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Pleomorphic liposarcoma

MedGen UID:
61457
Concept ID:
C0205825
Neoplastic Process
Synonyms: Liposarcoma, Pleomorphic; Pleomorphic Liposarcoma; Pleomorphic Liposarcomas
SNOMED CT: Pleomorphic liposarcoma (404071006); Pleomorphic liposarcoma (112683004)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
Concept ID:
CN307044
Finding
Source: Orphanet
clinical entity without genetic inheritance.
 
Monarch Initiative: MONDO:0020562
Orphanet: ORPHA99969

Definition

Pleomorphic liposarcoma (PLS), the rarest subtype of liposarcoma (LS; see this term), is an aggressive, fast growing tumor located usually in the deep soft tissues of the lower and upper extremities. It is characterized by a variable number of pleomorphic lipoblasts and, in contrast to dedifferentiated liposarcoma, it lacks any association with well-differentiated liposarcoma (see these terms). [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPleomorphic liposarcoma
Follow this link to review classifications for Pleomorphic liposarcoma in Orphanet.

Professional guidelines

PubMed

Schöffski P
Oncol Res Treat 2022;45(9):525-543. Epub 2022 May 24 doi: 10.1159/000524939. PMID: 35609512
Anderson WJ, Jo VY
Semin Diagn Pathol 2019 Mar;36(2):122-128. Epub 2019 Feb 28 doi: 10.1053/j.semdp.2019.02.007. PMID: 30852046
Crago AM, Dickson MA
Surg Oncol Clin N Am 2016 Oct;25(4):761-73. Epub 2016 Jul 30 doi: 10.1016/j.soc.2016.05.007. PMID: 27591497Free PMC Article

Curated

NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Soft Tissue Sarcoma, 2024

Recent clinical studies

Etiology

Wan L, Tu C, Qi L, Li Z
J Orthop Surg Res 2021 Mar 4;16(1):175. doi: 10.1186/s13018-021-02327-3. PMID: 33663547Free PMC Article
Creytens D
Virchows Arch 2020 Jan;476(1):29-39. Epub 2019 Sep 9 doi: 10.1007/s00428-019-02652-3. PMID: 31501988
Creytens D
Semin Diagn Pathol 2019 Mar;36(2):129-141. Epub 2019 Feb 28 doi: 10.1053/j.semdp.2019.02.008. PMID: 30853315
Hornick JL
Ann Diagn Pathol 2018 Dec;37:118-124. Epub 2018 Oct 11 doi: 10.1016/j.anndiagpath.2018.10.006. PMID: 30340082
Crago AM, Dickson MA
Surg Oncol Clin N Am 2016 Oct;25(4):761-73. Epub 2016 Jul 30 doi: 10.1016/j.soc.2016.05.007. PMID: 27591497Free PMC Article

Diagnosis

Dermawan JK
Surg Pathol Clin 2024 Mar;17(1):25-29. Epub 2023 Aug 1 doi: 10.1016/j.path.2023.06.005. PMID: 38278605
Hadjimichael AC, Bekos A, Tsukamoto S, Nitta Y, Righi A, Errani C, Mavrogenis AF
Orthopedics 2023 Mar-Apr;46(2):e72-e80. Epub 2022 Jul 25 doi: 10.3928/01477447-20220719-05. PMID: 35876778
Creytens D
Virchows Arch 2020 Jan;476(1):29-39. Epub 2019 Sep 9 doi: 10.1007/s00428-019-02652-3. PMID: 31501988
Anderson WJ, Jo VY
Semin Diagn Pathol 2019 Mar;36(2):122-128. Epub 2019 Feb 28 doi: 10.1053/j.semdp.2019.02.007. PMID: 30852046
Lee ATJ, Thway K, Huang PH, Jones RL
J Clin Oncol 2018 Jan 10;36(2):151-159. Epub 2017 Dec 8 doi: 10.1200/JCO.2017.74.9598. PMID: 29220294Free PMC Article

Therapy

Assi T, Ngo C, Faron M, Verret B, Lévy A, Honoré C, Hénon C, Le Péchoux C, Bahleda R, Le Cesne A
Curr Treat Options Oncol 2023 Nov;24(11):1598-1613. Epub 2023 Oct 16 doi: 10.1007/s11864-023-01139-3. PMID: 37843627
Schöffski P
Oncol Res Treat 2022;45(9):525-543. Epub 2022 May 24 doi: 10.1159/000524939. PMID: 35609512
Saponara M, Stacchiotti S, Gronchi A
Expert Rev Clin Pharmacol 2017 Apr;10(4):361-377. Epub 2017 Feb 13 doi: 10.1080/17512433.2017.1289086. PMID: 28135854
Crago AM, Dickson MA
Surg Oncol Clin N Am 2016 Oct;25(4):761-73. Epub 2016 Jul 30 doi: 10.1016/j.soc.2016.05.007. PMID: 27591497Free PMC Article
Manji GA, Schwartz GK
J Oncol Pract 2016 Mar;12(3):221-7. doi: 10.1200/JOP.2015.009860. PMID: 26962163

Prognosis

Wan L, Tu C, Qi L, Li Z
J Orthop Surg Res 2021 Mar 4;16(1):175. doi: 10.1186/s13018-021-02327-3. PMID: 33663547Free PMC Article
Creytens D
Virchows Arch 2020 Jan;476(1):29-39. Epub 2019 Sep 9 doi: 10.1007/s00428-019-02652-3. PMID: 31501988
Lee ATJ, Thway K, Huang PH, Jones RL
J Clin Oncol 2018 Jan 10;36(2):151-159. Epub 2017 Dec 8 doi: 10.1200/JCO.2017.74.9598. PMID: 29220294Free PMC Article
Saponara M, Stacchiotti S, Gronchi A
Expert Rev Clin Pharmacol 2017 Apr;10(4):361-377. Epub 2017 Feb 13 doi: 10.1080/17512433.2017.1289086. PMID: 28135854
Oliveira AM, Nascimento AG
Semin Diagn Pathol 2001 Nov;18(4):274-85. PMID: 11757868

Clinical prediction guides

Kojima N, Kubo T, Mori T, Satomi K, Matsushita Y, Iwata S, Yatabe Y, Ichimura K, Kawai A, Ichikawa H, Yoshida A
Virchows Arch 2024 Jan;484(1):71-81. Epub 2023 Sep 13 doi: 10.1007/s00428-023-03631-5. PMID: 37704823
Wan L, Tu C, Qi L, Li Z
J Orthop Surg Res 2021 Mar 4;16(1):175. doi: 10.1186/s13018-021-02327-3. PMID: 33663547Free PMC Article
Li CP, Liu DN, Zhou NN, Tian XY, Wang Z, Liu BN, Hao CY
Contrast Media Mol Imaging 2021;2021:7191363. Epub 2021 Jan 6 doi: 10.1155/2021/7191363. PMID: 33505228Free PMC Article
Saponara M, Stacchiotti S, Gronchi A
Expert Rev Clin Pharmacol 2017 Apr;10(4):361-377. Epub 2017 Feb 13 doi: 10.1080/17512433.2017.1289086. PMID: 28135854
Ghadimi MP, Liu P, Peng T, Bolshakov S, Young ED, Torres KE, Colombo C, Hoffman A, Broccoli D, Hornick JL, Lazar AJ, Pisters P, Pollock RE, Lev D
Cancer 2011 Dec 1;117(23):5359-69. Epub 2011 May 19 doi: 10.1002/cncr.26195. PMID: 21598240Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NCCN, 2024
      NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Soft Tissue Sarcoma, 2024

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