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Abnormal mast cell morphology

MedGen UID:
722854
Concept ID:
C1301149
Anatomical Abnormality
Synonyms: Abnormality of mast cells; Abnormality of mastocytes; Mast cell abnormality
SNOMED CT: Mast cell abnormality (397017008)
 
HPO: HP:0100494

Definition

Any structural anomaly of mast cells, which are found in almost all tissues and contain numerous basophilic granules and are capable of releasing large amounts of histamine and heparin upon activation. [from HPO]

Professional guidelines

PubMed

Valent P, Hartmann K, Schwaab J, Alvarez-Twose I, Brockow K, Bonadonna P, Hermine O, Niedoszytko M, Carter MC, Hoermann G, Sperr WR, Butterfield JH, Ustun C, Zanotti R, Radia DH, Castells M, Triggiani M, Schwartz LB, Orfao A, George TI, Sotlar K, Gotlib J, Reiter A, Horny HP, Arock M, Akin C, Metcalfe DD
J Allergy Clin Immunol Pract 2022 Aug;10(8):1999-2012.e6. Epub 2022 Mar 25 doi: 10.1016/j.jaip.2022.03.007. PMID: 35342031
Pardanani A
Am J Hematol 2021 Apr 1;96(4):508-525. Epub 2021 Feb 21 doi: 10.1002/ajh.26118. PMID: 33524167
Weiler CR, Butterfield J
Immunol Allergy Clin North Am 2014 May;34(2):423-32. Epub 2014 Mar 13 doi: 10.1016/j.iac.2014.01.004. PMID: 24745684

Recent clinical studies

Etiology

Pardanani A
Am J Hematol 2021 Apr 1;96(4):508-525. Epub 2021 Feb 21 doi: 10.1002/ajh.26118. PMID: 33524167
VAN Gysel D, DE Maeseneer H, Oranje AP
G Ital Dermatol Venereol 2016 Aug;151(4):385-96. Epub 2016 Apr 12 PMID: 27070304
Weiler CR, Butterfield J
Immunol Allergy Clin North Am 2014 May;34(2):423-32. Epub 2014 Mar 13 doi: 10.1016/j.iac.2014.01.004. PMID: 24745684
Andersen CL, Kristensen TK, Severinsen MT, Møller MB, Vestergaard H, Bergmann OJ, Hasselbalch HC, Bjerrum OW
Dan Med J 2012 Mar;59(3):A4397. PMID: 22381091
Brockow K, Metcalfe DD
Chem Immunol Allergy 2010;95:110-124. Epub 2010 Jun 1 doi: 10.1159/000315946. PMID: 20519885Free PMC Article

Diagnosis

Natal RA, Carneiro HC, de Carvalho Barra FF, Pagnano KBB, Soares FA, Vassallo J
Hum Pathol 2022 Aug;126:55-62. Epub 2022 May 10 doi: 10.1016/j.humpath.2022.05.007. PMID: 35550832
Pardanani A
Am J Hematol 2021 Apr 1;96(4):508-525. Epub 2021 Feb 21 doi: 10.1002/ajh.26118. PMID: 33524167
Gülen T, Akin C
Curr Opin Allergy Clin Immunol 2017 Aug;17(4):295-303. doi: 10.1097/ACI.0000000000000377. PMID: 28570344
Ozdemir D, Dagdelen S, Erbas T
Am J Med Sci 2011 Nov;342(5):409-15. doi: 10.1097/MAJ.0b013e3182121131. PMID: 21629042
Craig FE, Foon KA
Blood 2008 Apr 15;111(8):3941-67. Epub 2008 Jan 15 doi: 10.1182/blood-2007-11-120535. PMID: 18198345

Therapy

Pardanani A
Am J Hematol 2021 Apr 1;96(4):508-525. Epub 2021 Feb 21 doi: 10.1002/ajh.26118. PMID: 33524167
Rajanala S, Maymone MBC, Vashi NA
Dermatol Online J 2019 Oct 15;25(10) PMID: 31735001
O'Shea KM, Aceves SS, Dellon ES, Gupta SK, Spergel JM, Furuta GT, Rothenberg ME
Gastroenterology 2018 Jan;154(2):333-345. Epub 2017 Jul 27 doi: 10.1053/j.gastro.2017.06.065. PMID: 28757265Free PMC Article
Kwon SH, Hwang YJ, Lee SK, Park KC
Int J Mol Sci 2016 May 26;17(6) doi: 10.3390/ijms17060824. PMID: 27240341Free PMC Article
Weiler CR, Butterfield J
Immunol Allergy Clin North Am 2014 May;34(2):423-32. Epub 2014 Mar 13 doi: 10.1016/j.iac.2014.01.004. PMID: 24745684

Prognosis

Pardanani A
Am J Hematol 2021 Apr 1;96(4):508-525. Epub 2021 Feb 21 doi: 10.1002/ajh.26118. PMID: 33524167
Gülen T, Akin C
Curr Opin Allergy Clin Immunol 2017 Aug;17(4):295-303. doi: 10.1097/ACI.0000000000000377. PMID: 28570344
Weiler CR, Butterfield J
Immunol Allergy Clin North Am 2014 May;34(2):423-32. Epub 2014 Mar 13 doi: 10.1016/j.iac.2014.01.004. PMID: 24745684
Andersen CL, Kristensen TK, Severinsen MT, Møller MB, Vestergaard H, Bergmann OJ, Hasselbalch HC, Bjerrum OW
Dan Med J 2012 Mar;59(3):A4397. PMID: 22381091
Ozdemir D, Dagdelen S, Erbas T
Am J Med Sci 2011 Nov;342(5):409-15. doi: 10.1097/MAJ.0b013e3182121131. PMID: 21629042

Clinical prediction guides

Zmorzynski S, Kimicka-Szajwaj A, Szajwaj A, Czerwik-Marcinkowska J, Wojcierowski J
Genes (Basel) 2024 Jan 22;15(1) doi: 10.3390/genes15010137. PMID: 38275618Free PMC Article
Bălaşa Vîrzob CR, Cloşca RM, Poenaru M, Morar R, Balica NC, Sarău CA, Ioniţă I, Baderca F
Rom J Morphol Embryol 2023 Apr-Jun;64(2):189-197. doi: 10.47162/RJME.64.2.09. PMID: 37518876Free PMC Article
Valent P, Hartmann K, Schwaab J, Alvarez-Twose I, Brockow K, Bonadonna P, Hermine O, Niedoszytko M, Carter MC, Hoermann G, Sperr WR, Butterfield JH, Ustun C, Zanotti R, Radia DH, Castells M, Triggiani M, Schwartz LB, Orfao A, George TI, Sotlar K, Gotlib J, Reiter A, Horny HP, Arock M, Akin C, Metcalfe DD
J Allergy Clin Immunol Pract 2022 Aug;10(8):1999-2012.e6. Epub 2022 Mar 25 doi: 10.1016/j.jaip.2022.03.007. PMID: 35342031
Gülen T, Akin C
Curr Opin Allergy Clin Immunol 2017 Aug;17(4):295-303. doi: 10.1097/ACI.0000000000000377. PMID: 28570344
Kwon SH, Hwang YJ, Lee SK, Park KC
Int J Mol Sci 2016 May 26;17(6) doi: 10.3390/ijms17060824. PMID: 27240341Free PMC Article

Recent systematic reviews

Andersen CL, Kristensen TK, Severinsen MT, Møller MB, Vestergaard H, Bergmann OJ, Hasselbalch HC, Bjerrum OW
Dan Med J 2012 Mar;59(3):A4397. PMID: 22381091
Ford AC, Talley NJ
J Gastroenterol 2011 Apr;46(4):421-31. Epub 2011 Feb 18 doi: 10.1007/s00535-011-0379-9. PMID: 21331765

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