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Subacute cutaneous lupus erythematosus

MedGen UID:
7403
•Concept ID:
C0024140
•
Disease or Syndrome
Synonyms: Lupus Erythematosus, Cutaneous, Subacute; Lupus Erythematosus, Subacute Cutaneous
SNOMED CT: Subacute cutaneous lupus erythematosus (239891002); SCLE - Subacute cutaneous lupus erythematosus (239891002); SACLE - Subacute cutaneous lupus erythematosus (239891002)
 
Monarch Initiative: MONDO:0015573
Orphanet: ORPHA163525

Definition

A form of cutaneous lupus erythematosus (CLE) that can present either as a non-scarring, annular photo-distributed dermatosis or psoriasiform plaques. This disorder is associated with anti-Ro/SSA antibodies and can be drug-induced. [from ORDO]

Professional guidelines

PubMed

Cutaneous Immune-Related Adverse Events Secondary to Immune Checkpoint Inhibitors and Their Management.
Pach J, Leventhal JS
Crit Rev Immunol 2022;42(4):1-20. doi: 10.1615/CritRevImmunol.2023046895. PMID: 37022356
Recognition and Management of Cutaneous Connective Tissue Diseases.
Kus KJB, LaChance AH, Vleugels RA
Med Clin North Am 2021 Jul;105(4):757-782. doi: 10.1016/j.mcna.2021.04.011. PMID: 34059249
Annular Lesions: Diagnosis and Treatment.
Trayes KP, Savage K, Studdiford JS
Am Fam Physician 2018 Sep 1;98(5):283-291. PMID: 30216021

Recent clinical studies

Etiology

Cutaneous Lupus Erythematosus: Review and Considerations for Older Populations.
Heinly B, Allenzara A, Helm M, Foulke GT
Drugs Aging 2024 Jan;41(1):31-43. Epub 2023 Nov 22 doi: 10.1007/s40266-023-01079-5. PMID: 37991658
Autoimmune Skin Conditions: Cutaneous Lupus Erythematosus.
Foulke G, Helm LA, Clebak KT, Helm M
FP Essent 2023 Mar;526:25-36. PMID: 36913660
Sjögren's syndrome.
André F, Böckle BC
J Dtsch Dermatol Ges 2022 Jul;20(7):980-1002. Epub 2022 Jul 1 doi: 10.1111/ddg.14823. PMID: 35775593Free PMC Article
An update in drug-induced subacute cutaneous lupus erythematosus.
Michaelis TC, Sontheimer RD, Lowe GC
Dermatol Online J 2017 Mar 15;23(3) PMID: 28329511
Lupus erythematosus: considerations about clinical, cutaneous and therapeutic aspects.
Moura Filho JP, Peixoto RL, Martins LG, Melo SD, Carvalho LL, Pereira AK, Freire EA
An Bras Dermatol 2014 Jan-Feb;89(1):118-25. doi: 10.1590/abd1806-4841.20142146. PMID: 24626656Free PMC Article

Diagnosis

Autoimmune Skin Conditions: Cutaneous Lupus Erythematosus.
Foulke G, Helm LA, Clebak KT, Helm M
FP Essent 2023 Mar;526:25-36. PMID: 36913660
Sjögren's syndrome.
André F, Böckle BC
J Dtsch Dermatol Ges 2022 Jul;20(7):980-1002. Epub 2022 Jul 1 doi: 10.1111/ddg.14823. PMID: 35775593Free PMC Article
Annular lichenoid diseases.
McNally MA, Farooq S, Brown AE, Rees A, Hsu S, Motaparthi K
Clin Dermatol 2022 Sep-Oct;40(5):466-479. Epub 2021 Dec 31 doi: 10.1016/j.clindermatol.2021.12.009. PMID: 34979268
Mimics of Dermatitis.
Bailiff OA, Mowad CM
Immunol Allergy Clin North Am 2021 Aug;41(3):493-515. doi: 10.1016/j.iac.2021.04.009. PMID: 34225903
Annular Lesions: Diagnosis and Treatment.
Trayes KP, Savage K, Studdiford JS
Am Fam Physician 2018 Sep 1;98(5):283-291. PMID: 30216021

Therapy

Autoimmune Skin Conditions: Cutaneous Lupus Erythematosus.
Foulke G, Helm LA, Clebak KT, Helm M
FP Essent 2023 Mar;526:25-36. PMID: 36913660
Deucravacitinib in moderate-to-severe psoriasis.
Vu A, Maloney V, Gordon KB
Immunotherapy 2022 Nov;14(16):1279-1290. Epub 2022 Nov 14 doi: 10.2217/imt-2022-0109. PMID: 36373503
Drug-induced lupus erythematosus: an update on drugs and mechanisms.
He Y, Sawalha AH
Curr Opin Rheumatol 2018 Sep;30(5):490-497. doi: 10.1097/BOR.0000000000000522. PMID: 29870500Free PMC Article
An update in drug-induced subacute cutaneous lupus erythematosus.
Michaelis TC, Sontheimer RD, Lowe GC
Dermatol Online J 2017 Mar 15;23(3) PMID: 28329511
Drug-induced subacute cutaneous lupus erythematosus.
Callen JP
Lupus 2010 Aug;19(9):1107-11. doi: 10.1177/0961203310370349. PMID: 20693204

Prognosis

Sjögren's syndrome.
André F, Böckle BC
J Dtsch Dermatol Ges 2022 Jul;20(7):980-1002. Epub 2022 Jul 1 doi: 10.1111/ddg.14823. PMID: 35775593Free PMC Article
Proton pump inhibitor induced subacute cutaneous lupus erythematosus: Clinical characteristics and outcomes.
Poh YJ, Alrashid A, Sangle SR, Higgins E, Benton E, McGibbon D, D'Cruz DP
Lupus 2022 Aug;31(9):1078-1083. Epub 2022 May 30 doi: 10.1177/09612033221104237. PMID: 35635045
Subacute cutaneous lupus erythematosus triggered after measles vaccination.
de Mattos ABN, Garbo Baroni L, Zanotto LL, Furian MEA
Lupus 2021 Apr;30(5):833-835. Epub 2021 Feb 11 doi: 10.1177/0961203321990087. PMID: 33573457
Subacute cutaneous lupus erythematosus.
Furzeland J, Malcolm P
J R Army Med Corps 2017 Apr;163(2):149-151. Epub 2016 Jun 9 doi: 10.1136/jramc-2015-000566. PMID: 27286780
Systemic lupus erythematosus.
Pearce L
Nurs Stand 2016 Jun 22;30(43):17. doi: 10.7748/ns.30.43.17.s21. PMID: 27332581

Clinical prediction guides

Deucravacitinib in moderate-to-severe psoriasis.
Vu A, Maloney V, Gordon KB
Immunotherapy 2022 Nov;14(16):1279-1290. Epub 2022 Nov 14 doi: 10.2217/imt-2022-0109. PMID: 36373503
Proton pump inhibitors-related subacute cutaneous lupus erythematosus: Clinical characteristics, management, and outcome.
Deng Z, Guo A, Wu C, Wang C
J Cosmet Dermatol 2022 Dec;21(12):7202-7208. Epub 2022 Oct 31 doi: 10.1111/jocd.15450. PMID: 36214602
Drug-induced lupus erythematosus: an update on drugs and mechanisms.
He Y, Sawalha AH
Curr Opin Rheumatol 2018 Sep;30(5):490-497. doi: 10.1097/BOR.0000000000000522. PMID: 29870500Free PMC Article
Neonatal lupus erythematosus.
Boh EE
Clin Dermatol 2004 Mar-Apr;22(2):125-8. doi: 10.1016/j.clindermatol.2003.12.019. PMID: 15234013
Subacute cutaneous lupus erythematosus.
David-Bajar KM
J Invest Dermatol 1993 Jan;100(1):2S-8S. doi: 10.1111/1523-1747.ep12355164. PMID: 8423385

Recent systematic reviews

COVID-19 and exacerbation of dermatological diseases: A review of the available literature.
Aram K, Patil A, Goldust M, Rajabi F
Dermatol Ther 2021 Nov;34(6):e15113. Epub 2021 Sep 7 doi: 10.1111/dth.15113. PMID: 34453380Free PMC Article
Systematic Review: Monoclonal Antibody-Induced Subacute Cutaneous Lupus Erythematosus.
Bolton C, Chen Y, Hawthorne R, Schepel IRM, Harriss E, Hofmann SC, Ellis S, Clarke A, Wace H, Martin B, Smith J
Drugs R D 2020 Dec;20(4):319-330. doi: 10.1007/s40268-020-00320-5. PMID: 32960413Free PMC Article
Cutaneous effects of antihypertensive drugs.
Baccino D, Merlo G, Cozzani E, Rosa GM, Tini G, Burlando M, Parodi A
G Ital Dermatol Venereol 2020 Apr;155(2):202-211. Epub 2019 Jun 12 doi: 10.23736/S0392-0488.19.06360-0. PMID: 31195782
A systematic review of drug-induced subacute cutaneous lupus erythematosus.
Lowe GC, Henderson CL, Grau RH, Hansen CB, Sontheimer RD
Br J Dermatol 2011 Mar;164(3):465-72. Epub 2011 Feb 17 doi: 10.1111/j.1365-2133.2010.10110.x. PMID: 21039412
Lupus erythematosus and other autoimmune diseases related to statin therapy: a systematic review.
Noël B
J Eur Acad Dermatol Venereol 2007 Jan;21(1):17-24. doi: 10.1111/j.1468-3083.2006.01838.x. PMID: 17207162

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