body gastritis-A case report.
Bozhkova DM, Koleva-Ivanova MS, Belovejdov VT, Dikov DI
Indian J Pathol Microbiol 2021 Jun;64(Supplement):S89-S91. doi: 10.4103/IJPM.IJPM_842_19. PMID: 34135145
Malignant gastrointestinal stromal tumor of the tongue: case report and review of the literature.
Ibrahim HH, Ahmad MS, Eskaf WA, Schuütz P
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2011 May;111(5):e24-9. doi: 10.1016/j.tripleo.2010.12.024. PMID: 21497732
The radiology of gastrointestinal stromal tumours (GIST).
King DM
Cancer Imaging 2005 Dec 15;5(1):150-6. doi: 10.1102/1470-7330.2005.0109. PMID: 16361144Free PMC Article
Malignant gastrointestinal leiomyosarcoma and gastrointestinal stromal tumor with prominent osteoclast-like giant cells.
Insabato L, Di Vizio D, Ciancia G, Pettinato G, Tornillo L, Terracciano L
Arch Pathol Lab Med 2004 Apr;128(4):440-3. doi: 10.5858/2004-128-440-MGLAGS. PMID: 15043462
Malignant gastrointestinal stromal tumor: distribution, imaging features, and pattern of metastatic spread.
Burkill GJ, Badran M, Al-Muderis O, Meirion Thomas J, Judson IR, Fisher C, Moskovic EC
Radiology 2003 Feb;226(2):527-32. doi: 10.1148/radiol.2262011880. PMID: 12563150

Therapy

Recurrence of gastric gastrointestinal stromal tumor 12 years after repeat hepatectomies for liver metastases: report of a case.
Fujinaga A, Ohta M, Masuda T, Itai Y, Nakanuma H, Kawasaki T, Kawano Y, Hirashita T, Endo Y, Inomata M
Clin J Gastroenterol 2021 Dec;14(6):1637-1641. Epub 2021 Sep 6 doi: 10.1007/s12328-021-01513-4. PMID: 34486081
Supraclavicular lymph node metastases from malignant gastrointestinal stromal tumor of the jejunum: A case report with review of the literature.
Ma C, Hao SL, Liu XC, Nin JY, Wu GC, Jiang LX, Fancellu A, Porcu A, Zheng HT
World J Gastroenterol 2017 Mar 14;23(10):1920-1924. doi: 10.3748/wjg.v23.i10.1920. PMID: 28348499Free PMC Article
Imatinib mesylate neoadjuvant treatment for rectal malignant gastrointestinal stromal tumor.
Hou YY, Zhou Y, Lu SH, Qi WD, Xu C, Hou J, Tan YS
World J Gastroenterol 2009 Apr 21;15(15):1910-3. doi: 10.3748/wjg.15.1910. PMID: 19370794Free PMC Article
The radiology of gastrointestinal stromal tumours (GIST).
King DM
Cancer Imaging 2005 Dec 15;5(1):150-6. doi: 10.1102/1470-7330.2005.0109. PMID: 16361144Free PMC Article
Giant malignant gastrointestinal stromal tumors: recurrence and effects of treatment with STI-571.
Chen TW, Liu HD, Shyu RY, Yu JC, Shih ML, Chang TM, Hsieh CB
World J Gastroenterol 2005 Jan 14;11(2):260-3. doi: 10.3748/wjg.v11.i2.260. PMID: 15633227Free PMC Article

Prognosis

Recurrence of gastric gastrointestinal stromal tumor 12 years after repeat hepatectomies for liver metastases: report of a case.
Fujinaga A, Ohta M, Masuda T, Itai Y, Nakanuma H, Kawasaki T, Kawano Y, Hirashita T, Endo Y, Inomata M
Clin J Gastroenterol 2021 Dec;14(6):1637-1641. Epub 2021 Sep 6 doi: 10.1007/s12328-021-01513-4. PMID: 34486081
Malignant gastrointestinal stromal tumor of the tongue: case report and review of the literature.
Ibrahim HH, Ahmad MS, Eskaf WA, Schuütz P
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2011 May;111(5):e24-9. doi: 10.1016/j.tripleo.2010.12.024. PMID: 21497732
Malignant gastrointestinal stromal tumor presenting with hemoperitoneum in puerperium: report of a case with review of the literature.
Varras M, Vlachakos N, Akrivis C, Vasilakaki T, Skafida E
World J Surg Oncol 2010 Nov 7;8:95. doi: 10.1186/1477-7819-8-95. PMID: 21054898Free PMC Article
Giant malignant gastrointestinal stromal tumors: recurrence and effects of treatment with STI-571.
Chen TW, Liu HD, Shyu RY, Yu JC, Shih ML, Chang TM, Hsieh CB
World J Gastroenterol 2005 Jan 14;11(2):260-3. doi: 10.3748/wjg.v11.i2.260. PMID: 15633227Free PMC Article
Malignant gastrointestinal leiomyosarcoma and gastrointestinal stromal tumor with prominent osteoclast-like giant cells.
Insabato L, Di Vizio D, Ciancia G, Pettinato G, Tornillo L, Terracciano L
Arch Pathol Lab Med 2004 Apr;128(4):440-3. doi: 10.5858/2004-128-440-MGLAGS. PMID: 15043462

Clinical prediction guides

Recurrence of gastric gastrointestinal stromal tumor 12 years after repeat hepatectomies for liver metastases: report of a case.
Fujinaga A, Ohta M, Masuda T, Itai Y, Nakanuma H, Kawasaki T, Kawano Y, Hirashita T, Endo Y, Inomata M
Clin J Gastroenterol 2021 Dec;14(6):1637-1641. Epub 2021 Sep 6 doi: 10.1007/s12328-021-01513-4. PMID: 34486081
Loss of chromosome 9p21 and decreased p16 expression correlate with malignant gastrointestinal stromal tumor.
Zhang Y, Cao H, Wang M, Zhao WY, Shen ZY, Shen DP, Ni XZ, Wu ZY, Shen YY, Song YY
World J Gastroenterol 2010 Oct 7;16(37):4716-24. doi: 10.3748/wjg.v16.i37.4716. PMID: 20872974Free PMC Article
The epidemiology of malignant gastrointestinal stromal tumors: an analysis of 1,458 cases from 1992 to 2000.
Tran T, Davila JA, El-Serag HB
Am J Gastroenterol 2005 Jan;100(1):162-8. doi: 10.1111/j.1572-0241.2005.40709.x. PMID: 15654796
Malignant gastrointestinal stromal tumor originating in the lesser omentum, complicated by rapidly progressive glomerulonephritis and gastric carcinoma.
Nakaya I, Iwata Y, Abe T, Yokoyama H, Oda Y, Nomura G
Intern Med 2004 Feb;43(2):102-5. doi: 10.2169/internalmedicine.43.102. PMID: 15005250
Secondary amyloidosis and gastrointestinal stromal tumors. A case report and discussion of pathogenesis.
Overstreet K, Barone RM, Robin HS
Arch Pathol Lab Med 2003 Apr;127(4):470-3. doi: 10.5858/2003-127-0470-SAAGST. PMID: 12683877

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