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Abnormal basophil count

MedGen UID:
663422
•Concept ID:
C0580547
•
Finding
Synonyms: Basophil count abnormal; Basophil count outside reference range
SNOMED CT: Basophil count abnormal (165528007); Basophil count outside reference range (165528007)
 
HPO: HP:0031806

Definition

Any deviation from the normal number of basophils per volume in the blood circulation. [from HPO]

Professional guidelines

PubMed

Evaluation of the Beckman Coulter UniCel DxH 800 and Abbott Diagnostics Cell-Dyn Sapphire hematology analyzers on pediatric and neonatal specimens in a tertiary care hospital.
Tan BT, Nava AJ, George TI
Am J Clin Pathol 2011 Jun;135(6):929-38. doi: 10.1309/AJCP2EXNSLGGRVSQ. PMID: 21571966
Proposal of a morphologic bone marrow response score for imatinib mesylate treatment in chronic myelogenous leukemia.
Lugli A, Ebnoether M, Cogliatti SB, Gratwohl A, Passweg J, Hess U, Korte W, Hawle H, Tinguely M, Borisch B, Mach-Pascual S, Von Juergensonn S, Tichelli A, Dirnhofer S
Hum Pathol 2005 Jan;36(1):91-100. doi: 10.1016/j.humpath.2004.10.012. PMID: 15712187
Blast crisis of Philadelphia chromosome-positive chronic myelocytic leukemia (CML). Treatment results of 69 patients.
Anger B, Carbonell F, Braunger I, Heinze B, Gutensohn W, Thiel E, Heimpel H
Blut 1988 Sep;57(3):131-7. doi: 10.1007/BF00320153. PMID: 3166389

Recent clinical studies

Etiology

Shared Genetic Loci Between Schizophrenia and White Blood Cell Counts Suggest Genetically Determined Systemic Immune Abnormalities.
Steen NE, Rahman Z, Szabo A, Hindley GFL, Parker N, Cheng W, Lin A, O'Connell KS, Sheikh MA, Shadrin A, Bahrami S, Karthikeyan S, Hoseth EZ, Dale AM, Aukrust P, Smeland OB, Ueland T, Frei O, Djurovic S, Andreassen OA
Schizophr Bull 2023 Sep 7;49(5):1345-1354. doi: 10.1093/schbul/sbad082. PMID: 37319439Free PMC Article
Abnormal peripheral blood cell counts in neurofibromatosis type 1.
Nobeyama Y, Yasuda KI, Asahina A
Sci Rep 2022 Nov 5;12(1):18800. doi: 10.1038/s41598-022-23739-z. PMID: 36335228Free PMC Article
Blood counts in children with Down syndrome.
Harvey S, Wolter-Warmerdam K, Hickey F, Daniels D, DomBourian M, Ambruso DR, McKinney C
Pediatr Blood Cancer 2022 Dec;69(12):e30002. Epub 2022 Sep 24 doi: 10.1002/pbc.30002. PMID: 36151966
Retrospective Study of Aging and Sex-Specific Risk Factors of COVID-19 with Hypertension in China.
Wang J, Zhang Y, Li K, Du K, Huang X, Zhou Z, Ma Y, Guo S, Hou Y, Li Q, Xu H, Huang J, Huang Q, Na H, Wang J, Wang X, Xiao Y, Zhu J, Chen H, Liu Z, Wang M, Zhang L, Wang W, Wan H
Cardiovasc Ther 2022;2022:5978314. Epub 2022 Jun 28 doi: 10.1155/2022/5978314. PMID: 35846735Free PMC Article
Leukocytosis: basics of clinical assessment.
Abramson N, Melton B
Am Fam Physician 2000 Nov 1;62(9):2053-60. PMID: 11087187

Diagnosis

Retrospective Study of Aging and Sex-Specific Risk Factors of COVID-19 with Hypertension in China.
Wang J, Zhang Y, Li K, Du K, Huang X, Zhou Z, Ma Y, Guo S, Hou Y, Li Q, Xu H, Huang J, Huang Q, Na H, Wang J, Wang X, Xiao Y, Zhu J, Chen H, Liu Z, Wang M, Zhang L, Wang W, Wan H
Cardiovasc Ther 2022;2022:5978314. Epub 2022 Jun 28 doi: 10.1155/2022/5978314. PMID: 35846735Free PMC Article
Performance evaluation of new Abbott Alinity hq hematology analyzer.
Woo KS, Jeong IH, An GD, Lim HH, Han JY
Int J Lab Hematol 2019 Oct;41(5):657-663. Epub 2019 Jul 4 doi: 10.1111/ijlh.13082. PMID: 31271528
Comparison of performance and abnormal cell flagging of two automated hematology analyzers: Sysmex XN 3000 and Beckman Coulter DxH 800.
Genc S, Dervisoglu E, Erdem S, Arslan O, Aktan M, Omer B
Int J Lab Hematol 2017 Dec;39(6):633-640. Epub 2017 Oct 4 doi: 10.1111/ijlh.12717. PMID: 28980399
Leukocytosis: basics of clinical assessment.
Abramson N, Melton B
Am Fam Physician 2000 Nov 1;62(9):2053-60. PMID: 11087187
Therapy-related leukemia: a panmyelosis.
Foucar K, McKenna RW, Bloomfield CD, Bowers TK, Brunning RD
Cancer 1979 Apr;43(4):1285-96. doi: 10.1002/1097-0142(197904)43:4<1285::aid-cncr2820430416>3.0.co;2-j. PMID: 445330

Therapy

Shared Genetic Loci Between Schizophrenia and White Blood Cell Counts Suggest Genetically Determined Systemic Immune Abnormalities.
Steen NE, Rahman Z, Szabo A, Hindley GFL, Parker N, Cheng W, Lin A, O'Connell KS, Sheikh MA, Shadrin A, Bahrami S, Karthikeyan S, Hoseth EZ, Dale AM, Aukrust P, Smeland OB, Ueland T, Frei O, Djurovic S, Andreassen OA
Schizophr Bull 2023 Sep 7;49(5):1345-1354. doi: 10.1093/schbul/sbad082. PMID: 37319439Free PMC Article
Dynamic hematological changes in patients undergoing distal pancreatectomy with or without splenectomy: a population-based cohort study.
Cui M, Liu JK, Zheng B, Liu QF, Zhang L, Zhang L, Guo JC, Dai MH, Zhang TP, Liao Q
BMC Surg 2020 Oct 31;20(1):265. doi: 10.1186/s12893-020-00931-4. PMID: 33129308Free PMC Article
Prognostic factors in chronic myeloid leukaemia.
Hernández-Boluda JC, Cervantes F
Best Pract Res Clin Haematol 2009 Sep;22(3):343-53. doi: 10.1016/j.beha.2009.04.005. PMID: 19959085
Syndromes of acute nonlymphocytic leukemia.
Koeffler HP
Ann Intern Med 1987 Nov;107(5):748-58. doi: 10.7326/0003-4819-107-5-748. PMID: 3310797
Therapy-related leukemia: a panmyelosis.
Foucar K, McKenna RW, Bloomfield CD, Bowers TK, Brunning RD
Cancer 1979 Apr;43(4):1285-96. doi: 10.1002/1097-0142(197904)43:4<1285::aid-cncr2820430416>3.0.co;2-j. PMID: 445330

Prognosis

Platelet parameters and leukocyte morphology is altered in COVID-19 patients compared to non-COVID-19 patients with similar symptomatology.
Alnor A, Sandberg MB, Toftanes BE, Vinholt PJ
Scand J Clin Lab Invest 2021 May;81(3):213-217. Epub 2021 Mar 9 doi: 10.1080/00365513.2021.1894601. PMID: 33685285
Evaluation of Mindray BC-5000 hematology analyzer: a new miniature 5-part WBC differential instrument.
Xiang D, Yue J, Lan Y, Sha C, Ren S, Li Y, Li M, Wang C
Int J Lab Hematol 2015 Oct;37(5):597-605. Epub 2015 May 5 doi: 10.1111/ijlh.12370. PMID: 25944368
Low serum neutrophil count predicts a positive prostate biopsy.
Fujita K, Imamura R, Tanigawa G, Nakagawa M, Hayashi T, Kishimoto N, Hosomi M, Yamaguchi S
Prostate Cancer Prostatic Dis 2012 Dec;15(4):386-90. Epub 2012 Jul 10 doi: 10.1038/pcan.2012.27. PMID: 22777394
Prognostic factors in chronic myeloid leukaemia.
Hernández-Boluda JC, Cervantes F
Best Pract Res Clin Haematol 2009 Sep;22(3):343-53. doi: 10.1016/j.beha.2009.04.005. PMID: 19959085
Prevalence and clinical characteristics of myelodysplastic syndrome with bone marrow eosinophilia or basophilia.
Matsushima T, Handa H, Yokohama A, Nagasaki J, Koiso H, Kin Y, Tanaka Y, Sakura T, Tsukamoto N, Karasawa M, Itoh K, Hirabayashi H, Sawamura M, Shinonome S, Shimano S, Miyawaki S, Nojima Y, Murakami H
Blood 2003 May 1;101(9):3386-90. Epub 2002 Dec 27 doi: 10.1182/blood-2002-03-0947. PMID: 12506028

Clinical prediction guides

Shared Genetic Loci Between Schizophrenia and White Blood Cell Counts Suggest Genetically Determined Systemic Immune Abnormalities.
Steen NE, Rahman Z, Szabo A, Hindley GFL, Parker N, Cheng W, Lin A, O'Connell KS, Sheikh MA, Shadrin A, Bahrami S, Karthikeyan S, Hoseth EZ, Dale AM, Aukrust P, Smeland OB, Ueland T, Frei O, Djurovic S, Andreassen OA
Schizophr Bull 2023 Sep 7;49(5):1345-1354. doi: 10.1093/schbul/sbad082. PMID: 37319439Free PMC Article
Effects of Different Kinds of Hand Sanitizers on Complete Blood Count and Leukocyte Differential Count.
Li Z, Yang S, Yang B, Ding J, Cui L
Clin Lab 2022 Aug 1;68(8) doi: 10.7754/Clin.Lab.2021.211005. PMID: 35975494
Epidemiological and clinical implications of asymptomatic malaria and schistosomiasis co-infections in a rural community in western Kenya.
Kamau E, Yates A, Maisiba R, Singoei V, Opot B, Adeny R, Arima CO, Otieno V, Sumbi CS, Okoth RO, Abdi F, Mwalo M, Ochola J, Otieno J, Ake J, Imbach M, Turley HA, Juma D, Akala HM, Owuoth J, Andagalu B, Crowell TA, Nwoga C, Cowden J, Polyak CS; RV393 Study Group
BMC Infect Dis 2021 Sep 9;21(1):937. doi: 10.1186/s12879-021-06626-2. PMID: 34503469Free PMC Article
Clinical relevance of eosinophils, basophils, serum total IgE level, allergen-specific IgE, and clinical features in atopic dermatitis.
Hu Y, Liu S, Liu P, Mu Z, Zhang J
J Clin Lab Anal 2020 Jun;34(6):e23214. Epub 2020 Feb 18 doi: 10.1002/jcla.23214. PMID: 32068307Free PMC Article
Prognostic factors in chronic myeloid leukaemia.
Hernández-Boluda JC, Cervantes F
Best Pract Res Clin Haematol 2009 Sep;22(3):343-53. doi: 10.1016/j.beha.2009.04.005. PMID: 19959085

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