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Drug-induced agranulocytosis

MedGen UID:
543871
•Concept ID:
C0272178
•
Disease or Syndrome
Synonyms: Drug induced neutropenia; Drug-associated agranulocytosis; Drug-induced neutropenia; Idiosyncratic neutropenia
SNOMED CT: Drug-associated agranulocytosis (47318007); Drug induced neutropenia (47318007); Drug-induced neutropenia (47318007); Idiosyncratic neutropenia (47318007)
 
HPO: HP:0012235

Definition

A type of agranulocytosis related to ingestion of a specific medication. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDrug-induced agranulocytosis

Conditions with this feature

Carbimazole sensitivity
MedGen UID:
347127
•Concept ID:
C1859352
•
Finding
See: Condition Record
Carbimazole sensitivity

Professional guidelines

PubMed

Antithyroid Drug-Induced Agranulocytosis: State of the Art on Diagnosis and Management.
Vicente N, Cardoso L, Barros L, Carrilho F
Drugs R D 2017 Mar;17(1):91-96. doi: 10.1007/s40268-017-0172-1. PMID: 28105610Free PMC Article
Clinical presentation and management of drug-induced agranulocytosis.
Andrès E, Zimmer J, Mecili M, Weitten T, Alt M, Maloisel F
Expert Rev Hematol 2011 Apr;4(2):143-51. doi: 10.1586/ehm.11.12. PMID: 21495924
Idiosyncratic drug-induced agranulocytosis: possible mechanisms and management.
Tesfa D, Keisu M, Palmblad J
Am J Hematol 2009 Jul;84(7):428-34. doi: 10.1002/ajh.21433. PMID: 19459150

Recent clinical studies

Etiology

Antithyroid Drug-Induced Agranulocytosis: State of the Art on Diagnosis and Management.
Vicente N, Cardoso L, Barros L, Carrilho F
Drugs R D 2017 Mar;17(1):91-96. doi: 10.1007/s40268-017-0172-1. PMID: 28105610Free PMC Article
Nonchemotherapy drug-induced neutropenia and agranulocytosis: could medications be the culprit?
Pick AM, Nystrom KK
J Pharm Pract 2014 Oct;27(5):447-52. Epub 2014 Aug 14 doi: 10.1177/0897190014546115. PMID: 25124379
Non-chemotherapy drug-induced agranulocytosis.
Garbe E
Expert Opin Drug Saf 2007 May;6(3):323-35. doi: 10.1517/14740338.6.3.323. PMID: 17480181
Systematic review: agranulocytosis induced by nonchemotherapy drugs.
Andersohn F, Konzen C, Garbe E
Ann Intern Med 2007 May 1;146(9):657-65. doi: 10.7326/0003-4819-146-9-200705010-00009. PMID: 17470834
Population-based drug-induced agranulocytosis.
Ibáñez L, Vidal X, Ballarín E, Laporte JR
Arch Intern Med 2005 Apr 25;165(8):869-74. doi: 10.1001/archinte.165.8.869. PMID: 15851637

Diagnosis

Antithyroid Drug-Induced Agranulocytosis: State of the Art on Diagnosis and Management.
Vicente N, Cardoso L, Barros L, Carrilho F
Drugs R D 2017 Mar;17(1):91-96. doi: 10.1007/s40268-017-0172-1. PMID: 28105610Free PMC Article
Antithyroid drug-induced agranulocytosis.
Sun MT, Tsai CH, Shih KC
J Chin Med Assoc 2009 Aug;72(8):438-41. doi: 10.1016/S1726-4901(09)70402-2. PMID: 19687001
Systematic review: agranulocytosis induced by nonchemotherapy drugs.
Andersohn F, Konzen C, Garbe E
Ann Intern Med 2007 May 1;146(9):657-65. doi: 10.7326/0003-4819-146-9-200705010-00009. PMID: 17470834
Drug-induced agranulocytosis.
Drug Ther Bull 1997 Jul;35(7):49-52. doi: 10.1136/dtb.1997.35749. PMID: 9282424
Drug-induced agranulocytosis.
Pisciotta V
Drugs 1978 Feb;15(2):132-43. doi: 10.2165/00003495-197815020-00003. PMID: 342230

Therapy

Nitrofurantoin-induced agranulocytosis.
Lopes V, Ramos J, Dias P, Santos A
BMJ Case Rep 2021 Nov 11;14(11) doi: 10.1136/bcr-2021-246788. PMID: 34764131Free PMC Article
Non-chemotherapy drug-induced agranulocytosis.
Garbe E
Expert Opin Drug Saf 2007 May;6(3):323-35. doi: 10.1517/14740338.6.3.323. PMID: 17480181
Systematic review: agranulocytosis induced by nonchemotherapy drugs.
Andersohn F, Konzen C, Garbe E
Ann Intern Med 2007 May 1;146(9):657-65. doi: 10.7326/0003-4819-146-9-200705010-00009. PMID: 17470834
Population-based drug-induced agranulocytosis.
Ibáñez L, Vidal X, Ballarín E, Laporte JR
Arch Intern Med 2005 Apr 25;165(8):869-74. doi: 10.1001/archinte.165.8.869. PMID: 15851637
Drug-induced agranulocytosis.
Pisciotta V
Drugs 1978 Feb;15(2):132-43. doi: 10.2165/00003495-197815020-00003. PMID: 342230

Prognosis

Non-chemotherapy drug-induced neutropenia - an update.
Andrès E, Mourot-Cottet R
Expert Opin Drug Saf 2017 Nov;16(11):1235-1242. Epub 2017 Sep 17 doi: 10.1080/14740338.2017.1376645. PMID: 28879784
Antithyroid drug-induced agranulocytosis.
Sun MT, Tsai CH, Shih KC
J Chin Med Assoc 2009 Aug;72(8):438-41. doi: 10.1016/S1726-4901(09)70402-2. PMID: 19687001
Non-chemotherapy drug-induced agranulocytosis.
Garbe E
Expert Opin Drug Saf 2007 May;6(3):323-35. doi: 10.1517/14740338.6.3.323. PMID: 17480181
Population-based drug-induced agranulocytosis.
Ibáñez L, Vidal X, Ballarín E, Laporte JR
Arch Intern Med 2005 Apr 25;165(8):869-74. doi: 10.1001/archinte.165.8.869. PMID: 15851637
Spironolactone-induced agranulocytosis.
Whitling AM, Pérgola PE, Sang JL, Talbert RL
Ann Pharmacother 1997 May;31(5):582-5. doi: 10.1177/106002809703100511. PMID: 9161653

Clinical prediction guides

Non-chemotherapy drug-induced agranulocytosis in a tertiary hospital.
Navarro-Martínez R, Chover-Sierra E, Cauli O
Hum Exp Toxicol 2016 Mar;35(3):244-50. Epub 2015 Apr 5 doi: 10.1177/0960327115580603. PMID: 25845587
Current understanding of the mechanisms of idiosyncratic drug-induced agranulocytosis.
Johnston A, Uetrecht J
Expert Opin Drug Metab Toxicol 2015 Feb;11(2):243-57. Epub 2014 Nov 26 doi: 10.1517/17425255.2015.985649. PMID: 25424130
Idiosyncratic drug-induced agranulocytosis: possible mechanisms and management.
Tesfa D, Keisu M, Palmblad J
Am J Hematol 2009 Jul;84(7):428-34. doi: 10.1002/ajh.21433. PMID: 19459150
Antithyroid-drug-induced agranulocytosis complicated by life-threatening infections.
Sheng WH, Hung CC, Chen YC, Fang CT, Hsieh SM, Chang SC, Hsieh WC
QJM 1999 Aug;92(8):455-61. doi: 10.1093/qjmed/92.8.455. PMID: 10627862
Drug-induced agranulocytosis.
Heimpel H
Med Toxicol Adverse Drug Exp 1988 Nov-Dec;3(6):449-62. doi: 10.1007/BF03259896. PMID: 3063921

Recent systematic reviews

Associations of HLA genotypes with antithyroid drug-induced agranulocytosis: A systematic review and meta-analysis of pharmacogenomics studies.
Chen WT, Chi CC
Br J Clin Pharmacol 2019 Sep;85(9):1878-1887. Epub 2019 Jul 7 doi: 10.1111/bcp.13989. PMID: 31108563Free PMC Article
Systematic review: agranulocytosis induced by nonchemotherapy drugs.
Andersohn F, Konzen C, Garbe E
Ann Intern Med 2007 May 1;146(9):657-65. doi: 10.7326/0003-4819-146-9-200705010-00009. PMID: 17470834
Life-threatening sepsis following treatment for haemorrhoids: a systematic review.
McCloud JM, Jameson JS, Scott AN
Colorectal Dis 2006 Nov;8(9):748-55. doi: 10.1111/j.1463-1318.2006.01028.x. PMID: 17032319

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